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Taher, A., M. S. Elalfy, K. A. Zir, S. Daar, A. A. Jefri, D. Habr, U. Kriemler-Krahn, A. El-Ali, B. Roubert, and A. El-Beshlawy, "Achieving treatment goals of reducing or maintaining body iron burden with deferasirox in patients with b-thalassaemia: results from the ESCALATOR study", European Journal of Haematology, vol. 87, pp. 349-354, 2011. AbstractCU-PDF

This analysis evaluated the effects of deferasirox on liver iron concentration in moderate and heavily iron-overloaded patients with ?-thalassaemia from the ESCALATOR trial (n = 231).

Taher, A., M. S. Elalfy, K. A. Zir, S. Daar, A. A. Jefri, D. Habr, U. Kriemler-Krahn, B. Roubert, and A. El-Beshlawy, "Achieving treatment goals of reducing or maintaining body iron burden with deferasirox in patients with β-thalassaemia: results from the ESCALATOR study.", European journal of haematology, vol. 87, issue 4, pp. 349-54, 2011 Oct. Abstract

This analysis evaluated the effects of deferasirox on liver iron concentration in moderate and heavily iron-overloaded patients with β-thalassaemia from the ESCALATOR trial (n = 231). Mean liver iron concentrations (LIC) decreased significantly from 21.1 ± 8.2 to 14.2 ± 12.1 mg Fe/g dry weight (dw) at 2 yr (P < 0.001) in patients with LIC ≥ 7 mg Fe/g dw at baseline; patients with LIC < 7 mg Fe/g dw maintained these levels over the treatment period. The proportion of patients with LIC < 7 mg Fe/g dw increased from 9.4% at core baseline to 39.3% by the end of year 2. The results showed that deferasirox enabled therapeutic goals to be achieved, by maintaining LIC in patients with LIC < 7 mg Fe/g dw at a mean dose of 22.4 ± 5.2 mg/kg/d and significantly reducing LIC in patients with LIC ≥ 7 mg Fe/g dw at a mean dose of 25.7 ± 4.2 mg/kg/d, along with a manageable safety profile.

Darweesh, S. K., A. Yosry, M. Salah, N. Zayed, A. Khairy, A. B. Awad, M. Mabrouk, and A. Albuhairi, "Acoustic radiation forced impulse-based splenic prediction model using data mining for the noninvasive prediction of esophageal varices in hepatitis C virus advanced fibrosis.", European journal of gastroenterology & hepatology, vol. 31, issue 12, pp. 1533-1539, 2019. Abstract

BACKGROUND: Esophageal varices (EV) are serious complications of hepatitis C virus (HCV) cirrhosis. Endoscopic screening is expensive, invasive, and uncomfortable. Accordingly, noninvasive methods are mandatory to avoid unnecessary endoscopy. Acoustic radiation forced impulse (ARFI) imaging using point shear wave elastography as demonstrated with virtual touch quantification is a possible noninvasive EV predictor. We aimed to validate the reliability of liver stiffness (LS) and spleen stiffness (SS) by an ARFI-based study together with other noninvasive parameters for EV prediction in HCV patients. Also, we aimed to evaluate the diagnostic performance of a new simple prediction model (incorporating SS) using data mining analysis.

PATIENTS AND METHODS: This cross-sectional study included 200 HCV patients with advanced fibrosis. Labs, endoscopic, ultrasonographic, LS, and SS data were collected. Their accuracy in diagnosing EV was assessed and a data mining analysis was carried out.

RESULTS: Ninety patients (22/46% of F3/F4 patients) had EV (39/30/18/3 patients had grade I/II/III/IV, respectively). LS and SS by ARFI showed high significance in differentiating not only patients with/without EV (P = 0.000 for both) but also correlated with the grading of varices (R = 0.31 and 0.45, respectively; P = 0.000 for both). Spleen longitudinal diameter (SD), splenic vein diameter (SVD), platelets to spleen diameter ratio, LOK index, and FIB-4 score were the best ultrasonographic and biochemical predictors for the prediction of EV [area under receiver operating characteristic (AUROC) 0.79, 0.76, 0.76, 0.74, and 0.71, respectively]. SS (using ARFI) had better diagnostic performance than LS for the prediction of EV (AUROC = 0.76 and 0.70, respectively). The diagnostic performance increased using data mining to construct a simple prediction model: high probability for EV if [(SD cm) × 0.17 + (SVD mm) × 0.06 + (SS) × 0.97] more than 6.35 with AUROC 0.85.

