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2
Salem, M. E., A. F. Darweesh, A. E. M. Mekky, A. M. Farag, and A. H. M. Elwahy, "2‐Bromo‐1‐(1H‐pyrazol‐4‐yl) ethanone: Versatile Precursor for Novel Mono‐and Bis [pyrazolylthiazoles]", Journal of Heterocyclic Chemistry, vol. 54, issue 1: Wiley Online Library, pp. 226-234, 2017. Abstract
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El-Beialy, W., N. Galal, Y. Deyama, Y. Yoshimura, K. Suzuki, KanchuTei, and Y. Totsuka, "3. Effects of estrogen on PMCA 2 and 4 in Human Fibroblast-like Synovial cells and Mouse Macrophage-like cells", Endocrine Journal , vol. 57, issue 1, pp. 93-97, 2010.
Abdulaziz, A. M., H. L. Abdulridha, A. S. A. Dahab, S. Alhussainy, and A. K. Abbas, "3D mechanical earth model for optimized wellbore stability, a case study from South of Iraq", Journal of Petroleum Exploration and Production Technology , vol. 11, issue 1, pp. 3409–3420, 2021. 3d_mechanical_earth_model_for_optimized_wellbore_stability_a_case_study_from_south_of_iraq.pdf
Aguib, H., J. Chapron, M. Donya, Y. Sedky, H. Hosny, and M. Yacoub, "3D modelling of atrial and ventricular shape and function in a patient following the new modified Mustard operation.", Global cardiology science & practice, vol. 2015, pp. 5, 2015.
Dehis, H. M., F. A. El-Sharaby, and Y. A. Mostafa, "3D Soft Tissue Imaging: An Accurate and Economical Approach", Int J Dentistry Oral Sci, vol. 2, no. 6, pp. 87–93, 2015. Abstract
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Ramadan, H., E. Kandeel, L. Hegazy, A. Helal, T. Darwish, and S. E. tokhy, "4. Role of Urokinase-Type Plasminogen Activator Receptors as an Early Detector for Treatment Outcome in Adult Acute Myeloid Leukemia in Egyptian Patients", journal of cancer therapy, vol. 6, pp. 963-970, 2015. -8902212_1_saved__2.pdf
Galal, N., W. El-Beialy, Y. Deyama, Y. Yoshimura, KanchuTei, K. Suzuki, and Y. Totsuka, "4. Up-regulation of the G3PDH ‘housekeeping’ gene by estrogen", Molecular Medicine Reports , vol. 3, pp. 111-113, 2010.
Naguib, M. L., I. Schrijver, P. Gardner, L. M. Piquet, S. S. Doss, M. A. A. Zekry, M. Aziz, and S. Z. Nasré, "472 Incidence of Cystic Fibrosis in high-risk Egyptian children and CFTR mutation analysis", Journal of Cystic Fibrosis, vol. 5: Elsevier, pp. S103, 2006. Abstract
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5
Oing, C., I. Verem, W. Y. Mansour, C. Bokemeyer, S. Dyshlovoy, and F. Honecker, "5-Azacitidine Exerts Prolonged Pro-Apoptotic Effects and Overcomes Cisplatin-Resistance in Non-Seminomatous Germ Cell Tumor Cells.", International journal of molecular sciences, vol. 20, issue 1, pp. 21-32, 2018 Dec 21, 2019. Abstract

Despite high cure rates, about 20% of patients with advanced germ cell tumors (GCTs) fail cisplatin-based chemotherapy. High levels of DNA methylation have been identified in GCTs and linked to cisplatin resistance. Here, we examined the effects of DNA hypomethylating 5-azacitidine (5-aza) on two embryonal carcinoma cell lines (NCCIT, 2102Ep) and their cisplatin-resistant isogenic derivatives. Effects on cell viability and cisplatin sensitivity were assessed by the trypan blue exclusion method. Western blotting was used to examine induction of apoptosis 5-aza and results were validated by flow cytometry. Single agent treatment with 5-aza strongly impacted viability and induced apoptosis at low nanomolar concentrations, both in cisplatin-sensitive and -resistant cell lines. 5-aza exerted an immediate apoptotic response, followed by a prolonged inhibitory effect on cell viability and cell-cycle progression. Sequential treatment with 5-aza and cisplatin reduced cellular survival of the cisplatin-resistant sublines already at nanomolar concentrations, suggesting a partial restoration of cisplatin sensitivity by the compound. 5-aza demonstrated anti-tumor activity as a single agent at low nanomolar concentrations in GCT cells, irrespective of cisplatin-sensitivity. 5-aza may also have the potential at least to partially restore cisplatin-sensitivity in non-seminoma cells, supporting the hypothesis that combining DNA demethylating agents with cisplatin-based chemotherapy may be a valid therapeutic approach in patients with refractory GCTs.

