Modulation of caspase-3 gene expression and protective effects of garlic and spirulina against CNS neurotoxicity induced by lead exposure in male rats

Citation:
Modulation of caspase-3 gene expression and protective effects of garlic and spirulina against CNS neurotoxicity induced by lead exposure in male rats, Galala, Mona K., Elleithyb Ebtihal M. M., Abdraboub Mohamed I., Yasinb Noha A. E., and Shaheenb Youssef M. , Neurotoxicology, Volume 72, (2019)

Abstract:

Lead (Pb) is a ubiquitous environmental and industrial pollutant with worldwide health problems. The present
study was designed to investigate the neurotoxic effects of Pb in albino rats and to evaluate the ameliorative role
of garlic as well as Spirulina maxima against such toxic effects. Forty adult male rats were used in this investigation
(10 rats/group). Group I: served as control, Group II: rats received lead acetate (100 mg/kg), Group
III: rats received both lead acetate (100 mg/kg) and garlic (600 mg/kg) and Group IV: rats received both lead
acetate (100 mg/kg) and spirulina (500 mg/kg) daily by oral gavage for one month. Exposure to Pb acetate
adversely affected the measured acetyl cholinesterase enzyme activity, oxidative stress and lipid peroxidation
parameters as well as caspase-3 gene expression in brain tissue (cerebrum and cerebellum). Light and electron
microscopical examination of the cerebrum and cerebellum showed various lesions after exposure to Pb which
were confirmed by immunohistochemistry. On the other hand, administration of garlic and spirulina concomitantly
with lead acetate ameliorated most of the undesirable effects. It could be concluded that, the adverse
effects induced by lead acetate, were markedly ameliorated by co-treatment with S. maxima more than garlic.

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