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Aziz, A. E., M. Talaat, M. F. El-Asmer, T. Mostafa, S. Mostafa, H. Atta, M. Abdel Aziz Wassef, H. Fouad, L. Rashed, D. Sabry, et al., "ORIGINAL RESEARCH—BASIC SCIENCE: Heme Oxygenase vs. Nitric Oxide Synthase in Signaling Mediating Sildenafil Citrate Action", The journal of sexual medicine, vol. 4, no. 4ii: Wiley Online Library, pp. 1098–1107, 2007. Abstract
Aziz, A. M. T., A. E. H. M. c E.A. Abd El Nabi a, b, R. L. A. d D. Sabry a, H.M. Atta a, and A. Shamaa, "Endothelial Progenitor Cells and Development of Collateral Formation in Patients with Chronic Total Coronary Artery Occlusion and Transplantation of Epcs in an Experimental Model . ", EuroPCR and the European 2012 conference, Association of Percutaneous Cadiovascular Interventions (EAPCI) 2012 conference, 2012.
Aziz, R. K., M. Breitbart, and R. A. Edwards, "Transposases are the most abundant, most ubiquitous genes in nature", Nucleic acids research, vol. 38, no. 13: Oxford University Press, pp. 4207–4217, 2010. Abstract
Aziz, R. K., and P. Binfield, "Open Access: The Next Revolution in Scholarly Publishing", Publishing Scientific Papers in the Developing World. TWAS/ Biovision Alexandria.NXT 2010, Alexandria, Egypt: Bibliotheca Alexandrina, pp. 43–51, 2012. Abstract
Aziz, T. A. M., T. Mostafa, H. Atta, L. Rashed, S. A. Marzouk, E. M. Obaia, D. Sabry, A. A. Hassouna, A. M. El-Shehaby, and A. A. T. Aziz, "The Role of PDE5 Inhibitors in Heme Oxygenase-cGMP Relationship in Rat Cavernous Tissues.", The Journal of Sexual Medicine, vol. 5, issue 7, pp. 1636–1645, 2008. Abstractthe_role_of_pde5_inhibitors_in_heme_oxygenase-cgmp_relationship_in_rat_cavernous_tissues..pdf

Introduction. Heme Oxygenase (HO) enzyme catalyzes Oxidative degradation of heme to biliverdin and carbon monoxide (CO). CO shares many properties with nitric oxide (NO) including the activation of soluble guanyl cyclase.
Aim. To assess cavernous tissue HO activity and cyclic guanosine monophosphate (cGMP) levels in response to oral phosphodiesterse type 5 (PDE5) inhibitors.
Methods. Seven hundred twenty male Sprague-Dawley rats, divided into six groups, were investigated. Group 1, controls; Group 2 received sildenafil citrate orally; Group 3 received vardenafil hydrochloride; and Group 4 received tadalafil. Group 5 was subdivided into three equal subgroups, received the same dose of each drug added to the HO inhibitor, Zn protoporphyrin.Group 6 was subedivided into three equal subgroups, received the same dose of each drug added to the NO inhibitor, L-nitroarginine methylester. Either rats from each group / subgroup were sacrificed at 0.5, 1, 2, 3, 4, 6, 18, 24 and 36 hours, respectively.
Main Outcome Measures. HO enzyme activity assay and cGMP tissue levels in dissected rat cavernous tissues.
Results. Both cavernous tissue HO enzyme activity and cGMP tissue levels were increased significantly in sildenafil-,vardenafil-, and tadalafil-treated rats compared with the controls, with significant decreases after either HO or NO inhibition.Cavernous tissue HO enzyme activity and cGMP showed a positive significant correlation (r = 0.854,P < 0.001).
Conclusion. The effects of PDE5 inhibitors in cavernous tissue are partly mediated through HO enzyme activity.
Keywords. Heme Oxygenase; cGMP; sildenafil; Vardenafil; Tadalafil; PDE5 inhibitors.

