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2021
Aboulhoda, B. E., L. A. Rashed, H. A. Ahmed, Eman MM Obaya, W. Ibrahim, Marwa AL Alkafass, Sarah A Abd El‐Aal, and A. M. Shams Eldeen, "Hydrogen sulfide and mesenchymal stem cells‐extracted microvesicles attenuate LPS‐induced Alzheimer's disease", Journal of Cellular Physiology, vol. 236, issue 8, pp. 5994-6010, 2021.
El-Ghamrawy, M., A. Abdel-Motelib, A. Fikry, and H. Abu Salem, "Hydrogeological Characteristics of the North Eastern Part of El Farafra Oasis, Western Desert, Egypt.", Egyptian Journal of Geology, vol. 65, issue 1, pp. 13-26, 2021.
Al Badr, M., M. El Kammar, M. Yehia, A. El-Kammar, and H. Abu Salem, "Hydrogeological characteristics of the Quaternary aquifer in Beni Suef area, Egypt. ", Egyptian Journal of Geology, vol. 65, issue 1, pp. 73-89, 2021.
Warda, A. E. A., M. Tammam, R. M. S. Rabab Ahmed Elgazzar, and S. Gaber, "Hydroxychloroquine and Azithromycin Combination in The Management of COVID-19 Infection: Safety and Effectiveness Challenges", Curr Drug Saf. 2021., vol. 7, issue Kjuly2021, pp. 9, 2021.
Warda, A. E. A., M. Tammam, R. M. S. Rabab Ahmed Elgazzar, and S. Gaber, "Hydroxychloroquine and Azithromycin Combination in The Management of COVID-19 Infection: Safety and Effectiveness Challenges", Curr Drug Saf. 2021., vol. 7, issue Kjuly2021, pp. 9, 2021.
Hussein, H., and R. Brown, "Hydroxychloroquine and the treatment of Sjogren syndrome, chronic ulcerative stomatitis, and oral lichen planus in the age of COVID-19.", Oral surgery, oral medicine, oral pathology and oral radiology, vol. 131, issue 1, pp. e9-e13, 2021. Abstractarticle_in_journal.pdf

The Food and Drug Administration has recently approved the off-label use of hydroxychloroquine (HCQ) for the treatment of coronavirus disease 2019 (COVID-19) infections. However, a recent study not only failed to demonstrate HCQ efficacy but also documented a serious side effect of COVID-19 therapy with HCQ: QT prolongation and secondary arrhythmia. HCQ has been used as an off-label drug and deemed safe and effective for the treatment of oral lesions, such as Sjogren syndrome (SS), chronic ulcerative stomatitis (CUS), and oral lichen planus (OLP). Because HCQ may be appropriately used for the off-label treatment of SS, CUS, and OLP, relevant safety concerns regarding HCQ therapy with regard to dosage, drug-to-drug interactions, and QT prolongation and secondary arrhythmia are discussed here. Because of the possibility of decreased pharmacy supplies of HCQ, replacement drugs with respect to patients with SS, CUS, and OLP being successfully treated with HCQ are also discussed.

Hassan, R. R. A., a Salwa Moustafa Amer Mahmoud, M. A. Nessem, and R. T. A. Aty, "Hydroxypropyl Cellulose Loaded with ZnO Nanoparticles for Enhancing the Mechanical Properties of Papyrus (Cyperus papyrus L.) ", Bioresources, ., vol. 16, issue (2), pp. 2607- 2625., 2021.
Abd-Elhameed, W. M., J. A. Tenreiro Machado, and Y. H. Youssri, "Hypergeometric fractional derivatives formula of shifted Chebyshev polynomials: Tau algorithm for a type of fractional delay differential equations", International Journal of Nonlinear Sciences and Numerical Simulation, 2021. AbstractWebsite
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Elsharkawy, S. H., and F. A. Torad, "Hypertensive Cardiomyopathy as a Sequel to Hydronephrosis Induced by Transitional Cell Carcinoma.", Topics in companion animal medicine, vol. 45, pp. 100585, 2021. Abstract

A 10-year-old female Griffon dog was presented for evaluation due to a 5-month history of hematuria and systemic hypertension. Thoracic auscultation detected a grade II/VI left apical systolic murmur. Abdominal ultrasound revealed the presence of a heterogeneous mass at the trigonal area of the urinary bladder, extending to the left ureter cranially and caudally toward the bladder's neck. Marked left hydronephrosis and hydroureter were detected as well as mild right hydronephrosis. Cytological examination of urine sediment confirmed the presence of transitional cell carcinoma. Echocardiography disclosed marked left ventricular concentric hypertrophy, which likely developed as a consequence of systemic hypertension induced by the bilateral hydronephrosis due to bladder transitional cell carcinoma.

