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2023
Dabbous, AO, El Bohy, Z., Helal, A., and H. S. Hamdy, "Age effects on frequency amplitude ratio of cVEMP.", EJO, vol. 39, issue 28, pp. 1-12, 2023. age_effects_on_frequency_amplitude_ratio_of_cvemp.pdfWebsite
Hassan, S., S. S. Tahoun, M. Darwish, W. Bosworth, and A. E. Radwan, "The Albian–Cenomanian boundary on the southern Tethyan margin: Abu Gharadig Basin, Northern Western Desert, Egypt", Marine and Petroleum Geology, vol. 154, pp. 106334, 2023.
Omar, A. R., A. A. Nour, and A. E. Dakrory, "Amelioration of silymarin against cadmium-induced toxicity in pregnant rats and their fetuses", Birth Defects Research, vol. 115, issue 3, pp. 1192–1207, 2023.
Omar, A. R., A. A. Nour, and A. E. Dakrory, "Amelioration of silymarin against cadmium-induced toxicity in pregnant rats and their fetuses", Birth Defects Research, vol. 115, 2023.
Atef, I., W. Ahmed, A. M. Senousi, M. Baraka, and W. Darwish, "Analysis of Urban Heat Island Phenomenon in Fayoum Governorate Using Google Earth Engine and Terra-MODIS Satellite Technology", 2023 2nd International Conference on Smart Cities 4.0, pp. 324-327, 2023. Abstract
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Ahmed, O. M., A. A. Abdel Fattah, M. Abdul-Hamid, A. M. Abdel-Aziz, H. I. Sakr, A. A. Damanhory, S. H. Abdel-Kawi, N. Ghaboura, and M. M. Y. Awad, "Antidiabetic and Liver Histological and Ultrastructural Effects of Leaf and Flower Head Hydroethanolic Extracts in Nicotinamide/Streptozotocin-Induced Diabetic Rats.", Evidence-based complementary and alternative medicine : eCAM, vol. 2023, pp. 4223026, 2023. Abstract

This study aims to investigate the effect of hydroethanolic extracts of leaf (CLHE) and flower (CFHE) on the hepatic histopathological lesions and functional biochemical changes induced by type 2 diabetes mellitus (T2DM). The rat model of T2DM was induced by intraperitoneal injection of streptozotocin (STZ) in a dose of 60 mg/kg for 15 minutes following nicotinamide (NA) (60 mg/kg). The rats were allocated into four groups: group 1 (negative control), group 2 (diabetic control), group 3 (diabetic rats supplemented with 100 mg/kg/day CLHE), and group 4 (diabetic rats supplemented with 100 mg/kg/day CFHE). Treatment with CLHE and CFHE, for the study duration of 28 days, significantly improved the deteriorated hepatic glycogen content, glycogen phosphorylase, glucose-6-phosphatase activities, serum fructosamine levels, lipid profile, aspartate transaminase activities, and alanine transaminase activities as well as serum insulin and C-peptide levels. The elevated liver lipid peroxidation and the decreased activities of superoxide dismutase and glutathione peroxidase were significantly alleviated. The elevated expression of the proinflammatory cytokine tumor necrosis factor- in the liver of diabetic rats was significantly reduced by treatments with CLHE and CFHE. NA/STZ-induced T2DM exhibited hepatic histopathological changes in the form of disordered hepatocytes, cytoplasm dissolution, and mononuclear leukocytic infiltration. The electron microscopic ultrastructure study revealed damaged mitochondria with ill-defined cristae and fragmentation of the rough endoplasmic reticulum. Treatments with CLHE and CFHE remarkably amended these histopathological and EM ultrastructural changes. In conclusion, both CLHE and CFHE may have antidiabetic and improvement effects on the liver function and structural integrity, which may be mediated, at least in part, suppression of inflammation and oxidative stress and enhancement of the antioxidant defence system.

