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Atwa, A., R. Hegazy, N. Shaffie, N. Yassin, and S. Kenawy, "Protective Effects of Vasodilatory Βeta-Blockers Carvedilol and Nebivolol against Glycerol Model of Rhabdomyolysis-Induced Acute Renal Failure in Rats.", Open access Macedonian journal of medical sciences, vol. 4, issue 3, pp. 329-336, 2016. Abstract

BACKGROUND: Rhabdomyolysis (RM)-induced acute renal failure (ARF) accounts for about 10-40% of all cases of ARF.

AIM: The present study investigated the possible protective effect of two nitric oxides (NO)-releasing third generation β-blockers, carvedilol (Carv) and nebivolol (Nebi), against RM-mimicking glycerol (Gly)-induced ARF in rats.

MATERIAL AND METHODS: After 24 h dehydration, rats received a single dose of 50% Gly (8 ml/kg, im). They were treated with vehicle, Carv (2.5 mg/kg/day, po) or Nebi (10 mg/kg, po) for 3 successive days starting from an hour prior to Gly injection. Evaluation of blood pressure and locomotor activity was performed during the experiment. 72 h following Gly administration, total protein in the urine, serum levels of creatinine, blood urea nitrogen, sodium and potassium as well as the renal contents of malondialdehyde, reduced glutathione and NO were assessed, together with a histopathological examination of renal tissues.

RESULTS: Carv and Nebi attenuated Gly-induced renal dysfunction and histopathological alterations. They decreased the Gly-induced oxidative stress and increased renal NO concentration. Restoration of normal blood pressure and improvement of locomotor activity were also observed.

CONCLUSION: The results clearly demonstrate protective effects of Carv and Nebi against renal damage involved in RM-induced ARF and suggest a role of their antioxidant and NO-releasing properties.

Atwa, D.M., I. S., A. B. Stani, C, B. y. Grenni, P., and W. Soliman, "Biodeterioration Assessment of a Unique Old Pharaonic Kingdom Wooden Statue Using Advanced Diagnostic Techniques", Applied Sciences, vol. 12, 2022.
Atwa, A. S., Lamis Gomaa, W. Elmenofy, H. M. Amer, and B. M. Ahmed, "Expression of recombinant Florida clade 2 hemagglutinin in baculovirus expression system: A step for subunit vaccine development against H3N8 equine influenza virus.", Open veterinary journal, vol. 14, issue 1, pp. 350-359, 2024. Abstract42-eiv_baculovirus_2024.pdf

BACKGROUND: Equine influenza (EI) is a transmissible viral respiratory sickness of the family. Two viruses, H7N7 and H3N8 caused EI; however, H7N7 has not been detected for decades. H3N8 has circulated and bifurcated into Eurasian and American lineages. The latter subsequently diversified into Kentucky, South America, and Florida sub-lineages. Florida clade 1 (FC1) and Florida clade 2 (FC2) strains are the only circulating EI viruses (EIVs) in the meantime. Immunization is considered the major means for the prevention and control of EI infection. Using disparate technologies and platforms, several vaccines have been developed and commercialized. According to the recommendations of the World Organization for Animal Health (WOAH), all commercial vaccines shall comprise representatives of both FC1 and FC2 strains. Unfortunately, most of the commercially available vaccines were not updated to incorporate a representative of FC2 strains.

AIM: The purpose of this research was to develop a new EI vaccine candidate that incorporates the hemagglutinin (HA) antigen from the currently circulating FC2.

METHODS: In this study, we report the expression of the full-length recombinant HA gene of FC2 in the baculovirus expression system.

RESULTS: The HA recombinant protein has been proven to maintain its biological characteristics by hemadsorption (HAD) and hemagglutination tests. Moreover, using a reference-specific serum, the specificity of the HA has been confirmed through the implementation of immunoperoxidase and western immunoblotting assays.

