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DOAA M. MOSTAFA, W. A. F. A. M. KAMAL, and KHADIGA S. ABD EL-AZIZ, " Effect of Specific Exercise Program Augmented by Pelvic Support Belts on Symphysis Pubis Dysfunction M.Sc.; ", medical journal of cairo university, vol. 85, pp. 2553-2558, 2017. 17.pdf
El-Nagar, G. A., K. M. Dawood, M. S. El-Deab, and B. E. Al-Andouli, " Efficient direct formic acid fuel cell (DFAFC) anode of nano-sized palladium complex: High durability and activity origin", Applied Catalysis B: Environmental, vol. 213, pp. 118-126, 2017.
NH, E. - E., K. D, H. RA, and R. L, " Estimation of tissue osteopontin levels before and after different traditional therapeutic modalities in psoriatic patients", Journal of the European Academy of Dermatology and Venereology, vol. 27, issue 3, pp. 351–355, 2013. Abstract


Several lines of evidences support a major role for Th1 cells in psoriasis. Treatment of psoriasis with cyclosporine, methotrexate and psoralen plus ultraviolet A (PUVA) is associated with clinical improvement and decrease in epidermal hyperplasia. Osteopontin (OPN) exerts a T-helper type 1 (Th1) cytokine function, regulating inflammatory cell accumulation and function.

To detect the effects of methotrexate, cyclosporine and PUVA on OPN expression in psoriatic plaques, and whether these changes correlate with clinical response.

For three groups of psoriatic patients (each including 12 patients), the Psoriasis Area Severity Index (PASI) and levels of lesional skin OPN were determined using enzyme-linked immunosorbent assays before and after treatment with methotrexate, cyclosporine or PUVA. Skin biopsies from 20 healthy volunteers served as control for OPN levels in normal skin.

Baseline lesional skin of psoriatic patients showed a statistically significant elevation of OPN levels in comparison to controls. Three months after therapy, the three therapeutic modalities were associated with a significant decrease in the mean levels of PASI and tissue OPN, with the PUVA group showing the highest level of reduction in OPN levels and cyclosporine group showing the highest level of reduction in PASI.

Our study points to the possible role played by OPN in the pathogenesis of psoriasis and in reflecting disease severity. These standard therapeutic modalities used in the current study were associated with a significant decrease in PASI and OPN levels. They constitute highly effective therapeutic modalities for psoriasis, which might exert their anti-psoriatic activity partially through altering the expression of OPN.

© 2012 The Authors. Journal of the European Academy of Dermatology and Venereology © 2012 European Academy of Dermatology and Venereology.

