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2023
Abdelhamed, A. I., M. Fahmy, M. Shahien, and A. Elaraby, "The effects of Whole-Body Vibration Training in Patellofemoral Pain Syndrome: A Systematic Review and Meta-Analysis", Archives of Physical Medicine and Rehabilitation, 2023.
Elshennawy, S., A. A. Zahreldin, H. Mortada, M. Hozien, A. S. A. Youssef, A. Galal, M. Shahien, A. Elfeky, A. Elaraby, and M. Hamed, "The Efficacy of Physical Therapy Modalities in Patients With Hemophilia: A Systematic Review of Randomized Controlled Trials With Meta-analysis.", Archives of physical medicine and rehabilitation, vol. 104, issue 3, pp. 475-489, 2023. Abstract

OBJECTIVE: To evaluate the efficacy of different physical therapy interventions that could validate decisions taken by health care providers in the field of rehabilitation of patients with hemophilia according to the International Classification of Functioning, Disability and Health (ICF), including body functions and structures, activity, and participation.

DATA SOURCES: Seven databases-PubMed, Cochrane Library, Scopus, Web of Science, Physiotherapy Evidence Database, Google Scholar, and Clinicaltrials.gov-were systematically searched for randomized controlled trials evaluating any physical therapy modality to manage hemophilia.

STUDY SELECTION: After abstract and full-text filtration, a methodological quality assessment was performed using the Physiotherapy Evidence Database scale for the studies that met the eligibility criteria.

DATA EXTRACTION: Relevant data were extracted from eligible studies and outcomes were categorized according to the ICF.

DATA SYNTHESIS: Using Review Manager and Microsoft Excel, a quantitative analysis using standardized mean differences with the 95% confidence interval was completed. Statistical heterogeneity between studies was explored using the I test. A fixed effect model was applied to all data analyses. If heterogeneity was statistically significant, the Der Simonian and Laird random effects models were used instead.

RESULTS: 35 randomized controlled trials with 1216 participants were included in this systematic review; 13 of them dealt with pediatric patients. Most of the studies were of good quality; 12 studies were of low quality. Meta-analysis showed a significant difference in favor of manual therapy, laser, and therapeutic exercises on selected outcomes of body function and structure, activity, and participation categories of the ICF model.

CONCLUSION: This systematic review recommends using manual therapy and therapeutic exercise modalities to improve join health status in combination with educational sessions to improve the quality of life of patients with hemophilic arthropathy. For pediatric patients with hemophilic arthropathy, using laser therapy is promising for improving functional capacity.

Shahien, M., A. Elaraby, A. I. Abdelhamed, M. Fahmy, and M. Shafiek, "Efficacy of Virtual Reality Interventions on Mood and Cognition in Patients with Multiple Sclerosis. a Systematic Review", Middle East and North Africa Committee of Treatment and Research in Multiple Sclerosis (MENActrims), 2023.
Elaraby, A., M. Shahien, A. M. Jahan, M. Etoom, and A. H. Bekhet, "The Efficacy of Virtual Reality Training in the Rehabilitation of Orthopedic Ankle Injuries: A Systematic Review and Meta-analysis.", Advances in rehabilitation science and practice, vol. 12, pp. 11795727231151636, 2023. Abstract

INTRODUCTION: Orthopedic ankle injuries are considered among the most common musculoskeletal injuries. A wide variety of modalities and techniques have been used for the management of these injuries, and virtual reality (VR) is one modality that has been examined in ankle injuries rehabilitation.

PURPOSE: This study aims to systemically review previous studies evaluating the effect of virtual reality in rehabilitating orthopedic ankle injuries.

METHODS: We searched six online databases: PubMed, Web of Science (WOS), Scopus, the Physiotherapy Evidence Database (PEDro), Virtual Health Library (VHL), and Cochrane Central Register of Controlled Trials (CENTRAL).

RESULTS: Ten randomized clinical trials met the inclusion criteria. Our results showed that VR had a significant effect on overall balance compared to conventional physiotherapy (SMD = 0.359, 0.009-0.710  = 0.04), [ = 17%,  = 0.30]. Compared with conventional physiotherapy, VR programs significantly improved gait parameters such as speed and cadence, muscle power, and perceived ankle instability; however, no significant difference was detected in the foot and ankle ability measure (FAAM). Additionally, significant improvements in static balance and perceived ankle instability were reported after the use of VR balance and strengthening programs. Finally, only two articles were deemed to have good quality, and the other studies' quality ranged from poor to fair.

CONCLUSION: VR rehabilitation programs can be used to rehabilitate ankle injuries, as they are regarded as safe interventions and have promising effects. However, there is a need for studies with high quality since most included studies' quality varied from poor to fair.

