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2024
Hashim, A. R., D. W. Bashir, E. Rashad, Mona K Galal, M. M. Rashad, H. M. A. Khalil, N. M. Deraz, and E. - G. S. M, "Neuroprotective assessment of betaine against copper oxide nanoparticle-induced neurotoxicity in the brains of albino rats: a histopathological, neurochemical, and molecular investigation", ACS Chemical Neuroscience, vol. 15, no. 8: American Chemical Society, pp. 1684–1701, 2024. Abstract
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Asmaa R. Hashim, D. W. Bashir, E. Rashad, Mona K Galal, M. M. Rashad, H. M.A.Khalil, N. M. Deraz, and E. - G. S. M., "Neuroprotective Assessment of Betaine against Copper Oxide Nanoparticle-Induced Neurotoxicity in the Brains of Albino Rats: A Histopathological, Neurochemical, and Molecular Investigation ", ACS Chemical Neuroscience, 2024.
Hashim, A. R., D. W. Bashir, E. Rashad, Mona K Galal, M. M. Rashad, H. M. A. Khalil, N. M. Deraz, and E. - G. S. M, "Neuroprotective Assessment of Betaine against Copper Oxide Nanoparticle-Induced Neurotoxicity in the Brains of Albino Rats: A Histopathological, Neurochemical, and Molecular Investigation.", ACS chemical neuroscience, vol. 15, issue 8, pp. 1684-1701, 2024. Abstract

Copper oxide nanoparticles (CuO-NPs) are commonly used metal oxides. Betaine possesses antioxidant and neuroprotective activities. The current study aimed to investigate the neurotoxic effect of CuO-NPs on rats and the capability of betaine to mitigate neurotoxicity. Forty rats; 4 groups: group I a control, group II intraperitoneally CuO-NPs (0.5 mg/kg/day), group III orally betaine (250 mg/kg/day) and CuO-NPs, group IV orally betaine for 28 days. Rats were subjected to neurobehavioral assessments. Brain samples were processed for biochemical, molecular, histopathological, and immunohistochemical analyses. Behavioral performance of betaine demonstrated increasing locomotion and cognitive abilities. Group II exhibited significantly elevated malondialdehyde (MDA), overexpression of interleukin-1 beta (IL-1β), and tumor necrosis factor-alpha (TNF-α). Significant decrease in glutathione (GSH), and downregulation of acetylcholine esterase (AChE), nuclear factor erythroid 2-like protein 2 (Nrf-2), and superoxide dismutase (SOD). Histopathological alterations; neuronal degeneration, pericellular spaces, and neuropillar vacuolation. Immunohistochemically, an intense immunoreactivity is observed against IL-1β and glial fibrillary acidic protein (GFAP). Betaine partially neuroprotected against CuO-NPs associated alterations. A significant decrease at MDA, downregulation of IL-1β, and TNF-α, a significant increase at GSH, and upregulation of AChE, Nrf-2, and SOD. Histopathological alterations partially ameliorated. Immunohistochemical intensity of IL-1β and GFAP reduced. It is concluded that betaine neuroprotected against most of CuO-NP neurotoxic effects through antioxidant and cell redox system stimulating efficacy.

