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El-Hawagry, M., A. M. Soliman, M. S. Abdel-Dayem, and H. A. L. M. DHAFER, "New fly records of potential biological control importance in Saudi Arabia (order Diptera)", Egyptian Journal of Biological Pest Control, vol. 33, issue 78, pp. 1-8, 2023. new_fly_records_of_potential_biological_control_importance.pdf
Salim, S. A., N. M. Badawi, S. H. El-Moslamy, E. A. Kamoun, and B. A. Daihom, "Novel long-acting brimonidine tartrate loaded-PCL/PVP nanofibers for versatile biomedical applications: fabrication, characterization and antimicrobial evaluation.", RSC advances, vol. 13, issue 22, pp. 14943-14957, 2023. Abstract

The global state of antibiotic resistance highlights the necessity for new drugs that can treat a wide range of microbial infections. Drug repurposing has several advantages, including lower costs and improved safety compared to developing a new compound. The aim of the current study is to evaluate the repurposed antimicrobial activity of Brimonidine tartrate (BT), a well-known antiglaucoma drug, and to potentiate its antimicrobial effect by using electrospun nanofibrous scaffolds. BT-loaded nanofibers were fabricated in different drug concentrations (1.5, 3, 6, and 9%) the electrospinning technique using two biopolymers (PCL and PVP). Then, the prepared nanofibers were characterized by SEM, XRD, FTIR, swelling ratio, and drug release. Afterward, the antimicrobial activities of the prepared nanofibers were investigated using different methods against several human pathogens and compared to the free BT. The results showed that all nanofibers were prepared successfully with a smooth surface. The diameters of nanofibers were reduced after loading of BT compared to the unloaded ones. In addition, scaffolds showed controlled-drug release profiles that were maintained for more than 7 days. The antimicrobial assessments revealed good activities for all scaffolds against most of the investigated human pathogens, particularly the one prepared with 9% BT which showed superiority in the antimicrobial effect over other scaffolds. To conclude, our findings proved the capability of nanofibers in loading BT and improving its repurposed antimicrobial efficacy. Therefore, it could be a promising carrier for BT to be used in combating numerous human pathogens.

Darwish, M. I. M., A. M. Moustafa, A. M. Youssef, M. Mansour, A. I. Yousef, A. El Omri, H. H. Shawki, M. F. Mohamed, H. M. Hassaneen, and I. A. Abdelhamid, "Novel Tetrahydro-[1, 2, 4] triazolo [3, 4-a] isoquinoline Chalcones Suppress Breast Carcinoma through Cell Cycle Arrests and Apoptosis", Molecules, vol. 28, issue 8: MDPI, pp. 3338, 2023. Abstract
Ashraf M. Mohamed, Mohamed N. El-Bayaa, Dina H. Elnaggar, Naglaa A. Abdel-Hafez, Salwa F. Mohamed, M. A.ElSayed, Eman S. Abou-Amra, M. M. Omran, and W. A. El-Sayed, "Novel [1,2,3]triazoles, [1,2,3]triazolo[4,5-d]Pyrimidines, and Some of Their Glycoside Derivatives: Synthesis and Molecular Modeling as Potential Apoptotic Antitumor Agents", Polycyclic Aromatic Compounds, , 2023.
Doha, E.H., Abd El Kawy, M ostafa, Amin, and A. M. Lopes, "Numerical solutions for variable-order fractional Gross-Pitaevskii equation with two spectral collocation approaches", International Journal of Nonlinear Sciences and Numerical Simulation, vol. 24, issue 2, pp. 421-435, 2023.
Hendy, A.S., Zaky, M.A., and E. H. Doha, "On a discrete fractional stochastic Grönwall inequality and its application in the numerical analysis of stochastic FDEs involving a martingale", International Journal of Nonlinear Sciences and Numerical Simulation, vol. 24, issue 2, pp. 531-537, 2023.
van der Sluis, T. C., G. Beyrend, E. T. I. van der Gracht, T. Abdelaal, S. P. Jochems, R. A. Belderbos, T. H. Wesselink, S. van Duikeren, F. J. van Haften, A. Redeker, et al., "OX40 agonism enhances PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrum.", Cell reports. Medicine, vol. 4, issue 3, pp. 100939, 2023. Abstract

Immune checkpoint therapy (ICT) has the power to eradicate cancer, but the mechanisms that determine effective therapy-induced immune responses are not fully understood. Here, using high-dimensional single-cell profiling, we interrogate whether the landscape of T cell states in the peripheral blood predict responses to combinatorial targeting of the OX40 costimulatory and PD-1 inhibitory pathways. Single-cell RNA sequencing and mass cytometry expose systemic and dynamic activation states of therapy-responsive CD4 and CD8 T cells in tumor-bearing mice with expression of distinct natural killer (NK) cell receptors, granzymes, and chemokines/chemokine receptors. Moreover, similar NK cell receptor-expressing CD8 T cells are also detected in the blood of immunotherapy-responsive cancer patients. Targeting the NK cell and chemokine receptors in tumor-bearing mice shows the functional importance of these receptors for therapy-induced anti-tumor immunity. These findings provide a better understanding of ICT and highlight the use and targeting of dynamic biomarkers on T cells to improve cancer immunotherapy.

