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Aziz, R. K., B. J. Aronow, W. L. Taylor, S. L. Rowe, R. Kansal, M. J. Walker, and M. Kotb, "Integrating neighbor clustering, coexpression clustering and subsystems analysis to define dynamic changes in regulatory networks associated with group A streptococcal sociomicrobiology and niche adaptation", BMC Bioinformatics, vol. 11, no. Suppl 4: BioMed Central Ltd, pp. P12, 2010. Abstract
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Aziz, M. A., F. M. Owis, and M. M. Abdelrahman, "Design Optimization of a Transonic-Fan Rotor Using Numerical Computations of the Full Compressible Navier-Stokes Equations and Simplex Algorithm", International Journal of Rotating Machinery, vol. 2014: Hindawi Publishing Corporation, 2014. Abstract
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Aziz, A. S. A., M. Salama, A. E. Hassanien, and E. L. Sanaa, "Detectors generation using genetic algorithm for a negative selection inspired anomaly network intrusion detection system", Computer Science and Information Systems (FedCSIS), 2012 Federated Conference on: IEEE, pp. 597–602, 2012. Abstract
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Aziz, R. K., M. M. Khalifa, and R. R. Sharaf, "Contaminated water as a source of Helicobacter pylori infection", Journal of Advanced Research: Elsevier, 2013. Abstract
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Aziz, R. A. E., T. Heshmat, and R. Salam, "urinary iodine excretion in Egyptian females with nodular goiter ", American journal of research communications, vol. 1, issue 5, pp. 146-156, 2013. iodine_paper.pdf
Aziz, A. M. T., E. M. F. Asmer, T. Mostafa, H. Atta, S. Mahfouz, H. Fouad, L. Rashed, D. Sabry, A. Hassouna, A. A. T. Aziz, et al., "Effects of losartan, HO-1 inducers or HO-1 inhibitors on erectile signaling in diabetic rats", J Sex Med, vol. 6, issue 12, pp. 3254-3264, 2010.
Aziz, S. A. E. L., H. S. Hamza, and I. A. Saroit, "An energy-efficient hierarchical routing protocol for wireless sensor networks", Informatics and Systems (INFOS), 2010 The 7th International Conference on: IEEE, pp. 1-7, 2010. Abstract
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Aziz, M. A. T., T. Mostafa, H. Atta, S. Asaad, H. H. Fouad, G. Mohsen, L. Rashed, D. Sabry, and M. Abbas, "In vitro and in vivo lineage conversion of bone marrow stem cells into germ cells in experimental azoospermia in rat", Stem Cell Studies, vol. 1, no. 1, pp. e15–e15, 2011. Abstract
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Aziz, M., A. ElAshmaoui, N. S. Mohamed, M. M. Mahmoud, and M. M. Mohamed, "Assessment of Skin Microcirculation and Inflammatory Markers of Metabolic Syndrome in A Rat Model", Life Science Journal, vol. 8, issue 4, pp. 314-321, 2011. AbstractCU-PDF

Analysis of the literature reveals that metabolic syndrome is invariably linked to microvascular disturbances, such as abnormalities in arteriolar reactivity, capillary recruitment, permeability, and hemorheology. The aim of this study was to assess skin microcirculation under baseline conditions and maximum skin hyperemia in response to heating (vasodilatory capacity)

Aziz, R. K., V. Khaw, J. M. Monk, E. Brunk, R. Lewis, S. I. Loh, A. Mishra, A. A. Nagle, C. Satyanarayana, S. Dhakshinamoorthy, et al., "Model-driven discovery of synergistic inhibitors against E. coli and S. enterica serovar Typhimurium targeting a novel synthetic lethal pair, aldA and prpC", Frontiers in Microbiology, vol. 6: Frontiers, pp. 958, 2015. Abstract
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Aziz, M. S. A., H. F. Naguib, S. M. Sherif, and G. R. Saad, "Preparation and Characterization of Biodegradable Polyurethane Nanocomposites Based on Poly(3-hydroxybutyrate) and Poly(Butylene Adipate) Using Reactive Organoclay", Polymer - Plastics Technology and Engineering, vol. 53, issue 16, pp. 1671 - 1681, 2014. AbstractWebsite
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Aziz, T. A. M., F. M. Al-Asmar, T. Mostafa, H. Atta, L. Rashed, D. Sabry, S. Ashour, and A. A. T. Aziz, "Assessment of heme oxygenase-1 (HO-1) activity in the cavernous tissues of sildenafil citrate-treated rats.", Asian journal of andrology, vol. 9, issue 3, pp. 377-81, 2007 May. Abstract

AIM: To assess heme oxygenase-1 (HO-1) activity in the cavernous tissue of sildenafil citrate-treated rats.