Ragheb, M. A., F. G. Mohamed, H. M. Diab, M. S. Ragab, M. Emara, A. H. M. Elwahy, I. A. Abdelhamid, and M. H. Soliman, "Novel Bis (2‐cyanoacrylamide) Linked to Sulphamethoxazole: Synthesis, DNA Interaction, Anticancer, ADMET, Molecular Docking, and DFT Studies", Chemistry & Biodiversity, vol. 21, issue 4, pp. e202301341, 2024. Abstract
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El-Gabry, Y. A., M. E. Salem, N. S. Ibrahim, A. H. M. Elwahy, I. A. Abdelhamid, and H. M. Diab, "Novel diphenyl ether-heterocycles hybrids: Synthesis via Hantzsch and Biginelli reactions, molecular docking simulation, and antimicrobial activities", Journal of Molecular Structure, vol. 1296: Elsevier, pp. 136857, 2024. Abstract
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Meshaal, S., R. EI Hawary, D. S. Abd Elaziz, A. Eldash, R. Darwish, A. Erfan, S. Lotfy, M. Saad, E. Chohayeb, R. Alkady, et al., "Novel homozygous CARD11 variants in two patients with combined immunodeficiency and atopic skin disease", Egyptian Journal of Medical Human Genetics , vol. 25, 2024.
Dabbous, A. O., N. A. Hosni, A. A. - S. O. Emara, and A. S. El-Antably, "P1-N1-P2 Cortical Auditory Evoked Potentials in Chronic Unilateral Acquired Conductive Hearing Loss in Adults", J Int Adv Otol , vol. 20, issue 3, pp. 216-224, 2024.
Zaghlol, A., Z. Kandil, M. Yousif, R. S. E. Dine, and W. Elkady, "Phytochemical analysis of Euphorbia greenwayi aerial parts: antioxidant and anti-inflammatory potential", Egyptian Journal of Chemistry, vol. 67, issue 3: National Information and Documentation Centre (NIDOC), Academy of Scientific …, pp. 515-525, 2024. Abstract
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Kesba, H., S. EL-GANAİNY, W. Elmenofy, Samy Sayed, A. Abdel-Rahman, and S. DİAB, "POMEGRANATE (Punica granatum L.) GROWTH AND BİOCHEMİCAL ALTERATİONS İN RESPONSE TO MELOİDOGYNE İNCOGNİTA İNFECTİON, MİNERALS, AND NANO-FERTİLİZERS", Bioscience Journal , vol. 40, issue e40028, 2024. articlee40028-id70373.pdf
Osman, W. ’aA., H. Taher, H. Darweesh, M. A. Samie, O. G.Shaker, M. A. Samie, D. A. L., and H. Ateyya, "The possible anti-inflammatory effect of extra virgin olive oil with colchicine in treatment of resistant cases of familial Mediterranean fever in a cohort of pediatric Egyptian patients", Future journal of pharmaceutical sciences, vol. 10, issue 17@, 2024.
Osman, W. ’aA., H. Taher, H. Darweesh, M. A. Samie, O. G.Shaker, M. A. Samie, D. A. L., and H. Ateyya, "The possible anti-inflammatory effect of extra virgin olive oil with colchicine in treatment of resistant cases of familial Mediterranean fever in a cohort of pediatric Egyptian patients", Future journal of pharmaceutical sciences, vol. 10, issue 17@, 2024.
Osman, W. ’aA., H. Taher, H. Darweesh, M. A. Samie, O. G.Shaker, M. A. Samie, and D. A. L., "The possible anti-inflammatory effect of extra virgin olive oil with colchicine in treatment of resistant cases of familial Mediterranean fever in a cohort of pediatric Egyptian patients", Future journal of pharmaceutical sciences, vol. 10, issue 17@, 2024.
Dalia Zaafar, Heba M. A. Khalil, G. E. A. S. S. E., and M. K. Y. A. -zeidG. & Yasmine H. Ahmed, "Preparation and characterization of Sorafenib nano-emulsion: impact on pharmacokinetics and toxicity; an in vitro and in vivo study", Drug Delivery and Translational Research, 2024.
Abadir, M. F., E. H. M. Desoki, O. A. Ibrahim, and E. N. R. Sakka, "Preparation of insulating firebricks using date seeds", Bul. Nat. Res. Cent., vol. 48-50, pp. 1-11, 2024.
Omar, A., B. Soliman, A. Dakrory, M. Al-Hammady, and A. Mohamed, "Protective Effect of Heteroxenia fuscescens Extract against Sodium Arsenite-induced Infertility in Male Rats", Current Bioactive Compounds, vol. 20, issue 2, pp. 64–74, 2024.
Omar, A. R., B. Soliman, A. Dakrory, M. Al-Hammady, and A. Mohamed, Protective Effect of Heteroxenia fuscescens Extract against Sodium Arsenite-induced Infertility in Male Rats, , vol. 20, issue 2, pp. 64-74, 2024.
Rahman, A. A. N., H. H. Mahboub, G. E. Elshopakey, M. I. M. Darwish, H. S. A. - R. Gharib, M. Shaalan, E. M. Fahmy, H. M. Abdel-Ghany, S. H. Ismail, and H. M. Elsheshtawy, "Pseudomonas putida infection induces immune-antioxidant, hepato-renal, ethological, and histopathological/immunohistochemical disruptions in Oreochromis niloticus: the palliative role of titanium dioxide nanogel.", BMC veterinary research, vol. 20, issue 1, pp. 127, 2024. Abstract

BACKGROUND: Pseudomonas putida is a pathogenic bacterium that induces great losses in fishes, including Nile tilapia (Oreochromis niloticus). Currently, the application of nanomaterials in aquaculture practices has gained more success as it endows promising results in therapies compared to traditional protocols.