Elbendary, A., M. R. E. Abdel-Halim, R. Youssef, D. abd el halim, M. F. Elmasry, A. A. Gad, and D. A. El Sharkawy, "Hypopigmented lesions in pityriasis lichenoides chronica patients: Are they only post-inflammatory hypopigmentation?", The Australasian journal of dermatology, 2021. Abstract

BACKGROUND/OBJECTIVES: Pityriasis lichenoides chronica (PLC) lesions are reported to subside with post-inflammatory hypopigmentation (PIH); hence, the most widely perceived nature of hypopigmented macules in PLC is PIH. However, to the best of our knowledge, no studies describing histopathological findings in these lesions are reported in literature. The aim of this study is to evaluate the hypopigmented lesions encountered in PLC patients and to shed light on their histopathological features.

METHODS: A cross-sectional observational study included twenty-one patients with PLC recruited in a period of twelve months. Clinical characteristics of each patient were collected. A skin biopsy from hypopigmented lesions whenever present was taken and assessed with routine haematoxylin and eosin stain.

RESULTS: Seventeen patients (81%) were less than 13 years old. Most patients (85.7%) demonstrated diffuse distribution of lesions. Hypopigmented lesions were present on the face in 12 (57.14%) patients. Histopathologically, hypopigmented lesions showed features of post-inflammatory hypopigmentation in 19% of patients, residual PLC in 52.4% and active PLC 28.6% of patients.

CONCLUSION: Hypopigmented lesions in PLC were noted mainly in younger ages, histopathologically they may show features of active or residual disease, beyond post-inflammatory hypopigmentation. Consequently active treatment for patients presenting predominantly with hypopigmented lesions could be required to control the disease.

Mahantshetty, U., R. Poetter, S. Beriwal, S. Grover, G. Lavanya, B. Rai, P. Petric, K. Tanderup, H. Carvalho, N. Hegazy, et al., "IBS-GEC ESTRO-ABS recommendations for CT based contouring in image guided adaptive brachytherapy for cervical cancer.", Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, vol. 160, pp. 273-284, 2021. Abstract

MR Imaging is regarded asthe gold standardfor Image Gudied Adaptive Brachytherapy (IGABT) for cervical cancer. However, its wide applicability is limited by its availability, logistics and financial implications. Use of alternative imaging like CTand Ultrasound (US) for IGABT has been attempted. In order to arrive at a systematic, uniform and international approach for CT based definition and contouring of target structures, GEC ESTRO, IBS and ABS agreed to jointly develop such recommendations based on the concepts and terms as published in the ICRU Report 89. The minimum requirements are clinical examination & documentation, CT or MR imaging at diagnosis and at a minimum, CT imaging with the applicator in place. The recommendations are based on (i) assessment of the GTV at diagnosis and at brachytherapy, (ii) categorizing the response to external radiation into different clinical remission patterns, (iii) defining various clinico-radiological environments and (iv) definition & delineation of a target on CT imaging at the time of brachytherapy with the applicator in situ. CT based target contouring recommendations based on 4 remission categories within 8 defined environments, aim at improving the contouring accuracy for IGABT using CT, US and MRI as available. For each clinico-radiological environment, there is an attempt to minimize the specific uncertainties in order to arrive at the best possible contouring accuracy. Evaluating feasibility & reproducibility, to achieve a benchmark towards a gold standard MR IGABT and further clinical research including outcomes with CT Based IGABT will become the next steps.

Mankoula, A. F., W. Tawfik, J. E. Gagnon, B. J. Fryer, F. El-Mekawy, and M. E. Shaheen, "ICMMS-2: Assessment of Heavy Metals Content in The Agricultural Soils of Kafr El-Zayat Egypt Using Laser Ablation Inductively Coupled Plasma Mass Spectrometry and Inductively Coupled Plasma Optical Emission Spectroscopy", Egyptian Journal of Chemistry, vol. 64, no. 3: National Information and Documentation Centre (NIDOC), Academy of Scientific …, pp. 7–8, 2021. Abstract
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Mankoula, A. F., W. Tawfik, J. E. Gagnon, B. J. Fryer, F. El-Mekawy, and M. E. Shaheen, "ICMMS-2: Assessment of Heavy Metals Content in The Agricultural Soils of Kafr El-Zayat Egypt Using Laser Ablation Inductively Coupled Plasma Mass Spectrometry and Inductively Coupled Plasma Optical Emission Spectroscopy", Egyptian Journal of Chemistry, vol. 64, issue 3: National Information and Documentation Centre (NIDOC), Academy of Scientific …, pp. 7-8, 2021. Abstract
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Salem, M. A., A. Serag, H. E. R. Seedi, D. I. Hemdan, S. M. Ezzat, and A. Zayed, "Identification and analysis of toxic phytochemicals", Phytochemistry, the Military and Health: Elsevier, 2021.
Salem, M. A., A. Serag, H. E. R. Seedi, D. I. Hemdan, S. M. Ezzat, and A. Zayed, "Identification and analysis of toxic phytochemicals", Phytochemistry, the Military and Health: Elsevier, 2021.
Li, J., M. Haque, C. Shang, B. Hassan, D. Liu, W. Chen, and R. Lai, "Identification and Characterization of Cancer Stem-Like Cells in ALK-Positive Anaplastic Large Cell Lymphoma Using the SORE6 Reporter.", Current issues in molecular biology, vol. 43, issue 2, pp. 543-557, 2021. Abstract

