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2021
Mostafa, A. A., A. A. Mahmoud, M. A. A. Hamid, M. Basha, M. S. El-Okaily, A. A. Abdelkhalek, M. I. El-Anwar, S. El Moshy, A. Gibaly, and E. A. Hassan, "An in vitro/in vivo release test of risedronate drug loaded nano-bioactive glass composite scaffolds", International Journal of Pharmaceutics, vol. 607: Elsevier, pp. 120989, 2021. Abstract
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El-Aal, E. A. M., M. Shahen, Samy Sayed, H. Kesba, M. J. Ansari, R. M. El-Ashry, A. A. A. Aioub, A. S. A. Salma, and A. M. Eldeeb, "In vivo and in vitro management of Meloidogyne incognita (Tylenchida: Heteroderidae) using rhizosphere bacteria, Pseudomonas spp. and Serratia spp. compared with oxamyl", Saudi Journal of Biological Sciences, vol. 28 , pp. 4876–4883, 2021. 1-s2.0-s1319562x2100557x-main_1.pdf
Salem, M. A., R. A. El-Shiekh, R. A. Hashem, and M. Hassan, "In vivo Antibacterial Activity of Star Anise (Illicium verum Hook.) Extract Using Murine MRSA Skin Infection Model in Relation to Its Metabolite Profile", Infection and Drug Resistance, vol. 14, pp. 33—48, 2021. Website
Salem, M. A., R. A. El-Shiekh, R. A. Hashem, and M. Hassan, "In vivo Antibacterial Activity of Star Anise (Illicium verum Hook.) Extract Using Murine MRSA Skin Infection Model in Relation to Its Metabolite Profile", Infection and Drug Resistance, vol. 2021:14, pp. 33-48, 2021.
El‑Hawary, S. S., M. M. Mubarek, R. A. Lotfy, A. A. Sleem, and M. O. N. A. M. OKBA, "In vivo antidiabetic potential of standardized Gymnocarpos decandrus Forssk. Extract", Journal of Diabetes & Metabolic Disorders, vol. 20, pp. 1129–1135, 2021.
El‑Hawary, S. S., M. M. Mubarek, R. A. Lotfy, A. A. Sleem, and M. O. N. A. M. OKBA, "In vivo antidiabetic potential of standardized Gymnocarpos decandrus Forssk. Extract", Journal of Diabetes & Metabolic Disorders, vol. 20, pp. 1129–1135, 2021.
El‑Hawary, S. S., M. M. Mubarek, R. A. Lotfy, and M. O. N. A. M. OKBA, "In vivo antidiabetic potential of standardized Gymnocarpos decandrus Forssk. Extract", Journal of Diabetes & Metabolic Disorders, 2021.
Raya, S. A., A. M. Aboul-Enein, M. M. A. El-Nikeety, R. S. Mohamed, and W. M. A. Abdelwahid, "In Vivo Comet Assay of Food Additives’ Combinations and their Effects on Biochemical Parameters in Albino Rats", Biointerface Research in Applied Chemistry, vol. 11, issue 2, pp. 9170-9183, 2021.
Abo-Zalam, H. B., R. M. Abdelsalam, R. F. Abdel-Rahman, M. F. Abd-Ellah, and M. M. Khattab, "In Vivo Investigation of the Ameliorating Effect of Tempol against MIA-Induced Knee Osteoarthritis in Rats: Involvement of TGF-β1/SMAD3/NOX4 Cue.", Molecules (Basel, Switzerland), vol. 26, issue 22, 2021. Abstract