Mohamed, A. A., H. Soliman, M. Ismail, Z. A. Y. Elmageed, and M. A. E. Daly, " Evaluation of circulating ADH and MIC-1 as diagnostic markers in Egyptian patients with pancreatic cancer", Pancreatology, vol. 15, issue 1, pp. 34-39, 2015. pancreatic_cancer_1.pdf
A. M. El-Amir, M. Diab, I. R. Aly, M. Hendawy, and S. Kadry, " Fasciola gigantica Fatty Acid Binding Protein (FABP) as a Prophylactic Agent against Schistosoma mansoni Infection in CD1 Mice", Korean Journal of Parasitology, vol. 1, pp. 37-43, 2012.
S, A. - A., E. S. A. Gaber O, M. D, A. M, K. EZ, and E. I, " FLT3-ITD Mutations in Egyptian Patients of Acute Myeloid Leukemia: Correlation with Cytogenetic, FAB Subgroups and Prognosis", Clin Lab, vol. May(1)63, issue 5, pp. 1027-1034, 2017.
Xiao, K., S. H. Ho, A. E. Hassanien, V. N. Du, and Q. Salih, " Fuzzy C-means clustering with adjustable feature weighting distribution for brain MRI ventricles segmentation. ", SIP 2007: 466-471, Honolulu, Hawaii, USA, August 20-22, 2007.
NR, E. B., Z. MM, H. OM, R. MK, and O. D, " Giardia Assemblages A and B in Diarrheic Patients: A Comparative Study in Egyptian Children and Adults.", J Parasitol., vol. 102, issue 1, pp. 69-74, 2016.
Rashad, F. M., E. I. Dawoud, and S. A. El-Gizawy, " Growth patterns of Aeromonas spp. and plesomonas shigelloides in fresh Damietta cheese.", J. Agric. Sci. Mansoura Univ., vol. 20, issue 5, pp. 2209-2223, 1995.
Ashour, G., A. A. Neama, S. M. Dessouki, and O. H. Shihab, " Hormonal status (t3, igf-1 and leptin) and average growth rate of the newborn lambs and kids in relation to age, species and sex.", Egypt. J. Basic Appl. Physiol., vol. 14, issue 2, pp. 12-27, 2014.
Ali, A., and M. A. Dopita, " IFU Spectroscopy of Southern Planetary Nebulae V: Low-Ionisation Structures", PUBLICATIONS OF THE ASTRONOMICAL SOCIETY OF AUSTRALIA , vol. 34, pp. e036, 2017.
Kandeel, A., Y. Mohamed, M. Mohamed, M. Abougabal, H. A. N. A. N. DARWISH, and M. A. L. Daly, " Impact of 18F-FDG-PET/CT in the initial staging and changing the management intent in head and neck squamous cell carcinoma", EANM'19, 26 August, 2019.
HM, A., E. - S. SA, S. MF, H. HS, N. HH, A. - A. DM, and T. AE, " Incomplete RV Remodeling After Transcatheter ASD Closure in Pediatric Age.", Pediatr Cardiol, vol. Oct;36, issue 7, pp. 1523-1531, 2015. 8-transcatheter_asd_closure.pdf
S, T., F. A, T. S, H. A, Darwish AD, E. T, and D. E., " Increased Serum Endoglin and Transforming Growth Factor β1 mRNA Expression and Risk of Hepatocellular Carcinoma in Cirrhotic Egyptian Patients.", Asian Pac J Cancer Prev. , vol. 17, issue 5, pp. 2429-34, 2016. endoglin_april_2016.pdf
Daw, Z. Y.;, G. S.; EL-Baroty, and E. A. Mahmud, " Inhibition of Aspergillus parasiticus growth and aflatoxin production by some essential oils.", Chem. Mikrobiol. Technol .Lebensm., vol. 16 , issue (5/6, pp. 129- 135. , 1994.
Troschel, F. M., A. Minte, Y. M. Ismail, A. Kamal, M. S. Abdullah, S. H. Ahmed, M. Deffner, B. Kemper, L. Kiesel, H. T. Eich, et al., " Knockdown of Musashi RNA Binding Proteins Decreases Radioresistance but Enhances Cell Motility and Invasion in Triple-Negative Breast Cancer ", International Journal of Molecular Sciences, vol. 21, issue 6, pp. 2169., 2020. international_journal_of_molecular_sciences.pdf
Dabbous, A. O., A. M. El-Shennawy, M. M. Medhat, and D. F. Abdel-Latief, " Narrow Band CE-chirp Stimulus in Auditory Steady State Response Threshold Estimation in Normal Hearers and Patients with Various Degrees of Sensorineural Hearing Loss", Hearing, Balance and Communication, 2017.
Dalia M. Kamel, P. D., and P. D. Amel M. Yousif, " Neuromuscular Electrical Stimulation and Strength Recovery of Postnatal Diastasis Recti Abdominis Muscles", Annals of Rehabilitation Medicine, vol. 41, issue 3, 2017.
Elansary, A. A., A. E. A. Damatty, and A. E. M. Ansary, " Nonlinear Behaviour of Reinforced Concrete Conical Tanks under Hydrostatic Pressure", Canadian Journal of Civil Engineering, vol. 43, issue 2, pp. 85-98, 2015.
Ahmed, N., N. Radwan, A. Salam, K. A. E. Ela, and H. S. E. Din, " Oral contraceptive steroid "Norminest" in relation to certain amino acid neurotransmitters in rat brain. ", New Egypt. J. Med., vol. 3 , issue 5, pp. 1597-1602, 1989.
Dreisoerner, H., M. Refai, and H. Rieth, " Otitis externa durch Microsporum canis bei Katzen. ", Kleintier Prax. , vol. 9, pp. 230-234, 1964. otitis_externa_in_cats_due_to_m._canis.pdf
IH, D., H. EF, W. G, I. DK, and M. BS, " Pneumococcal infection among hospitalized Egyptian children.", Journal of Egyptian Public Health Association , vol. 90, pp. 52-7, 2015. 3-_pneumococcal-epxv90n2-print-final.pdf
S.B.Mahmoud, M.K.Anwar, O.G.Shaker, and D.A.ElSharkawy, " Possible Relation between Vitamin D and Interleukin-17 in the Pathogenesis of Lichen Planus.", Dermatology, vol. 237, issue 6, pp. 896-901, 2021.