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Aziz, M. A. - E., M. R. Ali, K. S. M. Hammad, and N. F. S. Morsy, "Carboxymethyl cellulose coating enriched with Oregano (Origanum vulgare L.) essential oil to preserve Eel (Anguilla anguilla) fillets during cold storage", Egyptian Journal of Nutrition, vol. 34, issue 2, pp. 1-35, 2019.
Aziz, M. T., E. I. N. Ibrashy, D. P. Mikhailidis, R. A. M. AM, M. A. Wassef, H. H. Fouad, H. H. Ahmed, D. A. Sabry, H. M. Shawky, and R.E.Hussein, "Signaling mechanisms of a water soluble curcumin derivative in experimental type 1 diabetes with cardiomyopathy", Diabetology & Metabolic Syndrome, vol. 5, issue 1, pp. 13-24, 2013. curcumin_diabetic_cardiomyopathy_1758-5996-5-13.pdf
aziz, M. A. T., T. Mostafa, H. Atta, M. A. Wassef, H. H. Fouad, L. A. Rashed, and D. Sabry, "Putative role of carbon monoxide signaling pathway in penile erectile function", The Journal of Sexual Medicine, vol. 6, no. 1: Elsevier, pp. 49–60, 2009. Abstract
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Aziz, A. M. T., T. Mostafa, H. Atta, M. A. Wassef, H. H. Fouad, L. A. Rashed, and D. Sabry, "Putative role of carbon monoxide signaling pathway in penile erectile function", J Sex Med, vol. 6, issue 1, pp. 49-60, 2009.
Aziz, A. E., M. Talaat, M. F. El-Asmer, T. Mostafa, S. Mostafa, H. Atta, M. Abdel Aziz Wassef, H. Fouad, L. Rashed, D. Sabry, et al., "ORIGINAL RESEARCH—BASIC SCIENCE: Heme Oxygenase vs. Nitric Oxide Synthase in Signaling Mediating Sildenafil Citrate Action", The journal of sexual medicine, vol. 4, no. 4ii: Blackwell Publishing Inc, pp. 1098–1107, 2007. Abstract
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Aziz, A. S. A., A. T. Azar, A. E. Hassanien, and S. E. - O. Hanafy, "Continuous features discretization for anomaly intrusion detectors generation", Soft computing in industrial applications: Springer International Publishing, pp. 209–221, 2014. Abstract
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Aziz, M. M., I. K. Eyada, M. A. Abd El Megeid, and A. OM, "Bedside Evaluation of Fluid Responsiveness in Shock State using Electrical Cardiometry.", Indian Journal of Public Health Research & Development, vol. 10, no. 12, 2019. Abstract
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Aziz, T. A., M. A. Aziz, H. H. Fouad, L. A. Rashed, H. Salama, S. Abd-Alla, M. A. A. Wehab, and T. Ahmed, "Interferon-α gene therapy prevents aflatoxin and carbon tetrachloride promoted hepatic carcinogenesis in rats", International journal of molecular medicine, vol. 15, issue 1: Spandidos Publications, pp. 21-26, 2005. Abstract
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Aziz, A. M. T. A., H. M. E. Zahed, S. H. Ahmed, and W. Fathy, "Occupational Exposure to Heavy Metal Initiate Carcinogenesis Though BRAF/KRAS Over Expression and DNA Methylation.", Journal of Chemical Health Risks , 2020. Abstract

Colorectal cancer (CRC) is a leading cause of death especially in industries worker.
The aim of this study: is to identify the role of heavy elements exposure on CRC DNA methylation.
Methods: The study was conducted on 25 CRC patients. Biopsies were taken by colonoscopy from malignant tissue and adjacent normal tissues for comparative assessment of BRAF/KRAS, methylated MLH1 and MGMT between the normal and malignant tissues by using real time PCR. In an attempt to identify wither heavy metal like Lead, Aluminum and Mn have a role in cancer development or not, we compared their levels in the serum of 25 CRC patients and 25 normal volunteers by using atomic absorption.
Results: The expressions of BRAF/KRAS, methylated MLH1 and MGMT were significantly higher in malignant tissues compared to normal tissues (p value<0.001). Additionally, the levels of lead and aluminum but not Mn were significantly higher in CRC patients compared to normal controls (p value<0.001). Lead and Aluminum were positively correlated with all studied parameters.
Conclusion: Heavy metals act as starting signals for carcinogenesis through DNA methylation.
Keywords: Colorectal cancer; Heavy metals; DNA methylation.