Osteoarthritis (OA) is a complex disease characterized by structural, functional, and metabolic deteriorations of the whole joint and periarticular tissues. In the current study, we aimed to investigate the possible effects of tempol on knee OA induced by the chemical chondrotoxic monosodium iodoacetate (MIA) which closely mimics both the pain and structural changes associated with human OA. Rats were administrated oral tempol (100 mg/kg) one week post-MIA injection (3 mg/50 μL saline) at the right knee joints for 21 consecutive days. Tempol improved motor performance and debilitated the MIA-related radiological and histological alterations. Moreover, it subsided the knee joint swelling. Tempol decreased the cartilage degradation-related biomarkers as matrix metalloproteinase-13, bone alkaline phosphatase (bone ALP), and fibulin-3. The superoxide dismutase mimetic effect of tempol was accompanied by decreased NADPH oxidase 4 (NOX4), inflammatory mediators, nuclear factor-kappa B (NF-κB), over-released transforming growth factor-β1 (TGF-β1). Tempol decreased the expression of chemokine (C-C motif) ligand 2 (CCL2). On the molecular level, tempol reduced the phosphorylated protein levels of p38 mitogen-activated protein kinase (MAPK), and small mother against decapentaplegic 3 homologs (SMAD3). These findings suggest the promising role of tempol in ameliorating MIA-induced knee OA in rats via collateral suppression of the catabolic signaling cascades including TGF-β1/SMAD3/NOX4, and NOX4/p38MAPK/NF-κB and therefore modulation of oxidative stress, catabolic inflammatory cascades, chondrocyte metabolic homeostasis.

Elhassan, M. M., A. M. Mahmoud, M. A. Hegazy, and S. Mowaka, "In-line monitoring of sitagliptin dissolution profile from tablets utilizing an eco-friendly potentiometric sensor", Chemical Papers, vol. 75, issue 8: Springer, pp. 4165-4176, 2021. Abstract
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Osman, A. M., and H. M. A. El-Din, "In-Silico Screening of Potential Anti-Glycoprotein of Nipah Virus", Tenth International Conference on Intelligent Computing and Information Systems (ICICIS), vol. 1, issue 1, pp. 473-479, 2021.
Osman, A. M., and H. M. A. El-Din, "In-Silico Screening of Potential Anti-Glycoprotein of Nipah Virus", Tenth International Conference on Intelligent Computing and Information Systems (ICICIS), vol. 1, issue 1, pp. 473-479, 2021.
Depenbrock, S., S. Aly, J. Wenz, Deniece Williams, W. ElAshmawy, K. Clothier, H. Fritz, G. McArthur, M. Heller, and M. Chigerwe, "In-vitro antibiotic resistance phenotypes of respiratory and enteric bacterial isolates from weaned dairy heifers in California", PLOS ONE, vol. 16, issue 11, pp. e0260292, 2021. Abstractjournal.pone_.0260292.pdfWebsite

Antimicrobial drug (AMD) use for bovine respiratory disease (BRD) continues to be concerning for development of antimicrobial resistance (AMR) in respiratory and enteric bacteria of cattle. This study aimed to provide data regarding AMR in respiratory isolates, and identify relationships between respiratory and enteric AMD susceptibility, in weaned dairy heifers. A cross-sectional study was performed between June of 2019 and February 2020, on 6 calf rearing facilities in California. Deep nasopharyngeal and rectal swabs were collected from 341 weaned heifers and submitted for selective bacterial culture and AMR testing. Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni were selectively isolated from respiratory samples; Escherichia coli and Enterococcus spp. were selectively isolated from rectal swabs. Minimum inhibitory concentrations (MIC) were determined for selected isolates against 19 AMD. The proportion of resistant isolates was calculated using Clinical Laboratory Standards Institute (respiratory) or USDA NARMS (enteric) breakpoints; when no applicable breakpoint was available, the distribution of MIC was described and compared. Association between AMR in a calf's respiratory isolate and a higher or lower MIC of the matched enteric isolates was determined. More than 50% of P. multocida isolates were resistant to each of 7 AMD commonly used to treat BRD (florfenicol, gamithromycin, tildipirosin, tilmicosin, danofloxacin, enrofloxacin and tetracycline). Resistance in respiratory isolates was only associated with higher matched enteric MIC for gamithromycin and tulathromycin. Multidrug resistance was reported in >70% of P. multocida and M. haemolytica isolates. Antimicrobial resistance, including multidrug resistance, in respiratory isolates appears to be widespread in weaned dairy heifers; this finding has not previously been reported and raises concern for the future efficacy of AMD used to treat respiratory diseases in weaned dairy heifers. Enteric bacterial MIC appear to have limited direct association with respiratory isolate AMR classification.

