Publications

Export 111479 results:
Sort by: Author Title Type [ Year  (Asc)]
2021
Benc, M., F. Strejcek, M. Morovic, A. Bartkova, M. Murin, A. Gad, A. Bonnet-Garnier, F. P. Percinic, and J. Laurincik, "Improving the Quality of Oocytes with the Help of Nucleolotransfer Therapy", Pharmaceuticals, vol. 14, no. 4, 2021. AbstractWebsite

The nucleolus is an important nucleus sub-organelle found in almost all eukaryotic cells. On the one hand, it is known as a differentiated active site of ribosome biogenesis in somatic cells, but on the other hand, in fully grown oocytes, zygotes, and early embryos (up to the major embryonic genome activation), it is in the form of a particular homogenous and compact structure called a fibrillar sphere. Nowadays, thanks to recent studies, we know many important functions of this, no doubt, interesting membraneless nucleus sub-organelle involved in oocyte maturation, embryonic genome activation, rRNA synthesis, etc. However, many questions are still unexplained and remain a mystery. Our aim is to create a comprehensive overview of the recent knowledge on the fibrillar sphere and envision how this knowledge could be utilized in further research in the field of biotechnology and nucleolotransfer therapy.

Ahmed, M. I., A. Elshorbagy, A. Pietroniro, and D. Princz, "Improving the representation of the non-contributing area dynamics in land surface models for better simulation of prairie hydrology", Journal of Hydrology, vol. 600: Elsevier, pp. 126562, 2021. Abstract
n/a
Elghazouli, A. Y., D. V. Bompa, S. A. Mourad, and A. Elyamani, "In plane lateral cyclic behaviour of lime mortar and clay brick masonry walls in dry and wet conditions", Bulletin of Earthquake Engineering, issue Article 1170, 2021.
Ahmed, M. I., and others, In Pursuit of Improving Peak Flow Prediction in the Canadian Prairies, : University of Saskatchewan, 2021. Abstract
n/a
Abdel-Moneim, M. A., "In search of a school façade: Explaining the centrality of private tutoring among high-performing students in Egypt", International Journal of Educational Development, vol. 83, 2021.
Khater, I., and A. Nassar, "In Silico Molecular Docking Analysis for Repurposing Approved Antiviral Drugs against SARS-CoV-2 Main Protease", Biochemistry and Biophysics Reports, vol. 27: Elsevier, pp. 101032, 2021. Abstract
n/a
Khater, I., and A. Nassar, "In silico molecular docking analysis for repurposing approved antiviral drugs against SARS-CoV-2 main protease.", Biochemistry and biophysics reports, vol. 27, pp. 101032, 2021. Abstract

Developing a safe and effective antiviral treatment takes a decade, however, when it comes to the coronavirus disease (COVID-19), time is a sensitive matter to slow the spread of the pandemic. Screening approved antiviral drugs against COVID-19 would speed the process of finding therapeutic treatment. The current study examines commercially approved drugs to repurpose them against COVID-19 virus main protease using structure-based in-silico screening. The main protease of the coronavirus is essential in the viral replication and is involved in polyprotein cleavage and immune regulation, making it an effective target when developing the treatment. A Number of approved antiviral drugs were tested against COVID-19 virus using molecular docking analysis by calculating the free natural affinity of the binding ligand to the active site pocket and the catalytic residues without forcing the docking of the ligand to active site. COVID-19 virus protease solved structure (PDB ID: 6LU7) is targeted by repurposed drugs. The molecular docking analysis results have shown that the binding of Remdesivir and Mycophenolic acid acyl glucuronide with the protein drug target has optimal binding features supporting that Remdesivir and Mycophenolic acid acyl glucuronide can be used as potential anti-viral treatment against COVID-19 disease.

Khater, I., and A. Nassar, "In Silico Study of Six FDA Approved Anti-HCV Drugs as Inhibitors for NS5 Methyltransferase of Dengue Virus Type 2 ", Journal of Vector-Borne Diseases, vol. 58, issue 1, 2021.
Haider, M., I. Elsayed, I. S. Ahmed, and A. R. Fares, "In Situ - Forming Microparticles for Controlled Release of Rivastigmine: In Vitro Optimization and In Vivo Evaluation", Pharmaceuticals, vol. 14, issue 1, pp. 1 - 21, 2021.
Abdelrahim, A.M., M. G. Abd El-Moghny, and M. S. El-Deab, "In situ generation of exfoliated graphene layers on recycled graphite rods for enhanced capacitive performance of Ni–Co binary hydroxide", RSC Advances, , vol. 11, issue 42, pp. 26258–26272, 2021.
Abdelrahim, A. M., A. M. G. El-Moghny, and M. S. El-Deab, "In situ generation of exfoliated graphene layers on recycled graphite rods for enhanced capacitive performance of Ni–Co binary hydroxide", RSC Advances, vol. 42, issue 11, pp. 26258-26272, 2021.
Safwat, N., A. M. Mahmoud, M. F. Abdel-Ghany, and M. F. Ayad, "In situ monitoring of triclosan in environmental water with subnanomolar detection limits using eco-friendly electrochemical sensors modified with cyclodextrins.", Environmental science. Processes & impacts, vol. 23, issue 3, pp. 457-466, 2021. Abstract

