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2024
Bashal, A. H., J. Dhahri, K. Dhahri, and K. D. Khalil, "Deep insight into physical properties of carboxymethyl cellulose-barium oxide nanocomposites", International Journal of Biological Macromolecules, vol. 269, pp. 131935, 2024.
Kheir, A. M. S., A. Govind, V. Nangia, M. Devkota, A. Elnashar, M. E. D. Omar, and T. Feike, "Developing automated machine learning approach for fast and robust crop yield prediction using a fusion of remote sensing, soil, and weather dataset", Environmental Research Communications, vol. 6, issue 4, pp. 041005, 2024. AbstractWebsite

Estimating smallholder crop yields robustly and timely is crucial for improving agronomic practices, determining yield gaps, guiding investment, and policymaking to ensure food security. However, there is poor estimation of yield for most smallholders due to lack of technology, and field scale data, particularly in Egypt. Automated machine learning (AutoML) can be used to automate the machine learning workflow, including automatic training and optimization of multiple models within a user-specified time frame, but it has less attention so far. Here, we combined extensive field survey yield across wheat cultivated area in Egypt with diverse dataset of remote sensing, soil, and weather to predict field-level wheat yield using 22 Ml models in AutoML. The models showed robust accuracies for yield predictions, recording Willmott degree of agreement, (d > 0.80) with higher accuracy when super learner (stacked ensemble) was used (R2 = 0.51, d = 0.82). The trained AutoML was deployed to predict yield using remote sensing (RS) vegetative indices (VIs), demonstrating a good correlation with actual yield (R2 = 0.7). This is very important since it is considered a low-cost tool and could be used to explore early yield predictions. Since climate change has negative impacts on agricultural production and food security with some uncertainties, AutoML was deployed to predict wheat yield under recent climate scenarios from the Coupled Model Intercomparison Project Phase 6 (CMIP6). These scenarios included single downscaled General Circulation Model (GCM) as CanESM5 and two shared socioeconomic pathways (SSPs) as SSP2-4.5and SSP5-8.5during the mid-term period (2050). The stacked ensemble model displayed declines in yield of 21% and 5% under SSP5-8.5 and SSP2-4.5 respectively during mid-century, with higher uncertainty under the highest emission scenario (SSP5-8.5). The developed approach could be used as a rapid, accurate and low-cost method to predict yield for stakeholder farms all over the world where ground data is scarce.

Decsi, K., M. Ahmed, R. Rizk, D. Abdul-Hamid, G. P. Kovács, and Z. Tóth, "Emerging Trends in Non-Protein Amino Acids as Potential Priming Agents: Implications for Stress Management Strategies and Unveiling Their Regulatory Functions", International Journal of Molecular Sciences, vol. 25, issue 11, 2024.
Derbala, M. K., and A. M. Abu-Seida, "Endoscopic Laser Ablation of Endometrial Cysts in Straight Egyptian Arabian Mares: Outcome on Embryo Recovery and Conception Rate", Egyptian Journal of Veterinary Science, vol. 55, issue 2, pp. 371-380, 2024. endometrial_cysts.pdf
AbdelMassih, A., M. Haroun, R. A. R. AbdelAziz Afifi, G. Hussein, M. AbdelHameed, M. G. Asaad, H. Tarabeh, N. E. El Din Taha, N. Diab, N. Shebl, et al., "Endothelial dysfunction linked to ventricular dysfunction in children with sickle cell disease, a 3D speckle tracking study", Journal of the Saudi Heart Association, vol. 36, no. 1: Elsevier, 2024. Abstract
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Deligiannis, N. I., R. Cantoro, M. S. Reorda, and S. E. D. Habib, "Evaluating the Reliability of Integer Multipliers With Respect to Permanent Faults", 2024 27th International Symposium on Design & Diagnostics of Electronic Circuits & Systems (DDECS): IEEE, pp. 124–129, 2024. Abstract
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RADWAN, M. S., M. Gobashy, S. DAHROUG, and S. Raslan, "Exploring carbonate reservoirs potential, north Egypt", Contributions to Geophysics and Geodesy, vol. 54, issue 1, pp. 49–66, 2024.
Alruwad, M. I., R. S. E. Dine, A. M. Gendy, M. M. Sabry, and H. M. El Hefnawy, "Exploring the Biological and Phytochemical Potential of Jordan’s Flora: A Review and Update of Eight Selected Genera from Mediterranean Region", Molecules, vol. 29, issue 5: MDPI, pp. 1160, 2024. Abstract
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Biancari, F., T. Juvonen, S. - M. Cho, F. J. Hernández Pérez, C. L'Acqua, A. A. Arafat, M. M. AlBarak, M. Laimoud, I. Djordjevic, R. Samalavicius, et al., "External validation of the PC-ECMO score in postcardiotomy veno-arterial extracorporeal membrane oxygenation.", The International journal of artificial organs, pp. 3913988241237701, 2024. Abstract