Sadek, K. M., W. Mamdouh, S. I. Habiba, M. Eldeftar, and N. A. A. Habib, "In-vitro Biological Evaluation of a Fabricated Polycaprolactone/Pomegranate Electrospun Scaffold for Bone Regeneration", ACS omega, vol. 6, pp. 34447−34459, 2021.
El-Beltagi, H. S., R. M. Romeilah, and E. A. Shalaby, "In-vitro evaluation of antioxidant and antiradical potential of successive extracts, semi-purified fractions and biosynthesized silver nanoparticles of Rumex vesicarius", Notulae Botanicae Horti Agrobotanici Cluj-Napoca, vol. 49, issue 1, pp. 12293, 2021.
Bakr, R. O., R. I. Amer, D. Attia, M. M. Abdelhafez, A. K. Al-Mokaddem, A. E. - N. G. El-Gendy, A. M. El-Fishawy, M. A. A. Fayed, and S. S. Gad, "In-vivo wound healing activity of a novel composite sponge loaded with mucilage and lipoidal matter of Hibiscus species", Biomedicine & Pharmacotherapy, vol. 135: Elsevier Masson, pp. 111225, 2021. Abstract
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Malak, N. M. L., K. M. A. Gehan, and A. N. Yassien, Incidence and control of Listeria monocytogenes in fishery products', , 2021.
Alzarah, M. I., A. A. Alaqil, A. O. Abbas, F. S. Nassar, G. M. K. Mehaisen, G. F. Gouda, H. K. Abd El-Atty, and E. S. Moustafa, "Inclusion of Citrullus colocynthis Seed Extract into Diets Induced a Hypolipidemic Effect and Improved Layer Performance", Agriculture, vol. 11, no. 9, 2021. AbstractWebsite

Citrullus colocynthis (CC) has been known as a natural medicinal plant with wide biological activities, including antioxidant, anti-inflammatory, and antilipidemic effects. The aim of this study was to investigate the effect of inclusion of the ethanolic extract of CC seeds (ECCs) into layer diets on the lipid profile, stress indicators, and physiological and productive performance of laying hens. A total of 216 forty-week-old commercial Hy-Line brown laying hens were randomly assigned into four equal groups (3 birds × 18 replicates per group) that received a basal diet supplemented with 0, 0.5, 1.0, and 2.0 g/kg of ECCs for 12 consecutive weeks. The first group served as a control. The results showed that ECCs at 1.0 and 2.0 g/kg significantly (p < 0.05) improved the productive and physiological performance compared to the other groups. In addition, stress indicators examined in the laying hens, including lipid peroxidation (malondialdehyde (MDA)), corticosterone hormone (CORT), tumor necrosis factor alpha (TNFα), and heat shock protein 70 (HSP70), were significantly alleviated after inclusion of ECCs into layer diets at the three levels compared to the control group. Furthermore, all ECC levels induced a significant reduction in plasma triglyceride (TG) and cholesterol (CH) levels in the plasma, liver, and egg yolk, whereas the highest levels were obtained with 2.0 g/kg of ECCs. Particularly important, a high linear correlation (R2 = 0.60–0.79) was observed between increasing doses of ECCs and MDA, liver CH, and egg yolk CH concentrations and egg weight, feed intake, and feed conversion ratio; moreover, the correlation was extremely high (R2 = 0.80–0.100) with the level of TG, CH, low-density lipoprotein CH, high-density lipoprotein CH, and CORT. These results indicated that dietary supplementation with 2.0 g/kg of ECCs could be considered a successful nutritional approach to producing healthier, lower-cholesterol eggs for consumers, in addition to enhancing the physiological and productive performance of laying hens by alleviating the stress of intensive commercial production.

Ehsan A. Yahia, A. E. - S. E., "Incorporating Innovative Nanotechnology Epilepsy Treating device in Nursing management of adult patients with epilepsy: COVID19 pandemic consideration", European Journal of Molecular and Clinical Medicine, vol. 8, issue 02: European Journal of Molecular and Clinical Medicine, pp. 625-637, 2021. Abstract
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Abaza, S. F., N. S. Elbialy, and N. Mohamed, "Incorporating silver nanoshell-coated mesoporous silica nanoparticles improves physicochemical and antimicrobial properties of chitosan films", International Journal of Biological Macromolecules, vol. 189, pp. 792-801, 2021.
Abaza, S. F., N. S. Elbialy, and N. Mohamed, "Incorporating silver nanoshell-coated mesoporous silica nanoparticles improves physicochemical and antimicrobial properties of chitosan films", International Journal of Biological Macromolecules, vol. 189, pp. 792-801, 2021.
Darweesh, S. K., N. Zayed, Mira Atef, E. Ramzy, A. Yousry, and S. Musa, "Increased liver stiffness by transient elastography and acoustic radiation force impulse imaging in patients with extrahepatic cholestasis.", European journal of gastroenterology & hepatology, vol. 33, issue 8, pp. 1097-1103, 2021. Abstract

BACKGROUND: Transient elastography and acoustic radiation force impulse (ARFI) imaging are noninvasive tools for liver stiffness measurement (LSM), which may be influenced by cholestasis.

