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Dafallah, E. S., H. I. Nimir, E. A. Ali, and M. R. Shehata, "SYNTHESIS, CHARACTERIZATION AND DFT CALCULATIONS OF SCHIFF-BASE VANADIUM (V) COMPLEXES DERIVED FROM SALICYLDEHYDE WITH 1, 2-DIAMINOPROPANE OR 2-PICOLYLAMINE", Al-Azhar Bulletin of Science, vol. 28, no. 1-A: Al-Azhar University, Faculty of Science (Boys), pp. 21–30, 2017. Abstractabsb_volume_28_issue_issue_1-a_pages_21-30.pdf

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Dafallah, E. S., H. I. Nimir, E. A. Ali, and M. R. Shehata, "SYNTHESIS, CHARACTERIZATION AND DFT CALCULATIONS OF SCHIFF-BASE VANADIUM (V) COMPLEXES DERIVED FROM SALICYLDEHYDE WITH 1, 2-DIAMINOPROPANE OR 2-PICOLYLAMINE", Al-Azhar Bulletin of Science, vol. 28, issue 1-A: Al-Azhar University, Faculty of Science (Boys), pp. 21-30, 2017. Abstract
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Daga, A., A. J. Majmundar, D. A. Braun, H. Y. Gee, J. A. Lawson, S. Shril, T. Jobst-Schwan, A. Vivante, D. Schapiro, W. Tan, et al., "Whole exome sequencing frequently detects a monogenic cause in early onset nephrolithiasis and nephrocalcinosis.", Kidney international, vol. 93, issue 1, pp. 204-213, 2018 Jan. Abstract

The incidence of nephrolithiasis continues to rise. Previously, we showed that a monogenic cause could be detected in 11.4% of individuals with adult-onset nephrolithiasis or nephrocalcinosis and in 16.7-20.8% of individuals with onset before 18 years of age, using gene panel sequencing of 30 genes known to cause nephrolithiasis/nephrocalcinosis. To overcome the limitations of panel sequencing, we utilized whole exome sequencing in 51 families, who presented before age 25 years with at least one renal stone or with a renal ultrasound finding of nephrocalcinosis to identify the underlying molecular genetic cause of disease. In 15 of 51 families, we detected a monogenic causative mutation by whole exome sequencing. A mutation in seven recessive genes (AGXT, ATP6V1B1, CLDN16, CLDN19, GRHPR, SLC3A1, SLC12A1), in one dominant gene (SLC9A3R1), and in one gene (SLC34A1) with both recessive and dominant inheritance was detected. Seven of the 19 different mutations were not previously described as disease-causing. In one family, a causative mutation in one of 117 genes that may represent phenocopies of nephrolithiasis-causing genes was detected. In nine of 15 families, the genetic diagnosis may have specific implications for stone management and prevention. Several factors that correlated with the higher detection rate in our cohort were younger age at onset of nephrolithiasis/nephrocalcinosis, presence of multiple affected members in a family, and presence of consanguinity. Thus, we established whole exome sequencing as an efficient approach toward a molecular genetic diagnosis in individuals with nephrolithiasis/nephrocalcinosis who manifest before age 25 years.

DAGHER, F. A. T. M. A. E., A. Attia, N. F. Mahmoud, and A. M. Badr, "Exploring Risk Factors with Ventilator Associated Pneumonia among Infants in Intensive Care Units", Med. J. Cairo Univ., vol. 86, issue 7, pp. 3505-3518, 2018.
DAGHER, F. A. T. M. A. E., A. Attia, and N. F. Mahmoud, "Exploring Risk Factors with Ventilator Associated Pneumonia among Infants in Intensive Care Units", Med. J. Cairo Univ., vol. 86, issue 7, pp. 3505-3518, 2018.
DAGHER, F. A. T. M. A. E., A. Attia, and N. F. Mahmoud, "Exploring Risk Factors with Ventilator Associated Pneumonia among Infants in Intensive Care Units", Med. J. Cairo Univ., vol. 86, issue 7, pp. 3505-3518, 2018.
Daghestani, M., M. Daghestani, M. Daghistani, A. Eldali, Z. K. Hassan, M. H. Elamin, and A. Warsy, "ADRB3 polymorphism rs4994 (Trp64Arg) associates significantly with bodyweight elevation and dyslipidaemias in Saudis but not rs1801253 (Arg389Gly) polymorphism in ARDB1.", Lipids in health and disease, vol. 17, issue 1, pp. 58, 2018. Abstract

