Publications

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In Press
medhat khafagy, E. M. A. Mayla, M. Gadalla, W. A. Gawad, and M. El-Dweik, "Postoperative Anaerobic Sepsis could be combated by Prophylactic Vaccinations", Society for General Microbiology (SGM) Annual Conference 2015. Birmingham, UK., In Press. , UK, In Press. sgm_annual_conference_2015_abstract_book.148.pdf
2021
Abdelgawad, H. A. H., A. Sayed, M. Munir, M. H. Elberry, I. M. Sayed, M. A. Kamal, A. Negida, M. Ebada, and E. Bahbah, "Clinical Review of COVID-19; Pathogenesis, Diagnosis, and Management", Current Pharmaceutical Design, vol. 27, issue 41, pp. 4232 - 4244, 2021.
Abdelgawad, H. A. H., A. Sayed, M. Munir, M. H. Elberry, I. M. Sayed, M. A. Kamal, A. Negida, M. Ebada, and E. Bahbah, "Clinical Review of COVID-19; Pathogenesis, Diagnosis, and Management", Current Pharmaceutical Design, vol. 27, issue 41, pp. 4232 - 4244, 2021.
2020
Elberry, M. H., and H. Ahmed, "Occult SARS-CoV-2 infection; a possible hypothesis for viral relapse.", Medical hypotheses, vol. 144, pp. 109980, 2020. Abstract1-s2.0-s0306987720313475-main.pdf

Coronavirus disease 2019 (COVID-19) has emerged as a global public health emergency, which is characterized by high infection rate and fatal course. Recent data reported that the test for Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) RNA might become positive again after one or two consecutively negative tests. Many researchers are currently evaluating the clinical characteristics of the SARS-CoV-2 reactivation. In this letter, we proposed a possible mechanism of SARS-CoV-2 reactivation or relapse after negative nasopharyngeal swabs PCR.

Elberry, M. H., and H. Ahmed, "Occult SARS-CoV-2 infection; a possible hypothesis for viral relapse.", Medical hypotheses, vol. 144, pp. 109980, 2020. Abstract

Coronavirus disease 2019 (COVID-19) has emerged as a global public health emergency, which is characterized by high infection rate and fatal course. Recent data reported that the test for Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) RNA might become positive again after one or two consecutively negative tests. Many researchers are currently evaluating the clinical characteristics of the SARS-CoV-2 reactivation. In this letter, we proposed a possible mechanism of SARS-CoV-2 reactivation or relapse after negative nasopharyngeal swabs PCR.

2017
Elberry, M. H., N. H. E. Darwish, and S. A. Mousa, "Hepatitis C virus management: potential impact of nanotechnology", Virology Journal, vol. 14, issue 1, pp. 88-99, 2017. s12985-017-0753-1.pdf
2016
Zekri, A. - R. N., A. S. E. - D. Youssef, Y. M. Bakr, R. M. Gabr, O. S. Ahmed, M. H. Elberry, A. M. Mayla, M. Abouelhoda, and A. A. Bahnassy, "Early detection of hepatocellular carcinoma co-occurring with hepatitis C virus infection: A mathematical model.", World journal of gastroenterology, vol. 22, issue 16, pp. 4168-82, 2016. Abstract

AIM: To develop a mathematical model for the early detection of hepatocellular carcinoma (HCC) with a panel of serum proteins in combination with α-fetoprotein (AFP).

METHODS: Serum levels of interleukin (IL)-8, soluble intercellular adhesion molecule-1 (sICAM-1), soluble tumor necrosis factor receptor II (sTNF-RII), proteasome, and β-catenin were measured in 479 subjects categorized into four groups: (1) HCC concurrent with hepatitis C virus (HCV) infection (n = 192); (2) HCV related liver cirrhosis (LC) (n = 96); (3) Chronic hepatitis C (CHC) (n = 96); and (4) Healthy controls (n = 95). The R package and different modules for binary and multi-class classifiers based on generalized linear models were used to model the data. Predictive power was used to evaluate the performance of the model. Receiver operating characteristic curve analysis over pairs of groups was used to identify the best cutoffs differentiating the different groups.

RESULTS: We revealed mathematical models, based on a binary classifier, made up of a unique panel of serum proteins that improved the individual performance of AFP in discriminating HCC patients from patients with chronic liver disease either with or without cirrhosis. We discriminated the HCC group from the cirrhotic liver group using a mathematical model (-11.3 + 7.38 × Prot + 0.00108 × sICAM + 0.2574 × β-catenin + 0.01597 × AFP) with a cutoff of 0.6552, which achieved 98.8% specificity and 89.1% sensitivity. For the discrimination of the HCC group from the CHC group, we used a mathematical model [-10.40 + 1.416 × proteasome + 0.002024 × IL + 0.004096 × sICAM-1 + (4.251 × 10(-4)) × sTNF + 0.02567 × β-catenin + 0.02442 × AFP] with a cutoff 0.744 and achieved 96.8% specificity and 89.7% sensitivity. Additionally, we derived an algorithm, based on a binary classifier, for resolving the multi-class classification problem by using three successive mathematical model predictions of liver disease status.

CONCLUSION: Our proposed mathematical model may be a useful method for the early detection of different statuses of liver disease co-occurring with HCV infection.

Alam El-Din, H. M., S. A. Loutfy, N. Fathy, M. H. Elberry, A. M. Mayla, S. Kassem, and A. Naqvi, "Molecular docking based screening of compounds against VP40 from Ebola virus.", Bioinformation, vol. 12, issue 3, pp. 192-196, 2016. Abstract

Ebola virus causes severe and often fatal hemorrhagic fevers in humans. The 2014 Ebola epidemic affected multiple countries. The virus matrix protein (VP40) plays a central role in virus assembly and budding. Since there is no FDA-approved vaccine or medicine against Ebola viral infection, discovering new compounds with different binding patterns against it is required. Therefore, we aim to identify small molecules that target the Arg 134 RNA binding and active site of VP40 protein. 1800 molecules were retrieved from PubChem compound database based on Structure Similarity and Conformers of pyrimidine-2, 4-dione. Molecular docking approach using Lamarckian Genetic Algorithm was carried out to find the potent inhibitors for VP40 based on calculated ligand-protein pairwise interaction energies. The grid maps representing the protein were calculated using auto grid and grid size was set to 60*60*60 points with grid spacing of 0.375 Ǻ. Ten independent docking runs were carried out for each ligand and results were clustered according to the 1.0 Ǻ RMSD criteria. The post-docking analysis showed that binding energies ranged from -8.87 to 0.6 Kcal/mol. We report 7 molecules, which showed promising ADMET results, LD-50, as well as H-bond interaction in the binding pocket. The small molecules discovered could act as potential inhibitors for VP40 and could interfere with virus assembly and budding process.

2015
Loutfy, S. A., M. B. Mohamed, A. M.Tamim, J. R, M. H. Elberry, H. F. Yousef, E. H. El-din, A. M. Abdellah, S. E. I. Elbehairi, and et al, Antiviral and Cytotoxic Activities of Silver Nanoparticles in an in vitro Liver Cancer Model., , 2015.
2014
Abdallah, Z. F., S. M. S. A. Loutfy, M. H. Elberry, A. M. Mayla, and A. - R. N. Zekri, "Presence of Mouse Mammary Tumor Virus (MMTV) like env Sequences among Women with Familial and Non-Familial Breast Cancer", The 5th International Conference of Virology. Hurgada, Egypt, 2014. , 2014.
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