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Saad, W. E., A. M. Fischman, G. Frey, D. B. Brown, R. Schenning, S. Kim, S. P. Kalva, S. Dariushnia, C. Wagner, and S. G. Naidu, "9: 04 AM Abstract No. 125-Balloon-occluded retrograde transvenous obliteration (BRTO) utilizing 3% sodium tetradecyl sulfate (STS)(3%) foam for the management of gastric variceal bleeding: a multicenter USA study of 100 patients", Journal of Vascular and Interventional Radiology, vol. 24, issue 4: Elsevier, pp. S62-S63, 2013. Abstract
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Torres, V. J., A. S. Attia, W. J. Mason, M. I. Hood, B. D. Corbin, F. C. Beasley, K. L. Anderson, D. L. Stauff, W. H. McDonald, L. J. Zimmerman, et al., "Staphylococcus aureus fur regulates the expression of virulence factors that contribute to the pathogenesis of pneumonia", Infection and immunity, 2010/01/27, vol. 78, no. 4, pp. 1618-28, Apr, 2010. AbstractWebsite

The tremendous success of Staphylococcus aureus as a pathogen is due to the controlled expression of a diverse array of virulence factors. The effects of host environments on the expression of virulence factors and the mechanisms by which S. aureus adapts to colonize distinct host tissues are largely unknown. Vertebrates have evolved to sequester nutrient iron from invading bacteria, and iron availability is a signal that alerts pathogenic microorganisms when they enter the hostile host environment. Consistent with this, we report here that S. aureus senses alterations in the iron status via the ferric uptake regulator (Fur) and alters the abundance of a large number of virulence factors. These Fur-mediated changes protect S. aureus against killing by neutrophils, and Fur is required for full staphylococcal virulence in a murine model of infection. A potential mechanistic explanation for the impact of Fur on virulence is provided by the observation that Fur coordinates the reciprocal expression of cytolysins and a subset of immunomodulatory proteins. More specifically, S. aureus lacking fur exhibits decreased expression of immunomodulatory proteins and increased expression of cytolysins. These findings reveal that Fur is involved in initiating a regulatory program that organizes the expression of virulence factors during the pathogenesis of S. aureus pneumonia.

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Abou-Leila, H., H. A. Ismail, S. M. Darwish, M. Kamel, and E. M. Ashry, ""A Method to Evaluate the Dependence of Ge(Li) Spectrometer Efficiency Slopes on the Counting Rate and Source-to-Detector Distances"", ATOMKERNENERGIE, vol. 33, issue 5, pp. 50-51, 1979.
Abou-Leila, H., H. A. Ismail, H. Hanafi, E. A. Kamhawy, S. M. Darwish, and A. E. A. Makssoud, ""A. 1391.35 KeV Level in 160Dy"", Arab Journal of Nuclear Science and Applications, vol. 11, issue 2, pp. 259-270, 1978.
Atta, H., L. Damiati, M. Alkaff, M. Abbas, M. Kotb, G. Karrouf, and S. Mahfouz, "AB0102 Cartilage Paste Impregnated with Mesenchymal Stem Cells (MSCS) Repair Focal Articular Cartilage Defects in Rabbits", Annals of the Rheumatic Diseases, vol. 74, no. Suppl 2: BMJ Publishing Group Ltd and European League Against Rheumatism, pp. 925–925, 2015. Abstract
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McGovern, R., D. Edgeworth, M. Hashim, A. Duggan, F. Irwin, W. Lan, and D. Harmon, AB213. 26. Uncertainty and chronic pain, , vol. 2, pp. AB213 - AB213, 2018/02/01. Abstract
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Asnafi, N., T. Balakrishna Bhat, Z. Ben-Liam, T. Besshi, B. Carlsson, C. S. Chang, S. L. Chen, A. P. Cherrill, J. S. Choi, J. Danckert, et al., "Abdel-Hamid, A., 97", Journal of Materials Processing Technology, vol. 73, pp. 303, 1998. Abstract
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Petit, J. Y., M. Rietjens, C. Garusi, A. Giraldo, F. De Lorenzi, P. Rey, E. C. Millen, B. P. da Silva, R. Bosco, and O. Youssef, "Abdominal complications and sequelae after breast reconstruction with pedicled TRAM flap: is there still an indication for pedicled TRAM in the year 2003?", Plastic and reconstructive surgery, vol. 112, no. 4: LWW, pp. 1063–1065, 2003. Abstract
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Mansour, W. Y., N. V. Bogdanova, U. Kasten-Pisula, T. Rieckmann, S. Kocher, K. Borgmann, M. Baumann, M. Krause, C. Petersen, H. Hu, et al., "Aberrant overexpression of miR-421 downregulates ATM and leads to a pronounced DSB repair defect and clinical hypersensitivity in SKX squamous cell carcinoma", Radiother Oncol, 2012/12/04, vol. 106, no. 1, pp. 147-54, Jan, 2013. Abstractmansour_2013.pdfWebsite