BACKGROUND: In some populations, obesity and body weight related disorders show a correlation with polymorphisms in three subtypes of beta-adrenoceptor (β1, β2, and β3) [ADRB1, ADRB2 and ADRB3] genes. We scanned for the polymorphism of Arg389Gly (rs1801253) in ADRB1 and Trp64Arg (rs4994) in ADRB3 genes in Saudi population to determine association, if any, of these polymorphisms with obesity and related disorders.

METHODS: We studied 329 non-related adults (33.1% men and 66.9% women), aged 18-36 years. Anthropometric measurements were recorded, and Body mass index (BMI) and waist/hip ratio were calculated; leptin, insulin, lipidogram, and glucose concentrations were determined. ADRB1 and ADRB3 polymorphisms (Arg389Gly and Trp64Arg, respectively) were screened by DNA sequencing. The subjects were divided into three groups according to BMI: normal weight (BMI < 25 kg/m), overweight (BMI ≥25.1-29.9 kg/m) subjects, and obese (≥30 kg/m).

RESULTS: In the age-matched groups of the normal weight, overweight and obese male and female subjects, all anthropometric parameters were found to be significantly higher, and in the obese group, all biochemical parameters were significantly elevated compared to the normal weight controls. The allelic frequency of Gly389 ADRB1 did not differ amongst the three groups, whereas the frequency of Arg64 of ADRB3 gene was significantly higher in the overweight and obese subjects, compared with the normal weight subjects. In addition, subjects carrying Arg64 allele regardless of their BMI had a greater waist and hip circumference, W/H ratio, plasma cholesterol, triglyceride, LDL, leptin, insulin, and glucose level compared to those with the wild-type Trp allele.

CONCLUSION: The results of this study have shown a significant association between the Trp64Arg polymorphism in ADRB3 gene and the development of overweight and obesity in Saudi populations. It also has an influence on the levels of lipid, insulin, leptin, and glucose, whereas, Arg389Gly polymorphism in ADRB1 is not associated with overweight, obesity or dyslipidaemias in Saudis.

Daghestani, L. F., L. F. Ibrahim, R. S. Al-Towirgi, and H. A. Salman, "Adapting gamified learning systems using educational data mining techniques", Computer Applications in Engineering EducationComputer Applications in Engineering Education, vol. 28, issue 3: John Wiley & Sons, Ltd, pp. 568 - 589, 2020. AbstractWebsite

Abstract Artificial intelligence (AI) provides opportunities to improve the effectiveness of e-learning by increasing students' engagement. Adaptive e-learning uses AI to support individual learners by responding to their different learning needs which can be determined by analyzing their navigation history of e-learning systems using data mining methods. Educational data mining (EDM) discovers new patterns of learning and teaching to facilitate the process of decision-making to serve education improvement. Gamification is another way of increasing students' engagement by using game elements in a nongame context. In this paper, the gamification technique and EDM methods were used in combination with adaptive learning to increase the students' engagement and learning performance. An adaptive gamified learning system (AGLS) was developed which combines gamification, classification, and adaptation techniques to increase the effectiveness of e-learning. This paper studies the impact of gamification and adaptive gamification on the effectiveness of e-learning through increasing students' engagement and learning performance. AGLS was applied to the data structure course. Results showed that adaptive gamification has a positive effect on students' engagement and learning performance compared to just gamification.