METHODS: One hundred and ninety-two Sprague-Dawley male rats, divided into four equal groups, were investigated. Group 1, the control group, received regular animal chow; group 2 received sildenafil citrate by intragastric tube; group 3 received sildenafil and HO inhibitor (zinc protoporphyrin, ZnPP); and group 4 received sildenafil and nitric oxide synthase (NOS) inhibitor L-nitroarginine methyl ester (L-NAME). Twelve rats from each group were killed after 0.5 h, 1 h, 2 h and 3 h of drug administration. Then HO-1 activity, cGMP levels and NOS enzymatic activity in the cavernous tissues were estimated.

RESULTS: In cavernous tissue, HO-1 activity, NOS enzymatic activity and cGMP concentration increased significantly in sildenafil-treated rats compared to other groups throughout the experiment. Rats receiving either HO or NOS inhibitors showed a significant decrease in these parameters. HO-1 cavernous tissue activity and NOS enzymatic activity demonstrated a positive significant correlation with cGMP levels (r = 0.646, r = 0.612 respectively; P < 0.001).

CONCLUSION: The actions of PDE5 inhibitor sildenafil citrate in the cavernous tissue are partly mediated through the interdependent relationship between both HO-1 and NOS activities.

Aziz, H. A., N. El Gayar, M. Saleh, and H. ElShishiny, "A Randomized Model for Group Reservations in a Revenue Management System", The 6th International Conference on Informatics and Systems INFOS IEEE, 2008. Abstract
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aziz, M. A. T., H. H. Fouad, N. K. Roshdy, L. A. Rashed, D. Sabry, A. A. Hassouna, F. M. Taha, W. Ibrahim, and M. Mahmoud, "Effect of Human Mesenchymal Stem Cells on Hepatoma Cell Line", Stem Cell Studies, vol. 1:e12, 2011. AbstractCU-PDF.pdf

Human mesenchymal stem cells (hMSCs) are mostly studied for their potential clinicaluse. Little is known about the underlying molecular mechanisms that link hMSCs to the targeted inhibition of tumor cells. The present study was conducted to evaluate the tumor suppressive effects of human mesenchymal stem cells (hMSCs) on human hepatoma cell line (HepG2) and their signaling mechanisms.

Aziz, M. T. A., M. F. El-Asmar, A. M. Rezq, M. A. A. Wassef, H. Fouad, N. K. Roshdy, H. H. Ahmed, L. A. Rashed, D. Sabry, F. M. Taha, et al., "Effects of a novel curcumin derivative on insulin synthesis and secretion in streptozotocin-treated rat pancreatic islets in vitro.", Chinese medicine, vol. 9, issue 1, pp. 3, 2014. Abstract

BACKGROUND: Hyperglycemia induces activation of the c-Jun N-terminal kinase (JNK) pathway, which suppresses insulin gene expression and reduces DNA binding of pancreatic and duodenal homeobox factor (PDX)-1. This study aims to investigate the effects of a novel curcumin derivative (NCD) on JNK signaling pathway on insulin synthesis and secretion in streptozotocin (STZ)-treated rat pancreatic islets in vitro.

METHODS: Isolated rat pancreatic islets were divided into five groups: untreated control group; group treated with NCD (10 μM); group exposed to STZ (5 mM); group treated with NCD (10 μM) and then exposed to STZ (5 mM); and group exposed to STZ (5 mM) and then treated with NCD (10 μM). The pancreatic islets from all groups were used for DNA fragmentation assays and quantitative assessments of the JNK, Pdx1, glucose transporter-2 (GLUT2), heme oxygenase (HO)-1, transcription factor 7-like 2 (TCF7L2), and glucagon-like peptide (GLP)-1 gene expression levels. The intracellular calcium, zinc, and the phosphorylated and total JNK protein levels were assessed. The insulin (secreted/total) and C-peptide levels were examined in islet culture medium.

RESULTS: NCD protected pancreatic islets against STZ-induced DNA damage, improved total insulin (P = 0.001), secreted insulin (P = 0.001), and C-peptide levels (P = 0.001), normalized mRNA expressions of insulin, Pdx1, and GLUT2 (P = 0.0001), and significantly elevated calcium and zinc levels (P = 0.0001). All effects were significant when islets were treated with NCD before STZ (P = 0.05). JNK gene overexpression and JNK protein levels induced by STZ were significantly inhibited after NCD treatment of islets ( P = 0.0001). NCD-treated islets showed significantly elevated gene expressions of HO-1, TCF7L2, and GLP-1 (P = 0.0001), and these upregulated gene expressions were more significantly elevated with NCD treatment before STZ than after STZ (P = 0.05).

