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Daoudi, A., Lotfi Aarab, and E. Abdel-Sattar, "Screening of immunomodulatory activity of total and protein extracts of some Moroccan medicinal plants", Toxicology and industrial health, vol. 29, no. 3: Sage Publications Sage UK: London, England, pp. 245–253, 2013. Abstract
Dar, A. A., K. Jamal, M. S. Shah, M. Ali, S. Sayed, A. Gaber, H. Kesba, and M. Salah, "Species richness, abundance, distributional pattern and trait composition of butterfly assemblage change along an altitudinal gradient in the Gulmarg region of Jammu & Kashmir, India", Saudi Journal of Biological Sciences, vol. 29, issue 4, pp. 2262-2269, 2022. sjbs_294__2262-2269.pdf
Dar, B. A., S. Al-Rowaily, A. M. Assaeed, M. I. El-Bana, A. K. Hegazy, and J. A. Malik, "Allelopathic potential of Argemone ochroleuca from different habitats on seed germination of native species and cultivated crops", Pakistan Journal of Botany , vol. 49, issue 5, pp. 1841-1848, 2017.
Dar-Odeh, N. S., and et al, "The role of antifungal drugs in the management of denture-associated stomatitis. (Prof. Emad Daif was a peer reviewer for this article to promote an associate Prof. to a Prof.).", The International Arabic Journal of Antimicrobial Agents, vol. 2, issue 1, pp. 1-5, 2012.
Daralnakhla, H., O. Saher, S. Zamolo, S. Bazaz, J. P Bost, M. Heitz, K. E. Lundin, S. El Andaloussi, T. Darbre, J. - L. Reymond, et al., "Lipophilic Peptide Dendrimers for Delivery of Splice-Switching Oligonucleotides.", Pharmaceutics, vol. 13, issue 1, pp. 116-, 2021. Abstract

Non-viral transfection reagents are continuously being developed in attempt to replace viral vectors. Among those non-viral vectors, dendrimers have gained increasing interest due to their unique molecular structure and multivalency. However, more improvements are still needed to achieve higher efficacy and lower toxicity. In this study, we have examined 18 peptide dendrimers conjugated to lipophilic moieties, such as fatty acids or hydrophobic amino acids, that were previously explored for siRNA. Reporter cells were employed to investigate the transfection of single strand splice-switching oligonucleotides (ONs) using these peptide dendrimers. Luciferase level changes reflecting efficiency varied with amino acid composition, stereochemistry, and complexation media used. 3rd generation peptide dendrimers with D-amino acid configuration were superior to L-form. Lead formulations with 3rd generation, D-amino acid peptide dendrimers increased the correction level of the delivered ON up to 93-fold over untreated HeLa Luc/705 cells with minimal toxicity. To stabilize the formed complexes, Polyvinyl alcohol 18 (PVA18) polymer was added. Although PVA18 addition increased activity, toxicity when using our best candidates G 2,3KL-(Leu) (D) and G 2,3KL-diPalmitamide (D) was observed. Our findings demonstrate the potential of lipid-conjugated, D-amino acid-containing peptide dendrimers to be utilized as an effective and safe delivery vector for splice-switching ONs.

Dardir, H. A., N. A. Aba-Alkhail, and A. A. A. Abdel-All, "Safety Evaluation of Enterococcal Strains Isolated from DairyProducts and Clinical Samples using RT-PCR", World Journal of Dairy & Food Sciences 6 (2): 234-240(2011), 2011. Abstract

Enterococci are part of the dominant microbiota of several dairy products, which can be used in thedairy industry as starter or probiotic cultures. However, they are also implicated in severe multi-resistantnosocomial human infections. In this study, phenotypic tests using API 20 S strip were used for speciesidentification of 60 and 55 enterococcal strains isolated from dairy products and clinical samples, respectively.

