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Aziz, M. S. A., M. G. Elsoholy, and G. R. Saad, "Preparation and characterization of bio-based polyurethanes obtained from castor oil and poly (3-hydroxybutyrate) and their nanocomposites", Polymer Composites, vol. 39, pp. E489 - E499, 2018. AbstractWebsite

Bio-based polyurethanes (PUs) were synthesized from castor oil (CO) and poly(3-hydroxybutyrate)-diol (PHB-diol) using 1,6-hexamethylene diisocyanate, as nontoxic connecting agent. The PHB content in the obtained PUs was adjusted from 0 to 60.0 wt%. The synthesis was carried out by one pot solution polymerization. PUs nanocomposites loaded with different contents of cloisite®25A (C25A) were prepared by means of in situ solution polymerization. The molecular structure of the obtained PUs was confirmed by FT-IR. The thermal properties of the neat PUs and the resulting nanocomposites were investigated using DSC and TGA. It was found that the cold crystallization of the PHB component was enhanced, while its melt crystallization was retarded with increasing its own content in the PUs. The incorporated C25A in the PU matrix shifted the cold crystallization peak to higher temperature. TGA studies reveal that neat PUs and nanocomposites exhibited three main decompositions steps. The thermal stability of the neat PUs decreased with increasing the PHB content and increased with increasing the C25A content. Tensile mechanical testing revealed that increasing the content of the PHB and C25A made the PUs rigid and strong. The elastic modulus and ultimate tensile strength of the neat PUs were found to increase with increasing the PHB content and enhanced with incorporation of C25A, while the elongation decreased with increasing the PHB and C25A content. The equilibrium swelling in 1,2-dichloroethane decreased with increasing both the PHB and C25A content in PU matrix. POLYM. COMPOS., 39:E489–E499, 2018. © 2017 Society of Plastics Engineers. © 2017 Society of Plastics Engineers

Aziz, A. S. A., A. T. Azar, M. A. Salama, A. E. Hassanien, and S. E. - O. Hanafy, "Genetic algorithm with different feature selection techniques for anomaly detectors generation", Computer Science and Information Systems (FedCSIS), 2013 Federated Conference on: IEEE, pp. 769–774, 2013. Abstract
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Aziz, T. A., M. A. Aziz, H. H. Fouad, L. A. Rashed, H. Salama, S. Abd-Alla, M. A. A. Wehab, and T. Ahmed, "Interferon-alpha gene therapy prevents aflatoxin and carbon tetrachloride promoted hepatic carcinogenesis in rats.", International journal of molecular medicine, vol. 15, issue 1, pp. 21-6, 2005 Jan. Abstract

Retrovirus-mediated interferon alpha (IFN-alpha) gene transfer was evaluated with regard to its possible protective effects against aflatoxin B1 (AFB1)-initiated and carbon tetrachloride (CCl4)-promoted hepatic carcinogenesis in rats. To our knowledge, this is the first time an experimental in vivo gene therapy trial was conducted in Egypt. Two genes were examined in liver tissue by RT-PCR: the first was glutathione-S-transferase placental (GST-P) isoenzyme, as an early marker to detect hepatic malignancy; the second was IFN-alpha gene expression to detect the efficiency of gene uptake and its persistence after transduction. Forty male rats, divided equally into 4 groups, were included in the study: the first group was the control; the second group received CCl4 0.2 ml subcutaneously twice weekly for 12 weeks and AFB1 0.25 mg/kg body wt intraperitoneally twice weekly for 6 weeks; the third group received IFN-alpha (10(8) pfu) intravenously in the tail vein prior to the start of CCl4 and AFB1 injections; and the fourth group received IFN-alpha (10(8) pfu) by intrahepatic injection under ultrasonography guide after termination of the CCl4 and AFB1 injection schedule. The results showed that IFN-alpha has a marked and significant protective effect against hepatic fibrogenesis as well as hepatic carcinogenesis. Pathological examination of liver tissue proved that IFN-alpha minimized both fibrotic and cirrhotic processes. The amount of fibrosis was less in both groups receiving IFN-alpha, with more protection in the group that received IFN-alpha intravenously prior to CCl4 and AFB1. The results of RT-PCR showed that the IFN-alpha gene was significantly expressed in both groups receiving IFN-alpha, with a more intense expression in the group that received IFN-alpha by intrahepatic injection after termination of CCl4 and AFB1 injections. The IFN-alpha gene was detected after three months of gene transduction in rats receiving IFN-alpha intravenously prior to CCl4 and AFB1 and after one month of gene transduction in the post CCl4 and AFB1 rats. IFN-alpha gene was not expressed in the two groups that did not undergo gene transfer. Histopathological signs of premalignant macronodules were evident in the group receiving CCl4 and AFB1, but not IFN-alpha as well as in the group that received IFN-alpha at the end of the experiment. GST-P gene expression was also detected in these two groups, confirming early malignant transformation. In conclusion, IFN-alpha exerts significant protective effects, but more so when the gene is administered before fibrogenic and carcinogenic induction in hepatic tissues. IFN-alpha gene therapy may be justified in clinical trials for high-risk candidates with hepatic carcinogenesis.