Daghestani, M., H. H. Hakami, Z. K. Hassan, G. Badr, and M. A. R. S. B. H. & Maysoor H. Amin, "The anti-cancer effect of Echis coloratus and Walterinnesia aegyptia venoms on colon cancer cells", Toxin Reviews, 2019.
Daghestani, M. H., M. H. Daghestani, and A. El-Mazny, "Circulating ghrelin levels and the polycystic ovary syndrome: correlation with the clinical, hormonal and metabolic features", European Journal of Obstetrics & Gynecology and Reproductive Biology, vol. 155, no. 1, pp. 65 - 68, 2011. AbstractWebsite

Objectives Dysregulation of ghrelin levels may lead to physiological problems including obesity and polycystic ovary syndrome (PCOS). The aim of the study was to compare ghrelin levels in women with and without PCOS. Study design Serum ghrelin levels (pre- and post-prandial) were compared between 30 Saudi women suffering from \{PCOS\} and 30 healthy controls. The relationship between circulating ghrelin levels and other hormones was investigated. Anthropometric measurements were made for all subjects. Biochemical and hormonal investigations included plasma glucose, insulin, luteinizing hormone (LH), follicle-stimulating hormone (FSH), 17β-estradiol (E2), progesterone, testosterone and sex hormone binding globulin (SHGB), and serum ghrelin levels. The data were statistically analyzed using independent T-test and ANOVA. Correlation studies were performed between ghrelin levels and other variables. Results No differences were observed in the levels of ghrelin during fasting and the postprandial period in the \{PCOS\} (p = 0.487) and control groups (p = 0.378). A significant inverse correlation was observed in ghrelin levels (fasting and postprandial) levels and \{BMI\} (PCOS: r = −0.529; p = 0.009, controls: r = −0.670; p = 0.005); PCOS: r = −0.421; p = 0.007, controls: r = −0.491; p = 0.004 respectively). No correlations between ghrelin levels and other parameters were observed. Conclusion The findings of the study suggest that circulating plasma ghrelin levels were found to be normal and were inversely related to \{BMI\} in women with PCOS. No relationship between circulating ghrelin levels and the abnormal hormonal pattern of the \{PCOS\} were observed.

Daghestani, M. H., A. Warsy, M. H. Daghestani, A. N. Al-Odaib, A. Eldali, N. A. Al-Eisa, S. A. Omer, and Z. K. Hassan, "Arginine 16 Glycine Polymorphism in β2-Adrenergic Receptor Gene is Associated with Obesity, Hyperlipidemia, Hyperleptinemia, and Insulin Resistance in Saudis.", International journal of endocrinology, vol. 2012, pp. 945608, 2012. Abstract

Background. Several studies have shown an association between codon 16 polymorphism of the β2AR gene and obesity. Methods. We studied the association between Arg16Gly polymorphism and obesity and its influence on anthropometric parameters, lipids, insulin resistance and leptin in Saudi individuals. The study group included 329 individuals (males: 109 and females: 220). Metabolic parameters, including glucose, lipids, insulin, and leptin were analyzed and anthropometric parameters including waist and hip circumference, waist/hip (W/H) ratio, and body mass index (BMI) were measured and HOMA-IR was calculated. Genotyping was conducted by DNA sequencing of 353 bp fragments, carrying the Arg16Gly polymorphic site. Results and Conclusion. Overweight and obese subjects had a significantly higher frequency of Gly16 (0.375 and 0.38, resp.) compared with normal-weight subjects (0.200). In addition, subjects carrying Gly16 allele regardless of their BMI had greater waist and hip circumference, W/H ratio, plasma lipids, leptin, glucose level, and insulin resistance as judged from the HOMA-IR, compared to those with the wild-type allele. The findings of this study show a significant association between the Arg16Gly polymorphism in β2AR gene and the development of insulin resistance, overweight, and obesity in Saudi populations with an influence on the levels of lipid and leptin.