Dardiry, M. M., Dissection of cis and trans components of gene regulatory network evolution, : Max Planck Institute for developmental biology, 2015. Abstract
Darii, N., E. Anton, B. Doroftei, A. Ciobica, R. Maftei, S. C. Anton, and T. Mostafa, "Iatrogenic parasitic myoma and iatrogenic adenomyoma after laparoscopic morcellation: A mini-review.", J Adv Res, vol. 20, pp. 1-8, 2019.
Dark, M. L., L. T. Perelman, I. Itzkan, J. L. Schaffer, and M. S. Feld, "Physical properties of hydrated tissue determined by surface interferometry of laser-induced thermoelastic deformation", Physics in Medicine & Biology, vol. 45, issue 2: IOP Publishing, pp. 529, 2000. Abstract
Darmstadt, G. L., N. Badrawi, P. A. Law, S. Ahmed, M. Bashir, I. Iskander, D. Al Said, A. Elkholy, M. H. Husein, A. Alam, et al., "Topically applied sunflower seed oil prevents invasive bacterial infections in preterm infants in Egypt: a randomized, controlled clinical trial.", The Pediatric infectious disease journal, vol. 23, issue 8, pp. 719-25, 2004 Aug. Abstract

BACKGROUND: Because the therapeutic options for managing infections in neonates in developing countries are often limited, innovative approaches to preventing infections are needed. Topical therapy with skin barrier-enhancing products may be an effective strategy for improving neonatal outcomes, particularly among preterm, low birth weight infants whose skin barrier is temporarily but critically compromised as a result of immaturity.

METHODS: We tested the impact of topical application of sunflower seed oil 3 times daily to preterm infants <34 weeks gestational age at the Kasr El-Aini neonatal intensive care unit at Cairo University on skin condition, rates of nosocomial infections and mortality.

RESULTS: Treatment with sunflower seed oil (n = 51) resulted in a significant improvement in skin condition (P = 0.037) and a highly significant reduction in the incidence of nosocomial infections (adjusted incidence ratio, 0.46; 95% confidence interval, 0.26-0.81; P = 0.007) compared with infants not receiving topical prophylaxis (n = 52). There were no reported adverse events as a result of topical therapy.

CONCLUSIONS: Given the low cost (approximately .20 dollars for a course of therapy) and technologic simplicity of the intervention and the effect size observed in this study, a clinical trial with increased numbers of subjects is indicated to evaluate the potential of topical therapy to reduce infections and save newborn lives in developing countries.

Darmstadt, G. L., N. Badrawi, P. A. Law, S. Ahmed, M. Bashir, I. Iskander, D. Al Said, A. Elkholy, M. H. Husein, A. Alam, et al., "Topically applied sunflower seed oil prevents invasive bacterial infections in preterm infants in Egypt: a randomized, controlled clinical trial", The Pediatric infectious disease journal, vol. 23, no. 8: LWW, pp. 719–725, 2004. Abstract
Darouti, M. E. A., O. A. Zeid, D. M. ABDELHALIM, R. A. HEGAZY, D. Kadry, D. I. Shehab, H. S. Abdelhaliem, and M. A. Saleh, "Salty and spicy food; are they involved in the pathogenesis of acne vulgaris? A case controlled study.", J Cosmet Dermatol., vol. 15, issue 2, pp. 145-149, 2016.
Darouti, E. M. A., A. D. M. Halim, R. A. Hegazy, D. Kadry, D. I. Shehab, and H. S. Abdel, "Salty and spicy food; are they involved in the pathogenesis of acne vulgaris? A case controlled study", journal of cosmetic dermatology, vol. 15, pp. 145-149, 2015.
el Darouty, M. A., M. M. Fawzy, I. M. Amin, and R. M. mounir, "Mycophenolate mofetil: a novel immunosuppressant in the treatment of dystrophic epidermolysis bullosa, a randomized controlled trial", Journal of dermatological treatment, vol. 24, pp. 422-426, 2013. mofetil_in_eb_full.pdf
el Darouty, M. A., M. M. Fawzy, I. M. Amin, and R. M. mounir, "Treatment of dystrophic epidermolysis bullosa with bone marrow non-hematopoeitic stem cells: a randomized controlled trial", Dermatologic therapy, vol. 29, pp. 96-100, 2016. stem_cell_in_eb_full.pdf
Darweesh, A. F., A. M. Mansour, and A. H. M. Elwahy, "Novel bis (benzothiazole-oxime)-based Pd (II)-complex: synthesis, characterization, quantum chemical calculations, and catalytic significance in Suzuki–Miyaura and Heck–Mizoroki cross coupling reactions", Monatshefte für Chemie-Chemical Monthly, vol. 147, issue 7: Springer Vienna, pp. 1197-1205, 2016. Abstract
Darweesh, H. E. A., and G. A. Moneim, "Frequency of disease subsets and patterns of organ involvement among Egyptian patients with systemic sclerosis – A retrospective study Geilan", The Egyptian Rheumatologist, vol. 35, issue 1110-1164, pp. 145-149, 2013. ss_outcome_ejr.pdf
Darweesh, S. K., M. A. Elsabaawy, M. A. Eltahawy, H. S. Ghanem, and W. Abdel-Razek, "Serum ammonia as a non-invasive marker for early prediction of esophageal varices.", European journal of gastroenterology & hepatology, vol. 32, issue 2, pp. 230-236, 2021. Abstract