CONCLUSION: SS by ARFI represents a reliable noninvasive tool for the prediction of EV in HCV patients, especially when incorporated into a new data mining-based prediction model.

Khairallaha, M. I., Y. N. A. L.A. Kassem, G. M. A. el Din, and M. Zekri, "Activation of migration of endogenous stem cells by erythropoietin as potential rescue for neurodegenerative diseases", Brain Research Bulletin, vol. 121, pp. 148-157, Submitted.
Ibrahim SM, A. - S. MY, A. DM, and E. - A. HS, "Activation of α7 Nicotinic Acetylcholine Receptor Ameliorates Zymosan-Induced Acute Kidney Injury in BALB/c Mice", Sci Rep. , vol. 8, issue 1, pp. 16814, 2018.
Abdelshafy, M. O. H. A. M. E. D. A., M. A. H. M. O. U. D. S. Elsaholy, and M. G. Darwish, "An Active Attack on the Token-Based Security Protocol", JOURNAL OF ENGINEERING AND APPLIED SCIENCE-CAIRO-, vol. 48, no. 2: FACULTY OF ENGINEERING CAIRO UNIVERSITY, pp. 365–384, 2001. Abstract
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Ahmed, M. H., A. AboHussien, A. El-Shafei, A. M. Darwish, and A. H. Abdel-gawad, "Active control of flexible rotors using deep reinforcement learning with application of multi-actor-critic deep deterministic policy gradient", Engineering Applications of Artificial Intelligence, vol. 124: Elsevier, pp. 106593, 2023. Abstract
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Khalafalla, M. M., E. Abdellatef, H. M. Dafalla, A. A. Nassrallah, K. M. Aboul-Enein, D. A. Lightfoot, F. E. El-Deeb, and H. A. EL-SHEMY, "Active principle from Moringa oleifera Lam leaves effective against two leukemias and a hepatocarcinoma", African Journal of Biotechnology, vol. 9, issue 49: Academic Journals (Kenya), pp. 8467-8471, 2010. Abstract
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Dahaba, M. M., and F. A. Abd-Elsayed, "THE ACTIVITY OF THE ALVEOLAR BONE DURING AND POST-EXTRUSIVE TOOTH MOVEMENT (RADIOMETRIC ANALYSIS)", Official Journal of the Egyptian Dental Association, vol. 46, no. 1, 2000. Abstract
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Rizk, S. R. Y., G. El Said, L. B. Daniels, J. C. Burns, H. El Said, K. A. Sorour, S. Gharib, and J. B. Gordon, "Acute myocardial ischemia in adults secondary to missed Kawasaki disease in childhood", The American journal of cardiology, vol. 115, no. 4: Elsevier, pp. 423–427, 2015. Abstract
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Rizk, S. R. Y., G. El Said, L. Daniels, J. C. Burns, H. El Said, K. A. Sorour, S. Gharib, and J. Gordon, "Acute myocardial ischemia in adults secondary to missed Kawasaki disease in childhood", Journal of the American College of Cardiology, vol. 63, no. 12\_S: Am Coll Cardio Found, 2014. Abstract
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Rizk, S. R. Y., G. El Said, L. B. Daniels, J. C. Burns, H. El Said, K. A. Sorour, S. Gharib, and J. B. Gordon, "Acute myocardial ischemia in adults secondary to missed Kawasaki disease in childhood.", The American journal of cardiology, vol. 115, issue 4, pp. 423-7, 2015 Feb 15. Abstract

