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Journal Article
Aita, N. A. A., M. A. Hashesh, and A. H. Mohamed, "Clinicopathological and Cytogenetic Studies on the Ameliorative Effect of Propolis Against Profenofos Toxicity in Rats", Global Veterinaria, vol. 9, issue 6, pp. 669-682, 2012. prop.pdf
Aita, N. A. A., and F. F. Mohammed, "Effect of Marjoram Oil on the Clinicopathological, Cytogenetic and Histopathological Alterations Induced by Sodium Nitrite Toxicity in Rats", Global Veterinaria, vol. 12, issue 5, pp. 606-616, 2014. Abstract

The present study aimed to investigate the potential effect of marjoram oil in alleviating hematological, serum biochemical, chromosomal and histopathological alterations induced by sodium nitrite toxicity in rats. For this purpose, forty adult male rats were divided into four groups (10 rats each);Group (1): received distilled water and served as a control, Group (2) was daily administered marjoram oil at a dose of 0.5 ml/kg b.wt.by stomach tube for 2 months, Group (3) was daily administered sodium nitrite at dose of 30 mg/ kg b.wt. by stomach tube for 2 months and Group (4) was concurrently administered sodium nitrite and marjoram oil with similar doses that mentioned before. The obtained results indicated that sodium nitrite possesses a deleterious effect on blood cytology, induce oxidative damage, hepato-renal dysfunction, chromosomal abnormalities and histopathological alterations. The administration of marjoram oil in conjugation with sodium nitrite minimized the hazard effects of sodium nitrite, it improved RBCs count, PCV, Hb concentration and WBCs count. It increased the level of serum total antioxidant capacity (TAC) and diminished the level of serum malondialdehyde (MDA). Moreover, it decreased the elevated activities of AST, ALT and ALP, cholesterol, BUN, creatinine and glucose concentration and elevated the values of total proteins and albumin in comparison to sodium nitrite group. In addition, marjoram oil ameliorated the genotoxic effect of sodium nitrite as it reduced the frequency of chromosomal aberrations and improved the histopathological changes in liver, kidney and spleen in comparison to sodium nitrite intoxicated group.

Mahmoud, M. A., K. F. Mahrous, A. A. H. El-Rahim, M. Abdelsalam, N. A. Abu-Aita, and undefined, "The impact of several hydraulic fracking chemicals on Nile tilapia and evaluation of the protective effects of Spirulina platensis", Environmental Science and Pollution Research, vol. Jul;26(19):, pp. 19453-19467, 2019.
Nashwa, A. A. A., and undefined, "Impact of vitamin C on genotoxicity, sperm abnormalities and serum biochemical alterations in deltamethrin exposed rats", Egypt. J. Comp. Path. Clinic. Path., 21(1):168-188., vol. 21, issue (1), pp. 168-188, 2008.
Fatma A. Fadl1*, Nashwa A. Abu aita1, M. A. Abdelaziz2, and A. H. Mohamed1, "In vitro Assessment of Antimicrobial Activity of Zinc Oxide Nanoparticles against Pathogenic Streptococcus parauberis", Advances in Animal and Veterinary Sciences, vol. 9, pp. 913-918, 2021.
El-Maatya, A. M. A., A. H.Mohamedb, N. A.Abu-Aita, and bHisham M.Morgan, "Markers for Predicting Overweight or Obesity of Broodmares", journal of Equine Veterinary Science , vol. 56, pp. 9-18, 2017.
Nashwa, A. - A. A., A. A. Kawkab, and S. M. Mouneir, "The Protective effect of Ginger and N- Acetyl Cysteine on Ciprofloxacin-Induced Reproductive Toxicity in Male Rats ", Journal of American Science, vol. 7, issue 7, pp. 741-752, 2011. Abstractginger.pdf

This study was conducted to evaluate the reproductive toxicity induced by ciprofloxacin antibiotic and the protective effect of ginger and/or N-acetyl cysteine. For this purpose, forty- nine rats were divided into 7 groups (7 rats/group). Group (1) was orally given distilled water (solvent of the used drugs) and kept as a control. Group (2) was daily administered ginger at a dose of 100 mg⁄kg.b.wt. by a stomach tube for 65 days (5 days/week). Group (3) was daily administered N-acetyl cysteine (NAC) at a dose of 50 mg⁄kg.b.wt., by a stomach tube for 65 days (5 days/week). Group (4) was orally administered ciprofloxacin (CPX) at a dose of 12.5 mg⁄kg. b.wt. for 65 days (5 days/week). Group (5) was concurrently administered ciprofloxacin (12.5 mg⁄kg. b.wt) with ginger (100 mg⁄kg. b.wt.) by a stomach tube for 65 days (5 days/week). Group (6) was concurrently administered ciprofloxacin (12.5 mg⁄kg.b.wt) with N-acetyl cysteine (50 mg⁄kg.b.wt) by a stomach tube for 65 days. Group (7) was concurrently administered ciprofloxacin (12.5 mg⁄kg.b.wt.) with ginger (100mg⁄kg.b.wt.) and N- acetyl cysteine (50 mg⁄kg.b.wt) by a stomach tube for 65 days. Semen samples were collected at the end of experimental period and were used for sperm functions analysis. Blood samples were collected to separate serum for biochemical and hormonal studies. Testes homogenate was used for oxidative stress biomarkers (lipid peroxidation (TBARS), reduced glutathione (GSH) and DNA fragmentation test). Testes, epididymis and seminal vesicles were collected for histopathological study. The obtained data revealed that CPX promotes reproductive toxicity in rats through generating oxidative damage. It induces an adverse effect on reproductive organs weight, sperm parameters (sperm count, sperm motility and viability), reproductive hormones (testosterone, LH, and FSH) and histological structures. Ginger and/or NAC have an important role in ameliorating reproductive toxicity induced by CPX through restoring the oxidant- antioxidant balance.

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