BACKGROUND: Cellular and clinical sensitivity to ionizing radiation (IR) is determined by DNA double-strand breaks (DSB) repair. Here, we investigate the molecular mechanism underlying the extreme response of a head and neck tumor case (SKX) to standard radiotherapy. METHODS: Immunofluorescence (IF) was used for the assessment of DSB repair, Western blot and real-time PCR for protein and mRNA expression, respectively. RESULTS: SKX cells exhibited a pronounced radiosensitivity associated with numerous residual gamma-H2AX foci after IR. This was not associated with lacking canonical repair proteins. SKX cells did not express any ATM protein. Accordingly, immunoblotting revealed no ATM kinase activity toward substrates such as p-SMC1, p-CHK2 and p-KAP1. Sequencing of all 66 exons of ATM showed no mutation. ATM mRNA level was moderately reduced, which could be reverted by 5'-Aza-C treatment but without restoring protein levels. Importantly, we demonstrated a post-transcriptional regulation in SKX cells via 6-fold enhanced levels of miR-421, which targets the 3'-UTR of ATM mRNA. Transfection of SKX cells with either anti-miR-421 inhibitor or a microRNA-insensitive ATM vector recovered ATM expression and abrogated the hyper-radiosensitivity. CONCLUSION: This is the first report describing microRNA-mediated down-regulation of ATM leading to clinically manifest tumor radiosensitivity.

Mansour, W. Y., N. V. Bogdanova, U. Kasten-Pisula, T. Rieckmann, S. Köcher, K. Borgmann, M. Baumann, M. Krause, C. Petersen, H. Hu, et al., "Aberrant overexpression of miR-421 downregulates ATM and leads to a pronounced DSB repair defect and clinical hypersensitivity in SKX squamous cell carcinoma.", Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, vol. 106, issue 1, pp. 147-54, 2013 Jan. Abstract

BACKGROUND: Cellular and clinical sensitivity to ionizing radiation (IR) is determined by DNA double-strand breaks (DSB) repair. Here, we investigate the molecular mechanism underlying the extreme response of a head and neck tumor case (SKX) to standard radiotherapy.

METHODS: Immunofluorescence (IF) was used for the assessment of DSB repair, Western blot and real-time PCR for protein and mRNA expression, respectively.

RESULTS: SKX cells exhibited a pronounced radiosensitivity associated with numerous residual γ-H2AX foci after IR. This was not associated with lacking canonical repair proteins. SKX cells did not express any ATM protein. Accordingly, immunoblotting revealed no ATM kinase activity toward substrates such as p-SMC1, p-CHK2 and p-KAP1. Sequencing of all 66 exons of ATM showed no mutation. ATM mRNA level was moderately reduced, which could be reverted by 5'-Aza-C treatment but without restoring protein levels. Importantly, we demonstrated a post-transcriptional regulation in SKX cells via 6-fold enhanced levels of miR-421, which targets the 3'-UTR of ATM mRNA. Transfection of SKX cells with either anti-miR-421 inhibitor or a microRNA-insensitive ATM vector recovered ATM expression and abrogated the hyper-radiosensitivity.

CONCLUSION: This is the first report describing microRNA-mediated down-regulation of ATM leading to clinically manifest tumor radiosensitivity.