Aziz, M., H. Saleh, and A. Abd El-Rahman, "Development of a novel thermoacoustic flue-gas analyzer", AIP Advances, vol. 10, no. 11, pp. 115215, 2020. AbstractWebsite
Aziz, S. B. A., M. A. Mowafy, and Y. S. Galal, "Assessing the impact of a community-based health and nutrition education on the management of diarrhea in an urban district, Cairo, Egypt", Global Journal of Health Science, vol. 8, issue 2, pp. 46-55, 2016.
Aziz, S., A. Badawi, D. I. Nessem, and N. S. AbdelMalak, "Promising nanoparticulate system for topical delivery of diphenhydramine hydrochloride: In-vitro and in-vivo evaluation", journal of drug delivery science and technology, vol. 55, pp. 101454, 2020. paper_1.pdf
Aziz, M. Z., K. ayad, and M. M. Zaki, Maitland versus mulligan mobilization in treatment of knee osteoarthritis, : Cairo university, 2014.
Aziz, A. A., S. S. Shohdi, D. M. A. M. Osman, and E. I. Habib, "Childhood apraxia of speech and multiple phonoloical disorders in Cairo-Egyptian Arabic speaking children: Language, speech, and oromotor differences", International Journal of Pediatric Otolaryngology, vol. 74, pp. 578-858, 2010.
aziz, M. A. T., F. A. El-Batrawy, M. F. El-yamany, and A. F. Mohamed, A study of the anti-inflammatory effect of histamine H1 and H4 receptor antagonists on dermatitis in mice, , 2015.
Aziz, R. K., "Interview with Prof. Ramy K. Aziz, Cairo University. The Dawn of Pharmacomicrobiomics", OMICS: A Journal of Integrative Biology, vol. 22, no. 4: Mary Ann Liebert, Inc. 140 Huguenot Street, 3rd Floor New Rochelle, NY 10801 USA, pp. 295–297, 2018. Abstract
Aziz, H. A., "Diagnosis of Neonatal Sepsis using different sepsis markers", 4th international Conference on Biomarkers and Clinical Research, Philadelphia, USA, 16 July 2013.
Aziz, M. S. A., and H. E. Salama, "Effect of vinyl montmorillonite on the physical, responsive and antimicrobial properties of the optimized polyacrylic acid/chitosan superabsorbent via Box-Behnken model", International Journal of Biological Macromolecules, vol. 116, pp. 840 - 848, 2018. AbstractWebsite
Aziz, M. T. A., M. F. El-Asmar, T. Mostafa, H. Atta, M. A. A. Wassef, H. H. Fouad, N. K. Roshdy, L. A. Rashed, and D. Sabry, "Effects of nitric oxide synthase and heme oxygenase inducers and inhibitors on molecular signaling of erectile function", Journal of Clinical Biochemistry and Nutrition, vol. 37, no. 3: 日本酸化ストレス学会 JCBN 事務局, pp. 103–111, 2005. Abstract
Aziz, N. A., J. K. Nono, T. Mpotje, and F. Brombacher, "The Foxp3+ regulatory T-cell population requires IL-4Rα signaling to control inflammation during helminth infections.", PLoS biology, vol. 16, issue 10, pp. e2005850, 2018 Oct. Abstract

Forkhead box P3 (Foxp3+) regulatory T (Treg)-cell function is controlled by environmental cues of which cytokine-mediated signaling is a dominant component. In vivo, interleukin-4 (IL-4)-mediated signaling via IL-4 receptor alpha (IL-4Rα) mediates Treg cell transdifferentiation into ex-Foxp3 T helper 2 (Th2) or T helper 17 (Th17) cells. However, IL-4-mediated signaling also reinforces the Foxp3 Treg compartment in vitro. We generated Foxp3-specific IL-4Rα-deficient mice and demonstrated differential efficiency of IL-4Rα deletion in male (approximately 90%) and female (approximately 40%) animals, because of cyclic recombinase (Cre)-mediated X-linked foxp3 inactivation. Irrespective of the degree of IL-4Rα deletion within the Foxp3+ Treg cell population, mice showed exacerbation of immune effector responses with aggravated tissue pathology in tissue-dwelling helminth infections (Schistosoma mansoni or Nippostrongylus brasiliensis). Mechanistically, IL-4Rα deletion in males and females led to a reduced expression of Foxp3 and subsequently an impaired accumulation of Foxp3+ Treg cells to inflamed tissues. In-depth cellular typing by flow cytometry revealed that the impairment of IL-4Rα-mediated signaling during helminth infections decreased the ability of central Treg cells to convert into effector Treg (eTreg) cells and caused a significant down-regulation of markers associated with Treg cell migration (C-X-C motif chemokine receptor 3 [CXCR3]) and accumulation in inflamed tissues (GATA binding protein 3 [GATA3]) as well as survival (B cell lymphoma 2 [Bcl-2]). These findings unprecedentedly, to our knowledge, uncover a role for IL-4Rα signaling in the positive regulation of Foxp3+ Treg cell function in vivo. Complementing our past knowledge on a widely reported role for IL-4Rα signaling in the negative regulation and transdifferentiation of Foxp3+ Treg cells in vivo, our present findings reveal the host requirement for an intact, but not reduced or potentiated, IL-4Rα-mediated signaling on Foxp3+ Treg cells to optimally control inflammation during helminth infections.

Aziz, M. T., I. N. El Ibrashy, D. P. Mikhailidis, A. M. Rezq, M. A. A. Wassef, H. H. Fouad, H. H. Ahmed, D. A. Sabry, H. M. Shawky, and R. E. Hussein, "Signaling mechanisms of a water soluble curcumin derivative in experimental type 1 diabetes with cardiomyopathy", Diabetology & metabolic syndrome, vol. 5, issue 1: BioMed Central Ltd, pp. 13, 2013. Abstract
Aziz, R. K., "A hundred-year-old insight into the gut microbiome!", Gut pathogens, vol. 1, no. 1: Springer, pp. 1–5, 2009. Abstract
Aziz, F. A. A. E., and H. M. Abdel, "Alveolar Bone Density Change During Canine Retraction With Power Chain Elastics Vs Coil Spring", Egyptian Dental journal, vol. 46, no. January: Egyptian Dental Association, pp. 161–166, 2000. Abstract
Aziz, M. T., M. F. El-Asmar, A. M. Rezq, M. A. Wassef, H. Fouad, N. K. Roshdy, H. H. Ahmed, L. A. Rashed, D. Sabry, and F. M. Taha, "Effects of a novel curcumin derivative on insulin synthesis and secretion in streptozotocin-treated rat pancreatic islets in vitro", Chinese medicine, vol. 9, issue 1: BioMed Central Ltd, pp. 3, 2014. Abstract
Aziz, D. E. A., P. D. E. M. Thabet, and P. D. A. E. Galal, Comparative Study of Two Restorative Modalities for Kennedy Class II Mandibular cases , , Giza, Cairo, 1998.