INTRODUCTION: There is a growing need for identification of non-endoscopic, non-invasive methods that can accurately predict esophageal varices (EV). Previous studies found an inconclusive correlation between blood ammonia level and the presence and size of EV.

AIM: We aimed at assessing the value of serum ammonia as a non-invasive method for early prediction of EV.

PATIENT AND METHODS: The study included 204 patients with HCV-related cirrhosis. The selected patients were categorized into two groups: patients with EV and those without, also patients with no or small EV and with large EV group. All patients underwent a complete biochemical workup, ultrasound and upper GI endoscopy. Child-Pugh class, Model of End-Stage Liver Disease (MELD) score and platelet count/splenic diameter ratio, and serum ammonia level.

RESULTS: There was a statistical difference between the two groups of patients regarding the following parameters: serum ammonia, international normalized ratio, portal vein diameter, spleen diameter, Child-Pugh class, MELD score, platelet count/splenic diameter ratio, aspartate aminotransferase-to-platelet ratio index, alanine aminotransferase-to-aspartate aminotransferase ratio, Forns index, FIB-4 and King's score. Serum ammonia could predict the presence of EV using a cutoff value of 82 (µmol/L) with a sensitivity of 92.3%, specificity 92%. In addition, a cutoff of 95.5 (µmol/L) could predict large EV with a sensitivity of 92.7% and a specificity of 92.3%. Serum Ammonia in cirrhosis with large EV was 143 ± 39 µmol/L and in cirrhosis with small/without EV was 80.7 ± 9.7 µmol/L (P < 0.0001). Platelet/spleen ratio was 555.9 ± 187.3 in cirrhosis with EV and 694.4 ± 74.2 in cirrhosis without EV (P < 0.0001). Platelet/spleen ratio was 407.7 ± 107.1 in cirrhosis with large EV and 690.4 ± 103.7 in cirrhosis with small/without EV (P < 0.0001).

CONCLUSION: Serum ammonia can accurately predict the presence and the size of EV in patients with liver cirrhosis with high sensitivity and specificity.

Darweesh, A. F., S. K. Salama, I. A. Abdelhamid, and A. H. M. Elwahy, "Bis (aldehydes): Versatile precursors for novel bis (14 H‐dibenzo [a, j] xanthenes), bis (pyrano [3, 2‐c: 5, 6‐c'] dichromenedione), and bis (dihydrobenzo [a] xanthenones) via multicomponent reactions", Journal of Heterocyclic Chemistry, vol. 58, issue 1: John Wiley & Sons, Inc. Chichester, UK, pp. 315-328, 2021. Abstract
Darweesh, A. F., N. A. Abd El-Fatah, S. A. Abdel-Latif, I. A. Abdelhamid, and A. HM, "Synthesis and DFT studies of novel aminoimidazodipyridines using 2-(3H-imidazo [4, 5-b] pyrid-2-yl) acetonitrile as an efficient key precursor", ARKIVOC: ARKAT USA INC C/O ALAN R KATRITZKY, UNIV FLORIDA, DEPT CHEMISTRY, PO BOX …, pp. 23-37, 2021. Abstract
Darweesh, S. K., K. Elsaeed, H. Omar, M. E. Raziky, W. elakel, M. E. Serafy, S. A. Ismail, A. A. Gomaa, M. Mehrez, M. Elkassas, et al., "High SVR rate following retreatment of non-sustained virological responders to sofosbuvir based anti-HCV therapies regardless of RAS testing: A real-life multicenter study.", Expert review of gastroenterology & hepatology, vol. 13, issue 9, pp. 907-914, 2019. Abstract