Mohamed, A. H. A., I. H. Mahmoud, H. M. S. E. Dein, H. S. Wahba, and K. R. Sallam, Assessment of the validity of image-defined risk factors (IDRFs) in abdominal neuroblastoma, , Cairo, Cairo University, 2023.
Hamaky, A., M. A. Dina, A. A. Khalil, M. N. Elbahrawy, A. E. Elerian, and D. S. Abd Allah, "Athletes Trunk Proprioceptive Ability Versus Non athletes", The Egyptian Journal of Hospital Medicine, vol. 91, no. 1: Pan Arab League of Continuous Medical Education, pp. 4644–4647, 2023. Abstract
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Dawood, H., and N. Megahed, "Automatic Differentiation of Uncertainties: An Interval Computational Differentiation for First and Higher Derivatives with Implementation", PeerJ Computer Science, vol. 9, issue 5, pp. e1301, 2023. AbstractWebsite

Acquiring reliable knowledge amidst uncertainty is a topical issue of modern science. Interval mathematics has proved to be of central importance in coping with uncertainty and imprecision. Algorithmic differentiation, being superior to both numeric and symbolic differentiation, is nowadays one of the most celebrated techniques in the field of computational mathematics. In this connexion, laying out a concrete theory of interval differentiation arithmetic, combining subtlety of ordinary algorithmic differentiation with power and reliability of interval mathematics, can extend real differentiation arithmetic so markedly both in method and objective, and can so far surpass it in power as well as applicability. This article is intended to lay out a systematic theory of dyadic interval differentiation numbers that wholly addresses first and higher order automatic derivatives under uncertainty. We begin by axiomatizing a differential interval algebra and then we present the notion of an interval extension of a family of real functions, together with some analytic notions of interval functions. Next, we put forward an axiomatic theory of interval differentiation arithmetic, as a two-sorted extension of the theory of a differential interval algebra, and provide the proofs for its categoricity and consistency. Thereupon, we investigate the ensuing structure and show that it constitutes a multiplicatively non-associative S-semiring in which multiplication is subalternative and flexible. Finally, we show how to computationally realize interval automatic differentiation. Many examples are given, illustrating automatic differentiation of interval functions and families of real functions.

Dawood, H., and N. Megahed, "Automatic Differentiation of Uncertainties: An Interval Computational Differentiation for First and Higher Derivatives with Implementation", PeerJ Computer Science, vol. 9, issue 5, pp. e1301, 2023. Abstractpeerjcs1301_dawood.pdfWebsite

Acquiring reliable knowledge amidst uncertainty is a topical issue of modern science. Interval mathematics has proved to be of central importance in coping with uncertainty and imprecision. Algorithmic differentiation, being superior to both numeric and symbolic differentiation, is nowadays one of the most celebrated techniques in the field of computational mathematics. In this connexion, laying out a concrete theory of interval differentiation arithmetic, combining subtlety of ordinary algorithmic differentiation with power and reliability of interval mathematics, can extend real differentiation arithmetic so markedly both in method and objective, and can so far surpass it in power as well as applicability. This article is intended to lay out a systematic theory of dyadic interval differentiation numbers that wholly addresses first and higher order automatic derivatives under uncertainty. We begin by axiomatizing a differential interval algebra and then we present the notion of an interval extension of a family of real functions, together with some analytic notions of interval functions. Next, we put forward an axiomatic theory of interval differentiation arithmetic, as a two-sorted extension of the theory of a differential interval algebra, and provide the proofs for its categoricity and consistency. Thereupon, we investigate the ensuing structure and show that it constitutes a multiplicatively non-associative S-semiring in which multiplication is subalternative and flexible. Finally, we show how to computationally realize interval automatic differentiation. Many examples are given, illustrating automatic differentiation of interval functions and families of real functions.

Khaled, A. M., A. O. Dabbous, A. F. A. Hady, D. M. A. Sabour, and R. A. Koura, "Behavioral Temporal Auditory Processing Tests in Adult Stutterers", EJENTAS, vol. 24, issue 4, pp. 1-10, 2023.
Duan, C., M. Zhao, R. El-Bashar, S. S. A. Obayya, M. Hameed, and J. Dai, "Bottom interface passivation with benzylamine thiocyanate for improving the performance of inverted perovskite solar cells‏ ", Solid-State Electronics, vol. Volume 210, pp. 108799, 2023.
Sayed, A. A., A. M. Soliman, M. Marzouk, F. F. Mohammed, and S. Desouky, "Bromelain mitigates liver fibrosis via targeting hepatic stellate cells in vitro and in vivo", Tissue and Cell, vol. 82, issue 102118, 2023.
Hemida, M. H., H. Moustafa, S. Mehanny, M. Morsy, A. Dufresne, E. A. E. L. N. Rahman, and M. M. Ibrahim, "Cellulose nanocrystals from agricultural residues (Eichhornia crassipes): Extraction and characterization", Heliyon, vol. 9, no. 6: Elsevier, 2023. Abstract
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Hemida‎, M. H., H. M. ‎ M. H., S. Mehanny, M. Morsy, A. Dufresne, E. A. E. L. N. Rahman‎, and M. M. Ibrahim, "Cellulose nanocrystals from agricultural residues (Eichhornia ‎crassipes): Extraction and characterization‎", Heliyon‎, vol. 9, issue 6, 2023.
Hawary, R. E., S. Meshaal, S. Lotfy, D. A. Elaziz, R. Alkady, A. Eldash, A. Erfan, E. Chohayeb, M. Saad, R. Darwish, et al., "Cernunnos deficiency: Further delineation in 5 Egyptian patients.", European journal of medical genetics, vol. 66, issue 10, pp. 104840, 2023. Abstract

