Publications

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2023
Kasem, L. M., H. S. H. Attaby, D. A. El Amir, S. D. Ibrahim, K. H. Radwan, N. M. Khalil, and A. E. Ibrahim, "Impact of Thermotolerance Response on the Physiological and Genomic Variation of Fusarium oxysporum. ", Egyptian Journal of Botany, vol. 63, issue 2, pp. 491-504, 2023.
Khalil, N. M., "Recent Progress on Fungal Enzymes.", Plant Mycobiome.: Springer, Cham., 2023.
Kasem, L. M., H. S. H. Attaby, N. M. Khalil, D. A. El Amir, H. A. Ahmed, H. A. Ahmed, K. H. Radwan, and A. E. Ibrahim, "Tracking of thermal microbial shock proteins and genomic variation of Bacillus cereus due to some abiotic stresses. ", Brazilian Journal of Biology , vol. 83, 2023.
2022
Khalil, N. M., H. M. Ali, and A. E. Ibrahim, "Biochemical Activity of Propolis Alcoholic Extracts against Fusarium oxysporum hm89", Egyptian Journal of Botany, vol. 62, issue 1, pp. 197-212 , 2022.
Moussa, T. A. A., and N. M. Khalil, "Extremozymes from extremophilic microorganisms as sources of bioremediation", Microbial Extremozymes Novel Sources and Industrial Applications: Elsevier , 2022.
2021
Khalil, N. M., S. Rodríguez‑Couto, and M. A. N. El‑Ghany, "Characterization of Penicillium crustosum l‑asparaginase and its acrylamide alleviation efficiency in roasted coffee beans at non‑cytotoxic levels", Archives of Microbiology , vol. 203, pp. 2625–2637, 2021.
2020
Khalil, N. M., and R. S. Yousef, "Efficacy of Alternaria alternata NMK1 Secondary Metabolites against some Seed-borne Fungi", Egyptian Journal of Botany, vol. 60, issue 2, pp. 537-548 , 2020.
2019
Khalil, N. M., M. N. A. El-Ghany, and S. Rodríguez-Couto, "Antifungal and anti-mycotoxin efficacy of biogenic silver nanoparticles produced by Fusarium chlamydosporum and Penicillium chrysogenum at non-cytotoxic doses", Chemosphere , vol. 218, pp. 477-486, 2019.
Abdallah, Y. K., A. T. Estevez, D. Tantawy, A. M. Ibraheem, and N. M. Khalil, "Employing laccase producing Aspergillus sydowii NYKA 510 for cathodic biocatalyst in self-sufficient lighting microbial fuel cell", Journal of microbiology and biotechnology , vol. 29, issue 12, pp. 1861-1872, 2019.
Ali, M. I. A., I. K. Behiry, N. M. Khalil, and F. A. Marghany, "Hydrolytic Enzymes as Probable Virulence Factors For Aspergillus ochraceus Fm90 in Aspergillosis", Egyptian Journal of Botany , vol. 59, issue 2, pp. 425-438, 2019.
Abdel-Rahman, T. M., N. M. Khalil, M. N. A. El-Ghany, and E. Yosef, "Purification, characterization and medicinal application of tyrosinase extracted from Saccharomyces cerevisiae", Journal of Innovations in Pharmaceutical and Biological Sciences, vol. 6, issue 1, pp. 1-11, 2019.
2018
Abdel-Rahman, T. M., N. M. Khalil, M. N. Abd El-Ghany, S. M. Abu Elsoud, S. M. Abbass, E. E. Sayed, M. M. Mahmoud, A. M. Mahmoud, A. M. Ebrahim, R. R. Abdel-kader, et al., "Purification and characterization of Milk -Clotting Enzyme from the edible mushroom Pleurotus albidus. ", Research Journal of Pharmaceutical, Biological and Chemical Sciences, vol. 9, pp. 49-63, 2018.
2017
Ali, M., A. AbdElfattah, N. Khalil, and M. Sayed, "Biological Activities of the Alkaloid Quinazoline Extracted from Aspergillus nomius", Egyptian Journal of Botany , vol. 57, issue 3, pp. 565-582, 2017.
2016
Khalil, N. M., M. I. A. Ali, S. A. Ouf, and A. M. N. El-Ghany, "Characterization of Aspergillus flavus NG 85 Laccase and Its Dye Decolorization Efficiency", Research Journal of Pharmaceutical, Biological and Chemical Sciences, vol. 7, issue 4, pp. 817-829, 2016. laccase_decolorization_2016.pdf
Aly, E. E., N. M. Khalil, G. A. El-Hamid, M. A. Abo-El-Soued, and H. S. Mostafa, "Mutagenic Effect of Gamma Irradiation on Phenotype and Enzyme Activities in Aspergillus niger", Egyptian Journal of Botany , vol. 56, issue 2, pp. 507-526, 2016.
2015
Ali, M. I. A., S. A. Ouf, N. M. Khalil, and M. N. A. El-Ghany, "Biosynthesis of laccase by Aspergillus flavus NG85 Isolated from Saint Catherine protectorate", EGYPTIAN JOURNAL OF BOTANY , vol. 55, issue 1, pp. 127-147, 2015.
Ali, M. I. A., S. A. Ouf, N. M. Khalil, and M. N. A. El-Ghany, "Biosynthesis of laccase by Aspergillus flavus NG85 Isolated from Saint Catherine protectorate", EGYPTIAN JOURNAL OF BOTANY , vol. 55, issue 1, pp. 127-147, 2015.
2014
Khalil, N. M., E. A. Shalaby, D. M. I. A. Ali, E. M. ALI, and A. M. Aboul-Enein, "Biological activities of secondary metabolites from Emericella nidulans EGCU312", African Journal of Microbiology Research , vol. 8 , issue 20, pp. 2011-2021, 2014. emericella_nidulans.pdf
Moussa, T. A. A., N. M. Khalil, D. M. I. Ali, and F. A. Mostafa, "Purification and Biochemical Characterization of Xylanase from Sclerotium rolfsii", JOURNAL OF PURE AND APPLIED MICROBIOLOGY , vol. 8 , issue 6, pp. 4727-4733, 2014. xylanase.pdf
2013
Khalil, N. M., "Biogenic silver nanoparticles by Aspergillus terreus as a powerful nanoweapon against Aspergillus fumigatus", African Journal of Microbiology Research, vol. 7, issue 50, pp. 5645-5651, 2013. Abstractsilver_nanoparticles.pdf