Srinivas, U. S., J. Dyczkowski, T. Beißbarth, J. Gaedcke, W. Y. Mansour, K. Borgmann, and M. Dobbelstein, "5-Fluorouracil sensitizes colorectal tumor cells towards double stranded DNA breaks by interfering with homologous recombination repair.", Oncotarget, vol. 6, issue 14, pp. 12574-86, 2015 May 20. Abstractsrinivas-2015.pdf

Malignant tumors of the rectum are treated by neoadjuvant radiochemotherapy. This involves a combination of 5-fluorouracil (5-FU) and double stranded DNA-break (DSB)-inducing radiotherapy. Here we explored how 5-FU cooperates with DSB-induction to achieve sustainable DNA damage in colorectal cancer (CRC) cells. After DSB induction by neocarzinostatin, phosphorylated histone 2AX (γ-H2AX) rapidly accumulated but then largely vanished within a few hours. In contrast, when CRC cells were pre-treated with 5-FU, gammaH2AX remained for at least 24 hours. GFP-reporter assays revealed that 5-FU decreases the efficiency of homologous recombination (HR) repair. However, 5-FU did not prevent the initial steps of HR repair, such as the accumulation of RPA and Rad51 at nuclear foci. Thus, we propose that 5-FU interferes with the continuation of HR repair, e. g. the synthesis of new DNA strands. Two key mediators of HR, Rad51 and BRCA2, were found upregulated in CRC biopsies as compared to normal mucosa. Inhibition of HR by targeting Rad51 enhanced DNA damage upon DSB-inducing treatment, outlining an alternative way of enhancing therapeutic efficacy. Taken together, our results strongly suggest that interfering with HR represents a key mechanism to enhance the efficacy when treating CRC with DNA-damaging therapy.

Srinivas, U. S., J. Dyczkowski, T. Beißbarth, J. Gaedcke, W. Y. Mansour, K. Borgmann, and M. Dobbelstein, "5-Fluorouracil sensitizes colorectal tumor cells towards double stranded DNA breaks by interfering with homologous recombination repair.", Oncotarget, vol. 6, issue 14, pp. 12574-86, 2015 May 20. Abstract

Malignant tumors of the rectum are treated by neoadjuvant radiochemotherapy. This involves a combination of 5-fluorouracil (5-FU) and double stranded DNA-break (DSB)-inducing radiotherapy. Here we explored how 5-FU cooperates with DSB-induction to achieve sustainable DNA damage in colorectal cancer (CRC) cells. After DSB induction by neocarzinostatin, phosphorylated histone 2AX (γ-H2AX) rapidly accumulated but then largely vanished within a few hours. In contrast, when CRC cells were pre-treated with 5-FU, gammaH2AX remained for at least 24 hours. GFP-reporter assays revealed that 5-FU decreases the efficiency of homologous recombination (HR) repair. However, 5-FU did not prevent the initial steps of HR repair, such as the accumulation of RPA and Rad51 at nuclear foci. Thus, we propose that 5-FU interferes with the continuation of HR repair, e. g. the synthesis of new DNA strands. Two key mediators of HR, Rad51 and BRCA2, were found upregulated in CRC biopsies as compared to normal mucosa. Inhibition of HR by targeting Rad51 enhanced DNA damage upon DSB-inducing treatment, outlining an alternative way of enhancing therapeutic efficacy. Taken together, our results strongly suggest that interfering with HR represents a key mechanism to enhance the efficacy when treating CRC with DNA-damaging therapy.

El-Sheemy, M. S., A. M. Shouman, A. I. Shoukry, W. Aboulela, K. Daw, A. A. Hussein, and H. A. Morsi, "556 Selection criteria for initial urinary drainage in relation to definitive stone management in obstructive calcular anuria with acute renal failure in children less than 4 years in age", European Urology Supplements, vol. 13, no. 1: Elsevier Science, pp. e556–e556a, 2014. Abstract
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El-Sheemy, M. S., A. M. Shouman, A. I. Shoukry, W. Aboulela, K. Daw, A. A. Hussein, and H. A. Morsi, "556 Selection criteria for initial urinary drainage in relation to definitive stone management in obstructive calcular anuria with acute renal failure in children less than 4 years in age", European Urology Supplements, vol. 1, no. 13, pp. e556–e556a, 2014. Abstract
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El-Sheemy, M. S., A. M. Shouman, A. I. Shoukry, W. Aboulela, K. Daw, A. A. Hussein, and H. A. Morsi, "556 Selection criteria for initial urinary drainage in relation to definitive stone management in obstructive calcular anuria with acute renal failure in children less than 4 years in age", European Urology Supplements, vol. 1, no. 13, pp. e556–e556a, 2014. Abstract
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El-Sheemy, M. S., A. M. Shouman, A. I. Shoukry, W. Aboulela, K. Daw, A. A. Hussein, and H. A. Morsi, "556 Selection criteria for initial urinary drainage in relation to definitive stone management in obstructive calcular anuria with acute renal failure in children less than 4 years in age", European Urology Supplements, vol. 1, no. 13, pp. e556–e556a, 2014. Abstract

