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Aziz, S. G., W. I. Hassan, S. K. Alrouby, A. Alyoubi, and R. Hilal, "Ultrafast radiationless decay mechanisms through conical intersections in cytosine. A new semi-planar conical intersection", Indian J. Chem. A, vol. 53A, pp. 143-151, 2014.
Aziz, M. A. - E., "The Mixolab Parameters of Wheat/Quinoa Composite Flour and Their Relation to Quality Characteristics", Egyptian Journal of Nutrition, vol. 34, issue 2, pp. 89-112, 2019.
Aziz, S. A. E. L., H. S. Hamza, and I. A. Saroit, "An energy-efficient hierarchical routing protocol for wireless sensor networks", Informatics and Systems (INFOS), 2010 The 7th International Conference on: IEEE, pp. 1-7, 2010. Abstract
Aziz, T. A. M., T. Mostafa, H. Atta, L. Rashed, S. A. Marzouk, E. M. Obaia, D. Sabry, A. A. Hassouna, A. M. El-Shehaby, and A. A. T. Aziz, "The role of PDE5 inhibitors in heme oxygenase-cGMP relationship in rat cavernous tissues.", The journal of sexual medicine, vol. 5, issue 7, pp. 1636-45, 2008 Jul. Abstract

INTRODUCTION: Heme oxygenase (HO) enzyme catalyzes oxidative degradation of heme to biliverdin and carbon monoxide (CO). CO shares many properties with nitric oxide (NO) including the activation of soluble guanyl cyclase.

AIM: To assess cavernous tissue HO activity and cyclic guanosine monophosphate (cGMP) levels in response to oral phosphodiesterase type 5 (PDE5) inhibitors.

METHODS: Seven hundred twenty male Sprague-Dawley rats, divided into six groups, were investigated. Group 1, controls; group 2 received sildenafil citrate orally; group 3 received vardenafil hydrochloride; and group 4 received tadalafil. Group 5 was subdivided into three equal subgroups, received the same dose of each drug added to the HO inhibitor, Zn protoporphyrin. Group 6 was subdivided into three equal subgroups, received the same dose of each drug added to the NO inhibitor, L-nitroarginine methylester. Eight rats from each group/subgroup were sacrificed at 0.5, 1, 2, 3, 4, 6, 18, 24, and 36 hours, respectively.

MAIN OUTCOME MEASURES: HO enzyme activity assay and cGMP tissue levels in dissected rat cavernous tissues.

RESULTS: Both cavernous tissue HO enzyme activity and cGMP levels were increased significantly in sildenafil-, vardenafil-, and tadalafil-treated rats compared with the controls, with significant decreases after either HO or NO inhibition. Cavernous tissue HO enzyme activity and cGMP showed a positive significant correlation (r = 0.854, P < 0.001).

CONCLUSION: The effects of PDE5 inhibitors in cavernous tissue are partly mediated through HO enzyme activity.

Aziz, M. S. A., M. G. Elsoholy, and G. R. Saad, "Preparation and characterization of bio-based polyurethanes obtained from castor oil and poly (3-hydroxybutyrate) and their nanocomposites", Polymer Composites, vol. 39, pp. E489 - E499, 2018. AbstractWebsite
Aziz, R. K., and L. K. Mcneil, "Reconstructing the virulome of the human pathogen Streptococcus pyogenes using NMPDR subsystems-based annotation", BMC Bioinformatics, vol. 10, no. Suppl 7: BioMed Central Ltd, pp. A7, 2009. Abstract
Aziz, R. K., S. M. Hegazy, R. Yasser, M. R. Rizkallah, and M. T. Elrakaiby, Drug pharmacomicrobiomics and toxicomicrobiomics: from scattered reports to systematic studies of drug–microbiome interactions, , vol. 14, issue 10: Taylor & Francis, pp. 1043 - 1055, 2018. Abstract
Aziz, R. K., B. Dwivedi, S. Akhter, M. Breitbart, and R. A. Edwards, "Multidimensional metrics for estimating phage abundance, distribution, gene density, and sequence coverage in metagenomes", Frontiers in microbiology, vol. 6: Frontiers Media SA, 2015. Abstract
Aziz, T. A. M., M. F. El-Asmer, T. Mostafa, S. Mostafa, H. Atta, A. A. M. Wassef, H. Fouad, L. Rashed, D. Sabry, and S. Mahfouz, "BASIC SCIENCE: Heme Oxygenase vs. Nitric Oxide Synthase in Signaling Mediating Sildenafil Citrate Action", The Journal of Sexual Medicine, vol. 4, no. 4: Elsevier, pp. 1098–1107, 2007. Abstract
Aziz, M., A. ElAshmaoui, N. S. Mohamed, and M. M. M. M. M. Mahmoud, "Assessment of skin microcirculation and inflammatory markers of metabolic syndrome in a rat model ", Life Science Journal, 2011;, vol. 8(4):314 -321] (, issue ISSN: 1097-8135)., 2011.
Aziz, D. E., A. A. Abdelbary, and A. I. Elassasy, "Implementing Central Composite Design for Developing Transdermal Diacerein-Loaded Niosomes: Ex vivo Permeation and In vivo Deposition", Current Drug Delivery, vol. 15, pp. 1330-1342, 2018.
Aziz, R. K., M. R. Rizkallah, R. Saad, and M. T. Elrakaiby, "Translating pharmacomicrobiomics: Three actionable challenges/prospects in 2020", OMICS: A Journal of Integrative Biology, vol. 24, no. 2: Mary Ann Liebert, Inc., publishers 140 Huguenot Street, 3rd Floor New …, pp. 60–61, 2020. Abstract
Aziz, M. S. A., H. F. Naguib, and G. R. Saad, "Non-isothermal crystallization kinetics of bacterial poly(3- hydroxybutyrate) in poly(3-hydroxybutyrate-co-butylene adipate) urethanes", Thermochimica Acta, vol. 591, pp. 130 - 139, 2014. AbstractWebsite

