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Aziz, A. S. A., M. A. Salama, A. E. Hassanien, and S. E. - O. Hanafi, "Artificial Immune System Inspired Intrusion Detection System Using Genetic Algorithm.", Informatica (Slovenia), vol. 36, no. 4, pp. 347–357, 2012. Abstract
Aziz, K. A. E. M., and S. M. Metwalli, "Optimum Design of Pressure Vessels Using Hybrid HGP and Genetic Algorithm", ASME 2017 Pressure Vessels and Piping Conference, July 16-20, 2017, Waikoloa, Hawaii, United States, ASME, PVP2017-65538 , pp. 1-11, 2017.
Aziz, A. F., H. kamal, and M. A. Samy, "The role of fast track anesthesia in colorectal surgery", NCI anesthesia and pain management , Hurgada, 5 November 2014.
Aziz, A. M. T., T. Moustafa, H. Atta, L. Rashed, S. A. Marzouk, E. M. Obaia, D. Sabry, A. A. Hassouna, E. A. M. Shehaby, and A. A. T. Aziz, "Oral phosphodiesterase-5 inhibitors: Effect of heme oxygenase inhibition on cGMP signaling in rat cavernous tissue.", Andrologia, vol. 39, issue 2, pp. 66-70, 2007. Abstractoral_phosphodiesterase-5_inhibitors.pdf

Summary. This Work postulated that heme oxygenase (HO) is partly responsible for con-trolling phosphodiesterase-5 inhibitor actions by modulating cyclic guanosine monophosphate (cGMP) cavernous tissue levels. Five hundred and four maleSprague-Dawley rats, divided into five groups, were investigated.Group 1 (n = 72) included controls, Group 2 (n = 72) received sildenafil citrate (ViagraR) Orally, Group 3 (n = 72) received vardenafil hydrochloride (LevitraR), group 4 (n = 72) received tadalafil (cialisR). Group 5 (n = 216), subdivided into three subgroups (A, B and C, 72 each), received the same dose of each drug with the HO inhibitor, Zn proptoporphyrin. Eight rats from each group / subgroup were killed at 0.5, 1, 2, 3, 4, 6, 18, 24 and 36 h when cGMP levels in the cavernous tissue were estimated. Cavernous tissue cGMP levels increased significantly in sildenafil, vardenafil and tadalafil-treated rats compared to the controls with significant decreases after HO inhibition. It is concluded that the effects of these PDE-5 inhibitors in rat cavernous tissue are partly mediated through HO activity via the cGMP signalling pathway.
Keywords. cGMP—erectile dysfunction—heme oxygenase—PDF inhibitors—sildenafil— tadalafil —vardenafil.

Aziz, M. A. T., T. Mostafa, H. Atta, S. Assad, H. Fouad, G. Mohsen, L. Rashed, D. Sabry, and M. Abbas, "In Vitro and in Vivo Lineage Conversion of Bone Marrow Stem Cells Into Germ Cells in Experimental Azoospermia in Rat", Stem Cell Studies, 2011. Abstract

The present study is conducted to assess in vitro transdifferentiation of bone marrow derived mesenchymal stem cells (MSCs) into germ cells and in vivo transdifferentiation into spermatids and spermatocytes in the seminiferous tubules of azoospermic rats. Forty eight male rats were included in the study and were divided into: group 1; control rats, group 2; experimental azoospermic rats, group 3; azoospermic rats received undifferentiated MSCs. Group 4; azoospermic rats received transdifferentiated MSCs into germ cells. Quantitative real time PCR was conducted to assess gene expression of a primordial germ cell marker (VASA), stem cell specific markers (Oct4, SSEA-1 and SSEA-3), specific molecular markers of germ cells (c-Kit, Daz1); premeiotic marker (Daz1) and post-meiotic markers (c- Kit, Stra 8). Histopathological examination of rat testicular tissue was also conducted. Results revealed that 12 weeks after transplantation, fluorescent labeled MSCs were detected in the seminiferous tubules of the testes of group 3 and group 4 rats. In group 3 and 4, stem cell specific markers; Oct4, SSEA-1 and SSEA-3 were detected. In group 4, genes of primordial germ cell marker; VASA, premeiotic marker; Daz1and post-meiotic markers; c-Kit, Stra 8 were expressed. Daz1 was also expressed in group 3 rats to a significantly lower extent in comparison to group 4 rats. Spermatocytes and spermatids were detected in testicular tissue of group 4 rats. In conclusion, MSCs have potentials for in vitro transdifferentiation into germ cells and in vivo transdifferentiation into spermatids and spermatocytes.

