noura ragab abdelazeem abdelrahman

Background: Vitiligo is the commonest hypopigmented skin disorder. Taurine upregulated gene1(TUG1), one of Long noncoding RNAs (LncRNA) that plays a role in melanogenesis. microRNA-377 (miRNA-377) is a conserved non-coding RNA that regulates angiogenesis and promotes oxidative stress. Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily. PPARγ activators stimulate melanogenesis. Interleukin-17(IL17) has been implicated in the pathogenesis of several immunological diseases.
Aim: This work aimed to detect the expression levels of TUG1, miRNA-377, PPARγ and IL-17 among vitiligo subjects and to investigate their possible role in the pathogenesis of vitiligo.
Methods: This study was conducted on 30 healthy control and 30 vitiligo patients. TUG1 and miRNA-377 were detected in serum by real- time-PCR, Also PPARγ and IL-17 were assessed in tissue by Real-time PCR.
Results: TUG1and PPARγ level was significantly down regulated in vitiligo group compared to control group, on the other hand miRNA-377 and IL-17 was significantly up regulated in vitiligo group compared to control group.
Conclusion: This study demonstrated the dysregulated expressions of TUG1 and miR-377 in patients with vitiligo and suggested that both contributed to its pathogenesis and that might be through PPARγ and IL-17.
Key words: Vitiligo /TUG1/ miRNA377/ PPAR γ / IL17.