Publications

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2021
Kumar, A., R. Ishida, T. Strilets, J. Cole, J. Lopez-Orozco, N. Fayad, A. Felix-Lopez, M. Elaish, D. Evseev, and K. E. Magor, SARS-CoV-2 non-structural protein 1 inhibits the interferon response by causing depletion of key host signaling factors., : American Society for Microbiology 1752 N St., NW, Washington, DC, pp. JVI - 00266, 2021. Abstract
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2020
Mahesh, K. C., J. M. Ngunjiri, J. Lee, J. Ahn, M. Elaish, A. Ghorbani, M. E. C. Abundo, K. Lee, and C. - W. Lee, Avian Toll-like receptor 3 isoforms and evaluation of Toll-like receptor 3–mediated immune responses using knockout quail fibroblast cells, , vol. 99, issue 12: Elsevier, pp. 6513 - 6524, 2020. Abstract
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Abundo, M. E. C., J. M. Ngunjiri, K. J. M. Taylor, H. Ji, A. Ghorbani, M. Kc, M. Elaish, H. Jang, B. Weber, and T. J. Johnson, Evaluation of Sampling Methods for the Study of Avian Respiratory Microbiota, , vol. 64, issue 3: American Association of Avian Pathologists Inc, pp. 277 - 285, 2020. Abstract
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Heindel, D. W., S. Koppolu, Y. Zhang, B. Kasper, L. Meche, C. A. Vaiana, S. J. Bissel, C. E. Carter, A. A. Kelvin, and M. Elaish, Glycomic analysis of host response reveals high mannose as a key mediator of influenza severity, , vol. 117, issue 43: National Acad Sciences, pp. 26926 - 26935, 2020. Abstract
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Taylor, K. J. M., J. M. Ngunjiri, M. C. Abundo, H. Jang, M. Elaish, A. Ghorbani, M. Kc, B. P. Weber, T. J. Johnson, and C. - W. Lee, Respiratory and gut microbiota in commercial turkey flocks with disparate weight gain trajectories display differential compositional dynamics, , vol. 86, issue 12: American Society for Microbiology 1752 N St., NW, Washington, DC, pp. e00431 - 20, 2020. Abstract
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Abundo, M. E. C., J. M. Ngunjiri, K. J. M. Taylor, H. Ji, A. Ghorbani, M. Kc, M. Elaish, H. Jang, B. Weber, T. J. Johnson, et al., "Evaluation of Sampling Methods for the Study of Avian Respiratory Microbiota", Avian Dis, vol. 64, no. 3, pp. 277-285, 2020. AbstractWebsite
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2019
Ngunjiri, J. M., K. J. M. Taylor, M. C. Abundo, H. Jang, M. Elaish, M. Kc, A. Ghorbani, S. Wijeratne, B. P. Weber, and T. J. Johnson, Farm stage, bird age, and body site dominantly affect the quantity, taxonomic composition, and dynamics of respiratory and gut microbiota of commercial layer chickens, , vol. 85, issue 9: American Society for Microbiology 1752 N St., NW, Washington, DC, pp. e03137 - 18, 2019. Abstract
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Ghorbani, A., J. M. Ngunjiri, M. Xia, M. Elaish, H. Jang, K. C. Mahesh, M. C. Abundo, X. Jiang, and C. - W. Lee, Heterosubtypic protection against avian influenza virus by live attenuated and chimeric norovirus P-particle-M2e vaccines in chickens, , vol. 37, issue 10: Elsevier, pp. 1356 - 1364, 2019. Abstract
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Elaish, M., M. Xia, J. M. Ngunjiri, A. Ghorbani, H. Jang, K. C. Mahesh, M. C. Abundo, S. Dhakal, R. Gourapura, and X. Jiang, Protective immunity against influenza virus challenge by norovirus P particle-M2e and HA2-AtCYN vaccines in chickens, , vol. 37, issue 43: Elsevier, pp. 6454 - 6462, 2019. Abstract
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Ngunjiri, J. M., A. Ghorbani, H. Jang, S. Waliullah, M. Elaish, M. C. Abundo, K. C. Mahesh, K. J. M. Taylor, R. E. Porter, and C. - W. Lee, Specific-pathogen-free Turkey model for reoviral arthritis, , vol. 235: Elsevier, pp. 170 - 179, 2019. Abstract
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Ngunjiri, J. M., K. J. M. Taylor, M. C. Abundo, H. Jang, M. Elaish, K. C. Mahesh, A. Ghorbani, S. Wijeratne, B. P. Weber, and T. J. Johnson, "Farm stage, bird age, and body site dominantly affect the quantity, taxonomic composition, and dynamics of respiratory and gut microbiota of commercial layer chickens", Appl. Environ. Microbiol., vol. 85, issue 9: American Society for Microbiology, pp. e03137-18, 2019. Abstract
