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Aziz, A. E., M. Talaat, M. F. El Asmer, A. Rezq, T. A. Kumosani, S. Mostafa, T. Mostafa, H. Atta, M. A. A. Wassef, and H. H. Fouad, "Novel Water‐soluble Curcumin Derivative Mediating Erectile Signaling", The Journal of Sexual Medicine, vol. 7, issue 8: Wiley Online Library, pp. 2714-2722, 2010. Abstract
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Aziz, M. M., I. K. Eyada, M. A. Abd El Megeid, and A. OM, "Bedside Evaluation of Fluid Responsiveness in Shock State using Electrical Cardiometry.", Indian Journal of Public Health Research & Development, vol. 10, no. 12, 2019. Abstract
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Aziz, M. S. A., M. G. Elsoholy, and G. R. Saad, "Preparation and characterization of bio-based polyurethanes obtained from castor oil and poly (3-hydroxybutyrate) and their nanocomposites", Polymer Composites, vol. 39, pp. E489 - E499, 2018. AbstractWebsite
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Aziz, M. S. A., and H. E. Salama, "Developing multifunctional edible coatings based on alginate for active food packaging", International Journal of Biological Macromolecules, vol. 190, pp. 837 - 844, 2021. AbstractWebsite
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Aziz, R. K., B. Dwivedi, S. Akhter, M. Breitbart, and R. A. Edwards, "Multidimensional metrics for estimating phage abundance, distribution, gene density, and sequence coverage in metagenomes", Frontiers in microbiology, vol. 6: Frontiers Media SA, 2015. Abstract
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Aziz, A. S. A., M. Salama, A. E. Hassanien, and E. L. Sanaa, "Detectors generation using genetic algorithm for a negative selection inspired anomaly network intrusion detection system", Computer Science and Information Systems (FedCSIS), 2012 Federated Conference on: IEEE, pp. 597–602, 2012. Abstract
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Aziz, A. S. A., A. T. Azar, A. E. Hassanien, and S. E. - O. Hanafy, "Negative Selection Approach Application in Network Intrusion Detection Systems", arXiv preprint arXiv:1403.2716, 2014. Abstract
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Aziz, M. M., M. A. Abd El Fattah, K. A. Ahmed, and H. M. Sayed, "Protective effects of olmesartan and l-carnitine on doxorubicin-induced cardiotoxicity in rats.", Canadian journal of physiology and pharmacology, vol. 98, issue 4, pp. 183-193, 2020. Abstract

Doxorubicin (DOX), an anthracycline antibiotic, is an important antineoplastic agent due to its high antitumor efficacy in hematological as well as in solid malignancies. The clinical use of DOX is limited due to its cardiotoxic effects. The present study aimed to investigate the possible protective effect of olmesartan (Olm), l-carnitine (L-CA), and their combination in cardiotoxicity induced by DOX in rats. Male albino rats were randomly divided into seven experimental groups ( = 8): group I: normal control, group II: L-CA, group III: Olm, group IV: DOX. The other three groups were treated with Olm (10 mg/kg), L-CA (300 mg/kg), and their combination for 2 weeks after induction of cardiotoxicity by a single dose of DOX (20 mg/kg). In the results, DOX showed a significant elevation in serum troponin I, creatine kinase-MB (CK-MB), and lactate dehydrogenase (LDH) together with increased inflammation manifested by the rise of tumor necrosis factor-alpha (TNF-α), intercellular adhesion molecules-1 (ICAM-1), interleukin IL-1β (IL-1β), myeloperoxidase (MPO), nuclear factor-kappa B (NF-κB), and transforming growth factor beta (TGF-β) in cardiac tissues as well as DOX-induced oxidative stress by increasing in malondialdehyde (MDA) and decreasing in superoxide dismutase (SOD) and glutathione (GSH) in heart tissues. In addition, caspase-3 activity was boosted as indication of increased apoptosis. On the other hand, administration of L-CA and Olm attenuated the DOX-evoked disturbances in the abovementioned parameters. In addition, DOX exhibited echocardiographic changes and severe histopathological changes, which were significantly reversed by L-CA and Olm treatment. In conclusion, the present study data confirm the protective role of L-CA and Olm in DOX-induced cardiotoxicity, which may be related to its antioxidant, antiinflammatory, and antiapoptotic agents.