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El-Sheemy, M. S., A. M. Shouman, A. I. Shoukry, W. Aboulela, K. Daw, A. A. Hussein, and H. A. Morsi, "556 Selection criteria for initial urinary drainage in relation to definitive stone management in obstructive calcular anuria with acute renal failure in children less than 4 years in age", European Urology Supplements, vol. 1, no. 13, pp. e556–e556a, 2014. Abstract

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mohamed farid roaiah, yasser ibrahim elkhayat, L. A. Rashed, sameh fayek gamalEl Din, A. M. El Guindi, I. Fath, and M. A. A. E. Salam, "5HT-1A receptor polymorphism effects ejaculatory function in Egyptian patients with lifelong premature ejaculation", Rev Int Androl, vol. 17, issue 4, pp. 138-142, 2019.
mohamed farid roaiah, yasser ibrahim elkhayat, L. A. Rashed, sameh fayek gamalEl Din, A. M. El Guindi, I. F. Soliman, and M. A. A. E. Salam, "5HT-1A receptor polymorphism effects ejaculatory function in Egyptian patients with lifelong premature ejaculation.", Revista internacional de andrologia, vol. 17, issue 4, pp. 138-142, 2019. Abstract

INTRODUCTION AND OBJECTIVES: Lifelong premature ejaculation (LPE) is identified as the inability to delay ejaculation for more than 1min after vaginal penetration occurring on all or almost all sexual experiences together with feelings of frustration of both the patient and his partner with avoidance of sexual intimacy. Recently, a role for (HTR1A)-C (1019) G gene polymorphism in patients with LPE was postulated.

MATERIALS AND METHODS: Three hundred and fifty participants were prospectively enrolled in this study. They were recruited from the outpatient clinic of Andrology & STDs Department Cairo University from December 2015 to January 2017. Two hundred and forty-five of them were suffering from lifelong premature ejaculation joined this study, in addition to 105 controls. We instructed the wives of the patients to measure the intra-vaginal ejaculation latency time (IELT) of the first intercourse only using a stopwatch for 1 month. Genotyping was performed at the end of the study.

RESULTS: The results showed that the majority of the patients were CG, while; the controls were GG. This difference revealed a statistically significant association (p-value<0.001). A highly significant statistical association was found between the studied gene polymorphisms and the IELT among cases (p-values=0.001).

CONCLUSION: The study replicated the potential role of 5HT-1A receptor gene polymorphisms in patients with lifelong premature ejaculation.

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Griffith, D., F. Dulger, G. Feygin, and A. N. Mohieldin, "A 65nm CMOS DCXO system for generating 38.4MHz and a real time clock from a single crystal in 0.09mm2", IEEE Radio Frequency Integrated Circuits Symposium , Anaheim, California, May, 2010.
Shawali, A. S., S. M. Sherif, T. A. Farghaly, M. R. Sheahta, and M. A. A. Darwish, "68. Synthesis and tautomeric structure of azo-coupling products of 2-methyl-7-phenylpyrimido[l,2-b][l,2,4]triazepine-4,9(3H,5H)-dione A. S.", J. Chem. Res. 44 , 2007.
Elmahdy, N. A., A. S. Denikin, M. Ismail, and A. Y. Ellithi, "6Li breakup and suppression of complete fusion above the Coulomb barrier", European Physical Journal A, vol. 51, pp. 62, 2015. Abstract

We study the role of the projectile breakup in the fusion process by example of the 6Li reactions with the 59Co, 144Sm and 209Bi targets in vicinity of the Coulomb barrier. The coupled channel and distorted wave approaches are employed in order to calculate the complete fusion and the breakup cross sections, respectively. The partial cross sections in both the channels are compared in order to estimate the breakup fraction responsible for the suppression of complete fusion. The calculations are compared with available experimental data. The conclusions and recommendations are made.

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Payne, A., A. Daniel, A. Mehta, B. Thompson, C. S. Bamji, D. Snow, H. Oshima, L. Prather, M. Fenton, L. Kordus, et al., "7.6 a 512× 424 cmos 3d time-of-flight image sensor with multi-frequency photo-demodulation up to 130mhz and 2gs/s adc", 2014 IEEE International Solid-State Circuits Conference Digest of Technical Papers (ISSCC): IEEE, pp. 134-135, 2014. Abstract

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9
Afifi, A., H. M. Dobal, M. Mahmoud, and A. N. Moharram, "90/90 Bicortical, double-loop, interosseous wiring for fixation of transverse and short oblique metacarpal shaft fractures", Current Orthopaedic Practice, vol. 30, issue 2, pp. 164–169, 2019. 90_90_bicortical_double_loop_interosseous_wiring.15.pdf
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