Coronary artery aneurysms that occur in 25% of untreated Kawasaki disease (KD) patients may remain clinically silent for decades and then thrombose resulting in myocardial infarction. Although KD is now the most common cause of acquired heart disease in children in Asia, the United States, and Western Europe, the incidence of KD in Egypt is unknown. We tested the hypothesis that young adults in Egypt presenting with acute myocardial ischemia may have coronary artery lesions because of KD in childhood. We reviewed a total of 580 angiograms of patients ≤40 years presenting with symptoms of myocardial ischemia. Coronary artery aneurysms were noted in 46 patients (7.9%), of whom 9 presented with myocardial infarction. The likelihood of antecedent KD as the cause of the aneurysms was classified as definite (n = 10), probable (n = 29), or equivocal (n = 7). Compared with the definite and probable groups, the equivocal group had more traditional cardiovascular risk factors, smaller sized aneurysms, and fewer coronary arteries affected. In conclusion, in a major metropolitan center in Egypt, 6.7% of adults aged ≤40 years who underwent angiography for evaluation of possible myocardial ischemia had lesions consistent with antecedent KD. Because of the unique therapeutic challenges associated with these lesions, adult cardiologists should be aware that coronary artery aneurysms in young adults may be because of missed KD in childhood.

Lownik, J. C., A. J. Luker, S. R. Damle, L. F. Cooley, R. E. Sayed, A. Hutloff, C. Pitzalis, R. K. Martin, M. E. E. M. Shikh, and D. H. Conrad, "ADAM10-Mediated ICOS Ligand Shedding on B Cells Is Necessary for Proper T Cell ICOS Regulation and T Follicular Helper Responses", Journal of Immunology, vol. 199, issue 7, pp. 2305-2315 , 2017.
Darwish, N. R., and M. A. M. Ellatif, "Adaptation of GQM Method for Evaluating the Performance of Software Project Manager", International Journal of Computer Science and Information Security (IJCSIS) – ISSN 1947-5500, vol. 8, no. 9: International Journal of Computer Science and Information Security (IJCSIS) – ISSN 1947-5500, 2010. Abstract
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Darzi, A., M. Harfouche, T. Arayssi, S. A. Emadi, K. A. Alnaqbi, H. Badsha, F. A. Balushi, B. E. Zorkany, H. Halabi, M. Hamoudeh, et al., "Adaptation of the 2015 American College of Rheumatology Treatment Guideline for Rheumatoid Arthritis for the Eastern Mediterranian Region: an examplar of the GRADE Adolopment", Health and Quality of Life Outcomes (2017), 2017. adaptation_of_the_2015_american_college.pdf
Daghestani, L. F., L. F. Ibrahim, R. S. Al-Towirgi, and H. A. Salman, "Adapting gamified learning systems using educational data mining techniques", Computer Applications in Engineering EducationComputer Applications in Engineering Education, vol. 28, issue 3: John Wiley & Sons, Ltd, pp. 568 - 589, 2020. AbstractWebsite

Abstract Artificial intelligence (AI) provides opportunities to improve the effectiveness of e-learning by increasing students' engagement. Adaptive e-learning uses AI to support individual learners by responding to their different learning needs which can be determined by analyzing their navigation history of e-learning systems using data mining methods. Educational data mining (EDM) discovers new patterns of learning and teaching to facilitate the process of decision-making to serve education improvement. Gamification is another way of increasing students' engagement by using game elements in a nongame context. In this paper, the gamification technique and EDM methods were used in combination with adaptive learning to increase the students' engagement and learning performance. An adaptive gamified learning system (AGLS) was developed which combines gamification, classification, and adaptation techniques to increase the effectiveness of e-learning. This paper studies the impact of gamification and adaptive gamification on the effectiveness of e-learning through increasing students' engagement and learning performance. AGLS was applied to the data structure course. Results showed that adaptive gamification has a positive effect on students' engagement and learning performance compared to just gamification.

