Publications

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and Aziz, M.S.E.D.A., E. M. B. M. M. F., "Loss of Excitation Faults Detection in Hydro-Generators Using an Adaptive Neuro Fuzzy Inference System", TELKOMNIKA Indonesian Journal of Electrical Engineering, Vol. 17,, vol. 17, issue 2: Indonisia, 2016. Abstract
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aziz, M. A. T., D. Sabry, M. A. S. Al-Ghussein, A. M. A. Soliman, and A. A. Hassan, "IN VITRO AND IN VIVO EVALUATION ACTIVITIES OF EACH MESENCHYMAL STEM CELLS, DOXORUBICIN AND LPS OR COMBINED ON BREAST CARCINOMA ", WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, vol. 3, issue 8, pp. 157-176, 2014. abeer_paper.pdf
Aziz, M. Z., K. ayad, and M. M. Zaki, Maitland versus mulligan mobilization in treatment of knee osteoarthritis, : Cairo university, 2014.
Aziz, M. A. A., M. A. Shawky, and M. Atef, "Oral Squamous Cell Carcinoma Associated with Papillon-Lefevre Syndrome: Systematic Review and the First Reported Case ", International Journal of Dental Medicine, vol. 4, pp. 31-35, 2018.
Aziz, N. A., J. K. Nono, T. Mpotje, and F. Brombacher, "The Foxp3+ regulatory T-cell population requires IL-4Rα signaling to control inflammation during helminth infections.", PLoS biology, vol. 16, issue 10, pp. e2005850, 2018 Oct. Abstract

Forkhead box P3 (Foxp3+) regulatory T (Treg)-cell function is controlled by environmental cues of which cytokine-mediated signaling is a dominant component. In vivo, interleukin-4 (IL-4)-mediated signaling via IL-4 receptor alpha (IL-4Rα) mediates Treg cell transdifferentiation into ex-Foxp3 T helper 2 (Th2) or T helper 17 (Th17) cells. However, IL-4-mediated signaling also reinforces the Foxp3 Treg compartment in vitro. We generated Foxp3-specific IL-4Rα-deficient mice and demonstrated differential efficiency of IL-4Rα deletion in male (approximately 90%) and female (approximately 40%) animals, because of cyclic recombinase (Cre)-mediated X-linked foxp3 inactivation. Irrespective of the degree of IL-4Rα deletion within the Foxp3+ Treg cell population, mice showed exacerbation of immune effector responses with aggravated tissue pathology in tissue-dwelling helminth infections (Schistosoma mansoni or Nippostrongylus brasiliensis). Mechanistically, IL-4Rα deletion in males and females led to a reduced expression of Foxp3 and subsequently an impaired accumulation of Foxp3+ Treg cells to inflamed tissues. In-depth cellular typing by flow cytometry revealed that the impairment of IL-4Rα-mediated signaling during helminth infections decreased the ability of central Treg cells to convert into effector Treg (eTreg) cells and caused a significant down-regulation of markers associated with Treg cell migration (C-X-C motif chemokine receptor 3 [CXCR3]) and accumulation in inflamed tissues (GATA binding protein 3 [GATA3]) as well as survival (B cell lymphoma 2 [Bcl-2]). These findings unprecedentedly, to our knowledge, uncover a role for IL-4Rα signaling in the positive regulation of Foxp3+ Treg cell function in vivo. Complementing our past knowledge on a widely reported role for IL-4Rα signaling in the negative regulation and transdifferentiation of Foxp3+ Treg cells in vivo, our present findings reveal the host requirement for an intact, but not reduced or potentiated, IL-4Rα-mediated signaling on Foxp3+ Treg cells to optimally control inflammation during helminth infections.