The environmental emergence of unexpected contaminants has gained the attention of the scientific community. A broad spectrum antimicrobial compound named triclosan (TCS) was detected in the environment as an emerging contaminant. Owing to its inherent toxicity, we have proposed eco-friendly potentiometric liquid state sensors to be used for monitoring and quantifying TCS in environmental water samples. The proposed sensors have been optimized by modifying the inner filling solution using hydrophilic 2-hydroxypropyl β-cyclodextrin as a complexing agent to be capable of minimizing the trans-membrane ion flux and hence improving the selective and sensitive determination of TCS in environmental matrices with low LOD values. The obtained linear response of the optimized sensor was (1 × 10 to 1 × 10 M) compared to the control sensor (1 × 10 to 1 × 10 M). The obtained limit of detection (LOD) value was found to be 9.86 × 10 M compared to 9.78 × 10 M of the control sensor. The modification of the inner filling solution of the sensor with 2-hydroxypropyl β-cyclodextrin improves not only its sensitivity but also its response time to be only 5 seconds. The electrical performance of the proposed sensor was evaluated following IUPAC recommendations. Both the pH and temperature effects were studied and optimized. Two different greenness assessment tools, Analytical Eco-scale and Green Procedure Index, were adopted upon the evaluation of the proposed sensors' greenness.

Mostafa, A. A., A. A. Mahmoud, M. A. A. Hamid, M. Basha, M. S. El-Okaily, A. F. A. Abdelkhalek, M. I. El-Anwar, S. El Moshy, A. Gibaly, and E. A. Hassan, "An in vitro / in vivo release test of risedronate drug loaded nano-bioactive glass composite scaffolds", International Journal of Pharmaceutics, vol. 607, 2021. AbstractWebsite
n/a
Mostafa, A. A., A. A. Mahmoud, M. A. A. Hamid, M. Basha, M. S. El-Okaily, A. F. A. Abdelkhalek, M. I. El-Anwar, S. El Moshy, A. Gibaly, and E. A. Hassan, "An in vitro / in vivo release test of risedronate drug loaded nano-bioactive glass composite scaffolds", International Journal of Pharmaceutics, vol. 607, 2021. AbstractWebsite
n/a
Mostafa, A. A., A. A. Mahmoud, M. A. A. Hamid, M. Basha, M. S. El-Okaily, A. A. Abdelkhalek, M. I. El-Anwar, S. El Moshy, A. Gibaly, and E. A. Hassan, "An in vitro / in vivo release test of risedronate drug loaded nano-bioactive glass composite scaffolds", International Journal of Pharmaceutics, vol. 607, pp. 120989, 2021. AbstractWebsite

Three-dimensional (3D) matrices scaffolds play a noteworthy role in promoting cell generation and propagation. In this study, scaffolds prepared from chitosan/polyvinyl alcohol loaded with/without an osteoporotic drug (risedronate) and nano-bioactive glass (nBG) have been developed to promote healing of bone defects. The scaffolds were characterized by scanning electron microscopy (SEM), porosity test as well as mechanical strength. The pattern of drug release and ability to promote the proliferation of Saos-2osteosarcoma cells had also been reported. Osteogenic potential of the scaffolds was evaluated by testing their effect on healing critical-sized dog's mandibular bone defects. Increasing chitosan and nBG in the porous scaffolds induced decrease in drug release, increased the scaffold's strength and supported their cell proliferation, alkaline phosphatase (ALP) activities, as well as increased calcium deposition. Histological and histomorphometric results demonstrated newly formed bone trabeculae inside critical-sized mandibular defects when treated with scaffolds. Trabecular thickness, bone volume/tissue volume and the percentage of mature collagen fibers increased in groups treated with scaffolds loaded with 10% nBG and risedronate or loaded with 30% nBG with/without risedronate compared with those treated with non-loaded scaffolds and empty control groups. These findings confirmed the potential osteogenic activity of chitosan/polyvinyl alcohol-based scaffolds loaded with risedronate and nBG.

