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A., R., and N. A. Afifi, "The effect of ascogen on the immune response of tilapia fish to Aeromonas hydrophila vaccine.", Fish & Shellfish Immunology, vol. 4, pp. 159-165, 1994.
A., A. A., H. M. Salem, H. M. M., and A. M.M., "Molecular Identification of Resistance and Pathogenicity Genes of E. coli Isolated From Broiler Chicken Farms. Egypt.", Egyptian Journal of Veterinary Sciences, vol. 55, issue 6, pp. 1787-1800, 2024. ejvs_volume_55_issue_6_pages_1787-1800_1.pdf
A., E. - S., N. Metwally, S. El-Kilany, F. Fahmy, and A. Bakr, "Production and preliminary characterization of monoclonal antibodies to foot and mouth disease virus Egyptian strain", Zag. Vet. J., vol. 42(3), pp. 53-58, 1994.
A., A. N., R. A, el-Aziz MI, and S. EE, "Influence of dimethoate on testicular and epididymal organs, testosterone plasma level and their tissue residues in rats", Dtsch Tierarztl Wochenschr. , vol. 98(11), pp. 419- 423., 1991.
A., E. G., H. H., M. R., and A. - F. M., "Studies on Cryopreservation of Human Oocytes using Verification Technique", Asian Journal of Applied Sciences, vol. 2, issue 4, pp. 505-510, 2014.
A., A. H., safwat R, R. O, H. H, and F. A, "Central auditory processing and audio-vocal psycholinguistic abilities in children with attention deficit-hyperactivity disorder", Published in Egyptian Journal of Psychiatry(EJP)), vol. May 2013; volume.(34), issue , No.(2, pp. ,p:98:103, 2014. 6th_research.pdf
A., M., R. A. Karas, and M. A. Harith, "A promising protected ascorbic acid-hydroxyapatite nanocomposite as a skin anti-ager: A detailed photo-and thermal stability study", Journal of Photochemistry & Photobiology, B: Biology, vol. 173, pp. 661-667, 2017. jppb.pdf
A., R., H. AH, Ismail M. M., Dahaba M. M., and H. G. A., "Effects of Early Closed Kinetic Chain Exercises on the Rate of Callus Formation during Distraction Osteogenesis by Ilizarov's Method.", European Federation Of National Associations of Orthopaedics and Traumatology, Lisbon, Portugal, Poster # 3195, 2005.
A., K. N., "Response of winter sowing sunflower to rate and time of N application as compared to that of summer sowing.", Egypt. J. Appl. Sci., vol. 6, no. (10), pp. 616–626, 1991. Abstract
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A., R., N. A. Afifi, M. M.M, and S. A.M, "The effect of ascogen on the immune response of tilapia fish to Aeromonas hydrophila vaccine.", Fish & Shellfish Immunology, vol. , 4, pp. 159-165 , 1994.
A., A. - G., F. M. M., M. W., and E. - B. A., "Immuno-characterization of some Eimeria spp. Infecting chicken in Egypt. ", 21st International Conference WAAVP (World Association for the Advancement of Veterinary Parasitology)., Belgium., 19-23 August, 2007.
A., Y., Sequence Analyses of Novel Potato Virus YNTN and Resistance-Breaking PVYO Isolates from Sweden, , Uppsala, Swedish University of Agricultural Science (SLU), 2017.
A., B., A. A., E. A., E. R., A. A., and S. S, "Runtime Self-Monitoring Approach of Business Process Compliance in Cloud Environments", Cluster Computing, vol. 18, issue 4, pp. 1503-1526, 2015.
A., E. G., R. I, E. D. S, and E. A. A. M, "Importance of schistosoma mansoni thirodoxine glutathione reductase. 1-Evaluation of its role in schistosomiasis diagnosis in human", Journal of medical science, vol. 13, pp. 635-646, 2013.
A., A. - W., M. ElAshry, and R. Shabana, "Estimates of the variation among farmer seed lots. A varietal cross among some selected local and exotic sunflower genotypes and their value for breeding purpose in Egypt", 13th Inter. Con. Stat,Computer Sci. and demo.Res., pp. 197–210, 1988. Abstract
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A., S. N., "Morphometric Overview on the Vascularization in the Egyptian Domestic Cat (Feliscatus) Hind Paw", J. Vet. Anat. , vol. 7, issue 2, pp. 1-12, 2014.