Aziz, A. M. T. A., H. M. E. Zahed, S. H. Ahmed, B. E. A. Khaled, and E. H. Nadwa, "Cumulative Effect of Mesenchymal Stem Cells and Heme Oxygenase-1 Inducer in Ameliorating Induced Liver Toxicity in Rats.", Journal of Chemical Health Risks , 2020. Abstract

Liver diseases are most commonly occurring nowadays, that’s why we are in argent need to develop new strategies in treatment. to evaluate the role of MSCs in regenerating liver cells and to clarify the anti-inflammatory role of HO-1 either alone or as a combined therapy with MSCs. 72 rats were divided into seven groups (n=10 rats/group) as follows, group1: control rats, group 2: CCL4, group 3: CCL4 that received MSCs group 4: CCL4 that received HO-1 inhibitor, group 5: CCL4 that received HO-1 inducer, group 6: CCL4 that received combined MSCs and HO-1 inhibitor , and group 7: CCL4 that received combined MSCs and HO-1 inducer. All groups were evaluated histopathologically with assessment of liver functions. The combined MSCs and HO-1 inducer group showed the highest significant results in ALT (p-value ˂0.05), albumin (p-value ˂0.05), HO-1 activity (p-value ˂0.0001), and genes expression compared to other groups. This is due to the cumulative anti-inflammatory role of both MSCs and HO-1 together with the ability of MSCs to increase the HO-1 expression with further reduction in inflammation and fibrosis. MSCs and HO-1 inducer provide promising tool in treatment of liver disease.
Key words: MSCs; liver fibrosis; HO-1 inducer; HO-1 inhibitor.

Aziz, A. S., R. A. El-Khoribi, and S. A. Taie, "Afcm Model To Predict The Learner Style Based On Questionnaire And Fuzzy C Mean Algorithm", Journal of Theoretical and Applied Information Technology, vol. 99, issue 2, 2021. Abstract
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Aziz, R. K., "Subsystems-based servers for rapid annotation of genomes and metagenomes", BMC Bioinformatics, vol. 11, no. Suppl 4: BioMed Central Ltd, pp. O2, 2010. Abstract
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Aziz, R. K., M. J. Pabst, A. Jeng, R. Kansal, D. Low, V. Nizet, M. Kotb, and others, "Invasive M1T1 group A Streptococcus undergoes a phase-shift in vivo to prevent proteolytic degradation of multiple virulence factors by SpeB", Molecular microbiology, vol. 51, no. 1: Blackwell Science Ltd, pp. 123–134, 2004. Abstract
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Aziz, M., A. El-Hadad, and M. A. Kotb, "Polymorphisms of glutathione S transferase gene and CYP1A1 associated with childhood acute lymphoblastic leukemia.", Egypt Journal of Laboratory Medicine , vol. 17, issue 1,2, pp. 193-202, 2005.
Aziz, A. M. T., T. Mostafa, H. Atta, L. Rashed, S. A. Marzouk, E. M. Obaia, D. Sabry, A. A. Hassouna, A. M. El-Shehaby, and A. A. T. Aziz, "Oral phosphodiesterase-5 inhibitors: effect of heme oxygenase inhibition on cGMP signalling in rat cavernous tissue.", Andrologia, vol. 39, issue 2, pp. 66-70., 2007.
Aziz, R. K., R. Saad, and M. R. Rizkallah, "PharmacoMicrobiomics or how bugs modulate drugs: an educational initiative to explore the effects of human microbiome on drugs", BMC Bioinformatics, vol. 12, no. Suppl 7: BioMed Central Ltd, pp. A10, 2011. Abstract
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Aziz, A. N. Y., S. Mogawer, U. M. A. Garhi, M. A. Ansary, M. Rakha, and H. el shemy, "IMPROVEMENT IN FATIGUE STATUS IN PATIENTS WITH LIVER CIRRHOSIS DUE TO CHRONIC VIRAL HEPATITIS C AFTER VITAMIN D SUPPLEMENTATION", Acta Medica Mediterranea , 2021.
Aziz, K. A. E. M., and S. M. Metwalli, "Optimum Design of Pressure Vessels Using Hybrid HGP and Genetic Algorithm", ASME 2017 Pressure Vessels and Piping Conference, July 16-20, 2017, Waikoloa, Hawaii, United States, ASME, PVP2017-65538 , pp. 1-11, 2017.
Aziz, M. S. A., H. E. Salama, and G. R. Saad, "Diglycidyl ether of bisphenol A/chitosan-graft-polyaniline composites with electromagnetic interference shielding properties: Synthesis, characterization, and curing kinetics", Polymer Engineering and Science, vol. 59, issue 2, pp. 372 - 381, 2019. AbstractWebsite