and Aziz, M.S.E.D.A., E. M. B. M. M. F., "Loss of Excitation Faults Detection in Hydro-Generators Using an Adaptive Neuro Fuzzy Inference System", TELKOMNIKA Indonesian Journal of Electrical Engineering, Vol. 17,, vol. 17, issue 2: Indonisia, 2016. Abstract
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Aziz, S. G., O. I. Osman, S. A. Elroby, W. M. I. Hassan, A. Jedidi, and R. H. Hilal, "Proton-coupled electron transfer in dye-sensitized solar cells: a theoretical perspective", Struct Chem, vol. 29, issue 4, pp. 983-997, 2018.
Aziz, H. A., H. Omar, M. Khalil, A. Cordie, R. Mohamed, M. Abdallah, M. H. Abdel Maksoud, N. El Garhy, L. Ali, M. E. Serafy, et al., "Real-life experience of treating HCV co-infection among HIV-infected population in Egypt: single-center experience.", Expert review of anti-infective therapy, vol. 20, issue 5, pp. 789-795, 2022. Abstract

BACKGROUND: Liver disease has emerged as a leading cause of death among PLHIV coinfected with HCV.

METHODS: A retrospective study involving all HCV viremic patients coinfected with HIV who presented to HCV/HIV multidisciplinary clinics located at Embaba fever hospital. Patients were assigned to receive DAAs according to the national treatment guidelines. The primary endpoint was SVR12.

RESULTS: Of the 519 patients enrolled, 38.73% LTFU; either not initiated (n = 170) or did not complete the treatment (n = 31). The main identified reasons behind LTFU were schedule conflict (19%) or hospitalization (13%). Among 318 patients who completed their DAAs course, nine patients had a relapse after the end of treatment and 97% had attained SVR12. There were significant differences among different virological response groups in baseline factors including smoking (p = 0.005), history of dental procedure (p = 0.007), CD4 count (p = 0.007), and HIV viral load (p = <0.001). Among responders (n = 309), there was a significant reduction of baseline hemoglobin and significant improvement of baseline platelets (p = 0.005) at on-treatment week 8. Baseline necro-inflammatory markers showed significant improvement across follow-up time points (p < 0.001).

CONCLUSIONS: DAAs are an effective and safe choice to treat HCV in PLHIV. Social stigma could be a major cause for lacking adherence to follow-up visits. ALT: Alanine Aminotransferase; ARV: Antiretroviral treatment; AST: Aspartate Aminotransferase; DAAs: Direct acting antivirals; ARVs: antiretroviral therapy; EMR: Eastern Mediterranean region; HCV: Hepatitis C virus; kPa: Kilopascal; LTFU: Patient lost to follow up; NCCVH: The National Committee for Control of Viral Hepatitis; PWID: People who inject drugs; SVR: Sustained virological response;UNAIDS: The Joint United Nations Programme on HIV/AIDS.

Aziz, A. S. A., E. L. Sanaa, and A. E. Hassanien, "Comparison of classification techniques applied for network intrusion detection and classification", Journal of Applied Logic: Elsevier, 2016. Abstract
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Aziz, M. A. S., HYBRID PARTICLE SWARM OPTIMIZATION AND DESIGN OF EXPERIMENT, , Egypt, Cairo, 2017.
Aziz, D. E., A. A. Abdelbary, and A. I. Elassasy, "Implementing Central Composite Design for Developing Transdermal Diacerein-Loaded Niosomes: Ex vivo Permeation and In vivo Deposition", Current Drug Delivery, vol. 15, pp. 1330-1342, 2018.
Aziz, A. S. A., S. E. - O. Hanafy, and A. E. Hassanien, "Multi-agent artificial immune system for network intrusion detection and classification", 9th International Conference on Soft Computing Models in Industrial and Environmental Applications, Bilbao, Spain, 25th - 27th Jun, 2014.
Aziz, H. A., "Application of Different Body Fluids on Sysmex XE-5000", Egyptian Laboratory Mediceine, vol. 1, pp. 1- 6, 2014.
Aziz, M. S. A., H. F. Naguib, and G. R. Saad, "Non-isothermal crystallization kinetics of bacterial poly(3- hydroxybutyrate) in poly(3-hydroxybutyrate-co-butylene adipate) urethanes", Thermochimica Acta, vol. 591, pp. 130 - 139, 2014. AbstractWebsite

