Pulsed Dye Laser versus its sequential application with ND: YAG Laser in treatment of Psoriasis

Citation:
Shokeir, H. A., N. A. Samy, M. R. Abo-Eittah, and N. G. Abdallah.*, Pulsed Dye Laser versus its sequential application with ND: YAG Laser in treatment of Psoriasis , , 2015.

Abstract:

Background: Angiogenesis play an important role in the pathogenesis of psoriasis. Based on selective photothermolysis destruction of dilated blood vessels, a major component of psoriatic dermal papillae, can be achieved upon treatment with vascular lasers .
Objective:This study was designed to compare the efficacy of a 585 nm pulsed dye laser (PDL) and its sequential application with Nd: YAG laser for the treatment of plaque psoriasis.
Patients and Methods: Thirty patients with chronic and stable plaque type psoriasis were included in this study. Patients received seven PDL and combined PDL and Nd: YAG laser treatment sessions at two week-intervals. Clinical evaluation of the studied psoriatic plaques was performed by the modified Psoriasis Area and Severity Index (mPASI) score and by photographs.
Results: Both types of lasers induced a noticeable decrease in (mPASI) scores. The decrease was statistically significant with combined PDL and Nd: YAG laser versus PDL alone when compared with baseline (p< 0.03 ). Some plaques that had received the combined modality showed complete clearance at the 12thand 14th week.
Conclusion: The sequential application of PDL followed by Nd: YAG laser (multiplex) could be more promising than PDL alone in the treatment of plaque psoriasis.
Keywords: Angiogenesis, multiplex, Nd: YAG laser, psoriasis, pulsed dye laser.
Abbreviations: VEGFR, vascular endothelial growth factor receptor.

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