Aziz, T. A., M. A. Aziz, H. H. Fouad, L. A. Rashed, H. Salama, S. Abd-Alla, M. A. A. Wehab, and T. Ahmed, "Interferon-$\alpha$ gene therapy prevents aflatoxin and carbon tetrachloride promoted hepatic carcinogenesis in rats", International journal of molecular medicine, vol. 15, no. 1: Spandidos Publications, pp. 21–26, 2005. Abstract
Aziz, R. K., V. Khaw, J. M. Monk, E. Brunk, R. Lewis, S. I. Loh, A. Mishra, A. A. Nagle, C. Satyanarayana, S. Dhakshinamoorthy, et al., "Model-driven discovery of synergistic inhibitors against E. coli and S. enterica serovar Typhimurium targeting a novel synthetic lethal pair, aldA and prpC", Frontiers in Microbiology, vol. 6: Frontiers, pp. 958, 2015. Abstract
Aziz, M. T. A., M. F. El-Asmar, T. Mostafa, H. Atta, M. A. A. Wassef, H. H. Fouad, N. K. Roshdy, L. A. Rashed, and D. Sabry, "Effects of nitric oxide synthase and heme oxygenase inducers and inhibitors on molecular signaling of erectile function", Journal of Clinical Biochemistry and Nutrition, vol. 37, issue 3: 日本酸化ストレス学会 JCBN 事務局, pp. 103-111, 2005. Abstract
Aziz, M. S. A., and H. E. Salama, "Development of alginate-based edible coatings of optimized UV-barrier properties by response surface methodology for food packaging applications", International Journal of Biological Macromolecules, vol. 212, pp. 294 - 302, 2022. AbstractWebsite
Aziz, R. K., "Editorial [Rethinking Pharmacogenomics in an Ecosystem: Drug-microbiome Interactions, Pharmacomicrobiomics, and Personalized Medicine for the Human Supraorganism]", Current Pharmacogenomics and Personalized Medicine (Formerly Current Pharmacogenomics), vol. 10, no. 4: Bentham Science Publishers, pp. 258–261, 2012. Abstract
Aziz, M. A., G. A. R. Kamar, and A. Sharaf, "Effect of sex hormones on the endocrines of chickens", Cells Tissues Organs, vol. 81, issue 1: Karger Publishers, pp. 83-92, 1972. Abstract
Aziz, M., T. Mostafa, H. Atta, L. Rashed, S. A. Marzouk, E. M. Obaia, D. Sabry, A. A. Hassouna, A. M. El-Shehaby, and A. A. T. Aziz, "The role of PDE5 inhibitors in heme oxygenase–cGMP relationship in rat cavernous tissues", The Journal of Sexual Medicine, vol. 5, no. 7: Wiley Online Library, pp. 1636–1645, 2008. Abstract
Aziz, M. M., M. A. Abd El Fattah, K. A. Ahmed, and H. M. Sayed, "Protective effects of olmesartan and l-carnitine on doxorubicin-induced cardiotoxicity in rats.", Canadian journal of physiology and pharmacology, vol. 98, issue 4, pp. 183-193, 2020. Abstract