The non-isothermal melt crystallization kinetics of a series of copoly(ester-urethane)s, PUs, based on poly(3-hydroxybutyrate), PHB, and poly(butylene adipate), PBA, of different PHB content 20, 40, and 60 wt% were studied using DSC at different cooling rates. Various macrokinetic models, namely, Avrami, Tobin, Ozawa, and Mo models were applied to describe the crystallization process of PHB in the PU matrices. Avrami, Tobin, and Mo models could successfully describe the non-isothermal crystallization behavior of PHB segments in all samples, while Ozawa model provides a fair description of the non-isothermal crystallization process of PUs containing only 20 and 40 wt% PHB. The Avrami exponent was found to range from 3.6 to 4.0, while the Tobin exponent was found to range from 2.3 to 3.0. The spherulites shape and size were analyzed using polarized optical microscopy (POM). The results of kinetic parameters showed that the crystallization rate of PHB segments in the investigated PUs was increased with increasing the PHB content. The isoconversional method of Friedman was used to determine the effective activation energy of crystallization of the PUs and the Lauritzen-Hoffman parameters (Kg and U*) were calculated by applying the Vyazovkin method. © 2014 Elsevier B.V. All rights reserved.

Aziz, R. K., "Rethinking Pharmacogenomics in an Ecosystem: Drug-microbiome Interactions, Pharmacomicrobiomics, and Personalized Medicine for the Human Supraorganism", Current Pharmacogenomics and Personalized Medicine (Formerly Current Pharmacogenomics), vol. 10, no. 4: Bentham Science Publishers, pp. 258–261, 2012. Abstract
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Aziz, A. M. T., E.A. Abd El Nabi, A. M. Hamid, D. Sabry, H. M. Atta, L.A. Rahed, A. Shamaa, S. Mahfouz, F. M. Taha, S. Elref, et al., "Endothelial progenitor cells regenerate infracted myocardium with neovascularisation development", Journal of Advanced Research , 2013. myocardial_infarction_stem_cells.pdf
Aziz, A. S. A., M. Salama, A. E. Hassanien, and E. L. Sanaa, "Detectors generation using genetic algorithm for a negative selection inspired anomaly network intrusion detection system", Computer Science and Information Systems (FedCSIS), 2012 Federated Conference on: IEEE, pp. 597–602, 2012. Abstract
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Aziz, D., S. Mohamed, S. Tayel, and A. Makhlouf, "Implementing polymeric pseudorotaxanes for boosting corneal permeability and antiaspergillus activity of tolnaftate: formulation development, statistical optimization, ex vivo permeation and in vivo assessment.", Drug delivery, vol. 29, issue 1, pp. 2162-2176, 2022. Abstract

Fungal keratitis (FK) is a devastating ocular disease that can cause corneal opacity and blindness if not treated effectively. Tolnaftate (TOL) is a selective fungicidal drug against Aspergillus spp. which are among the most common causes of mycotic keratitis. TOL is lipophilic drug with low water solubility and permeation which act as obstacles for its clinical ocular efficacy. Hence, this study aimed to statistically optimize a novel polymeric pseudorotaxanes (PSRs) containing TOL for enhancing its ocular permeability and antifungal effect. For achieving this goal, a full 3.2 factorial design was fashioned for preparing and optimizing TOL-PSRs using film hydration technique. Three formulation variables were studied: drug amount (X), weight ratio of Pluronics to HPβCD (X) and Pluronic system (X). Entrapment efficiency percent (EE%) (Y), particle size (PS) (Y) and zeta potential (ZP) (Y) were set as dependent variables. The selected optimal TOL-PSRs (PSR1) showed EE% of 71.55 ± 2.90%, PS of 237.05 ± 12.80 nm and ZP of -32.65 ± 0.92 mV. In addition, PSR1 was compared to conventional polymeric mixed micelles (PMMs) and both carriers significantly increased the drug flux and resulted in higher amount permeated per unit area in 8 h compared to drug suspension. The histopathological studies assured the safety of PSR1 for ocular use. The in vivo susceptibility testing using Aspergillus niger confirmed that PSR1 displayed sustained antifungal activity up to 24 h. The obtained results revealed the admirable potential of PSR1 to be used as novel nanocarriers for promoting TOL ocular delivery.

Aziz, A. M. T., E. M. F. Asmer, T. Mostafa, H. Atta, S. Mahfouz, H. Fouad, L. Rashed, S. Sabry, A. Hassouna, A. A. T. Aziz, et al., "Effects of losartan, HO-1 inducers or HO-1 inhibitors on erectile signaling in diabetic rats", J Sex Med, vol. 6, issue 12, pp. 3254-3264, 2009.
Aziz, S. A. E. L., H. S. Hamza, and I. A. Saroit, "An energy-efficient hierarchical routing protocol for wireless sensor networks", Informatics and Systems (INFOS), 2010 The 7th International Conference on: IEEE, pp. 1-7, 2010. Abstract
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