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Ghorbani, A., J. M. Ngunjiri, M. Xia, M. Elaish, H. Jang, K. C. Mahesh, M. C. Abundo, X. Jiang, and C. W. Lee, "Heterosubtypic protection against avian influenza virus by live attenuated and chimeric norovirus P-particle-M2e vaccines in chickens", Vaccine, vol. 37, no. 10, pp. 1356-1364, 2019. AbstractWebsite
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Ghorbani, A., J. M. Ngunjiri, M. Xia, M. Elaish, H. Jang, K. C. Mahesh, M. C. Abundo, X. Jiang, and C. W. Lee, "Heterosubtypic protection against avian influenza virus by live attenuated and chimeric norovirus P-particle-M2e vaccines in chickens", Vaccine, vol. 37, no. 10, pp. 1356-1364, 2019. AbstractWebsite
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Ghorbani, A., J. M. Ngunjiri, M. Xia, M. Elaish, H. Jang, K. C. Mahesh, M. C. Abundo, X. Jiang, and C. - W. Lee, "Heterosubtypic protection against avian influenza virus by live attenuated and chimeric norovirus P-particle-M2e vaccines in chickens", Vaccine, vol. 37, issue 10: Elsevier, pp. 1356-1364, 2019. Abstract
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Elaish, M., M. Xia, J. M. Ngunjiri, A. Ghorbani, H. Jang, M. Kc, M. C. Abundo, S. Dhakal, R. Gourapura, X. Jiang, et al., "Protective immunity against influenza virus challenge by norovirus P particle-M2e and HA2-AtCYN vaccines in chickens", Vaccine, 2019. AbstractWebsite
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Elaish, M., M. Xia, J. M. Ngunjiri, A. Ghorbani, H. Jang, M. Kc, M. C. Abundo, S. Dhakal, R. Gourapura, X. Jiang, et al., "Protective immunity against influenza virus challenge by norovirus P particle-M2e and HA2-AtCYN vaccines in chickens", Vaccine, 2019. AbstractWebsite
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Elaish, M., M. Xia, J. M. Ngunjiri, A. Ghorbani, H. Jang, K. C. Mahesh, M. C. Abundo, S. Dhakal, R. Gourapura, and X. Jiang, "Protective immunity against influenza virus challenge by norovirus P particle-M2e and HA2-AtCYN vaccines in chickens", Vaccine, vol. 37, issue 43: Elsevier, pp. 6454-6462, 2019. Abstract
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Elaish, M., M. Xia, J. M. Ngunjiri, A. Ghorbani, H. Jang, M. Kc, M. C. Abundo, S. Dhakal, R. Gourapura, X. Jiang, et al., "Protective immunity against influenza virus challenge by norovirus P particle-M2e and HA2-AtCYN vaccines in chickens", Vaccine, vol. 37, no. 43, pp. 6454-6462, 2019. AbstractWebsite
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Ngunjiri, J. M., A. Ghorbani, H. Jang, S. Waliullah, M. Elaish, M. C. Abundo, K. C. Mahesh, K. J. M. Taylor, R. E. Porter, and C. - W. Lee, "Specific-pathogen-free Turkey model for reoviral arthritis", Veterinary microbiology, vol. 235: Elsevier, pp. 170-179, 2019. Abstract
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2018
Jang, H., M. Elaish, M. Kc, M. C. Abundo, A. Ghorbani, J. M. Ngunjiri, and C. - W. Lee, Efficacy and synergy of live-attenuated and inactivated influenza vaccines in young chickens, , vol. 13, issue 4: Public Library of Science San Francisco, CA USA, pp. e0195285, 2018. Abstract
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Jang, H., M. Elaish, M. Kc, M. C. Abundo, A. Ghorbani, J. M. Ngunjiri, and C. W. Lee, "Efficacy and synergy of live-attenuated and inactivated influenza vaccines in young chickens", PLoS One, vol. 13, no. 4, pp. e0195285, 2018. AbstractWebsite
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Jang, H., M. Elaish, K. C. Mahesh, M. C. Abundo, A. Ghorbani, J. M. Ngunjiri, and C. - W. Lee, "Efficacy and synergy of live-attenuated and inactivated influenza vaccines in young chickens", PloS one, vol. 13, issue 4: Public Library of Science, 2018. Abstract
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2017
Jang, H., Y. K. Jackson, J. B. Daniels, A. Ali, K. I. Kang, M. Elaish, and C. W. Lee, "Seroprevalence of three influenza A viruses (H1N1, H3N2, and H3N8) in pet dogs presented to a veterinary hospital in Ohio", J Vet Sci, vol. 18, issue S1, pp. 291-298, 2017. AbstractWebsite

