SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation
- Citation:
- Xu, Z., J. H. Choi, D. L. Dai, J. Luo, R. J. Ladak, Q. Li, Y. Wang, C. Zhang, S. Wiebe, A. C. H. Liu, et al., "SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation", Proc Natl Acad Sci U S A, vol. 119, no. 32, pp. e2204539119, 2022.
Abstract:
Viruses evade the innate immune response by suppressing the production or activity of cytokines such as type I interferons (IFNs). Here we report the discovery of a mechanism by which the SARS-CoV-2 virus coopts an intrinsic cellular machinery to suppress the production of the key immunostimulatory cytokine IFN-β. We reveal that the SARS-CoV-2 encoded nonstructural protein 2 (NSP2) directly interacts with the cellular GIGYF2 protein. This interaction enhances the binding of GIGYF2 to the mRNA cap-binding protein 4EHP, thereby repressing the translation of the
Notes:
Xu, Zhang Choi, Jung-Hyun Dai, David L Luo, Jun Ladak, Reese Jalal Li, Qian Wang, Yimeng Zhang, Christine Wiebe, Shane Liu, Alex C H Ran, Xiaozhuo Yang, Jiaqi Naeli, Parisa Garzia, Aitor Zhou, Lele Mahmood, Niaz Deng, Qiyun Elaish, Mohamed Lin, Rongtuan Mahal, Lara K Hobman, Tom C Pelletier, Jerry Alain, Tommy Vidal, Silvia M Duchaine, Thomas Mazhab-Jafari, Mohammad T Mao, Xiaojuan Jafarnejad, Seyed Mehdi Sonenberg, Nahum 2022/7/26