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Awadein, A., "Subconjunctival bevacizumab for vascularized rejected corneal grafts.", Journal of cataract and refractive surgery, vol. 33, issue 11, pp. 1991-3, 2007 Nov. Abstract

We describe 3 patients who experienced corneal neovascularization following keratoplasty and were treated with a single subconjunctival injection of 2.5 mg bevacizumab. Although there was immediate regression of the corneal vascularization and haze, as well as improvement in the anterior chamber reaction, the effects were short-lived and starting from the second week, the corneal vessels began to progress. All 3 cases ended in permanent graft failure. The series suggests a possible role for bevacizumab in the management of graft rejection with vascularization.

Awadein, A., "Inferior oblique myectomy for upshoots mimicking inferior oblique overaction in Duane retraction syndrome.", Journal of the American Association for Pediatric Ophthalmology and Strabismus, vol. 17, issue 3, pp. 253-258, 2013. AbstractWebsite

PURPOSE:
To evaluate the results of inferior oblique myectomy in selected patients with Duane retraction syndrome with upshoot on adduction.
METHODS:
This was a prospective, interventional study of consecutive patients with types 1, 2, or 3 Duane syndrome with isolated upshoot in adduction operated on from January 2007 to December 2011. Patients underwent inferior oblique myectomy on the side of the upshooting eye. Only patients with gradual elevation of the eye in adduction in a pattern similar to inferior oblique overaction or patients with hypertropia in the primary position were included. All patients were followed for at least 6 months. Ductions, versions, degree of upshoot, degree of fundus torsion, and pattern of strabismus were analyzed in all patients before and after surgery.
RESULTS:
A total of 11 patients were included in the study. Mean patient age at time of surgery was 6.4 ± 5.2 years (range, 3-22 years). Two patients had bilateral inferior oblique myectomy and 4 had simultaneous bilateral medial rectus muscle recession to correct horizontal misalignment. Mean duration of follow-up was 8.6 months (range, 6-36 months). Of the 11 patients, 10 (91%) had complete disappearance of the upshoot at last follow-up. None of the patients developed inferior oblique underaction postoperatively. There was a statistically significant improvement of V pattern after surgery (P < 0.01). Mean vertical misalignment in primary position was 5(Δ) before surgery and 1(Δ) after (P = 0.02). Most patients had no significant fundus torsion before or after surgery.
CONCLUSIONS:
Inferior oblique muscle weakening can improve upshoot in selected patients with Duane retraction syndrome without inducing inferior oblique muscle underaction.

Awadein, A., and M. A. Fakhry, "Evaluation of intralesional propranolol for periocular capillary hemangioma.", Clinical ophthalmology (Auckland, N.Z.), vol. 5, pp. 1135-40, 2011. Abstract

BACKGROUND: The purpose of this study was to evaluate the use of intralesional propranolol injection in the management of periocular capillary hemangioma.

METHODS: A prospective study was performed in 22 consecutive patients with periocular hemangioma. Twelve patients underwent intralesional propranolol injection and ten patients underwent intralesional triamcinolone injection. The size of the lesion was measured serially every week during the first month, every 2 weeks for the second month, and then monthly for another 2 months. The refractive error and degree of ptosis if present were measured before injection and at the end of the study.

RESULTS: There was reduction in the size of hemangioma, astigmatic error, and degree of ptosis in both groups. The difference in outcome between both groups was not statistically significant. Rebound growth occurred in 25% of the propranolol group and 30% of the steroid group but responded to reinjection. No adverse effects were reported during or after intralesional propranolol injection.

CONCLUSION: Intralesional propranolol injection is an alternative and effective method for treatment of infantile periocular hemangioma.

Awadein, A., and M. A. Fakhry, "Evaluation of intralesional propranolol for periocular capillary hemangioma", Cairo University Faculty of Medicine, vol. 5, 2011. cu_pdf.pdf
Awadein, A., "Clinical findings, orbital imaging, and intraoperative findings in patients with isolated inferior rectus muscle paresis or underaction.", Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, vol. 16, issue 4, pp. 345-9, 2012 Aug. Abstract

PURPOSE: To present the clinical findings, orbital imaging, and intraoperative findings of patients with inferior rectus muscle underaction and to determine whether specific findings can help discern the underlying cause.

METHODS: A retrospective observational study was performed on patients presenting with isolated inferior rectus muscle underaction between January 2007 and October 2011. Patient history, ocular motility, fundus torsion, Lancaster red-green plots, and radiographic findings were analyzed. For patients who had surgery, intraoperative findings also were considered.

