Sialic acid-containing glycolipids mediate binding and viral entry of SARS-CoV-2

Nguyen, L., K. A. McCord, D. T. Bui, K. M. Bouwman, E. N. Kitova, M. Elaish, D. Kumawat, G. C. Daskhan, I. Tomris, L. Han, et al., "Sialic acid-containing glycolipids mediate binding and viral entry of SARS-CoV-2", Nat Chem Biol, vol. 18, no. 1, pp. 81-90, 2022.


Emerging evidence suggests that host glycans influence severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Here, we reveal that the receptor-binding domain (RBD) of the spike (S) protein on SARS-CoV-2 recognizes oligosaccharides containing sialic acid (Sia), with preference for monosialylated gangliosides. Gangliosides embedded within an artificial membrane also bind to the RBD. The monomeric affinities (K


Nguyen, Linh McCord, Kelli A Bui, Duong T Bouwman, Kim M Kitova, Elena N Elaish, Mohamed Kumawat, Dhanraj Daskhan, Gour C Tomris, Ilhan Han, Ling Chopra, Pradeep Yang, Tzu-Jing Willows, Steven D Mason, Andrew L Mahal, Lara K Lowary, Todd L West, Lori J Hsu, Shang-Te Danny Hobman, Tom Tompkins, Stephen M Boons, Geert-Jan de Vries, Robert P Macauley, Matthew S Klassen, John S 2021/11/11

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