Conducting filler based on chitosan and grafted polyaniline (Ch-g-PANI) was prepared with different grafting ratios and used as fillers for polyester powder coating system. Differential scanning calorimetry is applied to study the effect of Ch-g-PANI on the curing of the polyester powder coating. The activation energy calculated by isoconversional Kissinger method was increased by either increasing the Ch-g-PANI content or the content of polyaniline in the filler, suggesting the contribution of the filler in the curing reactions. The cured samples were characterized using FTIR and TG analyses. Thermogravimetric analysis showed that the total thermal stability was enhanced upon the filler addition as detected from the values of integral procedural decomposition temperature. Furthermore, a dielectric study showed that the dielectric constant and loss were increased upon increasing of the filler. Vogel–Fulcher–Tammann equation was well-fitted when used to examine the dependence of α-relaxation on the temperature and the dielectrically calculated Tg values were comparable to that measured by DSC. The shielding effectiveness toward microwaves was enhanced by increasing the filler content. POLYM. ENG. SCI., 59:372–381, 2019. © 2018 Society of Plastics Engineers. © 2018 Society of Plastics Engineers

Aziz, M. M., M. A. Abd El Fattah, K. A. Ahmed, and H. M. Sayed, "Protective effects of olmesartan and l-carnitine on doxorubicin-induced cardiotoxicity in rats.", Canadian journal of physiology and pharmacology, vol. 98, issue 4, pp. 183-193, 2020. Abstract

Doxorubicin (DOX), an anthracycline antibiotic, is an important antineoplastic agent due to its high antitumor efficacy in hematological as well as in solid malignancies. The clinical use of DOX is limited due to its cardiotoxic effects. The present study aimed to investigate the possible protective effect of olmesartan (Olm), l-carnitine (L-CA), and their combination in cardiotoxicity induced by DOX in rats. Male albino rats were randomly divided into seven experimental groups ( = 8): group I: normal control, group II: L-CA, group III: Olm, group IV: DOX. The other three groups were treated with Olm (10 mg/kg), L-CA (300 mg/kg), and their combination for 2 weeks after induction of cardiotoxicity by a single dose of DOX (20 mg/kg). In the results, DOX showed a significant elevation in serum troponin I, creatine kinase-MB (CK-MB), and lactate dehydrogenase (LDH) together with increased inflammation manifested by the rise of tumor necrosis factor-alpha (TNF-α), intercellular adhesion molecules-1 (ICAM-1), interleukin IL-1β (IL-1β), myeloperoxidase (MPO), nuclear factor-kappa B (NF-κB), and transforming growth factor beta (TGF-β) in cardiac tissues as well as DOX-induced oxidative stress by increasing in malondialdehyde (MDA) and decreasing in superoxide dismutase (SOD) and glutathione (GSH) in heart tissues. In addition, caspase-3 activity was boosted as indication of increased apoptosis. On the other hand, administration of L-CA and Olm attenuated the DOX-evoked disturbances in the abovementioned parameters. In addition, DOX exhibited echocardiographic changes and severe histopathological changes, which were significantly reversed by L-CA and Olm treatment. In conclusion, the present study data confirm the protective role of L-CA and Olm in DOX-induced cardiotoxicity, which may be related to its antioxidant, antiinflammatory, and antiapoptotic agents.

aziz, M. A. T., M. F. El-Asmar, A. M. Rezq, S. M. Mahfouz, M. A. Wassef, H. H. Fouad, H. H. Ahmed, and F. M. Taha, "The effect of a novel curcumin derivative on pancreatic islet regeneration in experimental type-1 diabetes in rats (long term study)", Diabetology & metabolic syndrome, vol. 5, issue 1: BioMed Central Ltd, pp. 75, 2013. Abstract
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Aziz, M., H. Saleh, and A. Abd El-Rahman, "Development of a novel thermoacoustic flue-gas analyzer", AIP Advances, vol. 10, no. 11, pp. 115215, 2020. AbstractWebsite
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Aziz, M. S. A., H. F. Naguib, and G. R. Saad, "Non-isothermal crystallization kinetics of bacterial poly(3- hydroxybutyrate) in poly(3-hydroxybutyrate-co-butylene adipate) urethanes", Thermochimica Acta, vol. 591, pp. 130 - 139, 2014. AbstractWebsite
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Aziz, A. M. S., M. Elsamahy, M. M. A. Hassan, and F. M. A. Bendary, "A novel study for hydro-generators loss of excitation faults detection using ANFIS", International Journal of Modelling and Simulation, vol. 37, issue 1, pp. 36-45, 2017.
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