CONCLUSION: In conclusion, we report the expression of specific biologically active recombinant HA of FC2, which would act as a foundation for the generation of an updated EI subunit or virus vector vaccine candidates.

ATWA, A. A., M. M. SHAMSELDEAN, and F. A. YONİS, "Farklı pestisitlerin entomopatojenik nematodların üremesi üzerine etkisi", Turkish Journal of Entomology, vol. 37, issue 4, pp. 493-502, 2013. Abstract
Atwa, D. M., N. Aboulfotoh, A. A. El-Magd, and Y. Badr, "Spectroscopic study of Pbs nano-structured layer prepared by Pld utilized as a Hall-effect magnetic sensor", AIP Conference Proceedings, vol. 1558, pp. 560-563, 2013. Abstract
Atwa, A. A., and H. H. Kesba, "Suppression of Meloidogyne incognita with interaction of soil bacteria and entomopathogenic nematodes on tomato. ", Egyptian Journal of Applied Sciences, Zagazig University, Egypt, vol. 23, issue 1, pp. 293-304, 2008.
Atwa, A. A., M. M. Shamseldean, and F. A. Yonis, "The effect of different pesticides on reproduction of entomopathogenic nematodes", Türk. entomol. derg.(Turkey), vol. 37, issue (4), pp. 493-502, 2013. Abstract
Atwa, M. H., I. M. El-Sabagh, H. M. Amer, S. Saad, A. A. Yousif, and M. A. Shalaby, "ZH501-VSVRI: Is it Still the Best Choice for Vaccination Against Rift Valley Fever in Egypt?", Journal of Vaccines & Vaccination, vol. 2, issue 3, pp. 1-5, 2011. AbstractZH501-VSVRI: Is it Still the Best Choice for Vaccination Against Rift Valley Fever in Egypt?.pdf

ZH501 strain of Rift valley fever virus (RVFV) was originally isolated from a human patient during the outbreak of 1977 in Egypt. This virus strain was used since 1980 for preparation of an inactivated RVF vaccine at Veterinary Serum and Vaccine Research Institute (VSVRI), Egypt. Two subpopulations of ZH501 with a single nucleotide polymorphism (A/G) at nucleotide position 847 of Gn gene of M segment have been described. This nucleotide substitution affected signifcantly RVFV virulence in the mouse model. In this report, the genetic makeup of the Gn gene of ZH501-VRVSI vaccine virus stock was analyzed for verifcation of its safety and stability. Plaque assay of the vaccine stock virus revealed the presence of two populations that produced different plaque forms. The viruses that developed large plaques resembling those produced by the virulent virus strains were isolated for genetic analysis. Comparison of the Gn gene nucleotide sequence of the isolated viruses with those of the wild-type ZH501 and other reference strains identifed fve nucleotide substitutions, of which three are capable to induce amino acid changes in the mature protein. Protean analysis suggested a potential change in the three dimensional structure of the Gn protein in relation to the parent strain. The results of this study throw light on the changes occurred in the master seed virus used for preparation of RVFV vaccine in Egypt. Further studies focusing on the other gene segments of
ZH501-VSVRI are required to conclude is it still the best choice for vaccination against RVF in Egypt.