A., M., and H.M.Onsi, "A Proposed Textual Graph Based Model for Arabic Multi-document Summarization", International Journal of Advanced Computer Science and Applications(IJACSA), vol. 7, issue 6, pp. 435-439, 2016.
A., S. M., N. A. Afifi, E. - B. H. A., and Shimaa I. Ramadan, "Hepatoprotective and antioxidant effects of Marjorana hortensis plant in CCL4- intoxicated rats", Natural Products of Indian Journal, vol. accepted for puplication, 2013.
A., K. N., "Comparative.evaluation of some growth and yield characters in triticale and wheat.", Egypt. Appl. Sci., vol. 6, no. (4), pp. 439–4, 1991. Abstract
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A., E. - S., H. M. Madbouly, M. S. Saber, G. F. El-Bagoury, A. N. A. El-Bar, A. El-Batrawi, and I. M. Reda, "Infectious bursal disease virus infection among Egyptian flocks. III. Antigenic characterization of IBDV by the antigen-capture ELISA (AC-ELISA) using monoclonal antibodies (MAbs)", Beni-Suef Vet. Med. Res., vol. IV (1/2), pp. 300-308, 1994.
A., D., S. N.M., R. G.M., and H. H., "Olivocochlear reflex in migraineurs with phonophobia. . ", Journal of Hearing Science , vol. 2, issue 1, Submitted.
A., A. M., W. Y. M., Y. A. E. -salam S., and H. E. -sayed Z., "Impact of a Designed Nursing Intervention protocol on Myocardial Infarction Patient's Outcome at a selected University Hospital in Egypt", Journal of Biology, Agriculture and Healthcare, vol. Vol.3, No.17, 2013.
A., W. A., E. H. M., H. Y. E., A. M. S., O. A.H., and K. S. M., "Therapeutic and Protective Effects of Biphenyl Dimethyl Dicarboxylate (DDB) and Silymarin in Human Infected with HCV and in Carbon Tetrachloride Induced Hepatitis in Rats", Journal of American Science, 2011. Abstract

This investigation aimed to evaluate the therapeutic activity of pure and commercial products of Biphenyl Dimethyl Dicarboxylate (DDB) and Silymarin in humans suffering from HCV and therapeutic and protective effects of Carbon tetrachloride (CCL4) induced liver damage in rats. Humans were divided into two groups: Group I: Normal controls (N=20), and group II: Patients suffering from chronic HCV infection; which were subdivided into two subgroups: A, ten patients received Silymarin 140 mg twice daily for one month and B, twenty patients received DDB 10 pilules (15 mg) twice daily for one month. Samples from control and treated groups were collected and obtained serum was analyzed for Aspartate aminotransaminase (AST), Alanine aminotransaminase (ALT), Alkaline phosphatase (ALP or Alk.ph.), Gamma Glutamic transaminase (GGT) and Serum bilirubin (total and direct). In addition, the effect of DDB or Silymarin administration on the mentioned biochemical parameters was measured. Other experiment was conducted in which rats were divided into nine groups, each group comprising of six rats. All rats except the control group were subjected to administration of Silymarin or DDB in pure and commercial products, before and after treatment with CCL4. All serum samples of rats were subjected to liver function tests including: (AST), (ALT), (ALP.) and serum bilirubin as well as kidney functions tests including: blood urea and serum creatinine. Histopathological examination of liver tissues was also performed. The results revealed that DDB improved liver functions in patients suffering from HCV infection, while Silymarin showed insignificant alteration for the same parameters. The raw and commercial products of Silymarin or DDB were significantly improved liver, kidney functions and the histopathological changes after induction of CCL4 toxic hepatitis in rats. Administration of DDB (commercial) for one month to patients suffering from chronic viral hepatitis resulted in a rapid decrease in serum transaminases, especially ALT. Treatment of rats by pure and commercial DDB for 7 days showed improvement in acute hepatocellular necrosis or hepatitisassociated hepatocellular damage caused by carbon tetrachloride. Administration of commercial Silymarin for one month was largely ineffective in patients suffering from viral hepatitis. The results of 7 days treatment by pure and commercial products of Silymarin in rats showed protection of liver tissue. Silymarin has an antioxidant effect. In rats Silymarin increased the level of total protein which indicates hepatoprotective activity as results of accelerate of regeneration process and production of liver cells. Obtained histopathological study confirmed the results of biochemical studies. It is concluded that a superiority and efficacy of DDB over Silymarin in normalizing the liver enzymes and serum bilirubin (total and direct) levels were achieved after treatment of humans suffering from HCV.