Mansour, W. Y., K. Borgmann, C. Petersen, E. Dikomey, and J. Dahm-Daphi, "The absence of Ku but not defects in classical non-homologous end-joining is required to trigger PARP1-dependent end-joining.", DNA repair, vol. 12, issue 12, pp. 1134-42, 2013 Dec. Abstract

Classical-non-homologous end-joining (C-NHEJ) is considered the main pathway for repairing DNA double strand breaks (DSB) in mammalian cells. When C-NHEJ is defective, cells may switch DSB repair to an alternative-end-joining, which depends on PARP1 and is more erroneous. This PARP1-EJ is suggested to be active especially in tumor cells contributing to their genomic instability. Here, we define conditions under which cells would switch the repair to PARP1-EJ. Using the end jining repair substrate pEJ, we revealed that PARP1-EJ is solely used when Ku is deficient but not when either DNA-PKcs or Xrcc4 is lacking. In the latter case, DSB repair, however, could be shuttled to PARP1-EJ after additional Ku80 down-regulation, which partly rescued the DSB repair in these mutants. We demonstrate here that PARP-EJ may work on DSB ends at high fidelity manner, as evident from the unchanged efficiency upon blocking end resection by either roscovitin or mirin. Furthermore, we demonstrate for that PARP-EJ is likewise involved in the repair of multiple DSBs (I-PpoI- and IR-induced). Importantly, we identified a chromatin signature associated with the switch to PARP1-EJ which is characterized by a strong enrichment of both PARP1 and LigIII at damaged chromatin. Together, these data indicate that Ku is the main regulator for the hierarchal organization between C-NHEJ and PARP1-EJ.

Kato, S., S. Roujol, F. Delling, S. Akhtari, J. Jang, T. Basha, S. Berg, K. Kissinger, B. Goddu, and W. Manning, "Abstract 14783", Circulation, vol. 132, issue Suppl_3, pp. A14783, 2015. Abstract
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Saad, W. E., W. M. Darwish, M. G. Davies, and D. L. Waldman, "Abstract No. 65: Transhepatic dilation of anastomotic biliary strictures in liver transplant recipients: A comparison between a conventional balloon protocol vs. a combined cutting-conventional balloon protocol", Journal of Vascular and Interventional Radiology, vol. 21, issue 2: Elsevier, pp. S26-S27, 2010. Abstract
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Saad, W., C. L. Anderson, W. M. Darwish, M. G. Davies, D. L. Waldman, J. F. Angle, U. C. Turba, S. S. Sabri, J. Stone, and T. Kitanosono, "Abstract No. 77: Comparison between the technical results of TIPS in liver transplant recipients and native (non-transplanted) patients", Journal of Vascular and Interventional Radiology, vol. 22, issue 3: Elsevier, pp. S35-S36, 2011. Abstract
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Darwish, W. M., W. E. Saad, M. G. Davies, D. Butani, and D. L. Waldman, "Abstract No. 85: Transjugular intrahepatic portosystemic shunts in liver transplant recipients for management of refractory ascites: Clinical outcome", Journal of Vascular and Interventional Radiology, vol. 21, issue 2: Elsevier, pp. S34, 2010. Abstract
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Honeybul, S., K. Ho, C. R. P. Lind, G. R. Gillett, J. P. Dreier, A. Demertzi, A. Soddu, F. Gomez, L. Heine, and C. di Perri, "Abstracts from The 11th Symposium of the International Neurotrauma Society March 19–23, 2014 Budapest, Hungary", Journal of Neurotrauma, vol. 31, issue 5: Mary Ann Liebert, Inc. 140 Huguenot Street, 3rd Floor New Rochelle, NY 10801 USA, pp. A-1-A-73, 2014. Abstract
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Honeybul, S., K. Ho, C. R. P. Lind, G. R. Gillett, J. P. Dreier, A. Demertzi, A. Soddu, F. Gomez, L. Heine, and C. di Perri, Abstracts from The 11th Symposium of the International Neurotrauma Society March 19–23, 2014 Budapest, Hungary, , vol. 31, issue 5: Mary Ann Liebert, Inc. 140 Huguenot Street, 3rd Floor New Rochelle, NY 10801 USA, pp. A - 1, 2014. Abstract
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Ding, Y., M. S. Osman, and A. - M. Wazwaz, "Abundant complex wave solutions for the nonautonomous Fokas-Lenells equation in presence of perturbation terms", Optik, vol. 181, pp. 503-513, 2019.
EL-Taher, E. M. M., M. M. El-Sherei, R. S. E. Dine, D. M. Y. ElNaggar, W. K. B. Khalil, S. M. Kassem, A. Elkhateeb, and M. E. S. Kassem, "Acacia pennata L. leaves: chemical profiling and impact on DNA damage, alteration of genotoxicity—related genes expression and ROS generation in hepatic tissues of acetaminophen treated male rats", Advances in Traditional Medicine: Springer Singapore, pp. 1-9, 2021. Abstract
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Darwish, W. M., S. Darushnia, and W. E. Saad, "Accelerated balloon-occluded retrograde transvenous obliteration without indwelling balloon occlusion for gastric varices with small gastrorenal shunts using a terminal gelfoam plug", American Journal of Roentgenology, vol. 203, issue 2: Am Roentgen Ray Soc, pp. 439-441, 2014. Abstract
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Din, S. H. S. E., Accelerated Whole Breast Irradiation With Hypofractionation Plus Concurrent Boost After Conservative Surgery For Early Stage Breast Cancer, , cairo, cairo, 2017. Abstract