Daghestani, M. H., M. E. Selim, Y. M. Abd-Elhakim, E. N. Said, N. A. E. El-Hameed, S. R. Khalil, and O. S. El-Tawil, "The role of apitoxin in alleviating propionic acid-induced neurobehavioral impairments in rat pups: The expression pattern of Reelin gene.", Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, vol. 93, pp. 48-56, 2017 Sep. Abstract

The efficacy of apitoxin (bee venom; BV) in ameliorating propionic acid (PPA) -induced neurobehavioral impacts was studied. Sixty rat pups were enrolled in a split litter design to six groups: a control group, a PPA-treated group, a BV-treated group, a BV/PPA protective group, a PPA/BV therapeutic group, and a BV/PPA/BV protective and therapeutic group. Exploratory, social, locomotor, and repetitive/stereotype-like activities were assessed and prosocial, empathy, and acquired behavior were evaluated. Levels of neurotransmitter including serotonin, dopamine, and gamma-aminobutyric acid (GABA) were determined and a quantitative analysis of Reelin gene expression was performed. PPA treatment induced several behavioral alterations, as reduced exploratory activity and social behaviors, increased repetitive/stereotypic behaviors, and hyperactivity. In addition, a marked decline of neurotransmitters and down-regulation of Reelin mRNA expression were observed. BV exhibited high efficiency in ameliorating the PPA-induced neurobehavioral alterations, particularly when applied both before and after PPA administration. Overall, the results implied that BV has merit as a candidate therapeutic treatment to alleviate PPA-induced neurobehavioral disorders.

Daglar, B., G. B. Demirel, T. Khudiyev, T. Dogan, O. Tobail, and M. Bayindir, Nanoscale RSCPublishing, , 2014. Abstract

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Daglar, B., G. B. Demirel, T. Khudiyev, T. Dogan, O. Tobail, S. Altuntas, F. Buyukserin, and M. Bayindir, "Anemone-like nanostructures for non-lithographic, reproducible, large-area, and ultra-sensitive SERS substrates", Nanoscale, vol. 6, no. 21: The Royal Society of Chemistry, pp. 12710–12717, 2014. Abstract
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Dahab, M. Y., H. A. Hassan, and A. Rafea, "TextOntoEx: Automatic ontology construction from natural English text", Expert Systems with Applications, vol. 34, no. 2: Elsevier, pp. 1474–1480, 2008. Abstract
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Dahab, A. S., A. Omar, M. H. Sayyouh, and A. Heimeda, "Role of clays in influencing permeability damage, capillary pressure and wettability characteristics", Japan Petroleum Institute Journal, vol. 35, issue 3, 1993.
Dahab, Y. A., H. E. N. mahdy, and I. A. Saroit, "A Load Aware Routing Protocol for Mobile Ad hoc Networks", CiiT International Journal of Wireless Communication, vol. 3, issue 4, pp. 254-260, 2011. paper2.pdf
Dahab, M. Y., H. A. Hassan, and A. Rafea, "TextOntoEx: Automatic Ontology Construction from Natural English", Expert Systems with Applications, vol. Volume 34, issue Issue 2, pp. 1474-1480, 2008.
Dahab, A. E. M. M., S. M. Shahat, S. S. M. Mahmoud, and N. A. Mahana, "In vitro effect of curcumin on Schistosoma species viability, tegument ultrastructure and egg hatchability", Experimental Parasitology, vol. 199, pp. 1-8, 2019. published_schistosoma_paper_exp._para.2019.pdf
Dahab, A. E. M., A. Sayed, and N. Mahana, "Curcumin Impact on Ex Vivo Toxocara vitulorum Adult Worms And Eggs", International Journal Of Veterinary Science, vol. 11, issue 3, pp. 280-288, 2022.
Dahab, Y. A., H. E. N. mahdy, and I. A. Saroit, "Improving The Performance of IEEE 802.11e using A Dynamic Adaptation Approach", CiiT International Journal of Wireless Communication, vol. 2, issue 9, pp. 276-280, 2010.
Dahab, M. Y., H. A. Hassan, and A. Rafea, "TextOntoEx: Automatic ontology construction from natural English text", Expert Systems with Applications, vol. 34, issue 2: Elsevier, pp. 1474-1480, 2008. Abstract
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