@article {67375, title = {Safety and efficacy of rifampicin in children with cholestatic pruritus.}, journal = {Indian journal of pediatrics}, volume = {74}, year = {2007}, note = {n/a}, month = {2007 Mar}, pages = {279-81}, abstract = {

OBJECTIVE: The present study aimed at verifying the safety and efficacy of rifampicin in ameliorating pruritus in cholestatic children.

METHODS: Twenty-three Egyptian children (14 boys and 9 girls), suffering from intractable pruritus of cholestasis, were included. Rifampicin was started at a dose of 10 mg/Kg/day in two divided doses and increased gradually to a maximum of 20 mg/Kg/day if there was no response. Liver function tests were followed up weekly.

RESULTS: Seventeen patients (74\%) showed improvement of pruritus with rifampicin. None of the patients showed any deterioration in liver functions.

CONCLUSION: Rifampicin in a dose of 10-20 mg/Kg/day is safe and effective in ameliorating uncontrollable pruritus in children with persistent cholestasis.

}, keywords = {Adolescent, Child, Child, Preschool, Cholestasis, Female, Humans, Infant, Male, Pruritus, Rifampin}, issn = {0973-7693}, doi = {10.1016/j.dsx.2013.10.008}, author = {Hanaa El-Karaksy and Mansour, Samah and Rokaya El-Sayed and Mona El-Raziky and Nehal El-Koofy and Taha, Gamal} }