@article {RN23305,
	title = {SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation},
	journal = {Proc Natl Acad Sci U S A},
	volume = {119},
	number = {32},
	year = {2022},
	note = {<p>Xu, Zhang Choi, Jung-Hyun Dai, David L Luo, Jun Ladak, Reese Jalal Li, Qian Wang, Yimeng Zhang, Christine Wiebe, Shane Liu, Alex C H Ran, Xiaozhuo Yang, Jiaqi Naeli, Parisa Garzia, Aitor Zhou, Lele Mahmood, Niaz Deng, Qiyun Elaish, Mohamed Lin, Rongtuan Mahal, Lara K Hobman, Tom C Pelletier, Jerry Alain, Tommy Vidal, Silvia M Duchaine, Thomas Mazhab-Jafari, Mohammad T Mao, Xiaojuan Jafarnejad, Seyed Mehdi Sonenberg, Nahum 2022/7/26</p>
},
	pages = {e2204539119},
	type = {Journal Article},
	abstract = {<p>Viruses evade the innate immune response by suppressing the production or activity of cytokines such as type I interferons (IFNs). Here we report the discovery of a mechanism by which the SARS-CoV-2 virus coopts an intrinsic cellular machinery to suppress the production of the key immunostimulatory cytokine IFN-β. We reveal that the SARS-CoV-2 encoded nonstructural protein 2 (NSP2) directly interacts with the cellular GIGYF2 protein. This interaction enhances the binding of GIGYF2 to the mRNA cap-binding protein 4EHP, thereby repressing the translation of the</p>
},
	keywords = {COVID-19 Carrier Proteins Cell Line Eukaryotic Initiation Factor-4E Humans Immunity, Innate Interferon Type I Protein Biosynthesis RNA, Messenger SARS-CoV-2 Viral Nonstructural Proteins Virus Replication 4EHP GIGYF2 NSP2 SARS-CoV-2 mRNA translation},
	issn = {1091-6490},
	doi = {10.1073/pnas.2204539119},
	url = {https://www.ncbi.nlm.nih.gov/pubmed/35878012},
	author = {Xu, Z and Choi, J.H. and Dai, D. L. and Luo, J. and Ladak, R. J. and Li, Q. and Y. Wang and C. Zhang and Wiebe, S. and Liu, A. C. H. and Ran, X. and Yang, J and Naeli, P. and Garzia, A. and Zhou, L. and Mahmood, N. and Deng, Q. and Elaish, M. and Lin, R. and Mahal, L. K. and Hobman, T. C. and Pelletier, J. and Alain, T. and Vidal, S. M. and Duchaine, T. and Mazhab-Jafari, M. T. and Mao, X. and Jafarnejad, S. M. and Sonenberg, N.}
}