RESULTS: A total of 28 patients with inferior rectus muscle underaction were identified. Of these, 13 (46%) presented with inferior rectus muscle underaction after orbital trauma; 25 (89%) showed no increase in hypertropia >4(Δ) on head tilt to either side. Fundus intorsion was present in all patients. Of 15 patients evaluated by Lancaster red-green testing, 12 (80%) showed subjective intorsion. Twenty patients underwent orbital imaging via computed tomography or magnetic resonance imaging, and the results in 8 (40%) revealed obvious changes in the inferior rectus muscle. Nineteen patients underwent surgery; intraoperatively, the muscle appeared grossly normal in 8 patients (42%) and showed posterior muscle slippage in 4 (26%). Less common findings included stretched scar formation, flap tear, missing tissue, extensive muscle adhesions, or inability to identify the muscle.

CONCLUSIONS: Clinical findings in patients with inferior rectus muscle underaction are not sufficiently different to identify the cause, and orbital imaging identified a specific abnormality in only 40% of cases.

Awadein, A., and M. A. Fakhry, "Evaluation of intralesional propranolol for periocular capillary hemangioma", Clinical ophthalmology (Auckland, NZ), vol. 5: Dove Press, pp. 1135, 2011. Abstract
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Awadein, A., Shaimaa A Arfeen, P. Chougule, and R. Kekunnaya, Duane-minus (Duane sine retraction and Duane sine limitation): possible incomplete forms of Duane retraction syndrome., , 2020. Abstract

PURPOSE: To report ocular motility patterns that mimic, but do not fulfil the full clinical picture of Duane retraction syndrome (DRS) and to describe their clinical features and surgical management.

METHODS: This is a retrospective case series study conducted on patients with DRS, mimicking non-comitant exotropia or esotropia and a face turn. Patients were included only if they lacked either globe retraction on adduction (sine retraction) or limitation of adduction or abduction on ductions (sine limitation not >0.5). Any overshoots or pattern strabismus was recorded. The ocular motility and alignment, details of surgery and their surgical outcomes were analysed.

RESULTS: Twenty-one patients were identified; 13 in the sine retraction and 8 in the sine limitation group. All patients presented with a compensatory face turn. Overshoots were present in 10 (77%) and 7 patients (88%) in the sine retraction and sine limitation groups, respectively. Forced duction test showed tightness of the ipsilateral medial and the ipsilateral lateral rectus muscle in esotropic (n = 3) and exotropic patients (n = 18), respectively. Orthotropia was achieved in 82% of patients following ipsilateral medial or lateral rectus muscle recession.

CONCLUSIONS: There is a subset of patients who present with motility pattern similar to DRS but lack its complete diagnostic criteria. The presence of a face turn, overshoots on adduction or an ipsilateral tightness of the affected muscle should make one consider DRS sine retraction/sine limitation. The patients in our study responded well to lines of management similar to those of DRS.

Awadein, A., M. Sharma, M. G. Bazemore, H. A. Saeed, and D. L. Guyton, "Adjustable suture strabismus surgery in infants and children.", Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, vol. 12, issue 6, pp. 585-90, 2008. Abstract

PURPOSE: To evaluate the success rate of adjustable suture techniques in horizontal eye muscle surgery in children aged 10 years and younger.

METHODS: A retrospective review of children who had horizontal eye muscle surgery at or before the age of 10 years. Patients were divided into 1 of 2 groups according to whether a nonadjustable or an adjustable technique was used. The preoperative measurements, type of strabismus, and postoperative results were analyzed.

RESULTS: A total of 98 cases in the nonadjustable group and 298 cases in the adjustable group were identified. Early success rate, defined as alignment within 8(Delta) of straight at the end of 3 months, was notably greater in the adjustable group (79%) than in the nonadjustable group (64.5%). The difference was statistically significant (p < 0.01). In the adjustable group, adjustment was performed in 64% of the cases, either because of an undercorrection or overcorrection. The adjustment procedure was performed under topical proparacaine in 20% of cases and under intravenous propofol in 80%. No complications were reported during the adjustment procedure.

CONCLUSIONS: The use of adjustable sutures can provide an improved success rate over nonadjustable sutures in eye muscle surgery in children aged 10 years or younger.