OBJECTIVE: Therefore, the current perspective is considered the first report to assess the anti-bacterial efficacy of titanium dioxide nanogel (TDNG) against Pseudomonas putida (P. putida) in Nile tilapia.

METHODS: The fish (n = 200; average body weight: 47.50±1.32 g) were allocated into four random groups (control, TDNG, P. putida, and TDNG + P. putida), where 0.9 mg/L of TDNG was applied as bath treatment for ten days.

RESULTS: Outcomes revealed that P. putida infection caused ethological alterations (surfacing, abnormal movement, and aggression) and depression of immune-antioxidant variables (complement 3, lysozyme activity, total antioxidant capacity, superoxide dismutase, and reduced glutathione content). Additionally, a substantial elevation in hepatorenal biomarkers (aspartate and alanine aminotransferases and creatinine) with clear histopathological changes and immuno-histochemical alterations (very weak BCL-2 and potent caspase-3 immuno-expressions) were seen. Surprisingly, treating P. putida-infected fish with TDNG improved these variables and obvious restoration of the tissue architectures.

CONCLUSION: Overall, this report encompasses the key role of TDNG as an anti-bacterial agent for controlling P. putida infection and improving the health status of Nile tilapia.

Emad, Y., Y. Ragab, H. W. Farber, D. Erkan, O. Ibrahim, M. Kindermann, J. Tekavec-Trkanjec, B. Jayakrishnan, N. El-Shaarawy, M. Kechida, et al., "Pulmonary embolism versus pulmonary vasculitis in Hughes-Stovin syndrome: Characteristic computed tomography pulmonary angiographic findings and diagnostic and therapeutic implications. HSS International Study Group.", Thrombosis research, vol. 239, pp. 109040, 2024. Abstract

BACKGROUND AND AIM: Hughes-Stovin syndrome (HSS) is a rare systemic vasculitis with widespread venous/arterial thrombosis and pulmonary vasculitis. Distinguishing between pulmonary embolism (PE) and in-situ thrombosis in the early stages of HSS is challenging. The aim of the study is to compare clinical, laboratory, and computed tomography pulmonary angiography (CTPA) characteristics in patients diagnosed with PE versus those with HSS.

METHODS: This retrospective study included 40 HSS patients with complete CTPA studies available, previously published by the HSS study group, and 50 patients diagnosed with PE from a single center. Demographics, clinical and laboratory findings, vascular thrombotic events, were compared between both groups. The CTPA findings were reviewed, with emphasis on the distribution, adherence to the mural wall, pulmonary infarction, ground glass opacification, and intra-alveolar hemorrhage. Pulmonary artery aneurysms (PAAs) in HSS were assessed and classified.

RESULTS: The mean age of HSS patients was 35 ± 12.3 years, in PE 58.4 ± 17 (p < 0.0001). Among PE 39(78 %) had co-morbidities, among HSS none. In contrast to PE, in HSS both major venous and arterial thrombotic events are seen.. Various patterns of PAAs were observed in the HSS group, which were entirely absent in PE. Parenchymal hemorrhage was also more frequent in HSS compared to PE (P < 0.001).

CONCLUSION: Major vascular thrombosis with arterial aneurysms formation are characteristic of HSS. PE typically appear loosely-adherent and mobile whereas "in-situ thrombosis" seen in HSS is tightly-adherent to the mural wall. Mural wall enhancement and PAAs are distinctive pulmonary findings in HSS. The latter findings have significant therapeutic ramifications.

