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Essaa, S. S., E. M. El-Saied, O. S. El-Tawil, M. B. Mahmoud, and S. S.AbdEl-Rahman, "Modulating effect of MgO-SiO2 nanoparticles on immunological and histopathological alterations induced by aflatoxicosis in rats", Toxicon, vol. 140, pp. 94 -104, 2017.
Essam, T., M. A. Amin, O. E. L. Tayeb, B. Mattiasson, and B. Guieysse, "Kinetics and metabolic versatility of highly tolerant phenol degrading Alcaligenes strain TW1", Journal of Hazardous Materials, vol. 173, no. 1-3: Elsevier, pp. 783–788, 2010. Abstract
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Essam, A. - S., "Iridoids from Teucrium yemense", Archives of pharmacal research, vol. 21, no. 6: The Pharmaceutical Society of Korea, pp. 785–786, 1998. Abstract
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Essam, A. - S., Abdelhady Doaa H, A. Walied, G. E. W, E. Zizy, S. Mustafa, and Engy Abdelhameed, "Proanthocyanidins rich extract of Calligonum comosum ameliorates doxorubicin-induced immunosuppression and hepatorenal toxicity,", Pharmacognosy magazine, vol. 15, issue 66, pp. 545-552, 2019.
Essam, T., M. ElRakaiby, and azza agha, "Remediation of the effect of adding cyanides on an algal/bacterial treatment of a mixture of organic pollutants in a continuous photobioreactor", Biotechnology letters, vol. 36, no. 9: Springer Netherlands, pp. 1773–1781, 2014. Abstract
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Essam, A. A., "ON RECORD VALUES OF THE POWER LOMAX DISTRIBUTION", Advances and Applications in Statistics, vol. 50, issue 6, pp. 497-515, 2017. pph-1703040-adas_-_final_version.pdf
Essam, T., M. A. Amin, O. E. L. Tayeb, B. Mattiasson, and B. Guieysse, "Kinetics and metabolic versatility of highly tolerant phenol degrading Alcaligenes strain TW1", Journal of Hazardous Materials, vol. 173, no. 1-3: Elsevier, pp. 783–788, 2010. Abstract
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Essam, M., A. Yamany, A. Hanafy, N. Morcos, D. Seoudi, and M. S. Mogawer, "APRI/P3NP: CAN IT BE AN ACCURATE MARKER FOR NONINVASIVE EVALUATION OF LIVER FIBROSIS IN CHRONIC HCV", International Journal of Advanced Research (IJAR), vol. 4, issue 7, pp. 1589-1597, 2016. 532_ijar-11387.pdf
Essam, H. M., MN Saad, MS Mabrouk, E. S. Elzanfaly, and S. M. Amer, "Optimization and validation of eco-friendly RP-HPLC and univariate spectrophotometric methods for the simultaneous determination of Fluorometholone and Tetrahydrozoline hydrochloride", Acta Chromatographica, vol. 33, no. 3, pp. 216-227, 2021. AbstractWebsite
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Essam, T., M. A. Amin, O. E. L. Tayeb, B. Mattiasson, and B. Guieysse, "Sequential photochemical–biological degradation of chlorophenols", Chemosphere, vol. 66, no. 11: Pergamon, pp. 2201–2209, 2007. Abstract
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Essam, *Asmaa M. I., Samah H. El-Bably, N. A. Shaker, and S. H.H., "Morphological and Histological Studies on the Female Oviduct of Balady Duck (Anas boschas domesticus)", International Journal of Advanced Research in Biological Sciences, vol. 3, issue 7, pp. 171-180, 2016. ijarbs25.pdf
Essam, S., N. N. Nawar, M. ElBashaar, M. Soliman, and M. Abdelfattah, "In Vitro Activity of Plazomicin among Carbapenem-resistant Enterobacteriaceae", Open Access Macedonian Journal of Medical Sciences., vol. 9, 2021.
Essam, R. M., L. A. Ahmed, R. M. Abdelsalam, and A. S. El-Khatib, "Phosphodiestrase-1 and 4 inhibitors ameliorate liver fibrosis in rats: Modulation of cAMP/CREB/TLR4 inflammatory and fibrogenic pathways.", Life sciences, vol. 222, pp. 245-254, 2019. Abstract

BACKGROUND: Phosphodiestrase (PDE) enzymes are suggested to play a leading role in fibrogenesis of liver where studies showed the possible implication of PDE 1 & 4 in liver injury proposing them as possible targets for treating liver fibrosis.

AIM: The present study was designed to investigate, for the first time, the possible therapeutic effects of selective inhibitors of PDE-1 (vinpocetine) and PDE-4 (roflumilast) in liver fibrosis induced by diethylnitrosamine (DEN) in rats.

MAIN METHODS: Rats were given DEN (100 mg/kg, i.p.) once weekly for 6 weeks to induce liver fibrosis. Vinpocetine (10 mg/kg/day) or roflumilast (0.5 mg/kg/day) was then orally administered for 2 weeks.

KEY FINDINGS: Vinpocetine significantly suppressed the contents of hydroxyproline, transforming growth factor-beta 1 (TGF-β1), nuclear factor-kappa B (NF-κB) whereas roflumilast normalized them. Moreover, tumor necrosis factor-alpha (TNF-α) content and protein expressions of toll-like receptor 4 (TLR4) and tissue inhibitor of metalloproteinase-1 (TIMP-1) were markedly decreased whereas cAMP response element binding (CREB) protein expression was significantly elevated by both treatments. Additionally, vinpocetine and roflumilast up-regulated the gene expression of bone morphogenetic protein and activin membrane-bound inhibitor (BAMBI) receptor where roflumilast showed better results. PDE1 and 4 activities were inhibited by vinpocetine and roflumilast, respectively. The superior results offered by roflumilast could be related to the higher cAMP level obtained relative to vinpocetine.

SIGNIFICANCE: Our study manifested the up-regulation of PDE enzymes (1 & 4) in liver fibrosis and addressed the therapeutic role of vinpocetine and roflumilast as PDEIs through a cAMP-mediated TLR4 inflammatory and fibrogenic signaling pathways.

Essam, A., A. S. Hamed, S. M. Youssef, and G. F. Mohamadien, "THE FIRST PHOTOMETRIC ANALYSES OF THE ALGOL BINARY SYSTEMS GSC 04328-02164 AND GSC 03164-01558", Astronomical Journal, vol. 151, issue 91, 2016. Abstract2016_the_first_photometric_analyses__of_the_algol_binary_systems_gsc_04328-02164_-_aj_151_1_19.pdf

The CCD observations for the eclipsing Algol type binary systems GSC 04328-02164 in wideband BVRcIc
filters and GSC 03164-01558 in B and I filters have been analyzed using the PHOEBE package (v 0.31a) to
determine their orbital and physical parameters. The absolute parameters and evolutionary tracks of the two
systems have been determined. The results show that the mass ratio, inclination, distance, and age for the system
GSC 04328-02164 are equal to q=0.674±0.002, i=75.997±0.022, d=375.477±4.299 pc, and
τ=26.76±15.65 ∗ 108 years, respectively. For the other system, GSC 03164-01558, q=0.941±0.006,
i=88.0484±0.030, d=444.651±9.444 pc, and τ=53.63±9.16 ∗ 108 years.

Essam, R. M., L. A. Ahmed, R. M. Abdelsalam, and A. S. El-Khatib, "Phosphodiestrase-1 and 4 inhibitors ameliorate liver fibrosis in rats: Modulation of cAMP/CREB/TLR4 inflammatory and fibrogenic pathways", Life sciences, vol. 222, issue 1, pp. 245-254, 2019.