Doxorubicin (DOX), an anthracycline antibiotic, is an important antineoplastic agent due to its high antitumor efficacy in hematological as well as in solid malignancies. The clinical use of DOX is limited due to its cardiotoxic effects. The present study aimed to investigate the possible protective effect of olmesartan (Olm), l-carnitine (L-CA), and their combination in cardiotoxicity induced by DOX in rats. Male albino rats were randomly divided into seven experimental groups ( = 8): group I: normal control, group II: L-CA, group III: Olm, group IV: DOX. The other three groups were treated with Olm (10 mg/kg), L-CA (300 mg/kg), and their combination for 2 weeks after induction of cardiotoxicity by a single dose of DOX (20 mg/kg). In the results, DOX showed a significant elevation in serum troponin I, creatine kinase-MB (CK-MB), and lactate dehydrogenase (LDH) together with increased inflammation manifested by the rise of tumor necrosis factor-alpha (TNF-α), intercellular adhesion molecules-1 (ICAM-1), interleukin IL-1β (IL-1β), myeloperoxidase (MPO), nuclear factor-kappa B (NF-κB), and transforming growth factor beta (TGF-β) in cardiac tissues as well as DOX-induced oxidative stress by increasing in malondialdehyde (MDA) and decreasing in superoxide dismutase (SOD) and glutathione (GSH) in heart tissues. In addition, caspase-3 activity was boosted as indication of increased apoptosis. On the other hand, administration of L-CA and Olm attenuated the DOX-evoked disturbances in the abovementioned parameters. In addition, DOX exhibited echocardiographic changes and severe histopathological changes, which were significantly reversed by L-CA and Olm treatment. In conclusion, the present study data confirm the protective role of L-CA and Olm in DOX-induced cardiotoxicity, which may be related to its antioxidant, antiinflammatory, and antiapoptotic agents.

Aziz, M. T., M. F. Al-Asmar, T. Mostafa, H. Atta, L. Rashed, D. Sabry, S. Ashour, and A. T. Aziz, "Assessment of heme oxygenase-1 (HO-1) activity in the cavernous tissues of sildenafil citrate-treated rats.", Asian J Andrology, vol. 9, issue 3, pp. 377-381, 2007.
Aziz, H. A., M. Saleh, M. H. Rasmy, and H. ElShishiny, "Dynamic room pricing model for hotel revenue management systems", Egyptian Informatics Journal: Elsevier, 2011. Abstract
Aziz, M. S. A., H. F. Naguib, and G. R. Saad, "Nanocomposites based on chitosan-graft-poly(N-Vinyl-2-Pyrrolidone): Synthesis, characterization, and biological activity", International Journal of Polymeric Materials and Polymeric Biomaterials, vol. 64, issue 11, pp. 578 - 586, 2015. AbstractWebsite
Aziz, A. S. A., A. T. Azar, A. E. Hassanien, and S. E. - O. Hanafy, "Continuous features discretization for anomaly intrusion detectors generation", Soft computing in industrial applications: Springer International Publishing, pp. 209–221, 2014. Abstract
Aziz, M. M., I. K. Eyada, M. A. Abd El Megeid, and A. OM, "Bedside Evaluation of Fluid Responsiveness in Shock State using Electrical Cardiometry.", Indian Journal of Public Health Research & Development, vol. 10, no. 12, 2019. Abstract
Aziz, R. K., "Toxicomicrobiomics: Narrowing the Gap Between Environmental and Medicinal Toxicogenomics", OMICS: A Journal of Integrative Biology, vol. 22, no. 12: Mary Ann Liebert, Inc., publishers 140 Huguenot Street, 3rd Floor New …, pp. 788–789, 2018. Abstract
Aziz, N. A. A. E., "Water Sensitive Landscape Case Study: Public Open Green Spaces in Naser City, Egypt", Journal of Landscape Ecology, vol. 9, issue 3, pp. 66-83, 2016.
Aziz, M. T. A., M. F. El-Asmar, T. Mostafa, H. Atta, M. A. A. Wassef, H. H. Fouad, N. K. Roshdy, L. A. Rashed, and D. Sabry, "Effects of nitric oxide synthase and heme oxygenase inducers and inhibitors on molecular signaling of erectile function", Journal of Clinical Biochemistry and Nutrition, vol. 37, no. 3: 日本酸化ストレス学会 JCBN 事務局, pp. 103–111, 2005. Abstract