Transcription factors Sox2 and Oct4 are essential in maintaining the pluripotency of embryonic stem cells and conferring stemness in cancer stem-like (CSL) cells. SORE6, an in-vitro reporter system, was designed to quantify the transcription activity of Sox2/Oct4 and identify CSL cells in non-hematologic cancers. Using SORE6, we identified and enriched CSL cells in ALK-positive anaplastic large cell lymphoma (ALK + ALCL). Two ALK + ALCL cell lines, SupM2 and UCONN-L2, contained approximately 20% of SORE6+ cells, which were purified based on their expression of green fluorescent protein. We then performed functional studies using single-cell clones derived from SORE6- and SORE6+ cells. Compared to SORE6- cells, SORE6+ cells were significantly more chemoresistant and clonogenic in colony-formation assays. Sox2/Oct4 are directly involved in conferring these CSL properties, since the shRNA knockdown of Sox2 in SORE6+ significantly lowered their chemoresistance, while enforced expression of Sox2/Oct4 in SORE6- cells produced opposite effects. Using Western blots, we found that the expression and subcellular localization of Sox2/Oct4 were similar between SORE6- and SORE6+ cells. However, in SORE6+ but not SORE6- cells, Sox2 and Oct4 abundantly bound to a probe containing the SORE6 consensus sequence. c-Myc, previously shown to regulate cancer stemness in ALK + ALCL, regulated the SORE6 activity. In conclusion, SORE6 is useful in identifying/enriching CSL cells in ALK + ALCL.

AlZalaty, M., A. A. Hamed, and A. Maghraby, "IDENTIFICATION AND CHARACTERIZATION OF HEAT SHOCK PROTEIN (HSP) GENES IN Gossypium barbadense", Plant Cell Biotechnology and Molecular Biology, vol. 22(3&4), pp. 65- 76, 2021.
Mohamed, O. G., S. Dorandish, R. Lindow, M. Steltz, I. Shoukat, M. Shoukat, H. Chehade, S. Baghdadi, M. McAlister-Raeburn, A. Kamal, et al., "Identification of a New Antimicrobial, Desertomycin H, Utilizing a Modified Crowded Plate Technique", Marine Drugs, vol. 19, no. 8, 2021. AbstractWebsite

The antibiotic-resistant bacteria-associated infections are a major global healthcare threat. New classes of antimicrobial compounds are urgently needed as the frequency of infections caused by multidrug-resistant microbes continues to rise. Recent metagenomic data have demonstrated that there is still biosynthetic potential encoded in but transcriptionally silent in cultivatable bacterial genomes. However, the culture conditions required to identify and express silent biosynthetic gene clusters that yield natural products with antimicrobial activity are largely unknown. Here, we describe a new antibiotic discovery scheme, dubbed the modified crowded plate technique (mCPT), that utilizes complex microbial interactions to elicit antimicrobial production from otherwise silent biosynthetic gene clusters. Using the mCPT as part of the antibiotic crowdsourcing educational program Tiny EarthTM, we isolated over 1400 antibiotic-producing microbes, including 62 showing activity against multidrug-resistant pathogens. The natural product extracts generated from six microbial isolates showed potent activity against vancomycin-intermediate resistant Staphylococcus aureus. We utilized a targeted approach that coupled mass spectrometry data with bioactivity, yielding a new macrolactone class of metabolite, desertomycin H. In this study, we successfully demonstrate a concept that significantly increased our ability to quickly and efficiently identify microbes capable of the silent antibiotic production.