Reliable stratification of the risk of early mortality after postcardiotomy veno-arterial extracorporeal membrane oxygenation (V-A-ECMO) remains elusive. In this study, we externally validated the PC-ECMO score, a specific risk scoring method for prediction of in-hospital mortality after postcardiotomy V-A-ECMO. Overall, 614 patients who required V-A-ECMO after adult cardiac surgery were gathered from an individual patient data meta-analysis of nine studies on this topic. The AUC of the logistic PC-ECMO score in predicting in-hospital mortality was 0.678 (95%CI 0.630-0.726;  < 0.0001). The AUC of the logistic PC-ECMO score in predicting on V-A-ECMO mortality was 0.652 (95%CI 0.609-0.695;  < 0.0001). The Brier score of the logistic PC-ECMO score for in-hospital mortality was 0.193, the slope 0.909, the calibration-in-the-large 0.074 and the expected/observed mortality ratio 0.979. 95%CIs of the calibration belt of fit relationship between observed and predicted in-hospital mortality were never above or below the bisector ( = 0.072). The present findings suggest that the PC-ECMO score may be a valuable tool in clinical research for stratification of the risk of patients requiring postcardiotomy V-A-ECMO.

El‑Hawagry, M. S. A., A. M. Soliman, M. S. Abdel-Dayem, R. M. El-Hady, and H. A. L. M. DHAFER, "The Family Bibionidae (Diptera: Nematocera) in Egypt and Saudi Arabia..", Catrina: The International Journal of Environmental Sciences, vol. 29, issue 1, pp. 39-46, 2024. the_family_bibionidae_in_egypt_and_saudi_arabia.pdf
Sandhu, N. K., N. Ravichandraan, A. Nune, J. Day, P. Sen, E. Nikiphorou, A. L. Tan, M. Joshi, S. Saha, S. K. Shinjo, et al., "Flares of autoimmune rheumatic disease following COVID-19 infection: Observations from the COVAD study.", International journal of rheumatic diseases, vol. 27, issue 1, pp. e14961, 2024.
Zayed, H. M., N. K. E. H. Din, A. A. - M. Seida, A. A. A. Zeid, and O. M. Ezzatt, "Gingival-derived mesenchymal stem cell regenerated the radiated salivary glands: Functional and Histological evidence in murine model", Stem Cell Research and Therapy, vol. 15, pp. 46, 2024. stem_cells.pdf
Ziade, N., M. Aoude, I. Hmamouchi, N. R, J. B. Lilleker, P. Sen, M. Joshi, V. Agarwal, S. Kardes, J. Day, et al., "Global disparities in the treatment of idiopathic inflammatory myopathies: results from an international online survey study.", Rheumatology (Oxford, England), vol. 63, issue 3, pp. 657-664, 2024. Abstract

OBJECTIVES: We aimed to explore current practice and interregional differences in the treatment of idiopathic inflammatory myopathies (IIMs). We triangulated these observations considering countries' gross national income (GNI), disease subtypes, and symptoms using patient-reported information.

METHODS: A cross-sectional ancillary analysis of the 'COVID-19 vaccination in auto-immune disease' (COVAD) e-survey containing demographic characteristics, IIM subtypes (DM, PM, IBM, anti-synthetase syndrome [ASSD], immune-mediated necrotizing myopathy [IMNM], overlap myopathies [OM]), current symptoms (surrogate for organ involvement) and treatments (corticosteroids [CS], immunomodulators [IM], i.e. antimalarials, immunosuppressants [IS], IVIG, biologic treatments and targeted-synthetic small molecules). Treatments were presented descriptively according to continents, GNI, IIM and organ involvement, and associated factors were analysed using multivariable binary logistic regressions.

