Gamal, A. A., H. Y. Abbas, N. A. M. Abdelwahed, M. O. N. A. T. KASHEF, K. Mahmoud, M. A. Esawy, and M. A. Ramadan, "Optimization strategy of Bacillus subtilis MT453867 levansucrase and evaluation of levan role in pancreatic cancer treatment", International Journal of Biological Macromolecules, vol. 182, issue 2021, pp. 1590–1601, 2021.
ElDein, M. T. A., A. S. Yassin, O. El‑Tayeb, and M. O. N. A. T. KASHEF, "Chlorhexidine leads to the evolution of antibiotic‑resistant Pseudomonas aeruginosa", European Journal of Clinical Microbiology & Infectious Diseases, vol. 40, pp. 2349–2361, 2021.
Kahef, M. T., and R. K. Aziz, "Drug Factory Microbiome: Top Three Actionable Challenges and Prospects", OMICS A Journal of Integrative Biology, vol. 24, issue 1, pp. 55-56, 2020.
Hosny, A. E. - D. M. S., M. N. Fakhry, W. El-Khayat, and M. O. N. A. T. KASHEF, "Risk factors associated with preterm labor, with special emphasis on preterm premature rupture of membranes and severe preterm labor", Journal of chinese medical association, vol. 83, pp. 280-287, 2020. risk_factors_associated_with_preterm_labor_with.13.pdf
Hosny, A. E. - D. M. S., S. A. Rasmy, D. S. Aboul-Magd, M. O. N. A. T. KASHEF, and Z. E. El-Bazza, "The increasing threat of silver-resistance in clinical isolates from wounds and burns", Infection and drug resistance, vol. 12, pp. 1985-2001, 2019.
Safwat, N. A., M. O. N. A. T. KASHEF, R. K. Aziz, K. F. Amer, and M. A. Ramadan, "Quercetin 3-O-glucoside recovered from the wild Egyptian Sahara plant, Euphorbia paralias L., inhibits glutamine synthetase and has antimycobacterial activity", tuberculosis, vol. 108, pp. 106-113, 2018.
Hosny, A. M. S., M. O. N. A. T. KASHEF, S. A. Rasmy, D. S. Aboul-Magd, and Z. E. El-Bazza, "Antimicrobial activity of silver nanoparticles synthesized using honey and gamma radiation against silver-resistant bacteria from wounds and burns", Advances in Natural Sciences: Nanoscience and Nanotechnology, vol. 8, pp. 045009 (7pp), 2017.
Hosny, A. E. - D. M. S., M. O. N. A. T. KASHEF, H. A. Taher, and Z. E. El-Bazza, "The use of unirradiated and γ-irradiated zinc oxide nanoparticles as a preservative in cosmetic preparations.", International journal of nanomedicine, vol. 12, pp. 6799-6811, 2017. Abstract

PURPOSE: Microbial contamination of different cosmetic preparations, as a result of preservative failure, presents a major public health threat. Also, most of the known preservatives have serious consumer side effects. The antimicrobial activity of zinc oxide nanoparticles (ZnO NP) is well documented. Therefore, we aimed to determine the possible use of unirradiated and γ-irradiated ZnO NP as a cosmetic preservative.

METHODS: The possible use of ZnO NP as a preservative was tested and compared to commonly used preservatives using a challenge test. Their activity was tested in six different types of preparations. The effect of γ radiation on the antimicrobial activity of ZnO NP was tested through determination of the obtained zone diameters against different microorganisms and the total aerobic microbial count in tested preparations. The antimicrobial activity, of unirradiated and γ-irradiated ZnO NP during storage was also determined.

RESULTS: ZnO NP were superior to other commonly used preservatives in all tested cosmetic preparations. They pass the challenge test in all types of tested preparations. γ irradiation enhanced their antimicrobial activity in all tested preparations. The irradiation causes a reduction in NP sizes that is directly proportional to the applied radiation dose. Upon storage, ZnO NP were effective in maintaining the microbial count of the product within the acceptable range. Their activity in stored products was enhanced by γ irradiation.

CONCLUSION: Unirradiated and γ-irradiated ZnO NP can be used as effective preservatives. They are compatible with the components of all tested products. γ irradiation enhanced the antimicrobial activity of ZnO NP.

Akhter, S., R. K. Aziz, M. O. N. A. T. KASHEF, E. S. Ibrahim, B. Bailey, and R. A. Edwards, "Kullback Leibler divergence in complete bacterial and phage genomes.", PeerJ, vol. 5, pp. e4026, 2017. Abstract

The amino acid content of the proteins encoded by a genome may predict the coding potential of that genome and may reflect lifestyle restrictions of the organism. Here, we calculated the Kullback-Leibler divergence from the mean amino acid content as a metric to compare the amino acid composition for a large set of bacterial and phage genome sequences. Using these data, we demonstrate that (i) there is a significant difference between amino acid utilization in different phylogenetic groups of bacteria and phages; (ii) many of the bacteria with the most skewed amino acid utilization profiles, or the bacteria that host phages with the most skewed profiles, are endosymbionts or parasites; (iii) the skews in the distribution are not restricted to certain metabolic processes but are common across all bacterial genomic subsystems; (iv) amino acid utilization profiles strongly correlate with GC content in bacterial genomes but very weakly correlate with the G+C percent in phage genomes. These findings might be exploited to distinguish coding from non-coding sequences in large data sets, such as metagenomic sequence libraries, to help in prioritizing subsequent analyses.

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