O.A.Abdallah, S. F. G. E. Din, M.M.Tohamy, F.N.Abdelmohsen, and N.N.Ismail, "Adapting healthy life style program is more effective than atorvastatin in improving sexual function in hypercholestrolemic females: A pilot prospective study", sexologies, vol. 30, issue 4, pp. e155-e161, 2021.
Faheem, M. S. S., N. Ghanem, A. Gad, R. Procházka, and S. M. M. Dessouki, "Adaptive and Biological Responses of Buffalo Granulosa Cells Exposed to Heat Stress Under In Vitro Condition", Animals, vol. 11, no. 3, 2021. AbstractWebsite

The steroidogenesis capacity and adaptive response of follicular granulosa cells (GCs) to heat stress were assessed together with the underlying regulating molecular mechanisms in Egyptian buffalo. In vitro cultured GCs were exposed to heat stress treatments at 39.5, 40.5, or 41.5 °C for the final 24 h of the culture period (7 days), while the control group was kept under normal conditions (37 °C). Comparable viability was observed between the control and heat-treated GCs at 39.5 and 40.5 °C. A higher release of E2, P4 and IGF-1 was observed in the 40.5 °C group compared with the 39.5 or 41.5 °C groups. The total antioxidant capacity was higher in response to heat stress at 39.5 °C. At 40.5 °C, a significant upregulation pattern was found in the expression of the stress resistance transcripts (SOD2 and NFE2L2) and of CPT2. The relative abundance of ATP5F1A was significantly downregulated for all heat-treated groups compared to the control, while TNFα was downregulated in GCs at 39.5 °C. Expression analyses of stress-related miRNAs (miR-1246, miR-181a and miR-27b) exhibited a significant downregulation in the 40.5 °C group compared to the control, whereas miR-708 was upregulated in the 39.5 and 40.5 °C groups. In conclusion, buffalo GCs exhibited different adaptive responses, to the different heat stress conditions. The integration mechanism between the molecular and secretory actions of the GCs cultured at 40.5 °C might provide possible insights into the biological mechanism through which buffalo GCs react to heat stress.

Faheem, M. S., N. Ghanem, A. Gad, R. Procházka, and S. M. Dessouki, "Adaptive and Biological Responses of Buffalo Granulosa Cells Exposed to Heat Stress under In Vitro Condition", animals, vol. 11, pp. 1-13, 2021. animals-2021.pdf
Faheem, M. S., N. Ghanem, A. Gad, R. Procházka, and S. M. Dessouki, "Adaptive and Biological Responses of Buffalo Granulosa Cells Exposed to Heat Stress under In Vitro Condition.", Animals : an open access journal from MDPI, vol. 11, issue 3, 2021. Abstract

The steroidogenesis capacity and adaptive response of follicular granulosa cells (GCs) to heat stress were assessed together with the underlying regulating molecular mechanisms in Egyptian buffalo. In vitro cultured GCs were exposed to heat stress treatments at 39.5, 40.5, or 41.5 °C for the final 24 h of the culture period (7 days), while the control group was kept under normal conditions (37 °C). Comparable viability was observed between the control and heat-treated GCs at 39.5 and 40.5 °C. A higher release of E2, P4 and IGF-1 was observed in the 40.5 °C group compared with the 39.5 or 41.5 °C groups. The total antioxidant capacity was higher in response to heat stress at 39.5 °C. At 40.5 °C, a significant upregulation pattern was found in the expression of the stress resistance transcripts ( and ) and of . The relative abundance of was significantly downregulated for all heat-treated groups compared to the control, while was downregulated in GCs at 39.5 °C. Expression analyses of stress-related miRNAs (miR-1246, miR-181a and miR-27b) exhibited a significant downregulation in the 40.5 °C group compared to the control, whereas miR-708 was upregulated in the 39.5 and 40.5 °C groups. In conclusion, buffalo GCs exhibited different adaptive responses, to the different heat stress conditions. The integration mechanism between the molecular and secretory actions of the GCs cultured at 40.5 °C might provide possible insights into the biological mechanism through which buffalo GCs react to heat stress.

Ammar, M., and G. Dumont, "Adaptive cross-directional loop-shaping using spatial transfer functions", The proceedings of the 2008 Control Systems Pan-Pacific Conference, Vancouver, Canada., 2008. Abstract
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Ding, X., D. Dutta, A. M. Mahmoud, B. Tillman, S. Leers, and K. Kim, "An adaptive displacement estimation algorithm for improved reconstruction of thermal strain", IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 62, issue 1, pp. 138 - 151, 2015.