El-Ghany, A., Abdel-Shafy, H., M. M, El-Khateeb, R.M., E, A. M. M. Hammam, and Fahmy, "In vitro acaricidal activity of green synthesized nickel oxide nanoparticles against the camel tick, Hyalomma dromedarii (Ixodidae), and its toxicity on Swiss albino mice", Experimental and Applied Acarology,, pp. 1-23, 2021.
Abdel-Ghany, H. S., S. Abdel-Shafy, M. M. Abuowarda, R. M. El-Khateeb, Hoballah, E., A. M. M. Hammam, and M. M. Fahmy, "In vitro acaricidal activity of green synthesized nickel oxide nanoparticles against the camel tick, Hyalomma dromedarii (Ixodidae), and its toxicity on Swiss albino mice.", Experimental and Applied Acarology, vol. 83, issue 4, pp. 611-633, 2021.
Essam, S., N. N. Nawar, M. ElBashaar, M. Soliman, and M. Abdelfattah, "In Vitro Activity of Plazomicin among Carbapenem-resistant Enterobacteriaceae", Open Access Macedonian Journal of Medical Sciences., vol. 9, 2021.
Kadry, G. M., M. A. M. Ismail, N. M. El-Sayed, H. S. El-Kholy, and D. M. H. El-Akkad, "In vitro amoebicidal effect of Aloe vera ethanol extract and honey against Acanthamoeba spp. cysts", Journal of Parasitic Diseases, vol. 45, issue 1, pp. 159-168, 2021. Abstract

This study evaluated in vitro effect of different concentrations of Aloe vera (A. vera) ethanol extract and honey against Acanthamoeba spp. cysts in comparison with chlorhexidine (the drug of choice for treatment of Acanthamoeba infection) at different incubation periods. Four different concentrations of the tested agents were used, 100, 200, 400, and 600 μg/ml for A. vera ethanol extract and 25, 50, 100, and 200 μg/ml for honey. Isolated Acanthamoeba spp. cysts from keratitis patients were incubated with different concentrations of the tested agents as well as chlorhexidine 0.02% (drug control) for different incubation periods (24, 48, 72 h). After each incubation period, the effect of A. vera extract and honey against Acanthamoeba cysts was assessed by counting the number of viable cysts, determining the inhibitory percentage and detecting the morphological alternations of treated cysts compared to non-treated and drug controls. Both A. vera ethanol extract and honey showed a concentration and time-dependent effect on the viability of Acanthamoeba cysts. In comparison with chlorhexidine (the drug control), A. vera ethanol extract possessed a potent cysticidal activity at all tested concentrations throughout different incubation periods, except for concentration 100 μg/ml which recorded the lower inhibitory effect. With increasing the dose of A. vera ethanol extract to 200, 400, 600 µg/ml, the recorded inhibitory percentages of Acanthamoeba cysts viability were 82.3%, 92.9% and 97.9% respectively, after 72 h compared to 76.3% of chlorhexidine. Similarly, honey at concentrations of 50–100 µg/ml gave higher inhibitory effect of 59% and 76.7%, respectively compared to chlorhexidine which showed an inhibitory percentage of 55.7% after 24 h. Meanwhile, the lowest tested concentration of honey (25 µg/ml) gave an inhibitory effect by 47.7–67% which was less than that of chlorhexidine throughout different incubation periods. With increasing the dose of honey to 200 µg/ml, the inhibitory effect was 98.9% after 72 h higher than that of chlorhexidine (76.9%). Using a scanning electron microscope, Acanthamoeba cysts treated by A. vera ethanol extract showed alternations in their shapes with flattening, collapsing, and laceration of their walls. Also, treated cysts by honey were highly distorted and difficult to identify because most of them were shrinkage and collapsed to a tiny size. On the other hand, chlorhexidine showed less structural and morphological changes of Acanthamoeba cysts. A. vera ethanol extract and honey had considerable cysticidal effects on Acanthamoeba cysts. They may give promising results for treatment of Acanthamoeba keratitis.

Kim, N., M. Mannaa, J. Kim, J. - E. Ra, S. - M. Kim, C. Lee, H. - H. Lee, and Y. - S. Seo, "The in vitro and in planta interspecies interactions among rice-pathogenic Burkholderia species", Plant Disease, vol. 105, issue 1: The American Phytopathological Society, pp. 134-143, 2021. Abstract
n/a
Farid, A., A. Tawfik, B. Elsioufy, and G. Safwat, "In vitro and in vivo anti-Cryptosporidium and anti-inflammatory effects of Aloe vera gel in dexamethasone immunosuppressed mice", International Journal for Parasitology: Drugs and Drug Resistance , vol. 17, pp. 156-167, 2021.
Salama, M. M. Abd El-Ghani, sayed, Abeed, Amany, A. Kotp, and D. Abd El-Wahab, "In vitro anticancer and antioxidant potency of leaves extract of Ochradenus baccatus Delile. ", Bioscience Research, vol. 18, issue 1, pp. 77-89., 2021.
Elsayed, N., H. S. El-Din, A. B. Altemimi, H. Y. Ahmed, A. Pratap-Singh, and T. G. Abedelmaksoud, "In Vitro Antimicrobial, Antioxidant and Anticancer Activities of Egyptian Citrus Beebread", Molecules, vol. 26, issue 9, pp. 2433, 2021.
Fadl, F. A., N. A. A. Aita, M. A. Abdelaziz, and A. H. Mohamed, "In vitro Assessment of Antimicrobial Activity of Zinc Oxide Nanoparticles against Pathogenic Streptococcus parauberis", Advances in Animal and Veterinary Sciences, vol. 9, issue 6, pp. 913-918, 2021.