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Aziz, A. S. A., M. Salama, A. E. Hassanien, and E. L. Sanaa, "Detectors generation using genetic algorithm for a negative selection inspired anomaly network intrusion detection system", Computer Science and Information Systems (FedCSIS), 2012 Federated Conference on: IEEE, pp. 597–602, 2012. Abstract
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Aziz, M. S. A., and H. E. Salama, "Biocompatible and antimicrobial carboxymethyl xanthan/zinc physical hydrogels", Polymer Bulletin, vol. 79, issue 5, pp. 3219 - 3231, 2022. AbstractWebsite
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Aziz, M. T., M. F. El-Asmar, A. M. Rezq, M. A. Wassef, H. Fouad, N. K. Roshdy, H. H. Ahmed, L. A. Rashed, D. Sabry, and F. M. Taha, "Effects of a novel curcumin derivative on insulin synthesis and secretion in streptozotocin-treated rat pancreatic islets in vitro", Chinese medicine, vol. 9, issue 1: BioMed Central Ltd, pp. 3, 2014. Abstract
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Aziz, A. S. A., A. T. Azar, M. A. Salama, A. E. Hassanien, and S. E. - O. Hanafy, "Genetic algorithm with different feature selection techniques for anomaly detectors generation", Computer Science and Information Systems (FedCSIS), 2013 Federated Conference on: IEEE, pp. 769–774, 2013. Abstract
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Aziz, N. I. A., D. A. El Fadeel, A. Sadek, M. Fadel, and A. Tawfik, "Intralesional vitamin D3 versus new topical photodynamic therapy in recalcitrant palmoplanter warts Randomized comparative controlled study", Photodiagnosis and Photodynamic Therapy , vol. 32, 2020.
Aziz, D. A. E. A., F. M. Oqeel, M. M. Labib, and A. M. Yousef, "Effect of aerobic exercise on inflammation and sex hormones in obese polycystic ovarian syndrome women: A randomized controlled study", fizjoterapia polska, pp. 204-209, 2021.
Aziz, M. T. A., M. F. E. – Asmar, M. Haidara, H. M. Atta, N. K. Roshdy, L. A. Rashed, D. Sabry, M. A. Youssef, A. T. Abdel Aziz, and M. Moustafa, "Effect of Bone marrow derived Mesenchymal Stem Cells on cardiovascular complications in diabetic rats.", Med Sci Monit, vol. 14, issue 11, pp. 249-255, 2008. Abstracteffect_of_bone_marrow_derived_mesenchymal_stem_cells_on_cardiovascular_complications_in_diabetic_rats..pdf

Background : The purpose of this study was to investigate the effect of mesenchymal stem cells (MSCs) on cardiovascular complications of type 1 diabetes mellitus (DM) in rats.
Material/Methods : MSCs were derived from the bone marrow of male albino rats. The MSCs were characterized morphologically and by RT-PCR for CD29 expression. They were then infused into female rats which were made diabetic by IP injection of streptozocin(STZ) .The rats were divided into control, STZ,and STZ plus MSC groups. Serum insulin, glucose, and fibrinogen were estimated in all groups and the Y-chromosome gene sry was detected by PCR in pancreatic and cardiac tissues. Physiological cardiovascular functions (heart rate, systolic blood pressure) were assessed by a Langendorff apparatus.
Results: Diabetic rats which received MSCs showed signicantly lower serum glucose and increased serum insulin levels compared with the STZ group. Improvement of cardiovascular performance was also observed in the STZ/MSC group compared with the STZ group. The sry gene was detected by PCR in the pancreatic and cardiac tissues of the STZ/MSC group.
Conclusions: Rate bone marrow harbors cells that capacity to differentiate into functional insulin-producing cells capable of controlling blood glucose level in diabetic rats. This may provide a source of cell-based therapy for DM. Furthermore, MCS transplantation can improve cardiac function in DM.
Key words: mesenchymal stem cells, insulin, Diabetes mellitus, cardiovascular complications.

