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Bratberg, B., O. Helle, and M. Hilali, "Sarcocystis infection in sheep from south-western Norway.", Acta veterinaria Scandinavica, vol. 23, issue 2, pp. 221-234, 1981. Abstract
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Bratko, I., {PROLOG}: {Programming} for {Artificial} {Intelligence}, , 2nd, Wokingham, Addison Wesley, 1990. Abstract
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Braun, D. A., M. Schueler, J. Halbritter, H. Y. Gee, J. D. Porath, J. A. Lawson, R. Airik, S. Shril, S. J. Allen, D. Stein, et al., "Whole exome sequencing identifies causative mutations in the majority of consanguineous or familial cases with childhood-onset increased renal echogenicity.", Kidney international, 2015 Oct 21. AbstractWebsite

Chronically increased echogenicity on renal ultrasound is a sensitive early finding of chronic kidney disease that can be detected before manifestation of other symptoms. Increased echogenicity, however, is not specific for a certain etiology of chronic kidney disease. Here, we performed whole exome sequencing in 79 consanguineous or familial cases of suspected nephronophthisis in order to determine the underlying molecular disease cause. In 50 cases, there was a causative mutation in a known monogenic disease gene. In 32 of these cases whole exome sequencing confirmed the diagnosis of a nephronophthisis-related ciliopathy. In 8 cases it revealed the diagnosis of a renal tubulopathy. The remaining 10 cases were identified as Alport syndrome (4), autosomal-recessive polycystic kidney disease (2), congenital anomalies of the kidney and urinary tract (3), and APECED syndrome (1). In 5 families, in whom mutations in known monogenic genes were excluded, we applied homozygosity mapping for variant filtering and identified 5 novel candidate genes (RBM48, FAM186B, PIAS1, INCENP, and RCOR1) for renal ciliopathies. Thus, whole exome sequencing allows the detection of the causative mutation in 2/3 of affected individuals, thereby presenting the etiologic diagnosis, and allows identification of novel candidate genes.Kidney International advance online publication, 21 October 2015; doi:10.1038/ki.2015.317.

Braun, D. A., J. Rao, G. Mollet, D. Schapiro, M. - C. Daugeron, W. Tan, O. Gribouval, O. Boyer, P. Revy, T. Jobst-Schwan, et al., "Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly.", Nature genetics, vol. 49, issue 10, pp. 1529-1538, 2017 Oct. Abstract

Galloway-Mowat syndrome (GAMOS) is an autosomal-recessive disease characterized by the combination of early-onset nephrotic syndrome (SRNS) and microcephaly with brain anomalies. Here we identified recessive mutations in OSGEP, TP53RK, TPRKB, and LAGE3, genes encoding the four subunits of the KEOPS complex, in 37 individuals from 32 families with GAMOS. CRISPR-Cas9 knockout in zebrafish and mice recapitulated the human phenotype of primary microcephaly and resulted in early lethality. Knockdown of OSGEP, TP53RK, or TPRKB inhibited cell proliferation, which human mutations did not rescue. Furthermore, knockdown of these genes impaired protein translation, caused endoplasmic reticulum stress, activated DNA-damage-response signaling, and ultimately induced apoptosis. Knockdown of OSGEP or TP53RK induced defects in the actin cytoskeleton and decreased the migration rate of human podocytes, an established intermediate phenotype of SRNS. We thus identified four new monogenic causes of GAMOS, describe a link between KEOPS function and human disease, and delineate potential pathogenic mechanisms.