Aziz, A. A., S. S. Shohdi, D. M. A. M. Osman, and E. I. Habib, "Childhood apraxia of speech and multiple phonoloical disorders in Cairo-Egyptian Arabic speaking children: Language, speech, and oromotor differences", International Journal of Pediatric Otolaryngology, vol. 74, pp. 578-858, 2010.
Aziz, M. S. A., G. R. Saad, and H. F. Naguib, "Non-isothermal crystallization kinetics of poly(3-hydroxybutyrate) in copoly(ester-urethane) nanocomposites based on poly(3-hydroxybutyrate) and cloisite 30B", Thermochimica Acta, vol. 605, pp. 52 - 62, 2015. AbstractWebsite

The non-isothermal melt crystallization kinetics of PHB segment in copoly(ester-urethane)s based on poly(3-hydroxybutyrate) and poly(butylene adipate) and their nanocomposites with cloisite 30B (C30B) were investigated at different cooling rates (5, 10, 15, and 20 °C min-1) using DSC. Ozawa, Avrami, and the combined Avrami-Ozawa (Mo) methods were used for analyzing the non-isothermal crystallization behavior. The results showed that Avrami and Ozawa models provide a fair description of the non-isothermal crystallization process while Mo model was successful in describing it. The results indicated that C30B not only served as heterogeneous nucleating agents for PHB crystallization, at lower content (5 wt%), but also restricted the mobility and diffusion of PHB chains at higher content (10 wt%). Polarized optical microscope (POM) showed that the nucleation density of PHB segment was increased significantly in the case of nanocomposites. The isoconversional method of Friedman was used to determine the effective activation energy of crystallization of the PUs and the Lauritzen-Hoffman parameters (Kg and U∗) were calculated by applying the Vyazovkin method. © 2015 Published by Elsevier B.V.

Aziz, R. K., R. A. Edwards, W. W. Taylor, D. E. Low, A. McGeer, and M. Kotb, "Mosaic prophages with horizontally acquired genes account for the emergence and diversification of the globally disseminated M1T1 clone of Streptococcus pyogenes", Journal of bacteriology, vol. 187, no. 10: American Society for Microbiology, pp. 3311–3318, 2005. Abstract
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Aziz, A. S. A., M. Salama, A. E. Hassanien, and E. L. Sanaa, "Detectors generation using genetic algorithm for a negative selection inspired anomaly network intrusion detection system", Computer Science and Information Systems (FedCSIS), 2012 Federated Conference on: IEEE, pp. 597–602, 2012. Abstract
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Aziz, T. A. M., F. A. M. Asmar, T. Moustafa, H. Atta, L. Rashed, D. Sabry, S. Ashour, and A. A. T. Aziz, "Assessment of heme oxygenase-1 (HO-1) activity in the cavernous tissues of sildenafil citrate-treated rats", Asian Journal of Andrology, vol. 9, issue 3, pp. 377–381, 2007. Abstractassessment_of_heme_oxygenase_1_ho_1_activity_in_the_cavernous_t.pdf

