Assessing the applications of cortical auditory evoked potentials as a biomarker in children with cochlear implants

Ismail Zohdi Mostafa, M. I. Shabana, A. M. E. Shennawy, and H. M. Weheiba, "Assessing the applications of cortical auditory evoked potentials as a biomarker in children with cochlear implants", The Egyptian Journal of Otolaryngology , vol. 29, pp. 283-268, 2013.


Cortical auditory evoked potentials (CAEPs) are noninvasive measures used to
quantify central auditory system function in humans. More specifically, the P1–N1–P2
cortical auditory evoked potential has a unique role in identifying the central auditory
system that has benefited from amplification or implantation. P1 reflects the maturation
of the auditory system in general as it has developed over time.
The aims of this study were to assess the CAEP in children with cochlear implants
compared with age-matched controls, to study the different variables affecting the
results, and to compare the pattern of P1 CAEP in cochlear implant patients compared
with that in those with hearing aids.
Thirty-five hearing-impaired children (using cochlear implants) were compared with
20 age-matched and sex-matched children with normal hearing. In both groups,
P1 CAEP latency and waveform morphology were recorded using free-field auditory
stimulation with tone bursts at 500 and 2000 Hz at 100 dB sound pressure level in two
sessions that were 6 months apart.
Children using cochlear implants exhibited prolongation of P1 latencies, indicating an
overall delay in maturation when compared with that in children who could hear
normally. P1 CAEP latency and amplitude improved significantly after 6 months of
device use.
Standardized age-appropriate normative data on P1 CAEPs in the pediatric Egyptian
population could be used to determine implantation or amplification results.
children, cochlear implant, cortical auditory evoked potentials, free field, P1
Egypt J Otolaryngol 29:263–268
& 2013 The Egyptian Oto - Rhino - Laryngological Society