AIM: The aim of the study was to evaluate the performance of transient elastography and ARFI in extrahepatic cholestasis and correlate changes in LSM with biochemical activity.

MATERIALS AND METHODS: A total of 38 patients with extrahepatic cholestasis prospectively underwent transient elastography and ARFI. Changes in LSM by transient elastography/ARFI were evaluated after 1 week of ERCP and correlated with biochemical parameters. The optimal ARFI cutoffs according to stages of clinical interest were analyzed.

RESULTS: Biliary obstruction was calcular in 21 (55.3%) and noncalcular in 17 (44.7%) (benign n = 15, malignant n = 2). After 1 week, adequate biliary drainage reduced total bilirubin from 7.7 to 2.2 mg/dL (P < 0.001) which significantly correlated with reduction of LSM by transient elastography from 12.38 ± 6.68 kPa to 8.08 ± 3.21 kPa (P < 0.001), and by ARFI from 1.73 ± 0.51 m/s to 1.56 ± 0.70 m/s (P = 0.014). The LSM percentage change showed a decrease (nonsignificant, P = 0.843) by 25.83% using transient elastography and a significant decrease (P < 0.001) by 18.42% using ARFI in the improved patients. At initial visit, transient elastography positively correlated with ARFI, bilirubin and platelets, also, transient elastography had a positive correlation with ARFI, bilirubin, alkaline phosphatase (ALP), γ-glutamyl transpeptidase (GGT) in follow-up visit. LSM by ARFI (visit 1) negatively correlated with ALT, while in (visit 2), ARFI positively correlated with bilirubin, ALP, GGT and negatively correlated with albumin.

CONCLUSION: The increased LSM in patients with extrahepatic cholestasis is reduced after adequate biliary drainage, implying that increased values are not solely due to liver fibrosis, but due to biliary congestion leading temporarily to increased elasticity.

Amer, M. A., R. Wasfi, A. S. Attia, and M. A. Ramadan, "Indole Derivatives Obtained from Egyptian sp. Soil Isolates Exhibit Antivirulence Activities against Uropathogenic .", Antibiotics (Basel, Switzerland), vol. 10, issue 4, pp. 363, 2021. Abstractantibiotics-10-00363-v3.pdf

is a frequent cause of catheter associated urinary tract infections (CAUTIs). Several virulence factors contribute to its pathogenesis, but swarming motility, biofilm formation, and urease activity are considered the hallmarks. The increased prevalence in antibiotic resistance among uropathogens is alarming and requires searching for new treatment alternatives. With this in mind, our study aims to investigate antivirulence activity of indole derivatives against multidrug resistant isolates. Ethyl acetate (EtOAc) extracts from sp. (rhizobacterium), isolated from Egyptian soil samples were tested for their ability to antagonize the virulence capacity and biofilm activity of uropathogens. Extracts of two sp. isolates (coded Zch127 and Cbg70) showed the highest antivirulence activities against . The two promising rhizobacteria Zch127 and Cbg70 were isolated from soil surrounding: (Zucchini) and (Cabbage), respectively. Sub-minimum inhibitory concentrations (Sub-MICs) of the two extracts showed potent antibiofilm activity with significant biofilm reduction of ten clinical isolates (-value < 0.05) in a dose-dependent manner. Interestingly, the Zch127 extract showed anti-urease, anti-swarming and anti-swimming activity against the tested strains. Indole derivatives identified represented key components of indole pyruvate, indole acetamide pathways; involved in the synthesis of indole acetic acid. Additional compounds for indole acetonitrile pathway were detected in the Zch127 extract which showed higher antivirulence activity. Accordingly, the findings of the current study model the feasibility of using these extracts as promising antivirulence agent against the uropathogens and as potential therapy for treatment of urinary tract infections (UTIs).