Aim: To assess heme oxygenase-1 (HO-1) activity in the cavernous tissues of sildenafil citrate-treated rats.
Methods: One hudred and ninty-two Sprague-Dawley male rats, divided into four equal groups, were investigated. Group 1 the control group, received regular animal chow; group 2 received sildenafil citrate by intragastric tube; group 3 received sildenafil and HO inhibitor (zinc protoporphyrin, ZnPP); and group 4 received sildenafil and nitric oxide synthase (NOS) inhibitor L-nitroaginine methyl ester (L-NAME).Twelve rats from each group were killed after 0.5 h, 1h, 2h and 3h of drug administration. Then HO-1 activity, cGMP levels and NOS enzymatic activity and cGMP concentration increased significantly in sildenafil-treated rats compared to other groups throughout the experiment. Rats receiving either HO or NOS inhibitors showed a significant decrease in these parameters. HO-1 cavernous tissue activity and NOS enzymatic activity demonstrated a positive significant correlation with cGMP levels (r = 0.646, r = 0.612 respectively; P < 0.001).
Conclusion. The action of PDE5 inhibitor sildenafil citrate in the cavernous tissue are partly mediated through the interdependent relationship between both HO-1 and NOS activities.
Keywords. Erectile Dysfunction; heme oxygenase; sildenafil citrate; nitric oxide synthase; carbon monoxide.

Aziz, R. K., R. Saad, and M. R. Rizkallah, "PharmacoMicrobiomics or how bugs modulate drugs: an educational initiative to explore the effects of human microbiome on drugs", BMC Bioinformatics, vol. 12, no. Suppl 7: BioMed Central Ltd, pp. A10, 2011. Abstract
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Aziz, M. S. A., and H. E. Salama, "Biocompatible and antimicrobial carboxymethyl xanthan/zinc physical hydrogels", Polymer Bulletin, vol. 79, issue 5, pp. 3219 - 3231, 2022. AbstractWebsite
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Aziz, M. M., A. El-Sisi, A. A. Wahab Mohamed, and M. S. Ibrahim Salem, "Value of Cardiac Enzymes in Early Diagnosis of Cardiac Dysfunction in Pediatric Septic Shock.", Indian Journal of Public Health Research & Development, vol. 10, no. 11, 2019. Abstract
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Aziz, A. A., A. r Mohamed, and A. M. Gad, "comparative study between anatomic single bundle and anatomic double bundle ACL reconstruction", Egyption arthroscopy association international congress, Cairo, february, 2013.
aziz, M. A. T., M. E. F. Asmar, H. M. Atta, S. Mahfouz, H. H. Fouad, N. K. Roshdy, L. A. Rashed, D. Sabry, A. A. Hassouna, and F. M. Taha, "Efficacy of Mesenchymal Stem Cells in Suppression of Hepatocarcinorigenesis in Rats: Possible Role of Wnt Signaling", Journal of Experimental & Clinical Cancer Research, pp. 30-49, 2011. AbstractCU-PDF

Background: The present study was conducted to evaluate the tumor suppressive effects of bone marrow derived mesenchymal stem cells (MSCs) in an experimental hepatocellular carcinoma (HCC) model in rats and to investigate the possible role of Wnt signaling in hepato-carcinogenesis.

