, Cairo, Agricultur Cairo , 2009.
Conjugated linoleic acids (CLA isomers) are fatty acids found in milk and dairy products. These fatty acids may have potential biological properties interesting for human health. It is well established that milk and milk products are one of the major dietary sources of CLA but no work has been conducted until now to assess the CLA content levels in different Egyptian milks and their dairy products. In the present study a survey of Egyptian milks and their products such as cream, butter and ghee obtained from of Faculty of Agriculture, Cairo University, Giza Egypt during the annual four seasons (winter, spring, summer and autumn) as well as some commercial milks and milk products (cream, butter and ghee) obtained from Giza market was carried out to determined the content of fat and conjugated linoleic acids (CLA isomers) in the collected samples of different Egyptian ruminants (buffalo, cow, goat and sheep). The CLA isomers were determined by capillary gas chromatography. These were as a chemical analysis. In connection, the studies conducted to evaluate the influences of CLA (cis-9, trans-11 and trans-10, cis-12 isomers) as antidiabetic agents in streptozotocin diabetic male adult albino rats. In case of the chemical composition as the first part of these studies the present results showed that Sheep and buffalo milks had amounts of fat higher than those of cow and goat samples (farm ruminants). Fat levels of cream, butter and ghee samples did not differ very much from either for ruminants or in seasons. The high polar capillary gas chromatography analysis detected six CLA isomers CLA isomer (total or individual) content in milk was increased from winter to summer CLA isomers (total or individual) content in cream had the highest value in sheep followed by goat , then buffalo but cow had the lowest value like milk and cream, sheep butter had the highest content of CLA isomers the same trend was observed in individual CLA isomers or total of ghee which had the six detected CLA isomers during the four seasons. As regards to the biological evaluation of CLA isomers as antidiabetic agents there were not alterations by ingestion of CLA into normal control in rat physiology CLA isomers ingestion resulted In a significant reduction of blood glucose level of diabetic rats helped the diabetic rats to overcome the impaired body functions and consequently the feed efficiency ratio transaminase activity and protein (liver function) and helped the diabetic rats to overcome the impaired body functions and consequently the feed efficiency ratio. CLA isomers improved the dramatically disturbed in atherogenic risk indicator ratio and elevations in uric acid, urea and creatinine of plasma (kidney function) CLA isomers did not change plasma insulin levels but increased the adiponectin levels of diabetic rats. It means that, CLA isomers may be have not any toxicity in the normal or diabetic animals but the effects as the antidiabetic agents can be arranged in the following increasing order: glitazon > CLA mixture > CLA trans-10, cis-12 > CLA cis-9, trans-11.
Key wards: CLA, dairy fatty products, streptozotocin, glitazone, adiponectin