Break, L. M., M. A. M.Mohamed, O. A.A.Al-Thubaiti, and Fatma E. M.Ei-Baih, "Nucleosides 10: Synthesis of New Derivatives of Pyrimidine and Fused Pyrimidine Nucleosides of Expected Biological Activity,", International Journal of Organic Chemistr , vol. 9. , issue 9 , pp. 107-120 , 2019.
Break, L. M., M. A. Mohamed, and S. H. Abdel-Hafez, "Synthesis of New Organoselenium Compounds Containing Nucleosides as Antioxidant", Oriental Journal of Chemistry, vol. 30, issue 4, pp. 1639-1645, 2014. Abstract
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Bream, A. S., K. S. Ghoneim, M. A. Tanani, and M. i. Nassar, "Effectiveness of IGRs (CGA-184699) and (CGA-259205) on the respiratory metabolism of the red palm weevil, Rhynchophorus ferrugineous (Coleoptera:Curculionidae). ", Med. Fac. Landbouww. Univ. Gent Belgium , vol. 66/2a., 2001.
Bream, A. S., K. S. Ghoneim, M. A. Tanani, and M. I. Nassar, "EVALUATION OF AZADIRACHTIN AND JOJOBA ON THE RED PALM WEEVIL, RHYNCHOPHORUS FERRUGINEUS (OLIV.) (COLEOPTERA : CURCULIONIDAE)", Sec. Int. Conf. Date Palms, Fac. Agric. Al-Ain, UAEU , vol. _PID_GUID{916A, issue 9D90-11D5, pp. A586-444553540000, 2002. al-ainpalm1.doc
Bream, A. S., K. S. Ghoneim, M. A. Tanani, and M. I. Nassar, "Respiratory metabolic responsiveness, during the pupal stage of the red palm weevil, Rhynchophorus ferrugineous (Coleoptera:Curculionidae). To certain plant extracts.", Med. Fac. Landbouww. Univ. Gent Belgium , vol. 66/2a, pp. 491-502., 2001.
Bream, A. S., K. S. Ghoneim, M. A. Tanani, and M. M. Nassar, "Respiratory metabolic responsiveness, during the pupal stage, of the red palm weevil, Rhynchophorus ferrugineus (Coleoptera: Curculionidae) to certain plant extracts.", Med. Fac. Landbouww. Univ. Gent., vol. 66L2a, issue 2a, pp. 491 - 501, 2002. belgic2.doc
Bream, A. S., K. S. Ghoneim, M. A. Tanani, and M. I. Nassar, "Evaluation of plant extracts, Azadirachtin and Jojoba oil, on the red palm weevil, Rhynchophorus ferrugineous (Coleoptera:Curculionidae).", Sec. Int. Conf. Date Palms, Fac. Agric. Al-Ain, UAEU., vol. 1, pp. 40-51, 2002.
Breban, R., N. Arafa, S. Leroy, A. Mostafa, I. Bakr, M. Adbel-Hamid, G. Esmat, M. K. Mohamed, and A. Fontanet, "IMPACT OF MASS ANTIVIRAL TREATMENT ON HCV TRANSMISSION IN RURAL EGYPT", JOURNAL OF HEPATOLOGY, vol. 58, no. 1}, Meeting Abstract = {53, pp. S23, APR, 2013. Abstract
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Breban, R., N. Arafa, S. Leroy, A. Mostafa, I. Bakr, L. Tondeur, M. Abdel-Hamid, W. Doss, G. Esmat, M. K. Mohamed, et al., "Effect of preventive and curative interventions on hepatitis C virus transmission in Egypt (ANRS 1211): a modelling study.", The Lancet. Global health, vol. 2, issue 9, pp. e541-9, 2014 Sep. Abstract

BACKGROUND: Most hepatitis C virus (HCV) transmission in Egypt is related to medical injections and procedures. To control the spread of HCV, the Egyptian Ministry of Health initiated awareness and education campaigns, strengthened infection control in health-care facilities, and subsidised anti-HCV treatment. We aimed to investigate the effect of these interventions on the spread of HCV by mathematical modelling.

METHODS: We developed a mathematical model of HCV transmission in Zawyat Razin, a typical rural community. Our model assumes that each individual has two distinct types of medical procedures: injections and more invasive medical procedures. To quantify the severity of the spread of HCV, we used the notion of the basic reproduction number R0, a standard threshold parameter signalling whether transmission of an infectious disease is self-sustained and maintains an epidemic. If R0 is greater than 1, HCV is self-sustained; if R0 is 1 or less, HCV transmission is not self-sustained. We investigated whether heterogeneity in the rate of injection or invasive medical procedures is the determinant factor for HCV transmission and whether most iatrogenic transmission is caused by a small group of individuals who receive health-care interventions frequently. We then assessed whether interventions targeted at this group could reduce the spread of HCV.

FINDINGS: The R0 of the spread of HCV without treatment was 3·54 (95% CI 1·28-6·18), suggesting a self-sustained spread. Furthermore, the present national treatment programme only decreased R0 from 3·54 to 3·03 (95% CI 1·10-5·25). Individuals with high rates of medical injections seem to be responsible for the spread of HCV in Egypt; the R0 of the spread of HCV without treatment would be 0·64 (95% CI 0·41-0·93) if everybody followed the average behaviour. The effect of treatment on HCV transmission is greatly enhanced if treatment is provided a mean of 2·5 years (95% CI 0·1-9·2) after chronic infection and with drug regimens with more than 80% efficacy. With these treatment parameters, preventive and curative interventions targeting individuals with high rates of medical injections might decrease R0 below 1 for treatment coverage lower than 5%.

