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Aziz, A. E., M. Talaat, E. Asmer, M. Farid, T. Mostafa, H. Atta, S. Mahfouz, H. Fouad, L. Rashed, and D. Sabry, "Effects of Losartan, HO‐1 Inducers or HO‐1 Inhibitors on Erectile Signaling in Diabetic Rats", The journal of sexual medicine, vol. 6, issue 12: Blackwell Publishing Inc, pp. 3254-3264, 2009. Abstract
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Aziz, R. K., and M. Kotb, "Integrating proteomics, genomics, and bioinformatics tools to define unique features of the clonal M1T1 strain of Streptococcus pyogenes", International Congress Series, vol. 1289: Elsevier, pp. 175–179, 2006. Abstract
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m. Aziz, A. T., D. El-Miligy, M. Amin, E. A. Ansari, H. A. Hosny, S. A. Marzouk, and D. Sabry, "Molecular evaluation of apoptotic versus antiapoptotic angiogenic markers in hepatocellular carcinoma", Clinical Biochemistry, vol. 41, issue 12, pp. 1008–1014, 2008. molecular_evaluation_of_apoptotic_versus_antiapoptotic_angiogenic_markers_in_hepatocellular_carcinoma.pdf
Aziz, M. S. A., G. R. Saad, and H. F. Naguib, "Non-isothermal crystallization kinetics of poly(3-hydroxybutyrate) in copoly(ester-urethane) nanocomposites based on poly(3-hydroxybutyrate) and cloisite 30B", Thermochimica Acta, vol. 605, pp. 52 - 62, 2015. AbstractWebsite

The non-isothermal melt crystallization kinetics of PHB segment in copoly(ester-urethane)s based on poly(3-hydroxybutyrate) and poly(butylene adipate) and their nanocomposites with cloisite 30B (C30B) were investigated at different cooling rates (5, 10, 15, and 20 °C min-1) using DSC. Ozawa, Avrami, and the combined Avrami-Ozawa (Mo) methods were used for analyzing the non-isothermal crystallization behavior. The results showed that Avrami and Ozawa models provide a fair description of the non-isothermal crystallization process while Mo model was successful in describing it. The results indicated that C30B not only served as heterogeneous nucleating agents for PHB crystallization, at lower content (5 wt%), but also restricted the mobility and diffusion of PHB chains at higher content (10 wt%). Polarized optical microscope (POM) showed that the nucleation density of PHB segment was increased significantly in the case of nanocomposites. The isoconversional method of Friedman was used to determine the effective activation energy of crystallization of the PUs and the Lauritzen-Hoffman parameters (Kg and U∗) were calculated by applying the Vyazovkin method. © 2015 Published by Elsevier B.V.

Aziz, H. A., "Routine Use of Mini-pool Nucleic Acid Testing (MP-NAT) Multiplex Assay for Sero-negative Blood Donors", Journal of the Egyptian Society of Haematology & Research,, vol. 7, No 2, September, pp. 1-5, 2011.
Aziz, R. K., R. A. Edwards, W. W. Taylor, D. E. Low, A. McGeer, and M. Kotb, "Mosaic prophages with horizontally acquired genes account for the emergence and diversification of the globally disseminated M1T1 clone of Streptococcus pyogenes", Journal of bacteriology, vol. 187, no. 10: American Society for Microbiology, pp. 3311–3318, 2005. Abstract
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Aziz, M. S. A., and H. E. Salama, "Biocompatible and antimicrobial carboxymethyl xanthan/zinc physical hydrogels", Polymer Bulletin, vol. 79, issue 5, pp. 3219 - 3231, 2022. AbstractWebsite
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Aziz, A. E., M. Talaat, M. F. El-Asmer, T. Mostafa, S. Mostafa, H. Atta, M. Abdel Aziz Wassef, H. Fouad, L. Rashed, D. Sabry, et al., "ORIGINAL RESEARCH—BASIC SCIENCE: Heme Oxygenase vs. Nitric Oxide Synthase in Signaling Mediating Sildenafil Citrate Action", The journal of sexual medicine, vol. 4, no. 4ii: Wiley Online Library, pp. 1098–1107, 2007. Abstract
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aziz, M. A. T., F. A. El-Batrawy, M. F. El-yamany, and A. F. Mohamed, A study of the anti-inflammatory effect of histamine H1 and H4 receptor antagonists on dermatitis in mice, , 2015.
Aziz, T. A. M., F. A. M. Asmar, T. Moustafa, H. Atta, L. Rashed, D. Sabry, S. Ashour, and A. A. T. Aziz, "Assessment of heme oxygenase-1 (HO-1) activity in the cavernous tissues of sildenafil citrate-treated rats", Asian Journal of Andrology, vol. 9, issue 3, pp. 377–381, 2007. Abstractassessment_of_heme_oxygenase_1_ho_1_activity_in_the_cavernous_t.pdf