Thirty soil samples from different six localities representing Wadi Araba, Egypt were collected for
isolation of alkaliphilic and alkaline-resistant microorganisms as a possible source of new antimicrobial compounds.
The climatic factors and soil analysis of the study area are given. The soil samples were sandy and varied from
slightly to moderate alkaline, and also from non-saline to slightly saline. The number of microbial colonies from the
different soil samples varied from 102 to 104 CFU/g of soil. It was obvious that the viable microbial counts were
affected by the organic matter content and the pH of the soil. A total of 117 alkaliphilic and alkaline-resistant
microorganisms were isolated. Among them, 73 isolates were bacteria, 40 isolates were actinomycetes and the
remaining 4 isolates were fungi. The purified alkaliphilic and alkaline-resistant microorganisms were investigated
for their antimicrobial activities and the results revealed that 23 isolates of bacteria, 22 isolates of actinomycetes and
two fungal isolates have antimicrobial activities. Therefore, the results recommended the screening of extremophiles
as possible source of new secondary metabolites.

Moussa, T. A. A., D. M. Ali, N. M. Khalil, and F. A. Mostafa, "Molecular characterization of glyceraldehyde-3-phosphate dehydrogenase (gapdh) gene from Aspergillus fumigatus", Journal of Food, Agriculture & Environment , vol. 11, issue 3&4, pp. 235-241, 2013. Abstractgapdh_gene.pdf

First-strand cDNA was reverse transcribed from mRNA of
Aspergillus fumigatus
mycelium culture. The nucleotide sequence of
gapdh
was found to
contain an ORF of 1083 bp, capable of coding for a protein of 360 amino acid residues. The signal peptide was predicted to be 1
9 amino acids in length.
The alignment of sequence analysis of this fragment with the previously determined nucleotide sequence led to the definition of
the gene (
gapdh
-
cDNA, accession no. AB683056). Sequence analysis revealed the presence of a potential site for substrate binding (ASCTTNCV) at
position 172-
179. Amino acids potentially associated with catalysis were found at amino acid positions 174 (C) and 201 (H). Potential phosph
orylation sites were
located at positions 13-21, 204-212, 219-227, 272-280 and 339-346. The amino acid residues at positions 7 (D) and 311 (N) corre
sponded to the
putative NAD
+
binding sites. Amino acids at positions 145 (S), 150 (T), 204 (T) and 205 (R) were found to be probable sites for inorganic ph
osphate
binding. Positions 180 and 222 were found to be amino acid residues that putatively related to the binding of the phosphate fro
m the substrate (T and
R). The calculated molecular weight of deduced polypeptide is 38.7 kDa, and the estimated isoelectric point (pI) is 7.28. The d
educed amino acid
sequence revealed the most abundant amino acid was alanine followed by leucine, whereas the rare amino acids are methionine fol
lowed by
tryptophan.

2012
Ali, M. I. A., N. M. Khalil, and M. N. A. El-Ghany, "Biodegradation of some polycyclic aromatic hydrocarbons by Aspergillus terreus", African Journal of Microbiology Research , vol. 6 , issue 16, pp. 3783-3790, 2012.
Moussa, T. A. A., and N. M. Khalil, "Solid-state fermentation for the production of dextran from Saccharomyces cerevisiae and its cytotoxic effects ", Life Science Journal , vol. 9, issue 4, pp. 2210-2218, 2012.
2011
Sharaf, E. F., and N. M. Khalil, "Keratinolytic activity of purified alkaline keratinase produced by Scopulariopsis brevicaulis (Sacc.) and its amino acids profile", Saudi journal of biological sciences , vol. 18 , issue 2, pp. 117-121, 2011.