@article {241140,
	title = {Potential Antigenic Candidates for the Development of Peptide-Based Vaccines to Induce Immunization against  Infection in BALB/c Mice.},
	journal = {International journal of molecular sciences},
	volume = {23},
	year = {2022},
	abstract = {<p> () has been identified as a group-1 definite carcinogen. As of yet, there is no available vaccine for this microorganism. Our study aimed to identify antigenic peptides in  using an in silico proteomic approach, and to evaluate their effectiveness as potential vaccine candidates. Four different peptide sequences were prioritized using the reverse vaccinology, namely, CagA, CagA, VacA, and SabA. Peptides emulsified with Freunde{\textquoteright}s adjuvant were used to immunize BALB/C mice. Subcutaneously immunized mice were challenged by oral administration of  IgG, IgA, IL4, and IL17 were detected in mice sera. Histopathology of the dissected stomach of vaccinated and control mice were assessed using H\&amp;E stain. IgG was significantly higher in mice vaccinated with SabA. IL-4 was significantly increased in CagA, CagA, VacA, and SabA vaccinated mice compared to the adjuvant group. Additionally, histopathological examination of gastric tissue showed a protective effect in the vaccinated groups compared to adjuvant and PBS groups. Our findings indicate a promising effect of the tested epitopes, particularly the SabA antigen, to induce an immune response against .</p>
},
	author = {AlEraky, Doaa M and Abuohashish, Hatem M and Bugshan, Amr S and Abdelsalam, Maha M and AlHawaj, Hussain A and AlKhamis, Taleb T and AlDossary, Fatimah A and Alrayes, Nabras M and Yasser M. Ragab and AbdelKhalek, Zeinab and OMNEYA M. HELMY and Ramadan, Mohammed A}
}