Background: Conventional fractionated radiation therapy over 4-5 weeks with sequential boost is the standard of care for postoperative RT treatment for patients with early stage breast cancer who undergo BCS. However, the use of an accelerated RT course can be used in departments with high patients flow to reduce waiting list and machine loads as well as to improve patient compliance.

Patients and Methods: This is a prospective phase II study conducted at Kasr El-aini Center of Clinical Oncology and Nuclear Medicine (NEMROCK). Patients who underwent breast conservative surgery were recruited according to inclusion and exclusion criteria. Recruited patients were planned using 3D conformal technique to receive a hypofractionated radiation schedule using 40 Gy/2.67 Gy per fraction over 3 weeks to the whole breast with Concurrent boost 8.0 Gy/0.5 Gy per fraction over 3 weeks. Dosimetric parameters for the coverage of the breast CTV were set using V38, V36 Gy and the homogeneity using the Dmax and the Dmin. For the coverage of the boost PTV V45.6Gy and V43Gy were used and for dose homogeneity Dmax and Dmin. As regard dose constrain for organ at risk (OAR), no more than 20% of the ipsilateral lung exceeds 16 Gy, no more than 5% of the whole heart exceeds 20 Gy. All patients was evaluated for acute toxicity and cosmetic outcome.

Results: During the period from June 2014 to January 2017, a total of 63 patients with a median age of 51 years were included. The dosimetric parameters for the coverage of target volumes and dose constrain for OAR were in compliance with our protocol. Regarding acute skin toxicity, only 20% of patients developed GII skin toxicity, while 68% of patients developed G0-I skin toxicity, none of the patients developed GIII or more skin toxicity. The overall cosmetic assessment was excellent in 80.95 % of patients and good in 19% of patients.

Conclusions: Hypofractionated radiotherapy in three weeks to the whole
breast with a concomitant boost in patients undergoing breast conserving surgery (BCS), allows acceptable outcomes in terms of dosimetric parameters, acute toxicity and early cosmetic results and is a good approach for our department NEMROK due to the reduction of 15 days when compared to standard RT treatment of breast cancer. long- term follow up data are needed to assess late toxicity, cosmesis, and clinical outcomes.

Dönmez, E. A., A. G. Goswami, A. Raheja, A. Bhadani, A. E. S. El Kady, A. Alniemi, A. Awad, A. Aladl, A. Younis, A. Alwali, et al., "Access to and quality of elective care: a prospective cohort study using hernia surgery as a tracer condition in 83 countries", The Lancet Global Health, 2024. AbstractWebsite

