Penicillamine as an adjuvant to antimonial therapy, effect on electrocardiographic changes in dogs.

Citation:
Girgis, N. I., M. T. Khayyal, E. McConnell, and J. Norton, "Penicillamine as an adjuvant to antimonial therapy, effect on electrocardiographic changes in dogs.", East African medical journal, vol. 47, issue 11, pp. 576-81, 1970 Nov.

Abstract:

Intravenous injections of tartar emetic at 5 mg/kg body-weight daily for 4 days were given to 55 healthy dogs. Concomitant injections of 11 mg/kg penicillamine were given to 25 of the dogs. 26% of the dogs given tartar emetic alone died during or shortly after treatment, but the mortality of dogs receiving the combined treatment was only 8%. Changes in electrocardiographic pattern were observed in 90% of tartar emetic-treated dogs and in 55% of dogs treated with combined tartar emetic and penicillamine.

Notes:

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