The prevalence of canine H3N8 influenza and human H1N1 and H3N2 influenza in dogs in Ohio was estimated by conducting serologic tests on 1,082 canine serum samples. In addition, risk factors, such as health status and age were examined. The prevalences of human H1N1, H3N2, and canine H3N8 influenzas were 4.0%, 2.4%, and 2.3%, respectively. Two samples were seropositive for two subtypes (H1N1 and H3N2; H1N1 and canine influenza virus [CIV] H3N8). Compared to healthy dogs, dogs with respiratory signs were 5.795 times more likely to be seropositive against H1N1 virus (p = 0.042). The prevalence of human flu infection increased with dog age and varied by serum collection month. The commercial enzyme-linked immunosorbent assay used in this study did not detect nucleoprotein-specific antibodies from many hemagglutination inhibition positive sera, which indicates a need for the development and validation of rapid tests for influenza screening in canine populations. In summary, we observed low exposure of dogs to CIV and human influenza viruses in Ohio but identified potential risk factors for consideration in future investigations. Our findings support the need for establishment of reliable diagnostic standards for serologic detection of influenza infection in canine species.

Jang, H., Y. K. Jackson, J. B. Daniels, A. Ali, K. -il Kang, M. Elaish, and C. - W. Lee, Seroprevalence of three influenza A viruses (H1N1, H3N2, and H3N8) in pet dogs presented to a veterinary hospital in Ohio, , vol. 18, issue Suppl 1: The Korean Society of Veterinary Science, pp. 291, 2017. Abstract
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Elaish, M., J. M. Ngunjiri, A. Ali, M. Xia, M. Ibrahim, H. Jang, J. Hiremath, S. Dhakal, Y. A. Helmy, X. Jiang, et al., "Supplementation of inactivated influenza vaccine with norovirus P particle-M2e chimeric vaccine enhances protection against heterologous virus challenge in chickens", PLoS One, vol. 12, issue 2, pp. e0171174, 2017. AbstractWebsite

The current inactivated influenza vaccines provide satisfactory protection against homologous viruses but limited cross-protection against antigenically divergent strains. Consequently, there is a need to develop more broadly protective vaccines. The highly conserved extracellular domain of the matrix protein 2 (M2e) has shown promising results as one of the components of a universal influenza vaccine in different animal models. As an approach to overcome the limited, strain specific, protective efficacy of inactivated influenza vaccine (IIV), a combination of recombinant M2e expressed on the surface of norovirus P particle (M2eP) and IIV was tested in chickens. Co-immunization of birds with both vaccines did not affect the production of M2e-specific IgG antibodies compared to the group vaccinated with M2eP alone. However, the co-immunized birds developed significantly higher pre-challenge hemagglutination inhibition antibody titers against the homologous IIV antigen and heterologous challenge virus. These combined vaccine groups also had cross reactive antibody responses against different viruses (H5, H6, and H7 subtypes) compared to the IIV alone vaccinated group. Upon intranasal challenge with homologous and heterologous viruses, the combined vaccine groups showed greater reduction in viral shedding in tracheal swabs compared to those groups receiving IIV alone. Moreover, M2eP antisera from vaccinated birds were able to bind to the native M2 expressed on the surface of whole virus particles and infected cells, and inhibit virus replication in vitro. Our results support the potential benefit of supplementing IIV with M2eP, to expand the vaccine cross protective efficacy.

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