Aziz, A. M. T., E. M. F. Asmer, A. Rezk, T. A. Kumosani, S. Mostafa, T. Mostafa, H. Atta, A. A. M. Wassef, H. H. Fouad, L. Rashed, et al., "Novel water-soluble curcumin derivative mediating erectile signaling", J Sex Med, vol. 7, issue 8, pp. 2714-2722, 2010.
Aziz, R. K., and V. Nizet, "Pathogen microevolution in high resolution", Science translational medicine, vol. 2, no. 16: American Association for the Advancement of Science, pp. 16ps4–16ps4, 2010. Abstract
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Aziz, R. K., R. Saad, and M. R. Rizkallah, "PharmacoMicrobiomics or how bugs modulate drugs: an educational initiative to explore the effects of human microbiome on drugs", BMC Bioinformatics, vol. 12, no. Suppl 7: BioMed Central Ltd, pp. A10, 2011. Abstract
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Aziz, M. A. - E., "The Mixolab Parameters of Wheat/Quinoa Composite Flour and Their Relation to Quality Characteristics", Egyptian Journal of Nutrition, vol. 34, issue 2, pp. 89-112, 2019.
aziz, M. A. T., M. F. El-Asmar, A. M. Rezq, S. M. Mahfouz, M. A. Wassef, H. H. Fouad, H. H. Ahmed, and F. M. Taha, "The effect of a novel curcumin derivative on pancreatic islet regeneration in experimental type-1 diabetes in rats (long term study)", Diabetology & metabolic syndrome, vol. 5, issue 1: BioMed Central Ltd, pp. 75, 2013. Abstract
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Aziz, A. P. E. A., A. P. K. T. Shaker, and D. H. A. M. Salam, "Oral Appliances Versus Continuous Positive Air Pressure in the Management of Snoring and Obstructive Sleep Apnea", EDJ, vol. 55, issue jan, pp. 647-654, 2009. paper-2.pdf
Aziz, R. K., "Interview with Prof. Ramy K. Aziz, Cairo University. The Dawn of Pharmacomicrobiomics", OMICS: A Journal of Integrative Biology, vol. 22, no. 4: Mary Ann Liebert, Inc. 140 Huguenot Street, 3rd Floor New Rochelle, NY 10801 USA, pp. 295–297, 2018. Abstract
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aziz, M. A. T., T. Mostafa, H. Atta, M. A. Wassef, H. H. Fouad, L. A. Rashed, and D. Sabry, "Putative role of carbon monoxide signaling pathway in penile erectile function", The Journal of Sexual Medicine, vol. 6, no. 1: Elsevier, pp. 49–60, 2009. Abstract
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Aziz, S. B. A., Y. S. Galal, A. S. Sedrak, and D. S. Shaheen, "Association of Hepatitis C Virus Infection and Type 2 Diabetes in Egypt: A Hospital-based Study", Journal of Diabetes Mellitus, vol. 6, pp. 77-89, 2016.
AZIZ, R. A. N. I. O. S. A. M. A. A., E. H. AMIN, and H. Abou-Shady, "THE IMPACT OF GRAPHITE REFLECTOR MODIFICATION ON NEUTRONIC PARAMETERS OF A TYPICAL MTR TYPE RESEARCH REACTOR", Asian Academic Research Journal of Multidisciplinary, vol. 1, issue 26, pp. 91-108, 2014. AbstractWebsite

Abstract
Neutronic analysis of a typical swimming pool type research reactor, Pakistan research
Reactor-1 (PARR-1), was carried out for determine the effect of graphite reflector
configuration modification as a way to optimize the neutron flux in the irradiation positions.
Standard computer codes WIMSD and CITVAP were employed to calculate core excess
reactivity, neutron fluxes, power distribution, and burn-up distribution. A comparison
between four different core configurations is presented in this article.

Aziz, M. S. A., M. G. Elsoholy, and G. R. Saad, "Preparation and characterization of bio-based polyurethanes obtained from castor oil and poly (3-hydroxybutyrate) and their nanocomposites", Polymer Composites, vol. 39, pp. E489 - E499, 2018. AbstractWebsite
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Aziz, M. S. A., H. F. Naguib, and G. R. Saad, "Nanocomposites based on chitosan-graft-poly(N-Vinyl-2-Pyrrolidone): Synthesis, characterization, and biological activity", International Journal of Polymeric Materials and Polymeric Biomaterials, vol. 64, issue 11, pp. 578 - 586, 2015. AbstractWebsite

Organophilic montmorillonite (OMMT) was synthesized by cationic exchange between Na+-MMT and N-octyl-N-vinyl-2-pyrrolidonium bromide. Chitosan graft copolymer nanocomposites were synthesized by grafting N-vinyl-2-pyrrolidone onto chitosan in aqueous acetic acid in the presence of OMMT using free radical polymerization. The chemical structures were verified by FTIR. Scanning electron microscopy showed a surface roughness for chitosan graft nanocomposites. Wide-angle X-ray diffraction confirmed the intercalation of grafted chitosan chains between OMMT galleries. Thermogravimetric analysis indicated that the thermal stability of grafted chitosan was enhanced by OMMT incorporation. Preliminary studies showed that the nanocomposites exhibited antimicrobial activity compared with chitosan graft copolymer. © 2015 Taylor and Francis Group, LLC.

Aziz, R. K., "Rethinking Pharmacogenomics in an Ecosystem: Drug-microbiome Interactions, Pharmacomicrobiomics, and Personalized Medicine for the Human Supraorganism", Current Pharmacogenomics and Personalized Medicine (Formerly Current Pharmacogenomics), vol. 10, no. 4: Bentham Science Publishers, pp. 258–261, 2012. Abstract
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Aziz, R. K., B. Dwivedi, S. Akhter, M. Breitbart, and R. A. Edwards, "Multidimensional metrics for estimating phage abundance, distribution, gene density, and sequence coverage in metagenomes", Frontiers in microbiology, vol. 6: Frontiers Media SA, 2015. Abstract
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Aziz, M. A., F. M. Owis, and M. M. Abdelrahman, "Design Optimization of a Transonic-Fan Rotor Using Numerical Computations of the Full Compressible Navier-Stokes Equations and Simplex Algorithm", International Journal of Rotating Machinery, vol. 2014: Hindawi Publishing Corporation, 2014. Abstract
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Aziz, R. K., and L. K. Mcneil, "Reconstructing the virulome of the human pathogen Streptococcus pyogenes using NMPDR subsystems-based annotation", BMC Bioinformatics, vol. 10, no. Suppl 7: BioMed Central Ltd, pp. A7, 2009. Abstract
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Aziz, M., A. ElAshmaoui, N. S. Mohamed, and M. M. M. M. M. Mahmoud, "Assessment of skin microcirculation and inflammatory markers of metabolic syndrome in a rat model ", Life Science Journal, 2011;, vol. 8(4):314 -321] (, issue ISSN: 1097-8135)., 2011.