Aziz, S. A. E. L., H. S. Hamza, and I. A. Saroit, "An energy-efficient hierarchical routing protocol for wireless sensor networks", Informatics and Systems (INFOS), 2010 The 7th International Conference on: IEEE, pp. 1-7, 2010. Abstract
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aziz, M. A. T., M. F. El-Asmar, A. M. Rezq, S. M. Mahfouz, M. A. Wassef, H. H. Fouad, H. H. Ahmed, and F. M. Taha, "The effect of a novel curcumin derivative on pancreatic islet regeneration in experimental type-1 diabetes in rats (long term study)", Diabetology & metabolic syndrome, vol. 5, issue 1: BioMed Central Ltd, pp. 75, 2013. Abstract
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Aziz, H. A., "The Predisposing Role of NAD(P)H:quinine Oxidoreductase Gene Polymorphisms in the Development of Pediatric Acute Lymphoblastic Leukemia ", Journal of the Egyptian Society of Haematology & Research, vol. Vol 9, No 2, December, pp. 1- 6, 2013.
Aziz, M. S. A., H. E. Salama, and M. W. Sabaa, "Biobased alginate/castor oil edible films for active food packaging", LWT, vol. 96, pp. 455 - 460, 2018. AbstractWebsite
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Aziz, A. M. T., A. E. H. M. c E.A. Abd El Nabi a, b, R. L. A. d D. Sabry a, H.M. Atta a, and A. Shamaa, "Endothelial Progenitor Cells and Development of Collateral Formation in Patients with Chronic Total Coronary Artery Occlusion and Transplantation of Epcs in an Experimental Model . ", EuroPCR and the European 2012 conference, Association of Percutaneous Cadiovascular Interventions (EAPCI) 2012 conference, 2012.
Aziz, A. S. A., M. M. Fouad, and A. E. Hassanien, "Cloud Computing Forensic Analysis: Trends and Challenges", Multimedia Forensics and Security: Springer International Publishing, pp. 3–23, 2017. Abstract
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Aziz, T. A., M. A. Aziz, H. H. Fouad, L. A. Rashed, H. Salama, S. Abd-Alla, M. A. A. Wehab, and T. Ahmed, "Interferon-alpha gene therapy prevents aflatoxin and carbon tetrachloride promoted hepatic carcinogenesis in rats.", International journal of molecular medicine, vol. 15, issue 1, pp. 21-6, 2005 Jan. Abstract

Retrovirus-mediated interferon alpha (IFN-alpha) gene transfer was evaluated with regard to its possible protective effects against aflatoxin B1 (AFB1)-initiated and carbon tetrachloride (CCl4)-promoted hepatic carcinogenesis in rats. To our knowledge, this is the first time an experimental in vivo gene therapy trial was conducted in Egypt. Two genes were examined in liver tissue by RT-PCR: the first was glutathione-S-transferase placental (GST-P) isoenzyme, as an early marker to detect hepatic malignancy; the second was IFN-alpha gene expression to detect the efficiency of gene uptake and its persistence after transduction. Forty male rats, divided equally into 4 groups, were included in the study: the first group was the control; the second group received CCl4 0.2 ml subcutaneously twice weekly for 12 weeks and AFB1 0.25 mg/kg body wt intraperitoneally twice weekly for 6 weeks; the third group received IFN-alpha (10(8) pfu) intravenously in the tail vein prior to the start of CCl4 and AFB1 injections; and the fourth group received IFN-alpha (10(8) pfu) by intrahepatic injection under ultrasonography guide after termination of the CCl4 and AFB1 injection schedule. The results showed that IFN-alpha has a marked and significant protective effect against hepatic fibrogenesis as well as hepatic carcinogenesis. Pathological examination of liver tissue proved that IFN-alpha minimized both fibrotic and cirrhotic processes. The amount of fibrosis was less in both groups receiving IFN-alpha, with more protection in the group that received IFN-alpha intravenously prior to CCl4 and AFB1. The results of RT-PCR showed that the IFN-alpha gene was significantly expressed in both groups receiving IFN-alpha, with a more intense expression in the group that received IFN-alpha by intrahepatic injection after termination of CCl4 and AFB1 injections. The IFN-alpha gene was detected after three months of gene transduction in rats receiving IFN-alpha intravenously prior to CCl4 and AFB1 and after one month of gene transduction in the post CCl4 and AFB1 rats. IFN-alpha gene was not expressed in the two groups that did not undergo gene transfer. Histopathological signs of premalignant macronodules were evident in the group receiving CCl4 and AFB1, but not IFN-alpha as well as in the group that received IFN-alpha at the end of the experiment. GST-P gene expression was also detected in these two groups, confirming early malignant transformation. In conclusion, IFN-alpha exerts significant protective effects, but more so when the gene is administered before fibrogenic and carcinogenic induction in hepatic tissues. IFN-alpha gene therapy may be justified in clinical trials for high-risk candidates with hepatic carcinogenesis.

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