PERSPECTIVES ON TOLERANCE TO PARASITIC INFECTIOUS DISEASES

Citation:
Hassan, M. A., and M. A. M. Ismail, " PERSPECTIVES ON TOLERANCE TO PARASITIC INFECTIOUS DISEASES ", J. Egypt. Soc. Parasitol. (JESP), vol. 51, issue 3, pp. 485-492, 2021.

Abstract:

Immune responses to infectious parasitic diseases appear to be simply directed towards kill-
ing or clearing the parasite. However, the immunological strategies constitute a complex inco-
rporated network of immune mechanisms to eradicate the parasite itself in addition to preser-
vation of the integrity of host tissues. Resistance and tolerance are believed to be two distinct
complementary host defense immune strategies. Mechanisms triggering infectious tolerance to
parasitic infections are still poorly recognized but seem to be centered on controlling parasite-
induced tissue damage in the infected host. It is becoming obvious that realizing infectious tol-
erance as a prominent constituent of defense strategy deliver significant conceptions in coex-
istence of host-parasite relationship. This data may also pave the way to new therapeutic app-
roaches in many parasitosis.
Key words: Immune response, Tolerance, Parasitic infections, Resistance, Review