RESULTS: Of 18 851 respondents from 94 countries, 1418 with IIM were analysed (age 61 years, 62.5% females). DM (32.4%), IBM (24.5%) and OM (15.8%) were the most common subtypes. Treatment categories included IS (49.4%), CS (38.5%), IM (13.8%) and IVIG (9.4%). Notably, treatments varied across regions, GNI categories (IS mostly used in higher-middle income, IM in lower-middle income, IVIG and biologics largely limited to high-income countries), IIM subtypes (IS and CS associated with ASSD, IM with OM and DM, IVIG with IMNM, and biologic treatments with OM and ASSD) and disease manifestations (IS and CS with dyspnoea). Most inter-regional treatment disparities persisted after multivariable analysis.

CONCLUSION: We identified marked regional treatment disparities in a global cohort of IIM. These observations highlight the need for international consensus-driven management guidelines considering patient-centred care and available resources.

Zhang, H., G. Targher, C. D. Byrne, S. U. Kim, V. W. - S. Wong, L. Valenti, M. Glickman, J. Ponce, C. S. Mantzoros, J. Crespo, et al., "A global survey on the use of the international classification of diseases codes for metabolic dysfunction-associated fatty liver disease.", Hepatology international, 2024. Abstract

BACKGROUND: With the implementation of the 11th edition of the International Classification of Diseases (ICD-11) and the publication of the metabolic dysfunction-associated fatty liver disease (MAFLD) nomenclature in 2020, it is important to establish consensus for the coding of MAFLD in ICD-11. This will inform subsequent revisions of ICD-11.

METHODS: Using the Qualtrics XM and WJX platforms, questionnaires were sent online to MAFLD-ICD-11 coding collaborators, authors of papers, and relevant association members.

RESULTS: A total of 890 international experts in various fields from 61 countries responded to the survey. We also achieved full coverage of provincial-level administrative regions in China. 77.1% of respondents agreed that MAFLD should be represented in ICD-11 by updating NAFLD, with no significant regional differences (77.3% in Asia and 76.6% in non-Asia, p = 0.819). Over 80% of respondents agreed or somewhat agreed with the need to assign specific codes for progressive stages of MAFLD (i.e. steatohepatitis) (92.2%), MAFLD combined with comorbidities (84.1%), or MAFLD subtypes (i.e., lean, overweight/obese, and diabetic) (86.1%).

CONCLUSIONS: This global survey by a collaborative panel of clinical, coding, health management and policy experts, indicates agreement that MAFLD should be coded in ICD-11. The data serves as a foundation for corresponding adjustments in the ICD-11 revision.

Zayed, S. O., S. Abdel-Ghany, U. E. L. Dakrory, J. A. Hamid, S. H. Ibrahim, H. Sabit, and G. Abd El Aziz, "Graviola (Annona muricata) Extract Loaded on Chitosan Nanoparticles Modulates HDACs in Tongue Squamous Cell Carcinoma", Egyptian dental journal, 2024.
Abdel-Aal, N. M., A. S. A. S. EL-Azeim, R. M. Kamil, and M. R. M. Dalia I Tayel, Rania H Hamed, "Impact of adding Mediterranean diet to aerobic and strengthening exercise program on pain, inflammation, and muscle performance in females with rheumatoid arthritis: a randomized controlled trial", physiotherapy theory and practice, 2024.
Yoshida, A., Y. Li, V. Maroufy, M. Kuwana, S. Sazliyana Shaharir, A. Makol, P. Sen, J. B. Lilleker, V. Agarwal, E. Kadam, et al., "Impaired health-related quality of life in idiopathic inflammatory myopathies: a cross-sectional analysis from the COVAD-2 e-survey.", Rheumatology advances in practice, vol. 8, issue 2, pp. rkae028, 2024. Abstract

OBJECTIVES: To investigate health-related quality of life in patients with idiopathic inflammatory myopathies (IIMs) compared with those with non-IIM autoimmune rheumatic diseases (AIRDs), non-rheumatic autoimmune diseases (nrAIDs) and without autoimmune diseases (controls) using Patient-Reported Outcome Measurement Information System (PROMIS) instrument data obtained from the second COVID-19 vaccination in autoimmune disease (COVAD-2) e-survey database.

