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Awaad, M. H. H., A. Atta, B. SHALABY, H. B. Gharieb, M. Elmenawey, K. Madian, F. F. Eman, and A. N. Amal, The Efficacy of Na-Butyrate Encapsulated in Palm Fat on Experimentally Induced Necrotic Enteritis and Enumeration of intestinal resident Clostridium perfringens in Broiler Chickens, , Submitted. Abstract

Over more than five decades, cancer remains a national and international health problem regardless of the discovery of several dozens of novel anticancer drugs (natural and synthetic). Accordingly, screening of natural products for promising anti cancer activity is very initiative field of studies in several countries with diversity of gardenia. Breast and cervix cancers are of the most common gynecological female solid tumors that represent major health problem. Herein, we have assessed the cytotoxic characteristics of several molecules of natural origin (cerulinin, chrysin, honikiol, limonin, mevinolin, resveratrol, salicin, retinol, ascorbic acid and calciferol) against two different gynecological breast (MCF-7) and Cervix (HeLa) solid tumor cell lines. After exposure to serial concentrations of the test compounds, SRB-u assay was undertaken and viability assessment was performed via fitting to Emax model to identify the cytotoxicity parameters such as, IC50 and resistant fraction (R-value). Tested compounds showed cytotoxic efficacy against both gynecological solid tumor cell lines (MCF-7 and HeLa) with IC50's ranged from 0.61 to 131.1 μg/ml. In MCF-7 breast cancer cell line; cerulinin, honikiol, mevinolin and calciferol showed the highest potency with IC50 less than 5 μg/ml. Chrysin showed moderate potency with IC50 of 7.27 μg/ml. Ascorbic acid and resveratrol showed the weakest cytotoxic activity with IC50 more than 10 μg/ml. In HeLa cervix cancer cell line; cerulinin and mevinolin showed the highest potency with IC50 less than 5 μg/ml. Chrysin, honikiol, resveratrol and calciferol showed moderate potency with IC50 of ranging from 5-10 μg/ml. Ascorbic acid was the weakest cytotoxic molecule with IC50 more than 10 μg/ml. Limonine, salicin and retinol failed to exert any cytotoxic effect against MCF-7 or HeLa cancer cell lines in-vitro. RT-PCR analysis revealed that the cytotoxicity of these products is multi-factorial and not solely dependent on p53 expression. Impressively, molecules of potent and moderate potency (except chrysin) showed low resistant fraction in both gynecological solid tumor cancer cell lines. In conclusion, our data showed wide range of variable efficacy of several molecules of natural origin against two hormone dependent solid tumor cell lines.

Effat, D. H. E. A. D. H., D. H. E. G. D. N. Samer, D. S. S. D. A. E. Sherif, D. N. A. D. A. E. Sessi, and D. W. Radawan, "Efficacy of Recombinant Human Erythropoietin in Critically Ill Anaemic Septic Patients", The Medical Journal of Cairo University, vol. 73, issue 4, Submitted.
Gouda, O. E. - S., and T. M. Ahmed, Electrical Composite Materials for Industrial Applications, : LAP Lambert Academic Publishing (29 Jan. 2015), Submitted.
Almaz, A., and A. A. AbdelHamed, "energy expenditure of fast walking and slow running at the same speed compared with normal walking ,", 12th international physical therapy confrence, cairo, faculty of Physical therapy, Submitted.
Al-Shamiri, H. A. S., A. M. Khedr, and M. M. Sabry, "Energy transfer and photo stability of Rh - 6 G and Rh-B doped in polyacrylamide polymer", Optik - International Journal of Light and Electron Optics, vol. 182, pp. 716 - 726, Submitted. polyacrylamide_optik_paper.pdf
Sidky, G., "Enhancing Post Graduates Research Skills through an Intervention Program in light of EAP Approach ", Curriculum and Instruction, vol. 233, issue 233, pp. 1-28, Submitted.
(Author), O. E. - S. G., Environmental Impacts on Underground Power Distribution, : Idea Group,U.S., Submitted.
Mohamed, G., P. Murray, E. Nagy, and K. Vrzalikova, "Epstein–Barr virus, the germinal centre and the development of Hodgkin’s lymphoma", Journal of General Virology, vol. 95, issue 10.1099/vir.0.066712-0, pp. 1861–1869, Submitted. 1861.full_.pdf
Saadi, M. G., A. A. Elmeligi, M. S. Elansary, G. R. A. Ahmed, and A. K. Alkemary, Estimation of blood micro RNA192 in patients with diabetic nephropathy, , Cairo, Cairo university, Submitted. MD thesis.docx
G, Z., M. H, S. R, M. A, and E. - H. Sh, "Evaluating the 24 hours/4 hours of Tc99m MDP. A method of analysis for differentiation between bone metastases and degenerative bone lesions", European J Nucl Med, vol. 16(7), pp. 556, Submitted.
ElTaweel, M. E. S., and A. A. Ali, "Evaluation of Prolactin Levels in Male Patients with First Episode Schizophrenia and Its Correlation with Psychopathology", Middle East Current Psychiatry, Submitted.
Attia, G. M., M. J, R. L, E. - E. W, S. D3, L. C, and S. N, Evaluation of the effects of Eserine and JWH-133 on brain dysfunction associated with experimental endotoxemia., , Submitted.
. Osama E. Gouda, A. E. D. Z., "Experimental Techniques to Simulate Naturally Polluted High Voltage Transmission Line Insulators", IEEE Transactions on Dielectrics and Electrical Insulation , vol. Vol. 21, No. 5; October 2014, pp. 20199-2005, Submitted.
Ragab, H. M., H. M. Shaaban, N. Abd El Maksoud, S. M. Radwan, W. A. El Aziz, and N. E. S. R. E. E. N. H. HAFEZ, "Expression of Vascular Endothelial Growth Factor Protein in Both Serum Samples and Excised Tumor Tissues of Breast Carcinoma Patients", International Journal of Cancer Research, vol. 12, issue (3-4), pp. 152-161, Submitted. published_vegf_paper.pdf
nehal hamdy elsaid, F. Taha, ghada abelaziz, and marwa abdeltawab, feutin A level in type 2 diabetic patients,relation to microvascular complications, , Submitted.
nehal hamdy elsaid, F. Taha, ghada abelaziz, and marwa abdeltawab, "feutin A level in type 2 diabetic patients,relation to microvascular complications", Egyptian journal of internal medicine 2018, vol. vol 30,2018, Submitted.
Fayed, A., M. E. M. Nokeety, M. M. Naguib, Ahmed A. Heikal, D. O. Abdulazim, and U. S. E. A. A. Din, "Fibroblast growth factor-23 is a strong predictor of insulin resistance among chronic kidney disease patients", Renal Failure, vol. 40, issue 1, pp. 226-230, Submitted. Abstractfibroblast_growth_factor-23_is_a_strong_predictor_of_insulin_resistance_among_chronic_kidney_disease_patients.pdf

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