INTERPRETATION: Targeting preventive and curative interventions to individuals with high rates of medical injections in Egypt would result in a greater reduction the spread of HCV than would untargeted allocation. Such an approach might prove beneficial in other resource-limited countries with health-care-driven epidemics.

FUNDING: Agence Nationale de Recherche sur le SIDA et les Hépatites Virales (ANRS 1211), ANR grant Labex Integrative Biology of Emerging Infectious Diseases.

Breban, R., W. Doss, G. Esmat, M. Elsayed, M. Hellard, P. Ayscue, M. Albert, A. Fontanet, and M. K. Mohamed, "Towards realistic estimates of HCV incidence in Egypt", JOURNAL OF VIRAL HEPATITIS, vol. 20, no. 4, pp. 294-296, APR, 2013. Abstract
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Breban, R., W. Doss, G. Esmat, M. Elsayed, M. Hellard, P. Ayscue, M. Albert, A. Fontanet, and M. K. Mohamed, "Quantifying current hepatitis C virus incidence in Egypt - Response to letter by Miller and Abu-Raddad", JOURNAL OF VIRAL HEPATITIS, vol. 20, no. 9, pp. 668, SEP, 2013. Abstract
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Brent, B., "Technical advances in ear reconstruction with autogenous rib cartilage grafts", Personal experience with 1200 cases, vol. 1999, pp. 104, 1999. Abstract
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Brewick, P. T., M. Abdelbarr, A. Derkevorkian, A. R. Kolaini, S. F. Masri, and J. - S. Pei, "Fusing State-Space and Data-Driven Strategies for Computational Shock Response Prediction", AIAA Journal, vol. 56, no. 6, pp. 2308-2321, 2018. AbstractWebsite

This paper proposes a state-space-based approach for computational simulation and prediction of shock response for both time histories and shock response spectra. The method operates by developing a nominal model for the system through state-space identification and then modeling the resulting residual through an artificial neural network. The model for the residual is then folded back into the nominal system via Kalman filtering, allowing for forward computational simulation without any measurement information. The proposed identification method is applied to a three-degree-of-freedom system and a high-fidelity finite element model built in Abaqus. The proposed method provides reasonable predictions for time histories of excitations not seen during training or identification and produces useful predictions of the associated shock response spectra.

Briner, A. E., P. D. Donohoue, A. A. Gomaa, K. Selle, E. M. Slorach, C. H. Nye, R. E. Haurwitz, C. L. Beisel, A. P. May, and R. Barrangou, "Guide RNA Functional Modules Direct Cas9 Activity and Orthogonality", Molecular cell, vol. 56, no. 2: Cell Press, pp. 333–339, 2014. Abstract
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BRINK, D. M., A. L. I. Y. ELLITHI, and D. R. FARLEY, "Japan fujiwaraQrcnp. osaka-u. ac. jp", Nuclear Physics, vol. 738, pp. 535–539, 2004. Abstract
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Brito-Zerón, P., N. Acar-Denizli, W. - F. Ng, I. F. Horváth, A. Rasmussen, R. Seror, X. Li, C. Baldini, J. - E. Gottenberg, D. Danda, et al., "Epidemiological profile and north-south gradient driving baseline systemic involvement of primary Sjögren's syndrome.", Rheumatology (Oxford, England), vol. 59, issue 9, pp. 2350-2359, 2020. Abstract

OBJECTIVE: To characterize the systemic phenotype of primary Sjögren's syndrome at diagnosis by analysing the EULAR-SS disease activity index (ESSDAI) scores.

METHODS: The Sjögren Big Data Consortium is an international, multicentre registry based on worldwide data-sharing cooperative merging of pre-existing databases from leading centres in clinical research in Sjögren's syndrome from the five continents.

RESULTS: The cohort included 10 007 patients (9352 female, mean 53 years) with recorded ESSDAI scores available. At diagnosis, the mean total ESSDAI score was 6.1; 81.8% of patients had systemic activity (ESSDAI score ≥1). Males had a higher mean ESSDAI (8.1 vs 6.0, P < 0.001) compared with females, as did patients diagnosed at <35 years (6.7 vs 5.6 in patients diagnosed at >65 years, P < 0.001). The highest global ESSDAI score was reported in Black/African Americans, followed by White, Asian and Hispanic patients (6.7, 6.5, 5.4 and 4.8, respectively; P < 0.001). The frequency of involvement of each systemic organ also differed between ethnic groups, with Black/African American patients showing the highest frequencies in the lymphadenopathy, articular, peripheral nervous system, CNS and biological domains, White patients in the glandular, cutaneous and muscular domains, Asian patients in the pulmonary, renal and haematological domains and Hispanic patients in the constitutional domain. Systemic activity measured by the ESSDAI, clinical ESSDAI (clinESSDAI) and disease activity states was higher in patients from southern countries (P < 0.001).