The non-isothermal melt crystallization kinetics of a series of copoly(ester-urethane)s, PUs, based on poly(3-hydroxybutyrate), PHB, and poly(butylene adipate), PBA, of different PHB content 20, 40, and 60 wt% were studied using DSC at different cooling rates. Various macrokinetic models, namely, Avrami, Tobin, Ozawa, and Mo models were applied to describe the crystallization process of PHB in the PU matrices. Avrami, Tobin, and Mo models could successfully describe the non-isothermal crystallization behavior of PHB segments in all samples, while Ozawa model provides a fair description of the non-isothermal crystallization process of PUs containing only 20 and 40 wt% PHB. The Avrami exponent was found to range from 3.6 to 4.0, while the Tobin exponent was found to range from 2.3 to 3.0. The spherulites shape and size were analyzed using polarized optical microscopy (POM). The results of kinetic parameters showed that the crystallization rate of PHB segments in the investigated PUs was increased with increasing the PHB content. The isoconversional method of Friedman was used to determine the effective activation energy of crystallization of the PUs and the Lauritzen-Hoffman parameters (Kg and U*) were calculated by applying the Vyazovkin method. © 2014 Elsevier B.V. All rights reserved.

Aziz, A. M. T. A., H. M. E. Zahed, S. H. Ahmed, B. E. A. Khaled, and E. H. Nadwa, "Cumulative Effect of Mesenchymal Stem Cells and Heme Oxygenase-1 Inducer in Ameliorating Induced Liver Toxicity in Rats.", Journal of Chemical Health Risks , 2020. Abstract

Liver diseases are most commonly occurring nowadays, that’s why we are in argent need to develop new strategies in treatment. to evaluate the role of MSCs in regenerating liver cells and to clarify the anti-inflammatory role of HO-1 either alone or as a combined therapy with MSCs. 72 rats were divided into seven groups (n=10 rats/group) as follows, group1: control rats, group 2: CCL4, group 3: CCL4 that received MSCs group 4: CCL4 that received HO-1 inhibitor, group 5: CCL4 that received HO-1 inducer, group 6: CCL4 that received combined MSCs and HO-1 inhibitor , and group 7: CCL4 that received combined MSCs and HO-1 inducer. All groups were evaluated histopathologically with assessment of liver functions. The combined MSCs and HO-1 inducer group showed the highest significant results in ALT (p-value ˂0.05), albumin (p-value ˂0.05), HO-1 activity (p-value ˂0.0001), and genes expression compared to other groups. This is due to the cumulative anti-inflammatory role of both MSCs and HO-1 together with the ability of MSCs to increase the HO-1 expression with further reduction in inflammation and fibrosis. MSCs and HO-1 inducer provide promising tool in treatment of liver disease.
Key words: MSCs; liver fibrosis; HO-1 inducer; HO-1 inhibitor.

Aziz, A. S. A., A. E. Hassanien, S. E. - O. Hanaf, and M. F. Tolba, "Multi-layer hybrid machine learning techniques for anomalies detection and classification approach", Hybrid Intelligent Systems (HIS), 2013 13th International Conference on: IEEE, pp. 215–220, 2013. Abstract
Aziz, A. A., A. r Mohamed, and A. M. Gad, "comparative study between anatomic single bundle and anatomic double bundle ACL reconstruction", Egyption arthroscopy association international congress, Cairo, february, 2013.
Aziz, M. T. A., M. F. El-Asmar, A. M. Rezq, M. A. A. Wassef, H. Fouad, N. K. Roshy, H. H. Ahmed, L. A. Rashed, D. Sabry, F. M. Taha, et al., "Effects of a novel curcumin derivative on insulin synthesis and secretion in streptozotocin-treated rat pancreatic islets in vitro", Chinese medicine, vol. 9, issue 1, pp. 1-12, 2014.
Aziz, R. K., "Subsystems-based servers for rapid annotation of genomes and metagenomes", BMC Bioinformatics, vol. 11, no. Suppl 4: BioMed Central Ltd, pp. O2, 2010. Abstract
Aziz, A. E., M. Talaat, E. Asmer, M. Farid, T. Mostafa, H. Atta, S. Mahfouz, H. Fouad, L. Rashed, and D. Sabry, "Effects of Losartan, HO‐1 Inducers or HO‐1 Inhibitors on Erectile Signaling in Diabetic Rats", The journal of sexual medicine, vol. 6, issue 12: Blackwell Publishing Inc, pp. 3254-3264, 2009. Abstract
Aziz, R. K., and M. Kotb, "Integrating proteomics, genomics, and bioinformatics tools to define unique features of the clonal M1T1 strain of Streptococcus pyogenes", International Congress Series, vol. 1289: Elsevier, pp. 175–179, 2006. Abstract
Aziz, A. M. T., E.A. Abd El Nabi, A. M. Hamid, D. Sabry, H. M. Atta, L.A. Rahed, A. Shamaa, S. Mahfouz, F. M. Taha, S. Elref, et al., "Endothelial progenitor cells regenerate infracted myocardium with neovascularisation development", Journal of Advanced Research , 2013. myocardial_infarction_stem_cells.pdf