Summary Background Timely and safe elective health care facilitates return to normal activities for patients and prevents emergency admissions. Surgery is a cornerstone of elective care and relies on complex pathways. This study aimed to take a whole-system approach to evaluating access to and quality of elective health care globally, using inguinal hernia as a tracer condition. Methods This was a prospective, international, cohort study conducted between Jan 30 and May 21, 2023, in which any hospital performing inguinal hernia repairs was eligible to take part. Consecutive patients of any age undergoing primary inguinal hernia repair were included. A measurement set mapped to the attributes of WHO's Health System Building Blocks was defined to evaluate access (emergency surgery rates, bowel resection rates, and waiting times) and quality (mesh use, day-case rates, and postoperative complications). These were compared across World Bank income groups (high-income, upper-middle-income, lower-middle-income, and low-income countries), adjusted for hospital and country. Factors associated with postoperative complications were explored with a three-level multilevel logistic regression model. Findings 18 058 patients from 640 hospitals in 83 countries were included, of whom 1287 (7·1%) underwent emergency surgery. Emergency surgery rates increased from high-income to low-income countries (6·8%, 9·7%, 11·4%, 14·2%), accompanied by an increase in bowel resection rates (1·2%, 1·4%, 2·3%, 4·2%). Overall waiting times for elective surgery were similar around the world (median 8·0 months from symptoms to surgery), largely because of delays between symptom onset and diagnosis rather than waiting for treatment. In 14 768 elective operations in adults, mesh use decreased from high-income to low-income countries (97·6%, 94·3%, 80·6%, 61·0%). In patients eligible for day-case surgery (n=12 658), day-case rates were low and variable (50·0%, 38·0%, 42·1%, 44·5%). Complications occurred in 2415 (13·4%) of 18 018 patients and were more common after emergency surgery (adjusted odds ratio 2·06, 95% CI 1·72–2·46) and bowel resection (1·85, 1·31–2·63), and less common after day-case surgery (0·39, 0·34–0·44). Interpretation This study demonstrates that elective health care is essential to preventing over-reliance on emergency systems. We identified actionable targets for system strengthening: clear referral pathways and increasing mesh repair in lower-income settings, and boosting day-case surgery in all income settings. These measures might strengthen non-surgical pathways too, reducing the burden on society and health services. Funding NIHR Global Health Research Unit on Global Surgery and Portuguese Hernia and Abdominal Wall Society (Sociedade Portuguesa de Hernia e Parede Abdominal).

Dönmez, E. A., A. G. Goswami, A. Raheja, A. Bhadani, A. E. S. El Kady, A. Alniemi, A. Awad, A. Aladl, A. Younis, A. Alwali, et al., "Access to and quality of elective care: a prospective cohort study using hernia surgery as a tracer condition in 83 countries", The Lancet Global Health, 2024. AbstractWebsite

Summary Background Timely and safe elective health care facilitates return to normal activities for patients and prevents emergency admissions. Surgery is a cornerstone of elective care and relies on complex pathways. This study aimed to take a whole-system approach to evaluating access to and quality of elective health care globally, using inguinal hernia as a tracer condition. Methods This was a prospective, international, cohort study conducted between Jan 30 and May 21, 2023, in which any hospital performing inguinal hernia repairs was eligible to take part. Consecutive patients of any age undergoing primary inguinal hernia repair were included. A measurement set mapped to the attributes of WHO's Health System Building Blocks was defined to evaluate access (emergency surgery rates, bowel resection rates, and waiting times) and quality (mesh use, day-case rates, and postoperative complications). These were compared across World Bank income groups (high-income, upper-middle-income, lower-middle-income, and low-income countries), adjusted for hospital and country. Factors associated with postoperative complications were explored with a three-level multilevel logistic regression model. Findings 18 058 patients from 640 hospitals in 83 countries were included, of whom 1287 (7·1%) underwent emergency surgery. Emergency surgery rates increased from high-income to low-income countries (6·8%, 9·7%, 11·4%, 14·2%), accompanied by an increase in bowel resection rates (1·2%, 1·4%, 2·3%, 4·2%). Overall waiting times for elective surgery were similar around the world (median 8·0 months from symptoms to surgery), largely because of delays between symptom onset and diagnosis rather than waiting for treatment. In 14 768 elective operations in adults, mesh use decreased from high-income to low-income countries (97·6%, 94·3%, 80·6%, 61·0%). In patients eligible for day-case surgery (n=12 658), day-case rates were low and variable (50·0%, 38·0%, 42·1%, 44·5%). Complications occurred in 2415 (13·4%) of 18 018 patients and were more common after emergency surgery (adjusted odds ratio 2·06, 95% CI 1·72–2·46) and bowel resection (1·85, 1·31–2·63), and less common after day-case surgery (0·39, 0·34–0·44). Interpretation This study demonstrates that elective health care is essential to preventing over-reliance on emergency systems. We identified actionable targets for system strengthening: clear referral pathways and increasing mesh repair in lower-income settings, and boosting day-case surgery in all income settings. These measures might strengthen non-surgical pathways too, reducing the burden on society and health services. Funding NIHR Global Health Research Unit on Global Surgery and Portuguese Hernia and Abdominal Wall Society (Sociedade Portuguesa de Hernia e Parede Abdominal).

