Taha, A. M., M. M. Aboulwafa, H. Zedan, and O. M. N. E. Y. A. M. HELMY, "Ramucirumab combination with sorafenib enhances the inhibitory efect of sorafenib on HepG2 cancer cells", Scientific reports, vol. 12, pp. 1-16, 2022. s41598-022-21582-w.pdf
Hallol, M., O. Helmy, A. - E. Shawky, A. El-Batal, and M. R. O. A. - A. P. L. B. I. I. of by a paramycoides and on Chitosan, "Optimization of Alpha-Amylase Production by a Local Bacillus paramycoides Isolate and Immobilization on Chitosan-Loaded Barium Ferrite Nanoparticles", Fermentation, vol. 8, issue 5, 2022. fermentation-08-00241-v2.pdf
Hagras, S. A. A., A. E. - D. M. S. Hosny, O. M. N. E. Y. A. M. HELMY, M. M. Salem-Bekhit, F. Shakeel, and H. A. Farrag, "Effect of sub-inhibitory concentrations of cefepime on biofilm formation by Pseudomonas aeruginosa.", Canadian journal of microbiology, vol. 67, issue 12, pp. 894-901, 2021. Abstract

This study investigated the effect of cefepime at sub-minimum inhibitory concentrations (sub-MICs) on in vitro biofilm formation (BF) by clinical isolates of . The effect of cefepime at sub-MIC levels (½-/ MIC) on in vitro BF by six clinical isolates of was phenotypically assessed following 24 and 48 h of challenge using the tissue culture plate (TCP) assay. Quantitative real-time polymerase chain reaction (qRT-PCR) was employed to observe the change in expression of three biofilm-related genes, namely, a protease-encoding gene (), fimbrial protein-encoding gene (), and alginate-encoding gene (), in a weak biofilm-producing strain of following 24 and 48 h of challenge with sub-MICs of cefepime. The BF morphology in response to cefepime was imaged using scanning electron microscopy (SEM). The TCP assay showed strain-, time-, and concentration-dependent changes in in vitro BF in following challenge with sub-MICs of cefepime, with a profound increase in strains with inherently no or weak biofilm-producing ability. RT-PCR revealed time-dependent upregulation in the expression of the investigated genes following challenge with ½ and ¼ MIC levels, as confirmed by SEM. Cefepime at sub-MICs could upregulate the expression of BF-related genes and enhance BF by clinical isolates.

El-Korany, S. M., O. M. N. E. Y. A. M. HELMY, A. M. El-Halawany, Y. E. Ragab, and H. H. Zedan, "Kojic acid repurposing as a pancreatic lipase inhibitor and the optimization of its production from a local Aspergillus oryzae soil isolate", BMC Biotechnology, vol. 20, issue 52, pp. 1-16, 2020. s12896-020-00644-9.pdf
Ibrahim, K. A., O. M. N. E. Y. A. M. HELMY, M. O. N. A. T. KASHEF, T. R. Elkhamissy, and M. A. Ramadan, "Identification of Potential Drug Targets in Helicobacter pylori Using In Silico Subtractive Proteomics Approaches and Their Possible Inhibition through Drug Repurposing", Pathogens, vol. 9, issue 747, pp. 1-21, 2020.
Farrag, H. A., H. Alaa El-Dien M.S, A. M. Hawas, S. A. A. Hagras, and O. M. N. E. Y. A. M. HELMY, "Potential efficacy of garlic lock therapy in combating biofilm and catheter-associated infections; experimental studies on an animal model with focus on toxicological aspects", Saudi Pharmaceutical Journal, vol. 27, pp. 830-840, 2019.
Qadee, S. E., O. Helmy, T. Almorsy, and M. Ramadan, "MALDI-TOF MS BIOTYPER AND POLYMERASE CHAIN REACTION FOR RAPID IDENTIFICATION OF STAPHYLOCOCCUS AUREUS AND PSEUDOMONAS AERUGINOSA IN NON-STERILE PHARMACEUTICAL PREPARATIONS", International journal of Pharmaceutical sciences and research, vol. 9, issue 9, pp. 3656-3663, 2018. 8-vol.-9-issue-9-sep-2018-ijpsr-ra-9618_1.pdf
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