EVIDENCE OF ANTI-DOUBLE STRANDED DNA ANTIBODIES AND C-REACTIVE PROTEIN IN EGYPTIAN PATIENTS WITH HIGH ANTI-SCHISTOSOMA MANSONI ANTIBODY TITER

Citation:
FADL, H. O., M. A. M. Ismail, and E. A. El Saftawy, "EVIDENCE OF ANTI-DOUBLE STRANDED DNA ANTIBODIES AND C-REACTIVE PROTEIN IN EGYPTIAN PATIENTS WITH HIGH ANTI-SCHISTOSOMA MANSONI ANTIBODY TITER", J. Egypt. Soc. Parasitol. (JESP), vol. 51, issue 1, pp. 147 – 152, 2021.

Abstract:

Schistosomiasis is one of the major public health diseases that induced a diversity of immuno-
logic reactions. Significant association between autoreactive antibodies and autoimmune disor-
ders was suggested. This study investigated the presence of anti-double stranded DNA (anti-ds DNA) antibodies and inflammatory biomarker, C-reactive protein (CRP) in 89 Egyptian pa-
tients, with Schistosoma mansoni clinical evidence and high anti-Schistosoma antibody titer. The
results showed positive serum anti-ds DNA antibodies in 11/89(12.4%) of them, without signifi-
cance to age, sex or anti-Schistosoma antibody titers. CRP was positive in 20/89(22.5%) of pat-
ients, with significant correlation with anti-ds DNA antibodies (P=0.000).
Keywords: Egypt, Schistosoma mansoni-anti-ds DNA- CRP- autoimmune disease.

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