Evaluation of the efficacy and safety of sofosbuvir/daclatasvir/ribavirin (SOF/DCV/RBV) in treating non-sustained virological responders (non-SVR12) to prior sofosbuvir-based therapy, in absence of RAS testing in mass treatment, and determination of the optimal timing to start re-treatment. Real-life prospective observational study included prior non-responders to 24-weeks SOF-RBV (n = 679, 67%) or 12-weeks SOF- RBV- PEG (n = 335, 33%). Patients were re-treated with daily SOF/DCV/RBV for 12 (n = 270) or 24 weeks (n = 744). The primary efficacy endpoint was SVR12. The primary safety endpoints were reported adverse events (AEs) from baseline to SVR12 time point. We included 1,014 patients [age 52 ± 9 years, 58.48% men]. Cirrhosis was documented in 46.98% and 27.5% of SOF-RBV and SOF-RBV-PEG non-responders respectively. Overall, SVR12 was 90.6% [92.2% for 12 weeks therapy and 90.05% for 24 weeks therapy]. Mild AEs occurred in 5.13% (n=52) and 3.1% (n=32) discontinued treatment including eight on-treatment mortalities. Higher baseline FIB-4 and shorter interval before starting retreatment (<6 months) were independent predictors of non-SVR12 on multivariate regression analysis. SOF/DCV/RBV is an effective and safe treatment option for non-responders to prior sofosbuvir-based therapy. Six months interval before retreatment is optimal for achieving favorable SVR.

Darweesh, M. F., L. O. Elfarouk, and M. S. Negm, "Evaluation of the Proliferation Marker Ki-67 in Glioblastoma and its Correlation with the Histopathological Findings", Academic Journal of Cancer Research, vol. 9, issue 2, pp. 13-18, 2016.
Darweesh, E., F. Elhalim, M. Ishak, O. Shaker, and S. Abdelmissih, "{Impact of cyclic nucleotides on the antiseizure activity of acute and chronic diazepam administration in isoniazid-induced seizures and pentylenetetrazole kindling in rats}", Kasr Al Ainy Medical Journal, vol. 21, no. 3, pp. 101-108, 2015. AbstractWebsite

Background It is estimated that  10% of the population suffers a single convulsive episode during their lifetime. Epilepsy is the second most common chronic neurological disorder after stroke, affecting  0.5% of the population in developed countries and 1.5-2% in developing countries. Diazepam (DZ) is among the benzodiazepines used most widely in status epilepticus as well as resistant and refractory seizures. However, tolerance to its antiseizure activity is among the obstacles facing it use on a wider basis. Exploration of the role of cyclic nucleotides in seizures might enable finding ways to combat tolerance as well as discover new treatment modalities. Materials and methods Seizure severity, electroencephalography, and levels of γ-aminobutyric acid (GABA), glutamate, cyclic adenosine monophosphate (cAMP), and cyclic guanosine monophosphate (cGMP) in brain homogenate were assessed upon single administration of isoniazid and repeated pentylenetetrazole injections, whether untreated or treated with DZ, either acutely or on a chronic basis, respectively. Results A single DZ injection, 10 min after single isoniazid, could significantly improve seizure severity, associated with increased power of the fast β wave, implying ameliorated cognitive functions, together with an equal GABA/glutamate ratio versus significant reduction in the cAMP/cGMP ratio. Repeated DZ injections, 10 min after each pentylenetetrazole injection, on alternate days for 1 month and every 2 days for another month produced a significant improvement in seizure severity, accompanied by reduced power of the fast β and the slow δ waves, associated with an increased GABA/glutamate ratio and an unchanged cAMP/cGMP ratio. Conclusion The current study assumes that a certain interplay exists between GABA/glutamate on the one hand and cAMP/cGMP on the other so that DZ could exert an anticonvulsant effect on an acute basis despite an unchanged GABA/glutamate ratio as well as upon chronic administration in the presence of an unchanged cAMP/cGMP ratio. In addition, the unchanged cAMP/cGMP ratio associated with chronic DZ administration suggests that cyclic nucleotides might lead to loss of some of the effects of DZ, as shown by reduced β wave power, indicating a reduction in cognitive abilities, concentration, and learning abilities, in contrast to higher β power after single use.