Meili, C. H., A. L. Jones, A. X. Arreola, J. Habel, C. J. Pratt, R. A. Hanafy, Y. Wang, A. S. Yassin, M. A. Tag ElDein, C. D. Moon, et al., "Patterns and determinants of the global herbivorous mycobiome.", Nature communications, vol. 14, issue 1, pp. 3798, 2023. Abstract

Despite their role in host nutrition, the anaerobic gut fungal (AGF) component of the herbivorous gut microbiome remains poorly characterized. Here, to examine global patterns and determinants of AGF diversity, we generate and analyze an amplicon dataset from 661 fecal samples from 34 mammalian species, 9 families, and 6 continents. We identify 56 novel genera, greatly expanding AGF diversity beyond current estimates (31 genera and candidate genera). Community structure analysis indicates that host phylogenetic affiliation, not domestication status and biogeography, shapes the community rather than. Fungal-host associations are stronger and more specific in hindgut fermenters than in foregut fermenters. Transcriptomics-enabled phylogenomic and molecular clock analyses of 52 strains from 14 genera indicate that most genera with preferences for hindgut hosts evolved earlier (44-58 Mya) than those with preferences for foregut hosts (22-32 Mya). Our results greatly expand the documented scope of AGF diversity and provide an ecologically and evolutionary-grounded model to explain the observed patterns of AGF diversity in extant animal hosts.

Abdelmohsen, G. A., H. A. Gabel, J. A. Al-Ata, S. A. Bahaidarah, N. A. Alkhushi, M. H. Abdelsalam, S. B. Bekheet, A. R. Elakaby, Z. F. Zaher, K. A. Maghrabi, et al., "Percutaneous closure of postoperative residual ventricular septal defects, including dehiscence of surgical patches", Cardiovascular Diagnosis and Therapy, 2023. percutaneous_closure_of_postoperative_vsd.pdf
Mansour, A. T., A. M. Diab, R. H. Khalil, E. A. Eldessouki, N. E. S. El-Sabbagh, S. Elsamannoudy, and N. A. Younis, "Physiological and immunological responses of Nile tilapia fed dietary supplementation of sweet basil ethanolic and aqueous extracts", Frontiers in Marine Science,, vol. 9, 2881., 2023.
Younis, S.M., El Hadidi, N.M.N., Darwish, and M. F. Mohamed, "Preliminary study on the strength enhancement of Klucel E with cellulose nanofibrils (CNFs) for the conservation of wooden artifacts", Journal of Cultural Heritage , vol. 60, pp. 41-49, 2023. AbstractWebsite

Four concentrations of Klucel E and cellulose nanofiber (CNF) nanocomposite were prepared by adding 10, 20, 30, and 50 ml of 2% (wt./v) CNF to 3% (wt./v) of Klucel E to obtain a 100 ml. final volume of the composite. The composites were characterized using transmission electron microscopy (TEM), scan- ning electron microscopy (SEM), and X-ray diffraction (XRD). The addition of CNF to Klucel E improved the mechanical properties of the prepared composites; namely the composite which contains 50% CNF showed an improvement in tensile strength by 102% compared to pure Klucel E. Additionally, Young’s modulus, and hardness increased dramatically with the increase of CNF within the composite. To fur- ther evaluate the nanocomposites, CNF 30% and CNF 50%, were used to treat aged wood specimens. The compression strength of the untreated and treated specimen was measured, where the sample treated with Klucel E/30% CNF composite showed the highest compression strength value with an improvement of 14.5% compared to the untreated wood sample.

