SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation

Xu, Z., J. H. Choi, D. L. Dai, J. Luo, R. J. Ladak, Q. Li, Y. Wang, C. Zhang, S. Wiebe, A. C. H. Liu, et al., "SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation", Proc Natl Acad Sci U S A, vol. 119, no. 32, pp. e2204539119, 2022.


Viruses evade the innate immune response by suppressing the production or activity of cytokines such as type I interferons (IFNs). Here we report the discovery of a mechanism by which the SARS-CoV-2 virus coopts an intrinsic cellular machinery to suppress the production of the key immunostimulatory cytokine IFN-β. We reveal that the SARS-CoV-2 encoded nonstructural protein 2 (NSP2) directly interacts with the cellular GIGYF2 protein. This interaction enhances the binding of GIGYF2 to the mRNA cap-binding protein 4EHP, thereby repressing the translation of the


Xu, Zhang Choi, Jung-Hyun Dai, David L Luo, Jun Ladak, Reese Jalal Li, Qian Wang, Yimeng Zhang, Christine Wiebe, Shane Liu, Alex C H Ran, Xiaozhuo Yang, Jiaqi Naeli, Parisa Garzia, Aitor Zhou, Lele Mahmood, Niaz Deng, Qiyun Elaish, Mohamed Lin, Rongtuan Mahal, Lara K Hobman, Tom C Pelletier, Jerry Alain, Tommy Vidal, Silvia M Duchaine, Thomas Mazhab-Jafari, Mohammad T Mao, Xiaojuan Jafarnejad, Seyed Mehdi Sonenberg, Nahum 2022/7/26

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