Awadein, A., and Y. M. El Sayed, "Excision of Tenon Capsule in Pediatric Trabeculectomy: A Controlled Study.", Journal of glaucoma, vol. 25, issue 1, pp. 39-44, 2016 Jan. Abstract

PURPOSE: To compare the results of trabeculectomy alone and combined with partial tenonectomy in pediatric glaucoma patients.

METHODS: This was a prospective, controlled, cohort study that included 64 eyes of 46 children younger than 12 years with uncontrolled glaucoma, who underwent trabeculectomy with mitomycin C in an institutional setting. Patients were randomized to undergo a trabeculectomy either with (group A) or without (group B) tenonectomy. Children were followed up prospectively for 24 months. Kaplan-Meier survival analysis and mean survival times with 95% confidence intervals (CIs) were calculated. Postoperative results were compared at 3, 6, 12, and 24 months of follow-up. The main outcome measures were: intraocular pressure (IOP), surgical success, postoperative interventions, and complications in both groups.

RESULTS: Mean postoperative IOP was lower in group A at all postoperative visits (19.2 mm Hg in group A vs. 22.1 mm Hg in group B at 24 mo, P=0.05). There was a tendency toward greater use of glaucoma medications in group B (P<0.001). Cumulative probability of survival at 24 months was 70% (95% CI, 48%-86%) for group A, and 45% (95% CI, 28%-63%) for group B (P=0.09). Mean survival time was significantly longer (P=0.04) in group A (16.6 mo) than in group B (11.6 mo). Encapsulation occurred more frequently (P=0.03) in group B (25%) than in group A (3%).

CONCLUSIONS: Excision of the Tenon capsule could help achieve better IOP control in pediatric glaucoma surgery.

Awadein, A., "Clinical findings, orbital imaging, and intraoperative findings in patients with isolated inferior rectus muscle paresis or underaction", Journal of American Association for Pediatric Ophthalmology and Strabismus, vol. 16, no. 4: Mosby, pp. 345–349, 2012. Abstract
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Awadly, T. E. A., G. Wu, M. Ayad, and I. A. W. Radi, "A histomorphometric study on treated and untreated ceramic filled PEEK implants versus titanium implants: Preclinical in vivo study", Clinical Oral Implant Research, vol. 31, pp. 246-254, 2020.
Awady, M. E. K., M. H. Omran, M. K. Ibrahim, A. M. Moustafa, R. M. Dawood, N. B. E. G. Din, A. Elsharkawy, M. A. S. Aziz, R. E. Shenawy, Y. E. S. Abd, et al., "Low Molecular Mass Polypeptide 7 Single Nucleotide Polymorphism is Associated with the Progression of Liver Fibrosis in Patients Infected with Hepatitis C Virus Genotype 4", clinical laboratory, vol. 62, pp. 381-387, 2016.
Awady, M. E. S. A., K. H. Morsy, A. Hassan, and A. S. AboElFotouh, "REM Sleep Behavior Disorder and Excessive Daytime Sleepiness among Egyptians.", Egypt J Neurol Psychiat Neurosurg, vol. 51, issue 4, pp. 421-426., 2014.
Awady, M. E. K., M. H. Omran, M. K. Ibrahim, A. M. Moustafa, R. M. Dawood, N. B. E. G. Din, A. Elsharkawy, M. A. S. Aziz, R. E. Shenawy, Y. E. S. Abd, et al., "Low Molecular Mass Polypeptide 7 Single Nucleotide Polymorphism is Associated with the Progression of Liver Fibrosis in Patients Infected with Hepatitis C Virus Genotype 4", clinical laboratory, vol. 62, pp. 381-387, 2016.
Awady, M. E. S. A., K. H. Morsy, A. Hassan, and A. S. AboElFotouh, "Insomnia and Obstructive Sleep Apnea among Egyptians: A Hospital-Based Study.", Egypt J Neurol Psychiat Neurosurg, vol. 51, issue 1, pp. 89-95, 2014.
Awady, M. E. K., T. M. Elbaz, S. S. Hunter, and A. A. O. Aziz, "Predictors of Disease Recurrence Post Living Donor Liver Transplantation in End Stage Chronic HCV Patients", Disease Markers, vol. 2014, issue 2014, pp. 2025-2048, 2014.
Awaid, M., A. H. kandil, and S. A. Fawzi, "“Audio Search Based on Keyword Spotting in Arabic Language” ", (IJACSA) International Journal of Advanced Computer Science and Applications , vol. 5, issue 2, 2014.
Awaid, M., A. H. kandil, and S. A. Fawzi, "Audio Search Based on Keyword Spotting in Arabic Language", IJACSA) International Journal of Advanced Computer Science and Applications, vol. 5, 2014.
Awan, Z. A., M. A. Hegazy, and A. K. Kammoun, "Spectral signal processing approaches for selective quantification of the recently FDA approved brand-new combination of Vaborbactam and Meropenem; for conformity assessment of bulk and batch release", Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, vol. 230: Elsevier, pp. 118066, 2020. Abstract
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Awan, Z. A., U. A. Fahmy, S. M. Badr-Eldin, T. S. Ibrahim, H. Z. Asfour, M. W. Al-Rabia, A. Alfarsi, N. A. Alhakamy, W. H. Abdulaal, H. Al Sadoun, et al., "The Enhanced Cytotoxic and Pro-Apoptotic Effects of Optimized Simvastatin-Loaded Emulsomes on MCF-7 Breast Cancer Cells.", Pharmaceutics, vol. 12, issue 7, 2020. Abstract