Cernunnos deficiency is a rare genetic disorder characterized by immunodeficiency, microcephaly, growth retardation, bird-like facies, sensitivity to ionizing radiation, few autoimmune manifestations, premature aging of hematopoietic stem cells at an early age, and occasional myeloproliferative disease. Herein we present five Egyptian Cernunnos patients from 3 different families. We describe the patients' clinical phenotypes, their immunological profile as well as genetic results. Sequence analysis revealed three different mutations in the NHEJ1 gene: a nonsense variant c.532C > T; p.(Arg178Ter), an intronic variant c.178-1G > A and a frameshift insertion variant c.233dup; p.(Asn78LysfsTer14). In conclusion, Cernunnos deficiency can have a wide range of clinical features. The characteristic immune profile including a decrease in recent thymic emigrants and naive T cells, markedly elevated memory T cells together with normal to high IgM, and a decrease in IgG and IgA. This immune profile is highly suggestive of Cernunnos deficiency in T-B-NK + SCID patients especially surviving for older ages.

Dlamini, N. H., T. Nguyen, A. Gad, D. Tesfaye, S. F. Liao, S. T. Willard, P. L. Ryan, and J. M. Feugang, "Characterization of Extracellular Vesicle-Coupled miRNA Profiles in Seminal Plasma of Boars with Divergent Semen Quality Status", International Journal of Molecular Sciences, vol. 24, no. 4, 2023. AbstractWebsite

Sperm heterogeneity creates challenges for successful artificial insemination. Seminal plasma (SP) surrounding sperm is an excellent source for detecting reliable non-invasive biomarkers of sperm quality. Here, we isolated microRNAs (miRNAs) from SP-derived extracellular vesicles (SP-EV) of boars with divergent sperm quality statuses. Raw semen from sexually mature boars was collected for eight weeks. Sperm motility and normal morphology were analyzed, and the sperm was classified as poor- or good-quality based on standard cutoffs of 70% for the parameters measured. SP-EVs were isolated by ultracentrifugation and confirmed by electron microscopy, dynamic light scattering, and Western immunoblotting. The SP-EVs were subjected to total exosome RNA isolation, miRNA sequencing, and bioinformatics analysis. The isolated SP-EVs were round spherical structures approximately 30–400 nm in diameter expressing specific molecular markers. miRNAs were detected in both poor- (n = 281) and good (n = 271)-quality sperm, with fifteen being differentially expressed. Only three (ssc-miR-205, ssc-miR-493-5p, and ssc-miR-378b-3p) allowed gene targeting associated with cellular localization (nuclear and cytosol) and molecular functions (acetylation, Ubl conjugation, and protein kinase binding), potentially impairing sperm quality. PTEN and YWHAZ emerged as essential proteins for protein kinase binding. We conclude that SP-EV-derived miRNAs reflect boar sperm quality to enable therapeutic strategies to improve fertility.