METHODS: Demographics, diagnosis, comorbidities, disease activity, treatments and PROMIS instrument data were analysed. Primary outcomes were PROMIS Global Physical Health (GPH) and Global Mental Health (GMH) scores. Factors affecting GPH and GMH scores in IIMs were identified using multivariable regression analysis.

RESULTS: We analysed responses from 1582 IIM, 4700 non-IIM AIRD and 545 nrAID patients and 3675 controls gathered through 23 May 2022. The median GPH scores were the lowest in IIM and non-IIM AIRD patients {13 [interquartile range (IQR) 10-15] IIMs 13 [11-15] non-IIM AIRDs 15 [13-17] nrAIDs 17 [15-18] controls,  < 0.001}. The median GMH scores in IIM patients were also significantly lower compared with those without autoimmune diseases [13 (IQR 10-15) IIMs 15 (13-17) controls,  < 0.001]. Inclusion body myositis, comorbidities, active disease and glucocorticoid use were the determinants of lower GPH scores, whereas overlap myositis, interstitial lung disease, depression, active disease, lower PROMIS Physical Function 10a and higher PROMIS Fatigue 4a scores were associated with lower GMH scores in IIM patients.

CONCLUSION: Both physical and mental health are significantly impaired in IIM patients, particularly in those with comorbidities and increased fatigue, emphasizing the importance of patient-reported experiences and optimized multidisciplinary care to enhance well-being in people with IIMs.

Ahmed, M., D. A. Marrez, R. Rizk, mostafa zedan, D. Abdul-Hamid, K. Decsi, G. P. Kovács, and Z. Tóth, "The Influence of Zinc Oxide Nanoparticles and Salt Stress on the Morphological and Some Biochemical Characteristics of Solanum lycopersicum L. Plants", Plants, vol. 13, issue 10, 2024.
Adnan Awad, S., O. Dufva, J. Klievink, E. Karjalainen, A. Ianevski, P. Pietarinen, D. Kim, S. Potdar, M. Wolf, K. Lotfi, et al., "Integrated drug profiling and CRISPR screening identify BCR::ABL1-independent vulnerabilities in chronic myeloid leukemia.", Cell reports. Medicine, vol. 5, issue 5, pp. 101521, 2024. Abstract

BCR::ABL1-independent pathways contribute to primary resistance to tyrosine kinase inhibitor (TKI) treatment in chronic myeloid leukemia (CML) and play a role in leukemic stem cell persistence. Here, we perform ex vivo drug screening of CML CD34 leukemic stem/progenitor cells using 100 single drugs and TKI-drug combinations and identify sensitivities to Wee1, MDM2, and BCL2 inhibitors. These agents effectively inhibit primitive CD34CD38 CML cells and demonstrate potent synergies when combined with TKIs. Flow-cytometry-based drug screening identifies mepacrine to induce differentiation of CD34CD38 cells. We employ genome-wide CRISPR-Cas9 screening for six drugs, and mediator complex, apoptosis, and erythroid-lineage-related genes are identified as key resistance hits for TKIs, whereas the Wee1 inhibitor AZD1775 and mepacrine exhibit distinct resistance profiles. KCTD5, a consistent TKI-resistance-conferring gene, is found to mediate TKI-induced BCR::ABL1 ubiquitination. In summary, we delineate potential mechanisms for primary TKI resistance and non-BCR::ABL1-targeting drugs, offering insights for optimizing CML treatment.

Biancari, F., T. Mäkikallio, A. Loforte, A. Kaserer, V. G. Ruggieri, S. - M. Cho, J. K. Kang, M. Dalén, H. Welp, K. Jónsson, et al., "Inter-institutional analysis of the outcome after postcardiotomy veno-arterial extracorporeal membrane oxygenation.", The International journal of artificial organs, vol. 47, issue 1, pp. 25-34, 2024. Abstract

INTRODUCTION: Patients requiring postcardiotomy veno-arterial extracorporeal membrane oxygenation (V-A-ECMO) have a high risk of early mortality. In this analysis, we evaluated whether any interinstitutional difference exists in the results of postcardiotomy V-A-ECMO.

METHODS: Studies on postcardiotomy V-A-ECMO were identified through a systematic review for individual patient data (IPD) meta-analysis. Analysis of interinstitutional results was performed using direct standardization, estimation of observed/expected in-hospital mortality ratio and propensity score matching.