CONCLUSIONS: NCD improved insulin synthesis and secretion in vitro in isolated pancreatic islets treated with STZ through inhibition of the JNK pathway, up-regulation of the gene expressions of HO-1, TCF7L2, and GLP-1 and enhancing effects on calcium and zinc levels.

mahmoud mohamed adel abd el aziz, rania el hussieny, randa ali soliman, H. Sherif, and A. H. M. E. D. E. L. SHERIF, CORONARY FLOW RESERVE IN THE LEFT ANTERIOR DESCENDING ARTERY PATIENTS, DIAGNOSTIC AND PROGNOSTIC VALUE OF DOPPLER ECHOCARDIOGRAPHY, , cairo, cairo university, 2015. 1_abstract_2_md_m.adel_.pdf
Aziz, A. S. A., A. T. Azar, A. E. Hassanien, and S. E. - O. Hanafy, "Negative Selection Approach Application in Network Intrusion Detection Systems", arXiv preprint arXiv:1403.2716, 2014. Abstract
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Aziz, F. A. E. A., and H. M. Abdel, "Retntion After Rapid Maxillary Expansion", Cairo Dental Journal, vol. 17, no. May: Faculty of oral and dental medicine.Cairo University, pp. 97–100, 2001. Abstract
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Aziz, M. T., E. I. N. Ibrashy, D. P. Mikhailidis, R. A. M. AM, M. A. Wassef, H. H. Fouad, H. H. Ahmed, D. A. Sabry, H. M. Shawky, and R.E.Hussein, "Signaling mechanisms of a water soluble curcumin derivative in experimental type 1 diabetes with cardiomyopathy", Diabetology & Metabolic Syndrome, vol. 5, issue 1, pp. 13-24, 2013. curcumin_diabetic_cardiomyopathy_1758-5996-5-13.pdf
Aziz, T. A. M., T. Mostafa, H. Atta, L. Rashed, S. A. Marzouk, E. M. Obaia, D. Sabry, A. A. Hassouna, A. M. El-Shehaby, and A. A. T. Aziz, "The Role of PDE5 Inhibitors in Heme Oxygenase-cGMP Relationship in Rat Cavernous Tissues.", The Journal of Sexual Medicine, vol. 5, issue 7, pp. 1636–1645, 2008. Abstractthe_role_of_pde5_inhibitors_in_heme_oxygenase-cgmp_relationship_in_rat_cavernous_tissues..pdf

Introduction. Heme Oxygenase (HO) enzyme catalyzes Oxidative degradation of heme to biliverdin and carbon monoxide (CO). CO shares many properties with nitric oxide (NO) including the activation of soluble guanyl cyclase.
Aim. To assess cavernous tissue HO activity and cyclic guanosine monophosphate (cGMP) levels in response to oral phosphodiesterse type 5 (PDE5) inhibitors.
Methods. Seven hundred twenty male Sprague-Dawley rats, divided into six groups, were investigated. Group 1, controls; Group 2 received sildenafil citrate orally; Group 3 received vardenafil hydrochloride; and Group 4 received tadalafil. Group 5 was subdivided into three equal subgroups, received the same dose of each drug added to the HO inhibitor, Zn protoporphyrin.Group 6 was subedivided into three equal subgroups, received the same dose of each drug added to the NO inhibitor, L-nitroarginine methylester. Either rats from each group / subgroup were sacrificed at 0.5, 1, 2, 3, 4, 6, 18, 24 and 36 hours, respectively.
Main Outcome Measures. HO enzyme activity assay and cGMP tissue levels in dissected rat cavernous tissues.
Results. Both cavernous tissue HO enzyme activity and cGMP tissue levels were increased significantly in sildenafil-,vardenafil-, and tadalafil-treated rats compared with the controls, with significant decreases after either HO or NO inhibition.Cavernous tissue HO enzyme activity and cGMP showed a positive significant correlation (r = 0.854,P < 0.001).
Conclusion. The effects of PDE5 inhibitors in cavernous tissue are partly mediated through HO enzyme activity.
Keywords. Heme Oxygenase; cGMP; sildenafil; Vardenafil; Tadalafil; PDE5 inhibitors.

Aziz, R. K., R. Kansal, B. J. Aronow, W. L. Taylor, S. L. Rowe, M. Kubal, G. S. Chhatwal, M. J. Walker, and M. Kotb, "Microevolution of group A streptococci in vivo: capturing regulatory networks engaged in sociomicrobiology, niche adaptation, and hypervirulence", PLoS One, vol. 5, no. 4: Public Library of Science, pp. e9798, 2010. Abstract
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