Mohamed, O. G., S. Dorandish, R. Lindow, M. Steltz, I. Shoukat, M. Shoukat, H. Chehade, S. Baghdadi, M. McAlister-Raeburn, and A. Kamal, "Identification of a New Antimicrobial, Desertomycin H, Utilizing a Modified Crowded Plate Technique", Marine drugs, vol. 19, issue 8: Multidisciplinary Digital Publishing Institute, pp. 424, 2021. Abstract
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Saadah, O. I., B. Banaganapalli, N. M. Kamal, A. N. Sahly, H. A. Alsufyani, A. Mohammed, A. Ahmad, K. K. Nasser, J. Y. Al-Aama, N. A. Shaik, et al., "Identification of a Rare Exon 19 Skipping Mutation in ALMS1 Gene in Alström Syndrome Patients From Two Unrelated Saudi Families", Frontiers in pediatrics, vol. 9, pp. 652011, 2021. Abstractalstrom_2.pdf

Alström syndrome (AS) is a very rare childhood disorder characterized by cardiomyopathy, progressive hearing loss and blindness. Inherited genetic variants of ALMS1 gene are the known molecular cause of this disease. The objective of this study was to characterize the genetic basis and understand the genotype-phenotype relationship in Saudi AS patients. Clinical phenotyping and whole-exome sequencing (WES) analysis were performed on six AS patients belonging to two unrelated consanguineous Saudi families. Sanger sequencing was performed to determine the mode of inheritance of ALMS1 variant in first-degree family relatives and also to ensure its rare prevalence in 100 healthy population controls. We identified that Alström patients from both the families were sharing a very rare ALMS1, 3'-splice site acceptor (c.11873-2 A>T) variant, which skips entire exon-19 and shortens the protein by 80 amino acids. This disease variant was inherited by AS patients in autosomal recessive mode and is not yet reported in any population-specific genetic databases. AS patients carrying this mutation showed heterogeneity in clinical presentations. Computational analysis of the mutant centroid structure of ALMS1 mRNA revealed that exon-19 skipping enlarges the hairpin loop and decreases the free energy, eventually affecting its folding pattern, stability, and function. Hence, we propose c.11873-2A as an AS causative potential founder mutation in Saudi Arabia because it is found in two families lacking a common lineage. We conclude that WES analysis potentially helps in clinical phenotyping, early diagnosis, and better clinical management of Alström patients showing variable clinical expressivity.

Elkadi, O. A., R. Hassan, M. El anany, H. J. Byrne, and M. A. Ramadan, "Identification of Aspergillus species in human blood plasma by infrared spectroscopy and machine learning.", Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, vol. 248, pp. 119259, 2021. Abstract

Invasive Aspergillosis is a challenging infection that requires convenient, efficient, and cost-effective diagnostics. This study addresses the potential of infrared spectroscopy to satisfy this clinical need with the aid of machine learning. Two models, based on Partial Least Squares-Discriminant Analysis (PLS-DA), have been trained by a set of infrared spectral data of 9 Aspergillus-spiked and 7 Aspergillus-free plasma samples, and a set of 200 spectral data simulated by oversampling these 16 samples. Two further models have also been trained by the same sets but with auto-scaling performed prior to PLS-DA. These models were assessed using 45 mock samples, simulating the challenging samples of patients at risk of Invasive Aspergillosis, including the presence of drugs (9 tested) and other common pathogens (5 tested) as potential confounders. The simple model shows good prediction performance, yielding a total accuracy of 84.4%, while oversampling and autoscaling improved this accuracy to 93.3%. The results of this study have shown that infrared spectroscopy can identify Aspergillus species in blood plasma even in presence of potential confounders commonly present in blood of patients at risk of Invasive Aspergillosis.

Hussein, R. F., S. M. E. Mahdy, N. M. Saged, L. Rashed, and S. S. Ghaleb, "Identification of body fluids—menstrual blood, saliva, and nasal secretions—over different periods of time, using mRNA", Egyptian Journal of Forensic Sciences , vol. 11, issue 42, pp. 1-6, 2021.
López-Medina, C., S. Chevret, A. Molto, J. Sieper, T. Duruöz, U. Kiltz, B. E. Zorkany, N. Hajjaj-Hassouni, R. Burgos-Vargas, J. Maldonado-Cocco, et al., "Identification of clinical phenotypes of peripheral involvement in patients with spondyloarthritis, including psoriatic arthritis: a cluster analysis in the worldwide ASAS-PerSpA study", Rheumatic & Musculoskeletal Disease (RMD), vol. 7 , issue 3, pp. 1 - 12, 2021.
Abbas, M. S., A. M. Dobeie, C. R. Azzam, and A. S. Soliman, "Identification of Salt Tolerant Genotypes Among Egyptian and Nigerian Peanut (Arachis hypogaea L.) Using Biochemical and Molecular Tools", Mitigating Environmental Stresses for Agricultural Sustainability in Egypt, Switzerland, Springer, 2021. 2021_book_mitigatingenvironmentalstresse.pdf
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