RESULTS: Systematic review of the literature yielded 31 studies. Data from 10 studies on 1269 patients treated at 25 hospitals were available for the present analysis. In-hospital mortality was 66.7%. The relative risk of in-hospital mortality was significantly higher in six hospitals. Observed versus expected in-hospital mortality ratio showed that four hospitals were outliers with significantly increased mortality rates, and one hospital had significantly lower in-hospital mortality rate. Participating hospitals were classified as underperforming and overperforming hospitals if their observed/expected in-hospital mortality was higher or lower than 1.0, respectively. Among 395 propensity score matched pairs, the overperforming hospitals had significantly lower in-hospital mortality (60.3% vs 71.4%,  = 0.001) than underperforming hospitals. Low annual volume of postcardiotomy V-A-ECMO tended to be predictive of poor outcome only when adjusted for patients' risk profile.

CONCLUSIONS: In-hospital mortality after postcardiotomy V-A-ECMO differed significantly between participating hospitals. These findings suggest that in many centers there is room for improvement of the results of postcardiotomy V-A-ECMO.

Zhang, L., M. El-Shabrawi, L. A. Baur, C. D. Byrne, G. Targher, M. Kehar, G. Porta, W. S. Lee, S. Lefere, S. Turan, et al., "An international multidisciplinary consensus on pediatric metabolic dysfunction-associated fatty liver disease.", Med (New York, N.Y.), 2024. Abstract

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is highly prevalent in children and adolescents, particularly those with obesity. NAFLD is considered a hepatic manifestation of the metabolic syndrome due to its close associations with abdominal obesity, insulin resistance, and atherogenic dyslipidemia. Experts have proposed an alternative terminology, metabolic dysfunction-associated fatty liver disease (MAFLD), to better reflect its pathophysiology. This study aimed to develop consensus statements and recommendations for pediatric MAFLD through collaboration among international experts.

METHODS: A group of 65 experts from 35 countries and six continents, including pediatricians, hepatologists, and endocrinologists, participated in a consensus development process. The process encompassed various aspects of pediatric MAFLD, including epidemiology, mechanisms, screening, and management.

FINDINGS: In round 1, we received 65 surveys from 35 countries and analyzed these results, which informed us that 73.3% of respondents agreed with 20 draft statements while 23.8% agreed somewhat. The mean percentage of agreement or somewhat agreement increased to 80.85% and 15.75%, respectively, in round 2. The final statements covered a wide range of topics related to epidemiology, pathophysiology, and strategies for screening and managing pediatric MAFLD.

CONCLUSIONS: The consensus statements and recommendations developed by an international expert panel serve to optimize clinical outcomes and improve the quality of life for children and adolescents with MAFLD. These findings emphasize the need for standardized approaches in diagnosing and treating pediatric MAFLD.

FUNDING: This work was funded by the National Natural Science Foundation of China (82070588, 82370577), the National Key R&D Program of China (2023YFA1800801), National High Level Hospital Clinical Research Funding (2022-PUMCH-C-014), the Wuxi Taihu Talent Plan (DJTD202106), and the Medical Key Discipline Program of Wuxi Health Commission (ZDXK2021007).

Santos, D. K. C., M. A. Mustafa, P. Bansal, H. Kaur, M. Deorar, F. M. A. Altalbawy, D. Y. Alhameedi, M. H. shuhata Alubiady, A. M. Al‑Ani, S. S. Jumaa, et al., "Investigation of ORR and OER Mechanisms by Co‑ and Fe‑doped Silicon Nanocages (Si48 and Si60) and Co‑ and Fe‑doped Silicon Nanotubes (SiNT(5, 0) and SiNT(6, 0)) as Acceptable Catalysts", Silicon, 2024. 36-silicon.pdf
Fouad, Y., H. Ghazinyan, M. Alboraie, M. Alkhatry, H. Desalegn, F. Al-Ali, Mortada HF El-Shabrawi, Ola El-Sisi, P. Ocama, M. Derbala, S. Barakat, et al., "Joint position statement from the Middle East and North Africa and sub-Saharan Africa on continuing to endorse the MAFLD definition.", Journal of hepatology, vol. 80, issue 5, pp. e194-e197, 2024.