Aim: To assess heme oxygenase-1 (HO-1) activity in the cavernous tissues of sildenafil citrate-treated rats.
Methods: One hudred and ninty-two Sprague-Dawley male rats, divided into four equal groups, were investigated. Group 1 the control group, received regular animal chow; group 2 received sildenafil citrate by intragastric tube; group 3 received sildenafil and HO inhibitor (zinc protoporphyrin, ZnPP); and group 4 received sildenafil and nitric oxide synthase (NOS) inhibitor L-nitroaginine methyl ester (L-NAME).Twelve rats from each group were killed after 0.5 h, 1h, 2h and 3h of drug administration. Then HO-1 activity, cGMP levels and NOS enzymatic activity and cGMP concentration increased significantly in sildenafil-treated rats compared to other groups throughout the experiment. Rats receiving either HO or NOS inhibitors showed a significant decrease in these parameters. HO-1 cavernous tissue activity and NOS enzymatic activity demonstrated a positive significant correlation with cGMP levels (r = 0.646, r = 0.612 respectively; P < 0.001).
Conclusion. The action of PDE5 inhibitor sildenafil citrate in the cavernous tissue are partly mediated through the interdependent relationship between both HO-1 and NOS activities.
Keywords. Erectile Dysfunction; heme oxygenase; sildenafil citrate; nitric oxide synthase; carbon monoxide.

Aziz, M. T. A., M. F. El-Asmar, T. Mostafa, H. Atta, M. A. A. Wassef, H. H. Fouad, N. K. Roshdy, L. A. Rashed, and D. Sabry, "Effects of nitric oxide synthase and heme oxygenase inducers and inhibitors on molecular signaling of erectile function", Journal of Clinical Biochemistry and Nutrition, vol. 37, no. 3: SOCIETY FOR FREE RADICAL RESEARCH JAPAN, pp. 103–111, 2005. Abstract
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Aziz, T. A., M. A. Aziz, H. H. Fouad, L. A. Rashed, H. Salama, S. Abd-Alla, M. A. A. Wehab, and T. Ahmed, "Interferon-alpha gene therapy prevents aflatoxin and carbon tetrachloride promoted hepatic carcinogenesis in rats.", International journal of molecular medicine, vol. 15, issue 1, pp. 21-6, 2005 Jan. Abstract

Retrovirus-mediated interferon alpha (IFN-alpha) gene transfer was evaluated with regard to its possible protective effects against aflatoxin B1 (AFB1)-initiated and carbon tetrachloride (CCl4)-promoted hepatic carcinogenesis in rats. To our knowledge, this is the first time an experimental in vivo gene therapy trial was conducted in Egypt. Two genes were examined in liver tissue by RT-PCR: the first was glutathione-S-transferase placental (GST-P) isoenzyme, as an early marker to detect hepatic malignancy; the second was IFN-alpha gene expression to detect the efficiency of gene uptake and its persistence after transduction. Forty male rats, divided equally into 4 groups, were included in the study: the first group was the control; the second group received CCl4 0.2 ml subcutaneously twice weekly for 12 weeks and AFB1 0.25 mg/kg body wt intraperitoneally twice weekly for 6 weeks; the third group received IFN-alpha (10(8) pfu) intravenously in the tail vein prior to the start of CCl4 and AFB1 injections; and the fourth group received IFN-alpha (10(8) pfu) by intrahepatic injection under ultrasonography guide after termination of the CCl4 and AFB1 injection schedule. The results showed that IFN-alpha has a marked and significant protective effect against hepatic fibrogenesis as well as hepatic carcinogenesis. Pathological examination of liver tissue proved that IFN-alpha minimized both fibrotic and cirrhotic processes. The amount of fibrosis was less in both groups receiving IFN-alpha, with more protection in the group that received IFN-alpha intravenously prior to CCl4 and AFB1. The results of RT-PCR showed that the IFN-alpha gene was significantly expressed in both groups receiving IFN-alpha, with a more intense expression in the group that received IFN-alpha by intrahepatic injection after termination of CCl4 and AFB1 injections. The IFN-alpha gene was detected after three months of gene transduction in rats receiving IFN-alpha intravenously prior to CCl4 and AFB1 and after one month of gene transduction in the post CCl4 and AFB1 rats. IFN-alpha gene was not expressed in the two groups that did not undergo gene transfer. Histopathological signs of premalignant macronodules were evident in the group receiving CCl4 and AFB1, but not IFN-alpha as well as in the group that received IFN-alpha at the end of the experiment. GST-P gene expression was also detected in these two groups, confirming early malignant transformation. In conclusion, IFN-alpha exerts significant protective effects, but more so when the gene is administered before fibrogenic and carcinogenic induction in hepatic tissues. IFN-alpha gene therapy may be justified in clinical trials for high-risk candidates with hepatic carcinogenesis.