Younis, O. M., N. M. N. El Hadidi, S. S. Darwish, and M. F. Mohamed, "Preliminary study on the strength enhancement of Klucel E with cellulose nanofibrils (CNFs) for the conservation of wooden artifacts", Journal of Cultural Heritage, vol. 60, pp. 41-49, 2023.
Morgan, A. M., H. A. Ogaly, S. Kamel, M. M. Rashad, E. I. Hassanen, Marwa A Ibrahim, Mona K Galal, A. M. Yassin, S. A. A. Dulmani, F. A. M. Al-Zahrani, et al., "Protective effects of N-acetyl-l-cysteine against penconazole-triggered hepatorenal toxicity in adult rats", Journal of Veterinary Research, vol. 67, 2023.
Ahmed, M., D. A. Marrez, N. M. Abdelmoeen, E. A. Mahmoud, M. A. S. Ali, K. Decsi, and Z. Tóth, "Proximate Analysis of Moringa oleifera Leaves and the Antimicrobial Activities of Successive Leaf Ethanolic and Aqueous Extracts Compared with Green Chemically Synthesized Ag-NPs and Crude Aqueous Extract against Some Pathogens", International Journal of Molecular Sciences, vol. 24, issue 4, 2023. ijms-24-03529-v2.pdf
Alqahtani, S. M., A. F. Dawood, S. S. Kamar, M. A. Haidara, A. M. Shams Eldeen, M. Dallak, B. Al-Ani, and H. A. Ebrahim, "Quercetin and Resveratrol are Associated with the Downregulation of TNF-a/NF-kB/iNOS Axis-Mediated Acute Liver Injury in Rats Induced by Paracetamol Poisoning", Int. J. Morphol, vol. 41, issue 1, pp. 79-84,, 2023.
Alqahtani, S. M., Z. Khired, M. Y. Alshahrani, N. M. Alzamil, S. S. Kamar, M. Abd Ellatif, M. Dallak, B. Al-Ani, and A. F. Dawood, "Rat Model of Rheumatoid Arthritis: TDZD-8 is Associated with the Protection Against the Induction of the Synovium Knee Joint IL-17A/GSK3b/ROS/a-SMA Axis of Fibrosis", Int. J. Morphol, vol. 41, issue 2, pp. 583-590,, 2023.
Elkot, N.A., Doha, E.H., Ameen, I.G., Hendy, A.S., and M. A. Zaky, "A re-scaling spectral collocation method for the nonlinear fractional pantograph delay differential equations with non-smooth solutions", Communications in Nonlinear Science and Numerical Simulation, vol. 118, pp. 107017, 2023.
Zhang, Y., J. A. Miller, J. Park, B. P. Lelieveldt, B. Long, T. Abdelaal, B. D. Aevermann, T. Biancalani, C. Comiter, O. Dzyubachyk, et al., "Reference-based cell type matching of in situ image-based spatial transcriptomics data on primary visual cortex of mouse brain.", Scientific reports, vol. 13, issue 1, pp. 9567, 2023. Abstract

With the advent of multiplex fluorescence in situ hybridization (FISH) and in situ RNA sequencing technologies, spatial transcriptomics analysis is advancing rapidly, providing spatial location and gene expression information about cells in tissue sections at single cell resolution. Cell type classification of these spatially-resolved cells can be inferred by matching the spatial transcriptomics data to reference atlases derived from single cell RNA-sequencing (scRNA-seq) in which cell types are defined by differences in their gene expression profiles. However, robust cell type matching of the spatially-resolved cells to reference scRNA-seq atlases is challenging due to the intrinsic differences in resolution between the spatial and scRNA-seq data. In this study, we systematically evaluated six computational algorithms for cell type matching across four image-based spatial transcriptomics experimental protocols (MERFISH, smFISH, BaristaSeq, and ExSeq) conducted on the same mouse primary visual cortex (VISp) brain region. We find that many cells are assigned as the same type by multiple cell type matching algorithms and are present in spatial patterns previously reported from scRNA-seq studies in VISp. Furthermore, by combining the results of individual matching strategies into consensus cell type assignments, we see even greater alignment with biological expectations. We present two ensemble meta-analysis strategies used in this study and share the consensus cell type matching results in the Cytosplore Viewer ( ) for interactive visualization and data exploration. The consensus matching can also guide spatial data analysis using SSAM, allowing segmentation-free cell type assignment.

Alsuyuti, M. M., Doha, E.H., Bayoumi, and S. S. Ezz-Eldien, "Robust spectral treatment for time-fractional delay partial differential equations", Computational and Applied Mathematics, vol. 42, issue 4, pp. 159, 2023.
Essa, K. S., Z. E. Diab, and S. A. Mehanee, "Self-potential data inversion utilizing the Bat optimizing algorithm (BOA) with various application cases", Acta Geophysica, vol. 71, pp. 567-586, 2023.
Essa, K. S., Z. E. Diab, and S. A. Mehanee, "Self-potential data inversion utilizing the Bat optimizing algorithm (BOA) with various application cases", Acta Geophysica, vol. 71, pp. 567–586, 2023.
Essa, K. S., and Z. E. Diab, "Source parameters estimation from gravity data using Bat algorithm with application to geothermal and volcanic activity studies", International Journal of Environmental Science and Technology, vol. 20, pp. 4167–4187, 2023.
Essa, K. S., E. A. Abo-Ezz, Y. Géraud, and M. Diraison, "A successful inversion of magnetic anomalies related to 2D dyke-models by a particle swarm scheme", Journal of Earth System Science, vol. 132, pp. 65, 2023.
Abdelwahab, R. E., A. F. Darweesh, M. A. Ragheb, I. A. Abdelhamid, and A. H. M. Elwahy, "Synthesis of New 2-(4-(1, 4-Dihydropyridin-4-yl) Phenoxy)-N-Arylacetamides and Their Heterocyclic-Fused Derivatives via Hantzsch-Like Reaction", Polycyclic Aromatic Compounds, vol. 43, issue 3: Taylor & Francis, pp. 1974-1986, 2023. Abstract