Saad, H., N. F. A. El-Dien, N. E. A. El-Gamel, and A. A. S. Dena, "Removal of Bromophenol Blue from Polluted Water Using a Novel Azo-Functionalized Magnetic Nano-Adsorbent.", RSC Advance, vol. 14, pp. 1316-1329, 2024.
Gordon, R. A., Y. Nguyen, N. Foulquier, M. Beydon, T. A. Gheita, R. Hajji, I. Sahbudin, A. Hoi, W. - F. Ng, J. A. Mendonça, et al., "The Sjögren's Working Group: The 2023 OMERACT meeting and provisional domain generation.", Seminars in arthritis and rheumatism, vol. 65, pp. 152378, 2024. Abstract

Sjögren's disease (SjD) is a systemic autoimmune exocrinopathy with key features of dryness, pain, and fatigue. SjD can affect any organ system with a variety of presentations across individuals. This heterogeneity is one of the major barriers for developing effective disease modifying treatments. Defining core disease domains comprising both specific clinical features and incorporating the patient experience is a critical first step to define this complex disease. The OMERACT SjD Working Group held its first international collaborative hybrid meeting in 2023, applying the OMERACT 2.2 filter toward identification of core domains. We accomplished our first goal, a scoping literature review that was presented at the Special Interest Group held in May 2023. Building on the domains identified in the scoping review, we uniquely deployed multidisciplinary experts as part of our collaborative team to generate a provisional domain list that captures SjD heterogeneity.

Salem, M. E., Y. A. El-Gabry, I. A. Abdelhamid, A. H. M. Elwahy, M. E. A. Zaki, and H. M. Diab, "Synthesis of Novel Diphenyl Ether-Based Bis-Heterocycles as Novel Hybrid Molecules via Michael and Other Cyclocondensation Reactions", ACS Omega: American Chemical Society, 2024. Abstract
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Medhat, M., Dabbous, AO, and M. El Mesidy, "'The Vestibulospinal Reflex in Vitiligo Patients'", Egyptian Journal of Ear, Nose, Throat and Allied Sciences, EJENTAS, vol. 25, issue 25, pp. 1-11, 2024.
Wei, K., Y. Lu, X. Ma, A. Duan, X. Lu, H. Abdel-Shafy, and T. Deng, "Transcriptome-Wide Association Study Reveals Potentially Candidate Genes Responsible for Milk Production Traits in Buffalo.", International journal of molecular sciences, vol. 25, issue 5, 2024. Abstract

Identifying key causal genes is critical for unraveling the genetic basis of complex economic traits, yet it remains a formidable challenge. The advent of large-scale sequencing data and computational algorithms, such as transcriptome-wide association studies (TWASs), offers a promising avenue for identifying potential causal genes. In this study, we harnessed the power of TWAS to identify genes potentially responsible for milk production traits, including daily milk yield (MY), fat percentage (FP), and protein percentage (PP), within a cohort of 100 buffaloes. Our approach began by generating the genotype and expression profiles for these 100 buffaloes through whole-genome resequencing and RNA sequencing, respectively. Through comprehensive genome-wide association studies (GWAS), we pinpointed a total of seven and four single nucleotide polymorphisms (SNPs) significantly associated with MY and FP traits, respectively. By using TWAS, we identified 55, 71, and 101 genes as significant signals for MY, FP, and PP traits, respectively. To delve deeper, we conducted protein-protein interaction (PPI) analysis, revealing the categorization of these genes into distinct PPI networks. Interestingly, several TWAS-identified genes within the PPI network played a vital role in milk performance. These findings open new avenues for identifying potentially causal genes underlying important traits, thereby offering invaluable insights for genomics and breeding in buffalo populations.

Kheder, N. A., A. M. Fahim, N. S. Mahmoud, and K. M. Dawood, "Unexpected products using Biginelli reaction: Synthesis, antimicrobial potency, docking simulation, and DFT investigations of some new amidopyridines", Journal of Molecular Structure, vol. 1295, pp. 136772, 2024.
2023
Ahmed, M. R., A. E. Damatty, K. Dai, and W. Lu, "Comparison between Effects of Current Wind Turbine Design Loads and Downburst Loads", The Canadian Society for Civil Engineering CSCE, Annual Conference, Whistler, British Columbia, Canada, May 25-28, 2022, 2023.