Statins, including simvastatin (SMV), are commonly used for the control of hyperlipidaemia and have also proven therapeutic and preventative effects in cardiovascular diseases. Besides that, there is an emerging interest in their use as antineoplastic drugs as demonstrated by different studies showing their cytotoxic activity against different cancer cells. In this study, SMV-loaded emulsomes (SMV-EMLs) were formulated and evaluated for their cytotoxic activity in MCF-7 breast cancer cells. The emulsomes were prepared using a modified thin-film hydration technique. A Box-Behnken model was used to investigate the impact of formulation conditions on vesicle size and drug entrapment. The optimized formulation showed a spherical shape with a vesicle size of 112.42 ± 2.1 nm and an entrapment efficiency of 94.34 ± 1.11%. Assessment of cytotoxic activities indicated that the optimized SMV-EMLs formula exhibited significantly lower half maximal inhibitory concentration (IC50) against MCF-7 cells. Cell cycle analysis indicated the accumulation of cells in the G2-M phase as well as increased cell fraction in the pre-G1 phase, suggesting an enhancement of anti-apoptotic activity of SMV. The staining of cells with Annex V revealed an increase in early and late apoptosis, in line with the increased cellular content of caspase-3 and Bax. In addition, the mitochondrial membrane potential (MMP) was significantly decreased. In conclusion, SMV-EMLs demonstrated superior cell death-inducing activity against MCF-7 cells compared to pure SMV. This is mediated, at least in part, by enhanced pro-apoptotic activity and MMP modulation of SMV.

Awang, R. A., S. H. El-Gohary, N. - H. Kim, and K. M. Byun, "Enhancement of field–analyte interaction at metallic nanogap arrays for sensitive localized surface plasmon resonance detection", Applied optics, vol. 51, no. 31: Optical Society of America, pp. 7437–7442, 2012. Abstract
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Awang, R. A., S. H. El-Gohary, N. - H. Kim, and K. M. Byun, "Enhancement of field–analyte interaction at metallic nanogap arrays for sensitive localized surface plasmon resonance detection", Applied optics, vol. 51, no. 31: Optical Society of America, pp. 7437–7442, 2012. Abstract
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Awang, R. A., S. H. El-Gohary, N. - H. Kim, and K. M. Byun, "Enhancement of field&\#x2013;analyte interaction at metallic nanogap arrays for sensitive localized surface plasmon resonance detection", Appl. Opt., vol. 51, no. 31: OSA, pp. 7437–7442, Nov, 2012. AbstractWebsite

We investigated the near-field enhancement of a localized surface plasmon resonance (LSPR) structure based on gold nanograting pairs with a nanosized gap. The results calculated by finite-difference time-domain and rigorous coupled-wave analysis methods presented that the nanogap enclosed by two neighboring nanogratings produced significant confinement and enhancement of electromagnetic fields and allowed a sensitive detection in sensing of surface binding events. Gold gratings with a narrow gap distance less than 10&\#xA0;nm showed enhanced refractive index sensitivity due to the intensified optical field at the nanogap, outperforming the LSPR structure with noninteracting nanogratings. Also, we analyzed the effectiveness of using an overlap integral (OI) between analyte and local plasmon field to estimate the detection sensitivity. We found a strong correlation of field&\#x2013;analyte OI with far-field sensor sensitivity.

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