MOHAMAD, E. B. T. E. S. A. M. A., A. M. Gad, R. A. H. El-Rhman, and M. M. Darwish, "Chitosan and Aloe Vera decorated nanoparticulate system loaded with Minoxidil as a suggested topical formulation for alopecia therapy", Adv. Nat. Sci: Nanosci. Nanotechnol, vol. 14, issue 025002, 2023.
MOHAMAD, E. B. T. E. S. A. M. A., A. M. Shehata, A. M. Abobah, A. T. Kholief, M. A. Ahmed, M. E. Abdelhakeem, N. K. Dawood, and H. S. Mohammed, "Chitosan-based films blended with moringa leaves and MgO nanoparticles for application in active food packaging", International Journal of Biological Macromolecules, vol. 253: Elsevier, pp. 127045, 2023. Abstract
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Safir, F., N. Vu, L. F. Tadesse, K. Firouzi, N. Banaei, S. S. Jeffrey, A. A. E. Saleh, B. P. T. Khuri-Yakub, and J. A. Dionne, "Combining Acoustic Bioprinting with AI-Assisted Raman Spectroscopy for High-Throughput Identification of Bacteria in Blood.", Nano letters, vol. 23, issue 6, pp. 2065-2073, 2023. Abstract

Identifying pathogens in complex samples such as blood, urine, and wastewater is critical to detect infection and inform optimal treatment. Surface-enhanced Raman spectroscopy (SERS) and machine learning (ML) can distinguish among multiple pathogen species, but processing complex fluid samples to sensitively and specifically detect pathogens remains an outstanding challenge. Here, we develop an acoustic bioprinter to digitize samples into millions of droplets, each containing just a few cells, which are identified with SERS and ML. We demonstrate rapid printing of 2 pL droplets from solutions containing , , and blood; when they are mixed with gold nanorods (GNRs), SERS enhancements of up to 1500× are achieved.We then train a ML model and achieve ≥99% classification accuracy from cellularly pure samples and ≥87% accuracy from cellularly mixed samples. We also obtain ≥90% accuracy from droplets with pathogen:blood cell ratios <1. Our combined bioprinting and SERS platform could accelerate rapid, sensitive pathogen detection in clinical, environmental, and industrial settings.

Lefrant, J. - Y., D. Benhamou, M. - O. Fischer, R. Pirracchio, B. Allaouchiche, S. Bastide, M. Biais, A. Blet, L. Bouvet, O. Brissaud, et al., "Comments on: Reducing the Risks of Nuclear War-The Role of Health Professionals.", Anaesthesia, critical care & pain medicine, pp. 101314, 2023.
Deng, T., J. Wu, H. Abdel-Shafy, X. Wang, H. Lv, A. Shaukat, X. Zhou, Y. Zhou, H. Sun, P. Wei, et al., "Comparative Genomic Analysis of the Thiolase Family and Functional Characterization of the Acetyl-Coenzyme A Acyltransferase-1 Gene for Milk Biosynthesis and Production of Buffalo and Cattle.", Journal of agricultural and food chemistry, vol. 71, issue 7, pp. 3325-3337, 2023. Abstract

Cattle and buffalo served as the first and second largest dairy animals, respectively, providing 96% milk products worldwide. Understanding the mechanisms underlying milk synthesis is critical to develop the technique to improve milk production. Thiolases, also known as acetyl-coenzyme A acetyltransferases (ACAT), are an enzyme family that plays vital roles in lipid metabolism, including ACAT1, ACAT2, ACAA1, ACAA2, and HADHB. Our present study showed that these five members were orthologous in six livestock species including buffalo and cattle. Transcriptomic data analyses derived from different lactations stages showed that displayed different expression patterns between buffalo and cattle. Immunohistochemistry staining revealed that ACAA1 were dominantly located in the mammary epithelial cells of these two dairy animals. Knockdown of inhibited mammary epithelial cell proliferation and triglyceride and β-casein secretion by regulating related gene expressions in cattle and buffalo. In contrast, overexpression promoted cell proliferation and triglyceride secretion. Finally, three novel SNPs (g.-681A>T, g.-23117C>T, and g.-24348G>T) were detected and showed significant association with milk production traits of Mediterranean buffaloes. In addition, g.-681A>T mutation located in the promoter region changed transcriptional activity significantly. Our findings suggested that play a key role in regulating buffalo and cattle milk synthesis and provided basic information to further understand the dairy animal lactation physiology.

Darwish, M. H., M. S. El-Tamawy, H. M. Elsharkawy, F. Ali, and H. A. Khalifa, "CORRELATION BETWEEN LEG MUSCLE ACTIVITY AND BALANCE IN STROKE PATIENTS", Eur. Chem. Bull, vol. 12, issue Special Issue 1, Part-B, pp. 2089-2092 , 2023. b2402ee81f2a2766fa4f54db189a535e.pdf
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