Publications

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2023
Halim, P. A., S. M. Z. Sharkawi, and M. B. Labib, "Novel pyrazole-based COX-2 inhibitors as potential anticancer agents: Design, synthesis, cytotoxic effect against resistant cancer cells, cell cycle arrest, apoptosis induction and dual EGFR/Topo-1 inhibition", Bioorganic Chemistry, vol. 131, pp. 106273, 2023.
2022
Halim, P. A., H. B. El-Nassan, and Y. S. El-Dash, "Design and Synthesis of Novel Ibuprofen Derivatives as Selective COX-2 Inhibitors and Potential Anti-Inflammatory Agents: Evaluation of PGE2, TNF-α, IL-6 and Histopathological Study", Medicinal Chemistry, vol. 18, pp. 427-443, 2022.
application/pdf iconmedicinal_chemistry_2022.pdf
2021
Halim, P. A., H. H. Georgey, M. Y. George, A. E. M. Kerdawy, and M. F. Said, "Design and synthesis of novel 4-fluorobenzamide-based derivatives as promising anti-inflammatory and analgesic agents with an enhanced gastric tolerability and COX-inhibitory activity", Bioorganic Chemistry, vol. 115, pp. 105253, 2021.
2020
Labib, M. B., A. M. Fayez, E. L. - S. H. A. Y. M. A. A. EL-NAHASS, M. Awadallah, and P. A. Halim, "Novel tetrazole-based selective COX-2 inhibitors: Design, synthesis, anti-inflammatory activity, evaluation of PGE2, TNF-α, IL-6 and histopathological study", Bioorg. Chem., vol. 104, pp. 104308, 2020. bioorganic_cox_paper.pdf
, "Uses of cyclohexane-1,3-dione for the synthesis of 1,2,4-triazine derivatives as anti-proliferative agents and tyrosine kinases inhibitors", Bioorg. Chem., vol. 97, pp. 103667, 2020.
2019
, "Synthesis, and anti-proliferative, Pim-1 kinase inhibitors and molecular docking of thiophenes derived from estrone", Bioorg. Chem., vol. 83, pp. 402-413, 2019.
2018
, "Uses of Anthranilic Acid for the Synthesis of Dihydroquinazolin Derivatives with Antitumor, Antiproliferative and Pim-1 kinase Activities", Acta. Chem. Slov., vol. 65, pp. 554-568, 2018.
2014
, SYNTHESIS OF CERTAIN FUSED THIENOPYRIDINE DERIVATIVES OF BIOLOGICAL INTEREST, , 2014. abstract.docx
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