Aziz, M. T. A., M. F. El-Asmar, T. Mostafa, H. Atta, M. A. A. Wassef, H. H. Fouad, N. K. Roshdy, L. A. Rashed, and D. Sabry, "Effects of nitric oxide synthase and heme oxygenase inducers and inhibitors on molecular signaling of erectile function", Journal of Clinical Biochemistry and Nutrition, vol. 37, no. 3: 日本酸化ストレス学会 JCBN 事務局, pp. 103–111, 2005. Abstract
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Aziz, A. A., E. A. Shahin, D. M. A. M. Osman, and A. E. Sabagh, "Arabic psycholinguistic screening tool: a preliminary study", Egyptian Journal of Otolaryngology, vol. 28 (1), issue January, pp. 64-73, 2012.
Aziz, A. E., M. Talaat, T. Motawi, A. Rezq, T. Mostafa, H. H. Fouad, H. H. Ahmed, L. Rashed, D. Sabry, and A. Senbel, "Effects of a Water‐Soluble Curcumin Protein Conjugate vs. Pure Curcumin in a Diabetic Model of Erectile Dysfunction", The journal of sexual medicine, vol. 9, issue 7: Blackwell Publishing Inc, pp. 1815-1833, 2012. Abstract
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Aziz, R. K., "In silico analysis of a family of extracellular polysaccharide deacetylases involved in virulence of pathogenic gram-positive cocci", BMC Bioinformatics, vol. 11, no. Suppl 4: BioMed Central Ltd, pp. P8, 2010. Abstract
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Aziz, R. K., S. M. Hegazy, R. Yasser, M. R. Rizkallah, and M. T. Elrakaiby, Drug pharmacomicrobiomics and toxicomicrobiomics: from scattered reports to systematic studies of drug–microbiome interactions, , vol. 14, issue 10: Taylor & Francis, pp. 1043 - 1055, 2018. Abstract
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Aziz, A. E., M. Talaat, F. M. El‐Asmar, T. Mostafa, H. Atta, H. H. Fouad, N. K. Roshdy, L. A. Rashed, E. A. Obaia, and D. A. Sabry, "ORIGINAL RESEARCH—BASIC SCIENCE: Effect of Hemin and Carbon Monoxide Releasing Molecule (CORM‐3) on cGMP in Rat Penile Tissue", The Journal of Sexual Medicine, vol. 5, issue 2: Wiley Online Library, pp. 336-343, 2008. Abstract
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Aziz, R. K., S. M. Hegazy, R. Yasser, M. R. Rizkallah, and M. T. Elrakaiby, "Drug pharmacomicrobiomics and toxicomicrobiomics: from scattered reports to systematic studies of drug-microbiome interactions", Expert Opinion on Drug Metabolism & Toxicology, no. just-accepted: Taylor & Francis, 2018. Abstract
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Aziz, A. A., A. r Mohamed, and A. M. Gad, comparative study between anatomic single bundle and anatomic double bundle ACL reconstruction, , Cairo, Cairo, 2012.
Aziz, A. N., H. Tallima, E. A. Hafez, and E. R. Ridi, "Papain-Based Vaccination Modulates Schistosoma mansoni Infection-Induced Cytokine Signals", Scandinavian Journal of Immunology, vol. 2, issue 83, pp. 128-138, Submitted.
Aziz, M. S. A., M. Elsamahy, M. A. M. Hassan, and F. Bendary, "Detecting the Loss of Excitation in Hydro Generators Using a Neuro-Fuzzy Technique", The Annals of “Dunarea De Jos” University Of Galati, vol. 39, issue 1, pp. 34-43, 2016. Abstract
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Aziz, A. M. T. A., and S. Hassan, "THERAPEUTIC EFFECT OF METFORMIN ON THE SQUAMOUS CELL CARCINOMA CELL LINE.", The Arab Journal of Laboratory Medicine, vol. 44, issue 2, pp. 503-513, 2019. Abstracttherapeutic_effect_of_metformin_on_the_squamous_cell_carcinoma_cell_line.pdf

Background: Understanding the actions of metformin on cell cycle, and particularly its effect on mitochondrial functions and cycle regulators, is important in the context of interest in ‘repurposing’ the compound for possible applications as a chemotherapeutic and/or chemopreventive agent in oncology.
Aim: This research was conducted to study the effect of metformin drug on the proliferation of cells in squamous cell carcinoma cell line (HEp-2) and the effect of metformin on the expression of cyclin D1 and mitochondrial COX1 genes.
Material and methods: MTT assay was applied to assess the rate of proliferation of cells in squamous cell carcinoma cell line HEp-2 before and after application of metformin in concentrations 5, 10, and 20 mmol for a period of 24, 48, and 72 hours. We assessed the quantitative expression of two genes mitochondrial COX1 and cyclinD1 using RT- PCR amplification and statistical analysis were performed on.
Results: The results of the present study showed that metformin significantly decreased both the proliferation of cells and the expression of both genes in a dose and time dependent manner. The cells showed significant decreased proliferation, with a significant positive direct linear correlation between both genes over the whole period.
Conclusion: It was concluded from this study that metformin affects the viability of cells through cell cycle arrest and apoptosis, there was an increase in mitochondrial COX1 and cyclin D1 genes in cancer cells where metformin significantly decreased their expression and hence is strongly recommended as an effective anticancer agent.
Key words: Metformin, squamous carcinoma cells.

Aziz, M., P. Ferrandis, A. Mesli, R. H. Mari, J. F. Felix, A. Sellai, D. Jameel, N. Al Saqri, A. Khatab, D. Taylor, et al., "Deep-level transient spectroscopy of interfacial states in “buffer-free” pin GaSb/GaAs devices", Journal of Applied Physics, vol. 114, no. 13: AIP Publishing, pp. 134507, 2013. Abstract
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Aziz, R. K., "The case for biocentric microbiology", Gut pathogens, vol. 1, no. 1: BioMed Central, pp. 16, 2009. Abstract
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Aziz, A. M. T., T. Mostafa, H. Atta, L. Rashed, S. A. Marzouk, E. M. Obaia, D. Sabry, A. Hassouna, A. M. El-Shehaby, and A. A. T. Aziz, "The role of PDE5 inhibitors in heme oxygenase- cGMP relationship in rat cavernous tissues.", Journal of Sexual Medicine, vol. 5, issue 7, pp. 1636–1645, 2008. 3_the_role_of_pde-5_inhibitor.pdf
Aziz, R. K., B. J. Aronow, W. L. Taylor, S. L. Rowe, R. Kansal, M. J. Walker, and M. Kotb, "Integrating neighbor clustering, coexpression clustering and subsystems analysis to define dynamic changes in regulatory networks associated with group A streptococcal sociomicrobiology and niche adaptation", BMC Bioinformatics, vol. 11, no. Suppl 4: BioMed Central Ltd, pp. P12, 2010. Abstract
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