CONCLUSION: The systemic phenotype of primary Sjögren's syndrome is strongly influenced by personal determinants such as age, gender, ethnicity and place of residence, which are key geoepidemiological players in driving the expression of systemic disease at diagnosis.

Britton, K., S. Solanki, H. Ameral, A. Bhatangar, J. Katamihadja, J. Malamits, M. H, V. Soroa, F. Sundram, D. Warehan, et al., "Imaging of bacterial infection", European congress Nuclear Medicine, Paris , 2-6 September, Submitted.
Brockington, I., P. Chandra, H. Dubowitz, D. Jones, S. Moussa, J. Nakku, and I. Quadros Ferre, "WPA guidance on the protection and promotion of mental health in children of persons with severe mental disorders", World Psychiatry, vol. 10, issue 2, pp. 93 - 102, 2011. Abstract

This guidance details the needs of children, and the qualities of parenting that meet those needs. Parental mental disorders can damage the foetus during pregnancy through the action of drugs, prescribed or abused. Pregnancy and the puerperium can exacerbate or initiate mental illness in susceptible women. After their birth, the children may suffer from the social disadvantage associated with severe mental illness. The parents (depending on the disorder, its severity and its persistence) may have intermittent or prolonged difficulties with parenting, which may sometimes result in childhood psychological disturbance or child maltreatment. This guidance considers ways of preventing, minimizing and remedying these effects. Our recommendations include: education of psychiatrists and related professions about the effect of parental mental illness on children; revision of psychiatric training to increase awareness of patients as caregivers, and to incorporate relevant assessment and intervention into their treatment and rehabilitation; the optimum use of pharmacological treatment during pregnancy; pre-birth planning when women with severe mental illness become pregnant; development of specialist services for pregnant and puerperal women, with assessment of their efficacy; community support for parenting by mothers and fathers with severe mental disorders; standards
of good practice for the management of child maltreatment when parents suffer from mental illness; the importance of multi-disciplinary teamwork when helping these families, supporting their children and ensuring child protection; the development of child and adolescent mental health services worldwide.
Key words: Parenting, severe mental illness, mother-infant relationship, substance abuse, childhood mental disorders, child maltreatment, child and adolescent mental health services
(World Psychiatry 2011;10:93-102)
PMID: 21633678 [PubMed] Free PMC Article

Brockington, I., P. Chandra, H. Dubowitz, D. Jones, S. Moussa, J. Nakku, and I. Q. Ferre, "Wpa Guidance on the Protection and Promotion of Mental Health in Children of Persons with Severe Mental Disorders", World Psychiatry, 2011. Abstract

This guidance details the needs of children, and the qualities of parenting that meet those needs. Parental mental disorders can damage the foetus during pregnancy through the action of drugs, prescribed or abused. Pregnancy and the puerperium can exacerbate or initiate mental illness in susceptible women. After their birth, the children may suffer from the social disadvantage associated with severe mental illness. The parents (depending on the disorder, its severity and its persistence) may have intermittent or prolonged difficulties with parenting, which may sometimes result in childhood psychological disturbance or child maltreatment. This guidance considers ways of preventing, minimizing and remedying these effects. Our recommendations include: education of psychiatrists and related professions about the effect of parental mental illness on children; revision of psychiatric training to increase awareness of patients as caregivers, and to incorporate relevant assessment and intervention into their treatment and rehabilitation; the optimum use of pharmacological treatment during pregnancy; prebirth planning when women with severe mental illness become pregnant; development of specialist services for pregnant and puerperal women, with assessment of their efficacy; community support for parenting by mothers and fathers with severe mental disorders; standards of good practice for the management of child maltreatment when parents suffer from mental illness; the importance of multi-disciplinary teamwork when helping these families, supporting their children and ensuring child protection; the development of child and adolescent mental health services worldwide.

Broderick, G. A., A. Kadioglu, T. J. Bivalacqua, H. Ghanem, A. Nehra, and R. Shamloul, "Priapism: pathogenesis, epidemiology, and management", The journal of sexual medicine, vol. 7, no. 1pt2: Wiley Online Library, pp. 476–500, 2010. Abstract
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