Aziz, M. T., M. F. Al-Asmar, T. Mostafa, H. Atta, L. Rashed, D. Sabry, S. Ashour, and A. T. Aziz, "Assessment of heme oxygenase-1 (HO-1) activity in the cavernous tissues of sildenafil citrate-treated rats.", Asian J Andrology, vol. 9, issue 3, pp. 377-381, 2007.
aziz, M. A. T., M. F. El-Asmar, A. M. Rezq, H. H. Fouad, H. H. Ahmed, A. A. Hassouna, F. M. Taha, and H. F. Hafez, "Novel anticancer curcumin derivative with conserved functional groups", Cancer Therap. Res, vol. 1, no. 10, 2012. Abstract
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Aziz, A. S. A., A. T. Azar, A. E. Hassanien, and S. E. - O. Hanafy, "Negative Selection Approach Application in Network Intrusion Detection Systems", arXiv preprint arXiv:1403.2716, 2014. Abstract
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Aziz, S., A. Badawi, D. I. Nessem, and N. S. AbdelMalak, "Promising nanoparticulate system for topical delivery of diphenhydramine hydrochloride: In-vitro and in-vivo evaluation", journal of drug delivery science and technology, vol. 55, pp. 101454, 2020. paper_1.pdf
Aziz, F. A. A. E., and H. M. Abdel, "Alveolar Bone Density Change During Canine Retraction With Power Chain Elastics Vs Coil Spring", Egyptian Dental journal, vol. 46, no. January: Egyptian Dental Association, pp. 161–166, 2000. Abstract
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Aziz, A. S. A., M. Salama, A. E. Hassanien, and E. L. Sanaa, "Detectors generation using genetic algorithm for a negative selection inspired anomaly network intrusion detection system", Computer Science and Information Systems (FedCSIS), 2012 Federated Conference on: IEEE, pp. 597–602, 2012. Abstract
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Aziz, D. E. A., P. D. E. M. Thabet, and P. D. A. E. Galal, Comparative Study of Two Restorative Modalities for Kennedy Class II Mandibular cases , , Giza, Cairo, 1998.
Aziz, R. K., V. Khaw, J. M. Monk, E. Brunk, R. Lewis, S. I. Loh, A. Mishra, A. A. Nagle, C. Satyanarayana, S. Dhakshinamoorthy, et al., "Model-driven discovery of synergistic inhibitors against E. coli and S. enterica serovar Typhimurium targeting a novel synthetic lethal pair, aldA and prpC", Frontiers in Microbiology, vol. 6: Frontiers, pp. 958, 2015. Abstract
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Aziz, S. A. E. L., H. S. Hamza, and I. A. Saroit, "An energy-efficient hierarchical routing protocol for wireless sensor networks", Informatics and Systems (INFOS), 2010 The 7th International Conference on: IEEE, pp. 1-7, 2010. Abstract
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Aziz, M. M., M. Haroun, and O. M. Gad, "STRONGKIDS nutritional risk score and body mass index in malnourishment risk assessment in critically ill children", Int J Pharm Phytopharm Res, vol. 9, pp. 97–108, 2019. Abstract
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Aziz, A. S. A., M. Salama, A. E. Hassanien, and E. L. Sanaa, "Detectors generation using genetic algorithm for a negative selection inspired anomaly network intrusion detection system", Computer Science and Information Systems (FedCSIS), 2012 Federated Conference on: IEEE, pp. 597–602, 2012. Abstract
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