Dönmez, E. A., A. G. Goswami, A. Raheja, A. Bhadani, A. E. S. El Kady, A. Alniemi, A. Awad, A. Aladl, A. Younis, A. Alwali, et al., Access to and quality of elective care: a prospective cohort study using hernia surgery as a tracer condition in 83 countries, , 2024. AbstractWebsite

SummaryBackground
Timely and safe elective health care facilitates return to normal activities for patients and prevents emergency admissions. Surgery is a cornerstone of elective care and relies on complex pathways. This study aimed to take a whole-system approach to evaluating access to and quality of elective health care globally, using inguinal hernia as a tracer condition.
Methods
This was a prospective, international, cohort study conducted between Jan 30 and May 21, 2023, in which any hospital performing inguinal hernia repairs was eligible to take part. Consecutive patients of any age undergoing primary inguinal hernia repair were included. A measurement set mapped to the attributes of WHO's Health System Building Blocks was defined to evaluate access (emergency surgery rates, bowel resection rates, and waiting times) and quality (mesh use, day-case rates, and postoperative complications). These were compared across World Bank income groups (high-income, upper-middle-income, lower-middle-income, and low-income countries), adjusted for hospital and country. Factors associated with postoperative complications were explored with a three-level multilevel logistic regression model.
Findings
18 058 patients from 640 hospitals in 83 countries were included, of whom 1287 (7·1%) underwent emergency surgery. Emergency surgery rates increased from high-income to low-income countries (6·8%, 9·7%, 11·4%, 14·2%), accompanied by an increase in bowel resection rates (1·2%, 1·4%, 2·3%, 4·2%). Overall waiting times for elective surgery were similar around the world (median 8·0 months from symptoms to surgery), largely because of delays between symptom onset and diagnosis rather than waiting for treatment. In 14 768 elective operations in adults, mesh use decreased from high-income to low-income countries (97·6%, 94·3%, 80·6%, 61·0%). In patients eligible for day-case surgery (n=12 658), day-case rates were low and variable (50·0%, 38·0%, 42·1%, 44·5%). Complications occurred in 2415 (13·4%) of 18 018 patients and were more common after emergency surgery (adjusted odds ratio 2·06, 95% CI 1·72–2·46) and bowel resection (1·85, 1·31–2·63), and less common after day-case surgery (0·39, 0·34–0·44).
Interpretation
This study demonstrates that elective health care is essential to preventing over-reliance on emergency systems. We identified actionable targets for system strengthening: clear referral pathways and increasing mesh repair in lower-income settings, and boosting day-case surgery in all income settings. These measures might strengthen non-surgical pathways too, reducing the burden on society and health services.
Funding
NIHR Global Health Research Unit on Global Surgery and Portuguese Hernia and Abdominal Wall Society (Sociedade Portuguesa de Hernia e Parede Abdominal).

El Kassas, M., M. Alboraie, D. Omran, M. Salaheldin, M. N. Wifi, M. Elbadry, adel el tahan, S. Ezzat, E. Moaz, A. M. Farid, et al., "An account of the real-life hepatitis C management in a single specialized viral hepatitis treatment centre in Egypt: results of treating 7042 patients with 7 different direct acting antiviral regimens", Expert Review of Gastroenterology & Hepatology, vol. 12, issue 12, pp. 1265-1272, 2018. single_centre_paper.pdf
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