Publications

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2020
Elaskary, H. I., O. M. Sabry, A. M. Khalil, and S. E. M. Zalabani, "UPLC-PDA-ESI-MS/MS Profiling of Clerodendrum inerme and Clerodendrum splendens and Significant Activity Against Mycobacterium tuberculosis", Pharmacognosy Journal, vol. 12, issue (6, pp. 1518.-1524, 2020. clerodendrum_inerme.pdf
2019
M, S. O., E. G. M, H. S, L. S. J, J. L, and S. T, "A Novel Polyhalogenated Monoterpene Induces Cell Cycle Arrest and Apoptosis in Breast Cancer Cells", Marine Drugs, vol. 25;17, issue (8), pp. 1-16, 2019. a_novel_polyhalogenated.pdf
Sobeh, M., M. F. Mahmoud, S. Rezq, and O. M. Sabry, "Salix tetrasperma Roxb. Extract Alleviates Neuropathic Pain in Rats via Modulation of the NFκB/TNF-α/NOX/iNOS Pathway", Antioxidants, vol. 8, issue 10, pp. 482 - 496, 2019.
2018
2017
2016
Sabry, O. M. M., D. E. Goeger, F. A. Valeriote, and W. H. Gerwick, "Cytotoxic halogenated monoterpenes from Plocamium cartilagineum", Natural product research, vol. 31, issue 3 , pp. 261-267, 2016. cytotoxic_halogenated_monoterpenes_from_plocamium_cartilagineum.pdf
Sabry, O. M. M., A. M. E. Sayed, and S. K. Alshalmani, "GC/MS Analysis and Potential Cytotoxic Activity of Haplophyllum tuberculatum Essential Oils Against Lung and Liver Cancer Cells", Pharmacognosy Journal, vol. 8, issue 1, pp. 66-69, 2016.
2015
2014
Vogel, C. V., H. Pietraszkiewicz, O. M. Sabry, W. H. Gerwick, F. A. Valeriote, and C. D. Vanderwal, "Enantioselective divergent syntheses of several polyhalogenated Plocamium monoterpenes and evaluation of their selectivity for solid tumors.", Angewandte Chemie (International ed. in English), vol. 53, issue 45, pp. 12205-9, 2014 Nov 3. Abstract

The family of polyhalogenated monoterpenes from Plocamium counts over a hundred known members. Using glyceraldehyde acetonide as a chiral-pool precursor, an enantioselective and divergent strategy was developed that provides a blueprint for the synthesis of many of the small yet complex acyclic members of this family. The broad applicability of this approach is demonstrated with the short, eight-step synthesis of four natural products and three analogues. These syntheses are the first of any members of the acyclic polyhalogenated Plocamium monoterpenes and permitted the evaluation of their selectivity against a range of tumor cell lines.

Sabry, O. M. M., " Beneficial Health Effects of Olive Leaves Extracts", Journal of Natural Sciences Research , vol. 4, issue 19, pp. 1-9, 2014. Abstract

The olive leaves are well known for many useful pharmacological effects. Olive leaves extracts have anti-microbial, anti-inflammatory, anti-oxidant anti-hypertensive, anti-hypercholestermic, anti-hyperglycemic, anti-thrombotic, diuretic and anti-tumor properties. In this review article, we have showed huge collective medical activities of olive leaves extracts that can be applied for treating variety of health problems.

VOGEL, C. V., H. PIETRASZKIEWICZ, S. A. B. R. Y. M. OMAR, W. H. GERWICK, F. A. VALERIOTE, and C. D. VANDERWAL, "Enantioselective, Divergent Syntheses of Several Polyhalogenated Plocamium Monoterpenes and Evaluation of their Selectivity for Solid Tumors", Angewandte Chem. Int. Ed. , vol. 53, issue 45, pp. 12205–12209, 2014. plocamium_monoterpenes.pdf
2005
Sabry, O. M. M., S. Andrews, K. L. McPhail, D. E. Goeger, A. Yokochi, K. T. LePage, T. F. Murray, and W. H. Gerwick, "Neurotoxic meroditerpenoids from the tropical marine brown alga Stypopodium flabelliforme.", Journal of natural products, vol. 68, issue 7, pp. 1022-30, 2005 Jul. Abstract

Brine shrimp toxicity and TLC analysis guided the isolation of five new and biologically active meroditerpenoids [2beta,3alpha-epitaondiol (1), flabellinol (2), flabellinone (3), stypotriolaldehyde (4), and stypohydroperoxide (5)] along with five known compounds from the marine brown alga Stypopodium flabelliforme collected in Papua New Guinea. The planar structures of compounds 1-5 were determined by extensive spectroscopic analysis (1D and 2D NMR, LRMS, HRMS, IR, and UV), while relative configuration was determined by 1D and 2D NOE experiments. X-ray crystallography confirmed the relative configuration of 2beta,3alpha-epitaondiol (1), and the modified Mosher's ester method was used to establish its absolute configuration. All of the new metabolites were moderately toxic to murine neuro-2a cells (LC50 2-25 microM), and three [2beta,3alpha-epitaondiol (1), flabellinol (2), and flabellinone (3)] possessed potent sodium channel blocking activity. Stypotriolaldehyde (4) had a biphasic effect on the concentration of intracellular Ca2+ in rat cerebellar granule neurons (CGN). The previously known compound, stypoldione (6), also modulated intracellular calcium concentration and was cytotoxic in CGN. Metabolites 2beta,3alpha-epitaondiol (1), flabellinol (2), and flabellinone (3) displayed moderate cytotoxicity to the NCI-H460 human lung cancer cell line.

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