Atwa, M. T., N. I. S. Salem, and H. R. H. Mohamed, " EFFECT OF CRYPTOSPORIDIUM PARVUM INFECTION ON DNA DAMAGE AND CYTOKINES GENE EXPRESSION IN BLOOD OF IMMUNOCOMPROMISED MICE", Egyptian Zoology of Zoology, vol. 73, issue 73, pp. 16-25, 2020.
Atwan, E. F., A. S. Awad, S. M. Abdelrahman, S. H. Makar, and M. H. A. E. Ghobashy, "Surveillance and monitoring of early failing arteriovenous fistula using Doppler assessment in children on regular hemodialysis", Egyptian Journal of Radiology and Nuclear Medicine, vol. 53, issue 1: SpringerOpen, pp. 1-8, 2022. Abstract
Atwee, T., A. - S. Gadallah, M. A. Salim, and A. M. Ghander, "Effect of film thickness on structural, morphological, and optical properties of Cu2ZnSnS4 thin films prepared by sol–gel spin coating", Applied Physics A , vol. 125, pp. 270, 2019.
Atwine, D., Y. W. Karanja, A. Ahluwalia, C. D. Maria, D. Assefa, V. Konde, E. Khundi, P. N. Makobore, M. Moshi, M. Nzomo, et al., "Nurturing next-generation biomedical engineers in Africa: The impact of Innovators’ Summer Schools", Global Health Innovation, vol. 3, issue 2, 2020.
Aty, N. A. E., M. Rashwan, and R. Hamed, "A goal Programming Approach For Samples Overlap in Stratified Random Sampling ", Advances and Applications in Statistics), , vol. Vol 51, issue 1, 2017.
Atya, A. M., and G. M. Ahmed, "Pulsed Magnetic Field Versus Ultrasonic in Treatment of Patients with Chronic Mechanical low Back Pain", bullettin of faculty of physical therapy, vol. 13, issue 2, pp. 139-145, 2008. july2008.pdf
Atya, A. M., and K. H. Battecha, "Low Intensity Laser Therapy (LILT) Versus Transcutaneous Electrical Nerve Stimulation On Microcirculation In Diabetic Neuropathy", THE 8TH INTERNATIONAL CONFERENCE ON LASER APPLICATIONS, Egypt, 1– 5 May, 2011. getpdfservlet.pdf
Atya, H. B., S. A. Ali, M. I. Hegazy, and F. Z. El Sharkawi, "Is rs763780 in IL-17F gene considered risk factor to multiple sclerosis in Egyptian patients?", Meta Gene, vol. 14: Elsevier, pp. 124-128, 2017. Abstract
Atya, A. M., and G. M. Ahmed, "Effectiveness of Physical Therapy Intervention on Neck Proprioception and Balance Parameters in Patients With Chronic Mechanical Neck Pain", bulletin of faculty of physical therapy, vol. 14, issue 2, pp. 41-47, 2009. july2009.pdf
Atya, H. B., S. A. Ali, M. I. Hegazy, and F. Z. El Sharkawi, Urinary Urea, Uric Acid and Hippuric Acid as Potential Biomarkers in Multiple Sclerosis Patients, , vol. 33, issue 2: Springer India, pp. 163 - 170, 2018. Abstract
Atya, A. M., and N. A. Zaky, "Effect of Pulsed Low Frequency Magnetic Field on Balance and Ankle Function in Patients with Juvenile Rheumatoid Arthritis", Middle-East Journal of Scientific Research, vol. 21, issue 10, pp. 1848-1854, 2014. 26.pdf
Atya, A. M., "Efficacy of Microcurrent Electrical Stimulation on pain, proprioception accuracy and functional disability in Subacromial Impingement: RCT", Indian journal of physical therapy and occupational therapy, vol. 6, issue 1, pp. 15-18, 2012.
Atya, A. M., M. M. Nasser, and A. Hagag, "COMPARISON OF ASTYM THERAPY AND KINESIOTAPING FOR ROTATOR CUFF TENDINOPATHY IN DIABETIC PATIENTS: RANDOMIZED CONTROLLED TRIAL", International Journal of Physiotherapy, vol. 4, issue 1, pp. 12-18, 2017.
Atya, A. M., "Effect of Patellar Tracking on Pain, Repositioning Accuracy and Quadriceps Torque in knee Osteoarthritis", bullettin of faculty of physical therapy, vol. 15, issue 2, pp. 51-59, 2010. july_2010.pdf
Atya, A. M., and W. T, "Laser Versus Nerve and Tendon Gliding Exercise in Treating Carpal Tunnel Syndrome", bulletin of faculty of physical therapy, vol. 15, issue 1, pp. 19-27, 2010. 578-1105-1-sm.pdf