Mortada, H., A. A. Zahreldin, M. S. Saleh, M. Shahien, A. Elfeky, A. I. Abdelhamed, A. Elaraby, A. Anwar, Y. S. Hammad, and S. Elshennawy, "The Efficacy of Whole-Body Vibration in Managing Post-burn victims' complications: A Systematic Review.", Journal of burn care & research : official publication of the American Burn Association, 2023. Abstract

Burn injury is a complicated traumatic event with both systemic and local consequences. These complications include long periods of bed rest, pain, muscle weakness, vitamin D deficiency and bone-mineral density loss. Whole body vibration demonstrated effectiveness in improving muscle power and bone-mineral density in various musculoskeletal populations. This systematic review of randomized controlled trials aims to assess evidence for the effectiveness of using whole-body vibration on post burn survivors with at least 1% total body surface area on sensory and motor outcomes. A systematic search was conducted across six databases i.e., PubMed, Cochrane, PEDro, Scopus, Web of Science and Google Scholar, from inception till March 2022. Retrieved studies were screened by title and abstract and full-text in two-stages using Rayyan web-based. Included studies were assessed for risk of bias using the Cochrane risk of bias tool ROB 2.0. Six RCTs with 203 participants were included. Five of the included studies demonstrated overall high risk of bias. Compared to conventional physiotherapy programs, whole-body vibration demonstrated improvement in functional mobility and balance using Timed Up and Go and Biodex balance assessment respectively. However, there were no differences between whole-body vibration and conventional physiotherapy program alone in bone mineral density and muscle power. Although the current evidence of whole-body vibration is limited, whole body vibration combined with traditional physical therapy programs may improve functional mobility and balance in post-burn survivors compared to physical therapy programs alone.

Shahien, M., A. Elaraby, M. Gamal, E. Abdelazim, B. Abdelazeem, H. S. Ghaith, and A. Negida, "Physical therapy interventions for the management of hand tremors in patients with Parkinson's disease: a systematic review.", Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, vol. 44, issue 2, pp. 461-470, 2023. Abstract

BACKGROUND: Several physical therapy modalities have been used to improve hand tremors in patients with Parkinson's disease (PD). However, little is known about the efficacy of these techniques. Therefore, we conducted this study to synthesize evidence from published studies on the efficacy of physical therapy techniques for hand tremors in PD patients.

METHODS: We followed the PRISMA statement and Cochrane handbook guidelines when conducting this study. We conducted an electronic literature search of PubMed, Cochrane Central Register of Clinical Trials, Web of Science, Ovid, and Embase, and then we selected clinical trials assessing the efficacy of any physical therapy intervention for hand tremors in patients with PD. Study outcomes were extracted, and evidence was synthesized narratively.

RESULTS: A total of six modalities described in six studies were included in this systematic review. Out of the six interventions, the tremor's glove and electrical stimulation showed significant improvements in root mean square angular velocity (59% and 43.8%, respectively) and UPDRS tremor score (P < 0.05 for both). Also, eccentric exercises were associated with significant reductions in the mean resting tremor amplitude (P < 0.05). These data were dependent on single studies; therefore, a meta-analysis was not feasible.

CONCLUSION: Several physical therapy interventions, such as electrical stimulation, exercises, transcranial low voltage pulsed electromagnetic fields, weights, and virtual reality showed promising results in reducing hand tremors. However, this evidence was based on a limited number of included studies, and more RCTs with larger sample sizes are required to confirm the efficacy of these interventions.

2022
Elaraby, A., M. Shahein, A. H. Bekhet, P. B. Perrin, and A. S. Gorgey, "The COVID-19 pandemic impacts all domains of quality of life in Egyptians with spinal cord injury: a retrospective longitudinal study.", Spinal cord, vol. 60, issue 8, pp. 757-762, 2022. Abstract

BACKGROUND AND OBJECTIVE: During the COVID-19 pandemic, several aspects of life have been affected. These aspects have been impacted especially in persons with spinal cord injury (SCI). The current study explored the overall effect of the COVID-19 pandemic on quality of life (QOL) domains in persons with SCI as well as evaluated their adherence to WHO-COVID 19-preventive measures.

DESIGN: A retrospective longitudinal study was conducted after asking participants to complete an online validated Arabic version of the WHOQOL-BREF questionnaires including their demographics. The WHOQOL-BREF questionnaires were completed targeting two separate occasions to represent their scores prior to and during the pandemic. Participants were asked to rate their adherence to WHO-COVID-19 preventive measures on a 10-point scale.

SETTING AND PARTICIPANTS: 115 participants with complete/ incomplete SCI were recruited via social media and contacted by phone to complete the questionnaires.

RESULTS: Persons with SCI had lower QOL scores during the COVID-19 period compared to their QOL during the pre-COVID-19 period; all QOL domains (Physical Health, Psychological, Social Relationships, and Environment) showed a significant decrease (P < 0.001). Regarding COVID-19 preventative measures, participants were most likely to endorse self-isolation as well as staying home measures and least likely to adhere to hand washing and social distancing measures.

CONCLUSION: The robustly reduced QOL reported by individuals with SCI during the COVID-19 pandemic highlights the need for rehabilitation and mental health services, particularly administered via telehealth, to buffer the effects of the pandemic. Additionally, psychoeducation and support regarding COVID-19 preventative behaviors in this region would be critical.

Shahien, M., A. Elaraby, M. Gamal, A. Azam, and Y. Samir, "Efficacy of Non-Pharmacological interventions in patients with cervicogenic headache. A Systematic Review", European headach congress, 2022.
Shahien, M., A. Azzam, A. Ramadan, D. Hasan, and A. Elaraby, "Safety and efficacy of treadmill training combined with music on motor outcomes in patients with Parkinson's disease: A systematic review", movement disorder society , 2022.